DNA & RNA Element - miRTarBase Target Gene (Entrez ID) miRTarBase ID miRNA Species (miRNA) Target Gene Species (Target Gene) Experiments Support Type References (PMID) MIRT594381 mmu-miR-129-5p Mus musculus Isg15 100038882 Mus musculus HITS-CLIP Functional MTI (Weak) 23142080 MIRT586792 mmu-miR-1930-5p Mus musculus Isg15 100038882 Mus musculus HITS-CLIP Functional MTI (Weak) 25083871 MIRT586792 mmu-miR-1930-5p Mus musculus Isg15 100038882 Mus musculus HITS-CLIP Functional MTI (Weak) 21258322 MIRT586791 mmu-miR-3086-3p Mus musculus Isg15 100038882 Mus musculus HITS-CLIP Functional MTI (Weak) 25083871 MIRT586791 mmu-miR-3086-3p Mus musculus Isg15 100038882 Mus musculus HITS-CLIP Functional MTI (Weak) 21258322 MIRT586790 mmu-miR-5098 Mus musculus Isg15 100038882 Mus musculus HITS-CLIP Functional MTI (Weak) 25083871 MIRT594382 mmu-miR-5116 Mus musculus Isg15 100038882 Mus musculus HITS-CLIP Functional MTI (Weak) 23142080

DNA & RNA Element - microRNA Mirbase Acc miRNA Name Gene ID Gene Symbol miRNA Alignment Alignment Gene Alignment miRNA Start miRNA End Gene Start Gene End Genome Coordinates Conservation Align Score Seed Cat Energy mirSVR Score MIMAT0004643 mmu-miR-331-5p 100038882 Isg15 ccuagggacCCUGGUAUGGAUc ||| ||||||| uguaaacgaGGAAAAUACCUAa 2 14 81 102 [mm9:4:155573591-155573612:-] 0.4863 149 7 -14.48 -1.2655 MIMAT0003388 mmu-miR-376b* 100038882 Isg15 auugguAUCUUCCUUAUAGGUg ||||| |||||| | ccuaauUAGAAAAAAUAUCAAa 2 17 98 119 [mm9:4:155573574-155573595:-] 0.4863 132 0 -9.82 -0.4120 MIMAT0005295 mmu-miR-376c* 100038882 Isg15 auUUGUAUCUUCCUUAUAGGUg ||: ||||| |||||| | cuAAU-UAGAAAAAAUAUCAAa 2 21 99 119 [mm9:4:155573574-155573594:-] 0.4863 134 0 -8.98 -0.4120 MIMAT0003898 mmu-miR-760 100038882 Isg15 agGGGUGUCUGGGUCUCGGc ||| | |:|||||||| ggCCCCC--AUCCAGAGCCa 2 19 1 18 [mm9:4:155573675-155573692:-] 0.4637 155 7 -27.96 -1.0515 MIMAT0009393 mmu-miR-1930 100038882 Isg15 ugcgaCGUCCAUGAUACCUCCa | :|| : |||||||| augggGGGGGGGGUAUGGAGGa 2 18 38 59 [mm9:4:155573634-155573655:-] 0.4892 153 7 -22.56 -0.7804 MIMAT0000153 mmu-miR-141 100038882 Isg15 gguagaaauGGUCU--GUCACAAu ||||| ||||||| ggcccccauCCAGAGCCAGUGUUg 2 14 1 24 [mm9:4:155573669-155573692:-] 0.4710 152 7 -20.73 -0.8382 MIMAT0000159 mmu-miR-149 100038882 Isg15 cccucacuucUGUGCCUCGGUCu |: | ||||||| ---ggcccccAUCCAGAGCCAGu 2 14 1 20 [mm9:4:155573673-155573692:-] 0.4637 145 7 -15.80 -0.7851 MIMAT0000209 mmu-miR-129-5p 100038882 Isg15 cguucgggucuggcGUUUUUc |||||| auuagaaaaaauauCAAAAAa 2 8 102 122 [mm9:4:155573571-155573591:-] 0.4863 120 6 -4.22 -0.8185 MIMAT0000220 mmu-miR-190 100038882 Isg15 ugGAUUAUAUAGUUUGUAUAGu ||||| || ||| ||||| acCUAAU-UAGAAAAAAUAUCa 2 21 97 117 [mm9:4:155573576-155573596:-] 0.4863 138 0 -14.56 -0.1263 MIMAT0000235 mmu-miR-202-3p 100038882 Isg15 agaaggguacgcgaUAUGGAga |||||| uguaaacgaggaaaAUACCUaa 3 9 81 102 [mm9:4:155573591-155573612:-] 0.4863 120 0 -8.16 -0.2425 MIMAT0000519 mmu-miR-200a 100038882 Isg15 uguagcaauGGUCU--GUCACAAu ||||| ||||||| ggcccccauCCAGAGCCAGUGUUg 2 14 1 24 [mm9:4:155573669-155573692:-] 0.4710 152 7 -18.24 -0.8382 MIMAT0004852 mmu-miR-190b 100038882 Isg15 uuGGGUU-AUAGUUUGUAUAGu ||:|| || ||| ||||| uaCCUAAUUAGAAAAAAUAUCa 2 20 96 117 [mm9:4:155573576-155573597:-] 0.4863 134 0 -14.18 -0.1263

DNA & RNA Element - TRANSFAC Accession AS Description Species Entrez Pubmed Binding Info G043147 Isg15 Mus musculus 100038882 14578350 0 0 R29596; MOUSE$ISG15_01; Binding factors: ISGF3

