PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Bcar1 Cul5 24284072 biogrid exp Bcar1 Stat2 15102471 intact exp G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Inpp5d 16601135 biogrid exp G G G G G G G G G G G G G G G G G G G G Nck2 Bcar1 20637038 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Socs6 24284072 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Nrp1 Bcar1 24021649 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lyn Bcar1 10428862 mint,intact exp, ortho Fyn Bcar1 15102471 i2d,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Crk 9729467 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Pxn 16478788 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Crkl Bcar1 8978305 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptk2 Bcar1 9038154,7479864,18233957 biogrid,i2d,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Nphp1 10739664 i2d,intact exp, ortho G G G G G G G G G G G G G G G G G G G Bcar1 Nck1 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Src Bcar1 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Srcin1 14657239 intact exp, ortho Ywhae Bcar1 16615898 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h1c Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casp3 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Itgav Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hist1h2bm Bcar1 ortho Sfn Bcar1 ortho G G G G G G G G Id2 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Egfr Bcar1 ortho G G G G G G G G G G G G G G G G G G Ptpn12 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bmx Bcar1 ortho G Bcar1 Bcar3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tns3 Bcar1 ortho Bcar1 Cspg4 ortho G G G G G G G G G G G G G G G Bcar1 Armcx3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Gmpr2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptpra Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mmp14 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tuba4a Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mapk14 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snrpd3 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Ajuba ortho G G G G G G G G G G G G G G G G G Protein Rapgef1 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Set ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pkd1 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Snrpd1 Bcar1 ortho Actb Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Peak1 ortho G G G G Alk Bcar1 ortho G G G G G Pik3r1 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Tuba1b Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa5 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Zyx ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Arhgap32 ortho Bcar1 Vcl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gsn Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Rpl38 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G E2f2 Bcar1 ortho Ywhaz Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Sh2d3c ortho G G G G G G G G G G G G G G G G G Bcar1 Kifc1 ortho G G G G G G G G G G G G G Nedd9 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G Hist1h2ab, Hist1h2ac, Hist1h2ad, Hist1h2ae, Hist1h2ag, Hist1h2ai, Hist1h2an, Hist1h2ao Bcar1 ortho Bcar1 Tsen34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptprf Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr1 Bcar1 ortho G G G G G Abl1 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptpn1 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Erh Bcar1 ortho Ywhah Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Hyou1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ran Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Tns1 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Dock1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Uhrf2 ortho Ptpn11 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Epn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hck Bcar1 ortho G G G G G G G G G G G G G G G G G G Bcar1 Efs ortho G G G G G G G G G G G G G G G G G G G G Bcar1 Sh3kbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Eef1g ortho Bcar1 Trip6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Fyb Bcar1 ortho G G G G G G G G G G G G G G G G Lck Bcar1 ortho G G G G G G G G G G G G Grb2 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Vps11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Ppap2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct2 Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Fxyd6 ortho G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Inppl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Mapk8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbl Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp1r15a Bcar1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fes Bcar1 ortho G G G G G G G G Bcar1 Ptk2b ortho G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q64010 Q61140 - 11884618 - X 2 Q64010 Q61140 - 9729467 - X 2 Q61140 - 9032297 - X 2 Q61140 - 7479864 - X 2 Q61140 - 10739664 - X 2 A2APS1 Q61140 - 10739664 - X 2 Q61140 Q99M51 - 9032297 - X 2 Q61140 - 9032297 - X 2 Q61140 - 11278488 - X 2 Q61140 - 10739664 - X 2 Q61140 cosedimentation 16615898 colocalization C 1216 P34152 Q61140 anti bait coimmunoprecipitation 18233957 physical association X 2 P34152 Q61140 two hybrid 7479864 physical association X 2 P34152 Q61140 coimmunoprecipitation 7479864 physical association X 2 P39688 Q61140 two hybrid 15102471 physical association X 2 P97333 Q61140 fluorescence microscopy 24021649 colocalization X 2 P97333 Q61140 anti bait coimmunoprecipitation 24021649 physical association X 2 Q9QY53 Q61140 two hybrid 10739664 physical association X 