PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Tp53 Rchy1 24367557 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rchy1 Chek2 23449389 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G Fads6 Rchy1 ortho Nkd2 Rchy1 ortho G G Rchy1 Polh ortho Rnf2 Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2b Rchy1 ortho P G Cdk9 Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Srprb Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rchy1 Tp73 ortho G Rchy1 Idh3a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tmem14c Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atn1 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Eif3c Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubash3b Rchy1 ortho Rpl3 Rchy1 ortho P Rchy1 Sertad1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc3 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdm4 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Arf4 Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gorab Rchy1 ortho Rbm38 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G Camk2g Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rchy1 Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sema4c Rchy1 ortho Kat5 Rchy1 ortho Ube2d2 Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Arl5a Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Serpina5 Rchy1 ortho G G Tp63 Rchy1 ortho G G G G G G G Rilp Rchy1 ortho Gfi1b Rchy1 ortho G G G Rab11a Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nlk Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Krt8 Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G Msh3 Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk6 Rchy1 ortho P Hoxa2 Rchy1 ortho Lims2 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ar Rchy1 ortho G G G G G G G G G G G G G G G G Mdm2 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Meox2 Rchy1 ortho G G G G G G G G G G Rchy1 Aig1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Camk2a Rchy1 ortho G G G G Cdkn1b Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chd8 Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prdx4 Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Krt18 Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G F7 Rchy1 ortho G G Pmm1 Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp28 Rchy1 ortho Tmbim1 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chkb Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cyba Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Klhl41 Rchy1 ortho P Trim8 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tmem184a Rchy1 ortho G G G G G G G G G G G G G G G G Cope Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdr74 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adamtsl4 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Pgls Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rchy1 Rfwd2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Taok2 Rchy1 ortho Wdpcp Rchy1 ortho G G G G G G G G G Rchy1 Dcun1d5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rchy1 Rpn2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Aox1 Rchy1 ortho GP G G G G G G G G G G G G G G G G G Alg3 Rchy1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G plagl2 Rchy1 ortho G G G G G G G G G G G G G G G G G Krit1 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gm6484 Rchy1 ortho G G G Ube2d1 Rchy1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9CR50 Q9Z265 affinity chromatography technology 23449389 physical association X 2 Q9CR50 Q549C9 enzymatic study 24367557 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Rchy1 Chek2 MI:0004(affinity chromatography technology) 23449389 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_327324 bait prey Tp53 Rchy1 MI:0415(enzymatic study) 24367557 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_333057 prey bait

PPI - HINT Gene A Gene B PMID Method Quality TP53 RCHY1 24367557 0415 LC HOXA2 RCHY1 26496426 0090 LC IRF8 RCHY1 21731497 0007 LC RCHY1 CHEK2 23449389 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9CR50 P31245 RCHY1 HOXA2 0.309 26496426 Q9CR50 P02340 RCHY1 TP53 0.309 24367557 Q9Z265 Q9CR50 CHEK2 RCHY1 0.21 23449389