PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Epn1 Itsn1 17380122 mint,intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Epn1 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Eed 24457600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uba52 Epn1 19536136 mint,intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Ehd2 21115825 dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Ehd1 21115825 dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Flt4 Epn1 25314967 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G Epn1 Gtf3a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Gas2l1 ortho Ocln Epn1 ortho G G G G G G G G G G G G G G G G G G G G G G Cep126 Epn1 ortho Cdk1 Epn1 ortho G G G G G G G G G G G G G G G G G G G G G Epn1 Ufl1 ortho P Mov10 Epn1 ortho G G G G G G G G G G G G G G G G G G G G Smad1 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Ubqln2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Egfr Epn1 ortho GP G G G G G G G G G G G G G G G G G Scnn1a Epn1 ortho G G G G G G G G G G G G G G G G G G Vcam1 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15l1 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G MCG49644, Protein Tada2b Epn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ap1b1 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ap2m1 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tfap2a Epn1 ortho G G G G G G Laptm5 Epn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Scnn1g ortho G G Ap2a2 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2n Epn1 ortho P Epn1 Reps2 ortho P Ptpn12 Epn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ppp5c Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Plekhb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Arrdc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fn1 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ralbp1 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eps15 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Slc6a3 Epn1 ortho G Epn1 Tmem17 ortho Itga4 Epn1 ortho G G G G Ntrk1 Epn1 ortho Tuba1a Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad5 Epn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Met Epn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Ldlrad4 ortho G MCG3834, Protein Zbtb16, Zinc finger and BTB domain containing 16 Epn1 ortho G G G G G G G G G G G G G G G G G G Epn1 Dazap2 ortho Epn1 Ube2v1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubb Epn1 ortho P Crmp1 Epn1 ortho P G G G G G G G G G G Epn1 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Cnot10 ortho P Epn1 Med31 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uba1 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Epn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Notch1 Epn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Xpo1 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Clta Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dll1 Epn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ubiquitin carboxyl-terminal hydrolase Epn1 ortho P Phgdh Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Cltc Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k1 Epn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ap2a1 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Slc25a41 ortho Epn1 Gtse1 ortho G G G G G Pik3r1 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Fbxo25 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Epn3 ortho P G G G G G G G G G G Ap1g1 Epn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epn1 Ap1m2 ortho G G G G G G G G G G G G G G G G G Epn1 Scnn1b ortho G G G G G G G G G Epn1 Lppr2 ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q80VP1 O42287 pull down 9813051 direct interaction X 2 Q80VP1 enzymatic study 25260751 direct interaction X 2 Q80VP1 P35917 affinity chromatography technology 25314967 physical association X 2 Q80VP1 Q921E6 affinity chromatography technology 24457600 physical association X 2 Q80VP1 pull down 21115825 - C 3 Q80VP1 pull down 21115825 - C 3 Q80VP1 pull down 21115825 - C 3 Q80VP1 Q8BH64 pull down 21115825 physical association X 2 Q9WVK4 Q80VP1 pull down 21115825 physical association X 2 P42566 Q80VP1 pull down 21115825 physical association X 2 Q80VP1 Q9Z0R4 two hybrid 17380122 physical association X 2 Q80VP1 P62984 pull down 19536136 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Epn1 Itsn1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 16615898,17380122 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization) (intact)|(intact)|MI:0471(mint)|(intact)|(intact)|(intact) UniProt_90244|UniProt_184119|MINT_86795|UniProt_167505|UniProt_167115|UniProt_167114 prey|prey|prey|prey|neutral component|neutral component bait|bait|bait|bait|neutral component|neutral component Ubb Epn1 MI:0114(x-ray crystallography)|MI:0096(pull down)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 10,16615898,19536136 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0403(colocalization) MI:0471(mint)|(intact)|(intact)|(intact) MINT_77055|UniProt_170970|UniProt_167115|UniProt_167114 prey|prey|neutral component|neutral component bait|bait|neutral component|neutral component Epn1 Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332559 prey bait

PPI - HINT Gene A Gene B PMID Method Quality YWHAE EPN1 16615898 0027 LC EPN1 ITSN1 17380122 0018 LC UBC EPN1 19536136 0096 LC FLT4 EPN1 25314967 0004 LC UBA52 EPN1 19536136 0096 LC EPN1 EHD2 21115825 0096 LC EPN1 EED 24457600 0004 LC EPN1 EHD1 21115825 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q80VP1 P62259 EPN1 YWHAE 0.081 16615898 Q80VP1 O42287 EPN1 ITSN1 0.309 9813051 Q80VP1 P35917 EPN1 FLT4 0.21 25314967 Q80VP1 P62991 EPN1 UBA52 0.309 19536136 Q9Z0R4 Q80VP1 ITSN1 EPN1 0.309 17380122 Q921E6 Q80VP1 EED EPN1 0.126 24457600