2 Q9QY53 Q61140 coimmunoprecipitation 10739664 physical association X 2 P25911 Q61140 experimental interaction detection 10428862 phosphorylation reaction X 2 Q00944 Q61140 anti tag coimmunoprecipitation 9425168 physical association X 2 Q63768 Q61140 anti bait coimmunoprecipitation 12023880 physical association X 2 Q9QXJ2 Q61140 two hybrid 15102471 physical association X 2 Q9C0H9 Q61140 affinity chromatography technology 14657239 physical association X 2 Q9QWI6 Q61140 pull down 14657239 physical association X 2 Q9QWI6 Q61140 pull down 14657239 physical association X 2 Q8BQ28 Q61140 fluorescence microscopy 20637038 colocalization X 2 Q61140 A8K3M3 pull down 12023880 physical association X 2 Q61140 A8K3M3 anti tag coimmunoprecipitation 12023880 physical association X 2 Q61140 Q8VI36 fluorescence microscopy 16478788 colocalization X 2 Q61140 A8K3M3 phosphatase assay 16644720 dephosphorylation reaction X 2 Q61140 A8K3M3 phosphatase assay 9418872 dephosphorylation reaction X 2 Q61140 P05433 anti bait coimmunoprecipitation 9418872 physical association X 2 Q61140 A8K3M3 phosphatase assay 9418872 dephosphorylation reaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Bcar1 Srcin1 MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 14657239,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact) UniProt_167115|UniProt_167116|UniProt_161863|UniProt_161864 neutral component|neutral component|prey|bait neutral component|neutral component|bait|prey Bcar1 Stat2 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_163268 prey bait Ptk2 Bcar1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10,18233957,7479864,9038154 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact)|MI:0471(mint)|(biogrid)|(biogrid) UniProt_176723|UniProt_176724|UniProt_169312|MINT_74698|BIOGRID_321252|BIOGRID_321253 prey|bait|bait|bait|bait|bait bait|prey|prey|prey|prey|prey Bcar1 Cul5 MI:0004(affinity chromatography technology) 24284072 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_333027 prey bait Bcar1 Nphp1 MI:0018(two hybrid)|MI:0018(two hybrid) 10739664 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_160066|UniProt_160067 bait|bait prey|prey Bcar1 Socs6 MI:0004(affinity chromatography technology) 24284072 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_333028 prey bait Lyn Bcar1 MI:0096(pull down)|MI:0096(pull down) 10428862 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0217(phosphorylation reaction)|MI:0217(phosphorylation reaction) (intact)|MI:0471(mint) UniProt_161686|MINT_59914 unspecified role|unspecified role unspecified role|unspecified role Bcar1 Crk MI:0047(far western blotting) 9729467 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_329473 prey bait Fyn Bcar1 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_164972 bait prey Bcar1 Nck2 MI:0416(fluorescence microscopy) 20637038 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (intact) UniProt_173307 neutral component neutral component Bcar1 Inpp5d MI:0004(affinity chromatography technology) 16601135 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322035 prey bait Bcar1 Pxn MI:0027(cosedimentation)|MI:0055(fluorescent resonance energy transfer)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 16478788,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (intact)|(intact)|(intact)|(intact) UniProt_167130|UniProt_166055|UniProt_167122|UniProt_167134 neutral component|neutral component|neutral component|neutral component neutral component|neutral component|neutral component|neutral component Nrp1 Bcar1 MI:0027(cosedimentation)|MI:0107(surface plasmon resonance)|MI:0107(surface plasmon resonance) 16615898,24021649 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_167132|UniProt_177788|UniProt_177791 neutral component|unspecified role|bait neutral component|unspecified role|prey Crkl Bcar1 MI:0027(cosedimentation)|MI:0004(affinity chromatography technology) 16615898,8978305 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association) (intact)|(biogrid) UniProt_167130|BIOGRID_322764 neutral component|bait neutral component|prey

PPI - HINT Gene A Gene B PMID Method Quality NCK2 BCAR1 20637038 0416 LC SRC BCAR1 9032297,10739664,9032297,9032297 0045,0018,0019,0004 LC LYN BCAR1 10428862 0045 LC PTK2 BCAR1 9032297,9038154,9038154,9032297,7479864,7479864 0045,0018,0004,0019,0019,0018 LC FYN BCAR1 10739664,15102471 0018,0018 LC YWHAE BCAR1 16615898 0027 LC NRP1 BCAR1 24021649,24021649 0006,0416 LC BCAR1 CRK 15793570,11884618 0019,0019 LC BCAR1 PXN 16478788 0416 LC BCAR1 NCK1 9032297 0019 LC BCAR1 NPHP1 10739664,10739664 0019,0018 LC BCAR1 STAT2 15102471 0018 LC SRC BCAR1 11278488,9032297,9032297,9032297 0004,0045,0019,0004 LC PTK2 BCAR1 18233957,9038154,9038154 0006,0018,0004 LC CRKL BCAR1 8978305 0004 LC NRP1 BCAR1 24021649,24021649 0006,0416 LC BCAR1 CRK 9729467 0004 LC BCAR1 CUL5 24284072 0004 LC BCAR1 INPP5D 16601135 0004 LC BCAR1 SOCS6 24284072 0004 LC BCAR1 SRCIN1 14657239 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q61140 P05480 BCAR1 SRC 0.21 11038351 Q61140 P18031 BCAR1 PTPN1 0.436 12023880,9418872,16644720 Q61140 P39688 BCAR1 FYN 0.183 15102471 Q9QXJ2 Q61140 STAT2 BCAR1 0.183 15102471 Q61140 P62259 BCAR1 YWHAE 0.081 16615898 Q9JLY0 Q61140 SOCS6 BCAR1 0.21 24284072 Q63768 Q61140 CRK BCAR1 0.21 12023880 Q64010 Q61140 CRK BCAR1 0.21 9729467 Q8BQ28 Q61140 NCK2 BCAR1 0.126 20637038 Q61140 P05433 BCAR1 P05433 0.21 9418872 Q61140 P34152 BCAR1 PTK2 0.765 7479864,18233957,9038154 Q61140 P07332 BCAR1 FES 0.623 8999909 Q61140 P25911 BCAR1 LYN 0.033 10428862 Q9D5V5 Q61140 CUL5 BCAR1 0.21 24284072 Q9ES52 Q61140 INPP5D BCAR1 0.21 16601135 Q61140 P47941 BCAR1 CRKL 0.21 8978305 Q61140 P97333 BCAR1 NRP1 0.309 24021649