DNA & RNA Element - RepTar Gene Name miRNA Begin End Profile Isg15 mmu-miR-331-5p beg:84 end:102 pic:3' CCTAGGGACCCTGGTATGGATC 5'& | ||| ||||||| &5' ------CGAGGAAAATACCTA- 3' Isg15 mmu-miR-1930 beg:40 end:59 pic:3' TGCGACGTCCATGATACCTCCA 5'& | .|| . |||||||| &5' -----GGGGGGGGTATGGAGG- 3' Isg15 mmu-miR-760 beg:1 end:18 pic:3' AGGGGTGTCTGGGTCTCGGC 5'& |||||. |||||||| &5' -CCCCAT----CCAGAGCC- 3' Isg15 mmu-miR-200a beg:7 end:25 pic:3' TGTAGCAATGGTCT--GTCACAAT 5'& ||||| |||||||. &5' ---------CCAGAGCCAGTGTTG 3' Isg15 mcmv-miR-M23-2 beg:0 end:10 pic:3' GGCGAACTGGCTCCGGGGGTA 5'& ||||||||| &5' ------------GGCCCCCAT 3' Isg15 mmu-miR-136star beg:23 end:42 pic:3' TTCTGAGTAAACTCTGCTACTA 5'& |.|| |||.||||. &5' -----TTATAAAAGATGATGG- 3' Isg15 mmu-miR-141 beg:3 end:25 pic:3' GGTAGAAATGGTCT--GTCACAAT 5'& |||| ||||| |||||||. &5' CCAT-----CCAGAGCCAGTGTTG 3' Isg15 mmu-miR-145 beg:51 end:79 pic:3' TC-CCTAAGGACCCTTT--TGACCTG 5'& .| ||| |..||||| |.|||| &5' GGAGGACTTTTGGGATAGCATTGGA- 3' Isg15 mmu-miR-1937a beg:50 end:70 pic:3' ACCCCC-GAGCAGGCCCTAA 5'& ||| || || |..||||| &5' TGGAGGACT--TTTGGGAT- 3' Isg15 mmu-miR-205 beg:30 end:60 pic:3' GTCTGAGGCCA-----CCT-TACTTCCT 5'& |||. .|| ||. |||.|||| &5' -AGATGATGGGGGGGGGGGTATGGAGGA 3' Isg15 mmu-miR-3072 beg:34 end:53 pic:3' TCTTCCGAAGGACCTCCCCCGT 5'& || || ||.|||||.| &5' -GATGGG-----GGGGGGGGTA 3' Isg15 mmu-miR-429 beg:7 end:25 pic:3' TGCCGTAATGGTCT--GTCATAAT 5'& ||||| ||||.||. &5' ---------CCAGAGCCAGTGTTG 3' Isg15 mmu-miR-483star beg:34 end:56 pic:3' TTCTGCCCTCCCCTCCTCACT 5'& ||.|||.||||.|| ||. &5' --GATGGGGGGGGGGGTATGG 3' Isg15 mmu-miR-758 beg:15 end:33 pic:3' ATCACCTGGTCCAGTGTTT 5'& |||| |||.|.||| &5' -AGTGTT---GGTTATAAA 3' Isg15 mmu-miR-764-5p beg:41 end:62 pic:3' TCCTCCTGTACACTCGTGG 5'& .||.|| ||| ||| ||. &5' GGGGGGGTATG-GAGGACT 3' Isg15 mmu-miR-877star beg:36 end:61 pic:3' ACCCTCCTCCCTCT-TCTCCTGT 5'& ||||.||.|||. .|||||| &5' TGGGGGGGGGGGTATGGAGGAC- 3'

DNA & RNA Element - RAID2 Gene Name RAID ID Interactor 1 Category 1 ID 1 Interactor 2 Category 2 ID 2 Methods Score Isg15 RAID00244473 mmu-miR-200a-3p miRNA MIMAT0000519 Isg15 mRNA 100038882 Prediction 0.1828 Isg15 RAID00650347 mmu-miR-190a-5p miRNA MIMAT0000220 Isg15 mRNA 100038882 Prediction 0.1828 Isg15 RAID00657941 mmu-miR-7650-3p miRNA MIMAT0029803 Isg15 mRNA 100038882 Prediction 0.1828 Isg15 RAID01013415 mmu-miR-1930-5p miRNA MIMAT0009393 Isg15 mRNA 100038882 CLIP-seq 0.5483 Isg15 RAID01827782 mmu-miR-141-3p miRNA MIMAT0000153 Isg15 mRNA 100038882 Prediction 0.1828 Isg15 RAID01945202 mmu-miR-129-5p miRNA MIMAT0000209 Isg15 mRNA 100038882 CLIP-seq//Prediction 0.6308 Isg15 RAID02111540 mmu-miR-149-5p miRNA MIMAT0000159 Isg15 mRNA 100038882 Prediction 0.1828 Isg15 RAID02745465 mmu-miR-202-3p miRNA MIMAT0000235 Isg15 mRNA 100038882 Prediction 0.1828 Isg15 RAID03030697 mmu-miR-5116 miRNA MIMAT0020624 Isg15 mRNA 100038882 CLIP-seq 0.5483 Isg15 RAID03145961 mmu-miR-190b-5p miRNA MIMAT0004852 Isg15 mRNA 100038882 Prediction 0.1828 Isg15 RAID03420365 mmu-miR-5098 miRNA MIMAT0020605 Isg15 mRNA 100038882 CLIP-seq 0.5483 Isg15 RAID03870043 mmu-miR-3086-3p miRNA MIMAT0014881 Isg15 mRNA 100038882 CLIP-seq 0.5483