PTM - CPLM Gene Name UniProt ID Type Position Code Epn1 Q80VP1 Ubiquitination 86 K Epn1 Q80VP1 Ubiquitination 107 K Epn1 Q80VP1 Ubiquitination 117 K Epn1 Q80VP1 Ubiquitination 128 K Epn1 Q80VP1 Ubiquitination 468 K Epn1 Q80VP1 Ubiquitination 246 K Epn1 Q80VP1 Ubiquitination 97 K

PTM - dbPAF Gene Name UniProt ID Position Type Species Epn1 Q80VP1 411 T Mus musculus(Mouse) Epn1 Q80VP1 415 T Mus musculus(Mouse) Epn1 Q80VP1 416 S Mus musculus(Mouse) Epn1 Q80VP1 418 S Mus musculus(Mouse) Epn1 Q80VP1 419 S Mus musculus(Mouse) Epn1 Q80VP1 420 T Mus musculus(Mouse) Epn1 Q80VP1 434 S Mus musculus(Mouse) Epn1 Q80VP1 450 S Mus musculus(Mouse) Epn1 Q80VP1 453 S Mus musculus(Mouse) Epn1 Q80VP1 459 T Mus musculus(Mouse) Epn1 Q80VP1 461 T Mus musculus(Mouse) Epn1 Q80VP1 463 T Mus musculus(Mouse) Epn1 Q80VP1 469 T Mus musculus(Mouse) Epn1 Q80VP1 472 S Mus musculus(Mouse) Epn1 Q80VP1 488 S Mus musculus(Mouse) Epn1 Q80VP1 493 T Mus musculus(Mouse) Epn1 Q80VP1 497 S Mus musculus(Mouse) Epn1 Q80VP1 514 S Mus musculus(Mouse)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q80VP1 R533-m1 Methylation TLTLNQLrLSPVPPV Q80VP1 S416-gl O-GlcNAc LRTALPtsGsstGEL Q80VP1 T415-p Phosphorylation RLRTALPtsGsstGE Q80VP1 S416-p Phosphorylation LRTALPtsGsstGEL Q80VP1 S418-p Phosphorylation TALPtsGsstGELEL Q80VP1 S419-p Phosphorylation ALPtsGsstGELELL Q80VP1 T420-p Phosphorylation LPtsGsstGELELLA Q80VP1 S434-p Phosphorylation AGEVPARsPGAFDMS Q80VP1 S453-p Phosphorylation SLAESVGsPPPAAtP Q80VP1 T459-p Phosphorylation GsPPPAAtPtPTPPT Q80VP1 T461-p Phosphorylation PPPAAtPtPTPPTRk Q80VP1 T469-p Phosphorylation PTPPTRktPEsFLGP Q80VP1 S472-p Phosphorylation PTRktPEsFLGPNAA Q80VP1 S488-p Phosphorylation VDLDSLVsRPGPtPP Q80VP1 T493-p Phosphorylation LVsRPGPtPPGSKAS Q80VP1 S514-p Phosphorylation GAPPTGPsVTNPFQP Q80VP1 K11-ub Ubiquitination SSLRRQMkNIVHNYS Q80VP1 K23-ub Ubiquitination NYSEAEIkVREATSN Q80VP1 K86-ub Ubiquitination TLMEYLIkTGSERVS Q80VP1 K97-ub Ubiquitination ERVSQQCkENMYAVQ Q80VP1 K107-ub Ubiquitination MYAVQTLkDFQYVDR Q80VP1 K117-ub Ubiquitination QYVDRDGkDQGVNVR Q80VP1 K128-ub Ubiquitination VNVREKAkQLVALLR Q80VP1 K246-ub Ubiquitination QMAIEESkRETGGKE Q80VP1 K468-ub Ubiquitination tPTPPTRktPEsFLG

PTM - dbPTM UniProt ID Position Code Type Resources References Q80VP1 419 S Phosphorylation Swiss-Prot 1010711 17242355 Q80VP1 469 T Phosphorylation Swiss-Prot 1010711 19367708 Q80VP1 419 S Phosphorylation PhosphoELM.10011 17242355 Q80VP1 469 T Phosphorylation PhosphoELM.10011 19144319 Q80VP1 418 S Phosphorylation Phosphositeplus.1010730 19737024;20415495;21183079 Q80VP1 419 S Phosphorylation Phosphositeplus.1010730 19737024;21183079;21659604 Q80VP1 453 S Phosphorylation Phosphositeplus.1010730 20415495;21183079 Q80VP1 472 S Phosphorylation Phosphositeplus.1010730 21183079 Q80VP1 420 T Phosphorylation Phosphositeplus.1010730 19737024;21183079 Q80VP1 459 T Phosphorylation Phosphositeplus.1010730 21183079 Q80VP1 461 T Phosphorylation Phosphositeplus.1010730 21183079 Q80VP1 463 T Phosphorylation Phosphositeplus.1010730 21183079 Q80VP1 469 T Phosphorylation Phosphositeplus.1010730 18846507;19144319;19367708;20415495;20531401;21183079;21659605 Q80VP1 493 T Phosphorylation Phosphositeplus.1010730 21183079 Q80VP1 420 T Phosphorylation SysPTM 1.1 15345747

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q80VP1 469 T 19144319 HTP Phosphorylation Q80VP1 419 S 17242355 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q80VP1 418 Phosphoserine 21183079 Q80VP1 419 Phosphoserine 21183079 Q80VP1 420 Phosphothreonine 21183079 Q80VP1 459 Phosphothreonine 21183079 Q80VP1 469 Phosphothreonine 19144319;21183079 Q80VP1 472 Phosphoserine 21183079 Q80VP1 493 Phosphothreonine 21183079 Q80VP1 533 Omega-N-methylarginine 24129315

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type Epn1 IPI00330477 S 419 ALPTSGpSSTGELE phosphorylation Epn1 IPI00330477 S 420 LPTSGSpSTGELEL phosphorylation Epn1 IPI00330477 S 454 LAESVGpSPPPAAT phosphorylation Epn1 IPI00330477 T 421 PTSGSSpTGELELL phosphorylation Epn1 IPI00330477 T 464 AATPTPpTPPTRKT phosphorylation Epn1 IPI00330477 T 470 TPPTRKpTPESFLG phosphorylation Epn1 IPI00330477 T 494 VSRPGPpTPPGSKA phosphorylation

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID Epn1 Mus musculus (Mouse) 128; 86; 117; 107; 468; 246; 97; 23; 11 "128,NVREKAKQLVALL; 86,LMEYLIKTGSERV; 117,YVDRDGKDQGVNV; 107,YAVQTLKDFQYVD; 468,PTPPTRKTPESFL; 246,MAIEESKRETGGK; 97,RVSQQCKENMYAV; 23,YSEAEIKVREATS; 11,SLRRQMKNIVHNY" 128:22790023; 86:22790023; 117:22790023; 107:22790023; 468:22790023; 246:22790023; 97:22790023; 23:22790023; 11:22790023 Epn1 Mus musculus (Mouse) 128; 86; 117; 107; 468; 246; 97; 23; 11 "128,NVREKAKQLVALL; 86,LMEYLIKTGSERV; 117,YVDRDGKDQGVNV; 107,YAVQTLKDFQYVD; 468,PTPPTRKTPESFL; 246,MAIEESKRETGGK; 97,RVSQQCKENMYAV; 23,YSEAEIKVREATS; 11,SLRRQMKNIVHNY" 128:22790023; 86:22790023; 117:22790023; 107:22790023; 468:22790023; 246:22790023; 97:22790023; 23:22790023; 11:22790023