PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Syne2 Brap 23707952 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map2k1 Brap 18332145 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Numa1 Brap 23707952 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dnmt1 Brap 25820252 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ksr1 Brap 18332145 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Akap3 Brap 25820252 intact exp, ortho G Hras Brap 14724641 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Phlpp1 Brap 25820252 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brap Hmg20a 23707952 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brap Raf1 18332145 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brap Trim8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brap Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brap Chmp1b2 ortho Znf382 Brap ortho MCG2065, isoform CRA_c, PreS1 binding protein, Protein Gltscr2 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Notch1 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brap Lgals2 ortho G G G G G G G G G G Ypel3 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG19772, Protein Trim55 Brap ortho Znf521 Brap ortho G G G G G G G G G G G G G G G G G G G G Tanc2 Brap ortho Brap Ccdc105 ortho Brk1 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ino80 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nup93 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brap Cul2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nedd8 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atmin Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxo28 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Twist1 Brap ortho G G G Smarce1 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brca1 Brap ortho G G G G G G G G G G G G G Usp15 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tex35 Brap ortho Ube2h Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp4 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkb Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Fam184a Brap ortho Cdc14a Brap ortho Braf Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G Sprtn Brap ortho Apoa1 Brap ortho G G G G G G G G G G G G Trim41 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Znf526 Brap ortho Brap Cul1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rbm12 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddb1 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Cenpf Brap ortho G G G G G G G G G G G G G G G G Cdkn1a Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uncharacterized protein C5orf42 homolog Brap ortho Protein Cnksr1 Brap ortho Rangap1 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Klhdc3 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Shcbp1l Brap ortho Oard1 Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brap Efhc1 ortho Nfkbib Brap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q99MP8 Q61097 affinity chromatography technology 18332145 physical association X 2 Q99MP8 Q61097 affinity chromatography technology 18332145 physical association X 2 Q99MP8 affinity chromatography technology 23707952 physical association X 2 Q99MP8 Q6ZWQ0 affinity chromatography technology 23707952 physical association X 2 Q99MP8 affinity chromatography technology 23707952 physical association X 2 Q99MP8 Q6ZWQ0 affinity chromatography technology 23707952 physical association X 2 P31938 Q99MP8 affinity chromatography technology 18332145 physical association X 2 Q99N57 Q99MP8 affinity chromatography technology 18332145 physical association X 2 Q99N57 Q99MP8 affinity chromatography technology 18332145 physical association X 2 Q99MP8 Q61411-2 affinity chromatography technology 14724641 physical association X 2 Q99MP8 Q15843 two hybrid 23554956 direct interaction X 2 Q99MP8 Q9DC33 affinity chromatography technology 23707952 physical association X 2 Q99MP8 Q61097 anti bait coimmunoprecipitation 14724641 association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Map2k1 Brap MI:0004(affinity chromatography technology) 18332145 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322134 prey bait Ksr1 Brap MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18332145 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_322131|BIOGRID_322133 bait|prey prey|bait Brap Raf1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18332145 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_322128|BIOGRID_322132 prey|bait bait|prey Hras1 Brap MI:0004(affinity chromatography technology) 14724641 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321910 bait prey

PPI - HINT Gene A Gene B PMID Method Quality AKAP3 BRAP 25820252,25820252,25820252 0004,0416,0006 LC KSR1 BRAP 14724641,14724641 0019,0006 LC AKAP3 BRAP 25820252,25820252,25820252 0004,0416,0006 LC DNMT1 BRAP 25820252,25820252 0004,0006 LC MAP2K1 BRAP 18332145 0004 LC KSR1 BRAP 18332145,14724641,14724641 0004,0019,0006 LC HRAS BRAP 14724641 0004 LC SYNE2 BRAP 23707952 0004 LC NUMA1 BRAP 23707952 0004 LC PHLPP1 BRAP 25820252,25820252 0004,0006 LC BRAP RAF1 18332145 0004 LC BRAP HMG20A 23707952 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q99MP8 Q61411 BRAP HRAS 0.21 14724641 Q99MP8 Q8CHE4 BRAP PHLPP1 0.416 25820252 Q99MP8 P13864 BRAP DNMT1 0.236 25820252 Q99MP8 O88987 BRAP AKAP3 0.463 25820252 Q99MP8 P31938 BRAP MAP2K1 0.21 18332145 Q99MP8 Q61097 BRAP KSR1 0.376 18332145 Q99MP8 Q6ZWQ0 BRAP SYNE2 0.376 23707952 Q99N57 Q99MP8 RAF1 BRAP 0.376 18332145 Q9DC33 Q99MP8 HMG20A BRAP 0.21 23707952 Q99MP8 Q15843 BRAP NEDD8 0.309 23554956