PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Lepr Cish 16684815,16698021 innatedb,biogrid,mint,intact exp G G G G G G G G G Csf2rb Cish 7796808 innatedb exp G G G G G G G Abl1 Cish 11274764 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csf2rb2 Cish 7796808 dip exp G G G G G G G G G Bcl2l11 Cish 18420585 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkcb Cish 12618484 innatedb,biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Cish Cul5 18508766,19385048 innatedb,biogrid exp, ortho Epor Cish 7796808,12441334 innatedb,biogrid,dip exp, ortho G G G G G G G G G G G G G G G G G Prkca Cish 12618484 innatedb,biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G Prkcq Cish 12618484,10727460 innatedb,biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G Socs2 Cish 16684815,16956890 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ghr Cish ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Cish ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tceb1 Cish ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lck Cish ortho G G G G G G G G G G G G G G Kit Cish ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Cish Etv5 ortho G G G G G G G G G G G G Dynll1 Cish ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cish Nfkbia ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cish Smad2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myd88 Cish ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csf3r Cish ortho G G G G G G G Erbb2 Cish ortho G G G G G G G G G G G G Cish Ccnc ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Egfr Cish ortho G G G G G G G G G G G G G G G G G G Il3ra Cish ortho G G G Cish Tbc1d10b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccne1 Cish ortho G G G G G G G G G Il2rb Cish ortho G G G G G G Cish Cul2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb2l1 Cish ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prlr Cish ortho G G G G G G G G G G G G G G G G G G Ambra1 Cish ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q62225 - 12618484 - X 2 Q62225 - 12618484 - X 2 Q62225 - 12618484 - X 2 Q02111 Q62225 - 12618484 - X 2 Q62225 P0CG50 affinity chromatography technology 11274764 physical association X 2 Q62225 O35717 affinity chromatography technology 16684815 physical association X 2 Q62225 P19941 two hybrid 17666591 direct interaction X 2 Q62225 Q15369-2 biochemical 19385048 association X 2 Q62225 Q15369-2 x-ray crystallography 19385048 association X 2 Q62225 Q15369-2 pull down 19385048 direct interaction X 2 Q62225 Q9D5V5 pull down 19385048 direct interaction X 2 Q62225 affinity chromatography technology 12618484 physical association X 2 Q62225 affinity chromatography technology 11274764 physical association X 2 Q62225 P20444 affinity chromatography technology 12618484 physical association X 2 Q62225 P14753 affinity chromatography technology 12441334 physical association X 2 Q62225 P48356-3 affinity chromatography technology 16684815 physical association X 2 Q62225 Q15370-2 biochemical 19385048 association X 2 Q62225 Q15370-2 x-ray crystallography 19385048 association X 2 Q62225 Q15370-2 pull down 19385048 direct interaction X 2 Q02111 Q62225 affinity chromatography technology 12618484 physical association X 2 Q02111 Q62225 affinity chromatography technology 12618484 physical association X 2 Q62225 P14753 coimmunoprecipitation 7796808 physical association X 2 Q62225 P26954 coimmunoprecipitation 7796808 physical association X 2 Q62225 P19941 two hybrid 17666591 physical association X 2 Q62225 P19941 coimmunoprecipitation 17666591 association X 2 Q62225 P19235 mammalian protein protein interaction trap 11781573 physical association X 2 Q62225 P19235 mammalian protein protein interaction trap 15644415 physical association X 2 Q62225 P19235 mammalian protein protein interaction trap 15644415 physical association X 2 Q62225 P19235 mammalian protein protein interaction trap 15644415 physical association X 2 Q62225 P48356 two hybrid 16698021 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Lepr Cish MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 16684815,16698021 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint) UniProt_166884|BIOGRID_325476|MINT_81483 bait|bait|bait prey|prey|prey Prkca Cish MI:0004(affinity chromatography technology) 12618484 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324027 prey bait Socs2 Cish MI:0004(affinity chromatography technology) 16684815 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325477 bait prey Epor Cish MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology) 12441334,7796808 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid) DIP_32|BIOGRID_325228 -|bait -|prey Cish Cul5 MI:0401(biochemical) 19385048 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_319475 prey bait Ubc Cish MI:0415(enzymatic study) 11274764 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321784 prey bait Prkcb Cish MI:0004(affinity chromatography technology) 12618484 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324028 prey bait Abl1 Cish MI:0415(enzymatic study) 11274764 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321783 prey bait Prkcq Cish MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 12618484 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_327216|BIOGRID_324029 bait|prey prey|bait Csf2rb2 Cish MI:0019(coimmunoprecipitation) 7796808 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) MI:0465(dip) DIP_31 - -

PPI - HINT Gene A Gene B PMID Method Quality SOCS2 CISH 16684815,16684815,16684815 0232,0004,0007 LC EPOR CISH 7796808,7796808 0019,0007 LC CSF2RB2 CISH 7796808 0019 LC STAT5A CISH 9129017 0232 LC LEPR CISH 16698021 0018 LC SOCS2 CISH 16684815,16956890,16684815,16684815 0232,0007,0004,0007 LC BCL2L11 CISH 18420585 0007 LC ABL1 CISH 11274764,11274764 0004,0096 LC UBC CISH 11274764 0004 LC EPOR CISH 7796808,7796808,12441334 0019,0007,0004 LC PRKCA CISH 12618484 0004 LC CSF2RB CISH 7796808 0007 LC LEPR CISH 16684815 0004 LC PRKCB CISH 12618484 0004 LC PRKCQ CISH 12618484,12618484,10727460 0004,0007,0007 LC CISH CUL5 18508766,19385048 0007,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q62225 P20444 CISH PRKCA 0.21 12618484 Q62225 P68404 CISH PRKCB 0.21 12618484 Q62225 O35717 CISH SOCS2 0.21 16684815 Q62225 P14753 CISH EPOR 0.236 7796808,12441334 Q62225 P00520 CISH ABL1 0.454 11274764 Q62225 P48356 CISH LEPR 0.454 16698021,16684815 Q62225 Q15369 CISH TCEB1 0.416 19385048 Q62225 Q15370 CISH TCEB2 0.416 19385048 Q62225 P19941 CISH GHR 0.623 17666591 Q62225 P26954 CISH CSF2RB2 0.033 7796808 Q9D5V5 Q62225 CUL5 CISH 0.183 19385048 Q62225 P19235 CISH EPOR 0.376 15644415,11781573 Q62225 Q02111 CISH PRKCQ 0.376 12618484