PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Sec31a Pgls 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Eed 24457600 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Sec31a 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Hsd3b4 16615898 intact exp Sec23a Sec31a 21640725 mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Apc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Alg2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Tpd52l2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Protein Sec24b, Sec24 related gene family, member B (S. cerevisiae) ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Myom2 ortho GP G G G G G G Sec31a Protein Tfg, TFG protein, Trk-fused, Trk-fused protein ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rel Sec31a ortho G G G G Sec31a Scyl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Tmem17 ortho Atp6v1d Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Trim25 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnnt1 Sec31a ortho G G G G G G G G G Sec31a Serine hydroxymethyltransferase ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr1i2 Sec31a ortho G G G G G Sec31a Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dhx15 Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa8 Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Scrib ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntrk1 Sec31a ortho Itgb2 Sec31a ortho G G G G G G G G G G G G G G G G G G G G G Sec31a Cyb5b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Fdps ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tsta3 Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Armt1 Sec31a ortho GP G G G G G G G G G G G G Hsd17b10 Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Ppp5c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Sec23b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Atp6v1c1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Cdk9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Pfdn1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Itga4 Sec31a ortho G G G G Stam2 Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Sec31a ortho G G G G G G G G G G G G G G G G G G G G Sec31a Cth ortho GP G G G G G G G G G G G G G G G G G G G Eno2 Sec31a ortho P G G G G G G G G G G Sec31a Aldh5a1 ortho P Sec31a Sec13 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Xpo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tbca Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gdap1 Sec31a ortho P G G G G G G G G G G Sec31a Cul3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec31a Naprt ortho P Nsf Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Slc2a4 Sec31a ortho G G G G G G G G G G G G G G G G G G G G Sec31a Nudt13 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sar1a Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcam1 Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Pdcd6 Sec31a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q3UPL0 Q921E6 affinity chromatography technology 24457600 physical association X 2 Q01405 Q3UPL0 fluorescence microscopy 21640725 colocalization X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Sec31a Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332329 prey bait Sec23a Sec31a MI:0416(fluorescence microscopy) 21640725 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (intact) UniProt_173236 neutral component neutral component

PPI - HINT Gene A Gene B PMID Method Quality YWHAE SEC31A 16615898 0027 LC SEC23A SEC31A 21640725 0416 LC SEC31A HSD3B4 16615898 0027 LC SEC31A PGLS 16615898 0027 LC SEC31A EED 24457600 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q921E6 Q3UPL0 EED SEC31A 0.126 24457600 Q3UPL0 Q01405 SEC31A SEC23A 0.126 21640725