PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Vti1b Vps18 14668490 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps18 Eed 24457600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Stx1a Vps18 14623309 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G Vps41 Vps18 14668490 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Uvrag Vps18 26590968 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Hook1 Vps18 14668490 biogrid exp, ortho P Vps18 Stx6 14623309,14668490 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Stx8 Vps18 14623309 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps18 Vps39 14668490 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Stx7 Vps18 14623309,14668490 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Vps45 Vps18 14623309,14668490 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Vps18 Stx12 14668490 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Vps18 Vps16 14668490 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Vamp8 Vps18 14668490 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ldlrad4 Vps18 ortho G Zgrf1 Vps18 ortho Rab7a Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Vps18 Copb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Mia3 Vps18 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Aktip Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Tsen2 Vps18 ortho Ep300 Vps18 ortho P Rilp Vps18 ortho Tgfbrap1 Vps18 ortho Dnajb5 Vps18 ortho G G G G G G G G G G G G G G G G G G G G G G G Bin1 Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Vps18 Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G MCG140784, Protein Try10, Trypsin 10, Trypsinogen 10 Vps18 ortho P Polr1a Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Mon1b Vps18 ortho Vps18 Vps33a ortho P Smad1 Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Vps18 Synpo2 ortho GP G G G G G G G Utp20 Vps18 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Vps18 Serinc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps18 Rsrc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps8 Vps18 ortho Ube2d2 Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Vcp Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ntrk1 Vps18 ortho Elmo3 Vps18 ortho GP G G G G G G G G G G G G G G G G Gga3 Vps18 ortho Vps18 Vps11 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ccna1 Vps18 ortho G Vps18 Scly ortho G G G G G G G G G G G G G G G G G G G G G G G G Aldoa Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Med23 Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Gga1 Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Vps18 Tjap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90ab1 Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Upp1 Vps18 ortho P G G G G G G G G G G G Mta1 Vps18 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Ndufv3 Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Obscn Vps18 ortho P Gga2 Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8BIL5 Q8R307 affinity chromatography technology 14668490 physical association X 2 Q8BIL5 Q8R307 affinity chromatography technology 14668490 physical association X 2 O88983 Q8R307 affinity chromatography technology 14623309 physical association X 2 O35526 Q8R307 affinity chromatography technology 14623309 physical association X 2 Q8R307 B4DMB7 affinity chromatography technology 19109425 physical association X 2 Q8R307 B4DMB7 biochemical 19109425 colocalization X 2 Q8R307 B4DMB7 affinity chromatography technology 19109425 physical association X 2 Q8R307 Q3USV9 affinity chromatography technology 14668490 physical association X 2 Q8R307 affinity chromatography technology 14668490 physical association X 2 Q8R307 Q9ER00 affinity chromatography technology 14668490 physical association X 2 Q8R307 Q921E6 affinity chromatography technology 24457600 physical association X 2 Q9H267 Q8R307 affinity chromatography technology 19109425 physical association X 2 Q8R307 Q9JKK1 affinity chromatography technology 14623309 physical association X 2 Q8R307 affinity chromatography technology 14623309 physical association X 2 Q8R307 P97390 affinity chromatography technology 14623309 physical association X 2 Q8R307 affinity chromatography technology 14668490 physical association X 2 Q8R307 P97390 affinity chromatography technology 14668490 physical association X 2 Q8R307 Q9JKK1 affinity chromatography technology 14668490 physical association X 2 Q8R307 affinity chromatography technology 14668490 physical association X 2 Q8R307 affinity chromatography technology 14668490 physical association X 2 Q5KU39 Q8R307 affinity chromatography technology 14668490 physical association X 2 Q8R307 cosedimentation 19109425 physical association C 3 Q8R307 anti bait coimmunoprecipitation 19109425 association C 3 Q8R307 anti tag coimmunoprecipitation 19109425 association C 3 Q6IA61 Q8R307 anti bait coimmunoprecipitation 19109425 physical association X 2 Q6IA61 Q8R307 anti tag coimmunoprecipitation 19109425 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Vps16 Vps18 MI:0004(affinity chromatography technology)|MI:0047(far western blotting)|MI:0047(far western blotting) 14668490,19109425 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact) BIOGRID_328019|UniProt_99040|UniProt_168514 prey|neutral component|neutral component bait|neutral component|neutral component Vps18 Stx12 MI:0004(affinity chromatography technology) 14668490 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328024 bait prey Vti1b Vps18 MI:0004(affinity chromatography technology) 14668490 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328023 prey bait Eed Vps18 MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332605 bait prey Vps18 Vps39 MI:0004(affinity chromatography technology) 14668490 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328018 bait prey Vps45 Vps18 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 14623309,14668490 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_328009|BIOGRID_328020 prey|prey bait|bait Vps18 Stx6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 14623309,14668490 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_328021|BIOGRID_328006 bait|bait prey|prey Stx1a Vps18 MI:0004(affinity chromatography technology) 14623309 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328005 prey bait Vamp8 Vps18 MI:0004(affinity chromatography technology) 14668490 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328025 prey bait Stx8 Vps18 MI:0004(affinity chromatography technology) 14623309 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328008 prey bait Hook1 Vps18 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 14668490 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_328026|BIOGRID_328016 bait|prey prey|bait Stx7 Vps18 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 14623309,14668490 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_328022|BIOGRID_328007 prey|prey bait|bait Vps41 Vps18 MI:0004(affinity chromatography technology) 14668490 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328017 prey bait

PPI - HINT Gene A Gene B PMID Method Quality STX1A VPS18 14623309 0004 LC VAMP8 VPS18 14668490 0004 LC STX7 VPS18 14623309,14668490 0004,0004 LC VTI1B VPS18 14668490 0004 LC STX8 VPS18 14623309 0004 LC VPS45 VPS18 14623309,14668490 0004,0004 LC VPS41 VPS18 14668490 0004 LC HOOK1 VPS18 14668490 0004 LC UVRAG VPS18 26590968 0004 LC VPS18 VPS39 14668490 0004 LC VPS18 VPS16 14668490 0004 LC VPS18 EED 24457600 0004 LC VPS18 STX12 14668490 0004 LC VPS18 STX6 14623309,14668490 0004,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8R307 O14617 VPS18 AP3D1 0.21 21411634 Q8R307 Q8K245 VPS18 UVRAG 0.21 26590968 Q8R307 O35526 VPS18 STX1A 0.21 14623309 Q8R307 O70404 VPS18 VAMP8 0.21 14668490 Q8R307 O88983 VPS18 STX8 0.21 14623309 Q8R307 Q5KU39 VPS18 VPS41 0.21 14668490 Q8R307 Q8BIL5 VPS18 HOOK1 0.376 14668490 Q8R5L3 Q8R307 VPS39 VPS18 0.21 14668490 Q9ER00 Q8R307 STX12 VPS18 0.21 14668490 Q9H267 Q8R307 VPS33B VPS18 0.21 19109425 Q9H9C1 Q8R307 VIPAS39 VPS18 0.832 19109425 Q8R307 P97390 VPS18 VPS45 0.376 14668490,14623309 Q9JKK1 Q8R307 STX6 VPS18 0.376 14668490,14623309 Q921E6 Q8R307 EED VPS18 0.126 24457600