PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ubb Trim21 23222971 intact exp Trim21 Siglec10 23374343 intact exp Trim21 Psmd6 23222971 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc2 Trim21 23222971 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd1 Trim21 23222971 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Protein Uvrag 26590968 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc6 Trim21 23222971 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Stat1 Trim21 23222971 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc4 Trim21 23222971 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Psmd2 23222971 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd3 Trim21 23222971 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Ddx41 23222971 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G Psmc1 Trim21 23222971 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Uba52 Trim21 23222971 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Psmd11 23222971 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd14 Trim21 23222971 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc5 Trim21 23222971 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G Fcgr2 Trim21 18420815 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G Rps27a Trim21 23222971 intact exp Ubc Trim21 23222971 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Irf8 Trim21 17579016 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Sqstm1 19201866 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Uba1 Trim21 23222971 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Ube2v1 23222971 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Trim21 23222971 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Rnf111 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Ube2c ortho G G G G G G G G G G G G G G G G G Trim21 Ago4 ortho Fcgr3 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Cdc5l ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Irf3 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Cul1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Iqcb1 ortho Trim21 Rbck1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Usp4 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Skp2 ortho G G G G G G G G G G G G Usp19 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Dzip3 ortho Trim21 Gabarapl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ncoa1 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Dcp2 ortho Trim21 Casp8ap2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Myc Trim21 ortho G G G G G G G G G G G G G G G G G G G G G Hsp90ab1 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Trim39 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Txn2 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Fadd Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G Irf5 Trim21 ortho G G G G G G G G G G G G G G G G G G G Usp2 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G Tnni3 Trim21 ortho G G G G G G G Mnat1 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 Trim21 ortho G G G G Apc Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Map1lc3b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d1 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Daxx Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Erg Trim21 ortho Irf7 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Ago3 ortho Ube2l3 Trim21 ortho Nos2 Trim21 ortho G Vcp Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Ror1 ortho Trove2 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G Trim21 Nif3l1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Crebbp Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Cbl Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Map1lc3a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk2 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G Ncoa3 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G Cdkn1b Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Haus2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Ywhaz Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Ptbp3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2n Trim21 ortho Hdac1 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxw11 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Fbxo6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Gabarapl2 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Pfkfb2 Trim21 ortho G G G Trim21 Skp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2h Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2i Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkb Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Npm1 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Trim8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Gja1 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Usp15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Zfpm1 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G Ywhag Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Pan2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim27 Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Trim21 Grap ortho Eef1d Trim21 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q62191 anti bait coimmunoprecipitation 23222971 association C 21 Q62191 anti tag coimmunoprecipitation 23374343 association C 4 Q62191 Q91VN6 anti tag coimmunoprecipitation 23222971 physical association X 2 Q62191 Q91VN6 anti bait coimmunoprecipitation 23222971 physical association X 2 Q62191 Q91VN6 anti tag coimmunoprecipitation 23222971 physical association X 2 Q62191 Q91VN6 confocal microscopy 23222971 colocalization X 2 Q62191 Q91VN6 anti bait coimmunoprecipitation 23222971 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Trim21 Ddx41 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 23222971 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_173932|UniProt_173934|UniProt_173933|UniProt_173936|UniProt_173935|UniProt_173931 bait|prey|prey|neutral component|bait|bait prey|bait|bait|neutral component|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality IGHG TRIM21 18420815 0114 LC TRIM21 TRIM21 18420815 0114 LC PSMD14 TRIM21 23222971 0006 LC FCGR2 TRIM21 18420815,18420815 0004,0096 LC UBB TRIM21 23222971 0006 LC UBC TRIM21 23222971 0006 LC PSMD3 TRIM21 23222971 0006 LC IRF8 TRIM21 17579016,17579016 0007,0069 LC NFKB1 TRIM21 21343618 0007 LC STAT1 TRIM21 23222971 0006 LC PSMC2 TRIM21 23222971 0006 LC PSMC4 TRIM21 23222971 0006 LC PSMC1 TRIM21 23222971 0006 LC PSMC5 TRIM21 23222971 0006 LC PSMC6 TRIM21 23222971 0006 LC RPS27A TRIM21 23222971 0006 LC UBA52 TRIM21 23222971 0006 LC UBA1 TRIM21 23222971 0006 LC PSMD1 TRIM21 23222971 0006 LC TRIM21 TRIM21 23222971 0006 LC TRIM21 SQSTM1 19201866 0007 LC TRIM21 SIGLECG 23374343 0007 LC TRIM21 PSMD11 23222971 0006 LC TRIM21 UVRAG 26590968 0004 LC TRIM21 PSMD2 23222971 0006 LC TRIM21 DDX41 23222971,23222971,23222971,23222971 0004,0663,0007,0006 LC TRIM21 PSMD6 23222971 0006 LC TRIM21 UBE2V1 23222971 0006 LC TRIM21 STAT2 21343618 0007 LC