PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Isg15 Vars 16139798 biogrid exp P Usp5 Isg15 14673145 biogrid exp P Mapk3 Isg15 15485925 biogrid exp P Isg15 Isg15 18606809 innatedb exp P Isg15 Rars 16139798 biogrid exp P Isg15 Iars 16139798 biogrid exp P Anxa6 Isg15 16139798 biogrid exp P Mdh2 Isg15 16139798 biogrid exp P Isg15 Aldh18a1 16139798 biogrid exp P Isg15 Hsd3b7 16615898 intact exp Tubb5 Isg15 16139798 biogrid exp P Me1 Isg15 16139798 biogrid exp P Hsd3b4 Isg15 16615898 intact exp Ywhae Isg15 16615898 intact exp P Isg15 Sord 16139798 biogrid exp P Isg15 Lars 16139798 biogrid exp P Isg15 Taldo1 16139798 biogrid exp P Serpina3g Isg15 15485925,16139798 biogrid exp Isg15 Pgls 16615898 intact exp P Isg15 Nomo1 16139798 biogrid exp P Gapdh Isg15 16139798 biogrid exp P Tpi1 Isg15 16139798 biogrid exp P Serpinb2 Isg15 16139798 biogrid exp Eno1 Isg15 16139798 biogrid exp P Ywhaz Isg15 16615898 intact exp P Samhd1 Isg15 16139798 biogrid exp P Plcg1 Isg15 15485925 biogrid exp P Pkm Isg15 16139798 biogrid exp, ortho P Eef1a1 Isg15 16139798 biogrid exp, ortho P Stat1 Isg15 16139798 biogrid exp, ortho P Isg15 MCG18845, isoform CRA_d, Protein Uba7, Ubiquitin-activating enzyme E1-like 16139798 biogrid exp, ortho Isg15 Aars 16139798 biogrid exp, ortho P Hsp90aa1 Isg15 16139798 biogrid exp, ortho P Vcp Isg15 16139798 biogrid exp, ortho P Isg15 Ugp2 16139798 biogrid exp, ortho P Isg15 Tars 16139798 biogrid exp, ortho P Isg15 Myh9 16139798 biogrid exp, ortho P Eef2 Isg15 16139798 biogrid exp, ortho P Ldha Isg15 16139798 biogrid exp, ortho P Anxa2 Isg15 16139798 biogrid exp, ortho P Hsp90ab1 Isg15 16139798 biogrid exp, ortho P Hspa8 Isg15 16139798 biogrid exp, ortho P Isg15 Usp18 24533902 biogrid,intact exp, ortho Actb Isg15 16139798 biogrid exp, ortho P Isg15 Acly 16139798 biogrid exp, ortho P Pgk1 Isg15 16139798 biogrid exp, ortho P Uba1 Isg15 16139798 biogrid exp, ortho P Aldoa Isg15 16139798 biogrid exp, ortho P Gpi Isg15 16139798 biogrid exp, ortho P Rps27a Isg15 ortho P Rpl27a Isg15 ortho P Isg15 Clic1 ortho P Actn4 Isg15 ortho P Sfn Isg15 ortho P Isg15 Ppp1r10 ortho P Mdh1 Isg15 ortho P Isg15 Plod1 ortho Msn Isg15 ortho P Isg15 Fam120c ortho P Nup43 Isg15 ortho Eef1a2 Isg15 ortho P Isg15 Flnb ortho P Isg15 Aifm1 ortho P Isg15 Lap3 ortho P Isg15 Hnrnpu ortho P Isg15 Arid5b ortho G3bp1 Isg15 ortho P Pafah1b1 Isg15 ortho P Atp5b Isg15 ortho P Isg15 Rgs3 ortho Csnk2a1 Isg15 ortho P Hspb1 Isg15 ortho P Ube2d3 Isg15 ortho P Isg15 Ythdf3 ortho P Isg15 Iqgap1 ortho P Fasn Isg15 ortho P Isg15 Chmp5 ortho P Phgdh Isg15 ortho P Isg15 Stk38 ortho P Tkt Isg15 ortho P Isg15 Palld ortho P Hnrnpk Isg15 ortho P Elavl1 Isg15 ortho P Isg15 Usp21 ortho Cct3 Isg15 ortho P Cct4 Isg15 ortho P Tagln Isg15 ortho P Isg15 Lman2 ortho P Sin3a Isg15 ortho P Isg15 Fars2 ortho P Isg15 Hdac6 ortho P Sqstm1 Isg15 ortho P Isg15 Plec ortho P Isg15 Plod3 ortho Zc3hav1 Isg15 ortho P Isg15 Cand1 ortho P Isg15 Rpl24 ortho Fut4 Isg15 ortho Hnrnpa2b1 Isg15 ortho P Isg15 Myof ortho P Isg15 Znf318 ortho Clk1 Isg15 ortho Ctnnb1 Isg15 ortho P Gsr Isg15 ortho P Protein Ahnak Isg15 ortho P Ran Isg15 ortho P Aaas Isg15 ortho P Anxa3 Isg15 ortho P Isg15 Txnrd1 ortho P Isg15 Wdr33 ortho Wdr1 Isg15 ortho P Sept2 Isg15 ortho P Isg15 Actn1 ortho P Isg15 Tmod3 ortho P Vim Isg15 ortho P Isg15 Rbm15b ortho P Nfkb1 Isg15 ortho P Isg15 Ube2l6 ortho Prdx1 Isg15 ortho P Isg15 Ddx58 ortho P Hspa4 Isg15 ortho P Isg15 Dstn ortho P Isg15 Wibg ortho P Ogdh Isg15 ortho P Qtrtd1 Isg15 ortho Top2a Isg15 ortho Dyrk1a Isg15 ortho P Isg15 Cltc ortho P Isg15 Mynn ortho Isg15 Abcf2 ortho P Isg15 Flna ortho P Isg15 Mepce ortho Anxa5 Isg15 ortho P Protein Fubp3 Isg15 ortho P Isg15 Atic ortho P Isg15 Hnrnpl ortho P Gnb2l1 Isg15 ortho P Acta1 Isg15 ortho P Isg15 Serbp1 ortho P Pfn1 Isg15 ortho P Atxn2 Isg15 ortho P Isg15 Ganab ortho P Chd1 Isg15 ortho P Isg15 Pgd ortho P Map4 Isg15 ortho Isg15 Dnajb1 ortho P Atp5a1 Isg15 ortho P Isg15 Bag3 ortho P Cfl1 Isg15 ortho Ifit2 Isg15 ortho Cbx4 Isg15 ortho Xrcc5 Isg15 ortho P Wars Isg15 ortho P Elf3 Isg15 ortho Smad4 Isg15 ortho P Isg15 Depdc7 ortho Isg15 Sf3b4 ortho P Pls1 Isg15 ortho P Isg15 Cirh1a ortho P Eif2ak2 Isg15 ortho P Lmna Isg15 ortho P Isg15 Rdh11 ortho P Nfix Isg15 ortho Isg15 Ddx42 ortho P Rbbp4 Isg15 ortho P Trim25 Isg15 ortho P Senp1 Isg15 ortho Isg15 Taf2 ortho Irf9 Isg15 ortho Ube2n Isg15 ortho P Irf2 Isg15 ortho Naca Isg15 ortho P Helz2 Isg15 ortho P Isg15 Eppk1 ortho Hspd1 Isg15 ortho P Isg15 Atxn2l ortho P Isg15 Ddb2 ortho Lgmn Isg15 ortho P Isg15 Eif4g1 ortho P Ezr Isg15 ortho P Isg15 Eprs ortho P Isg15 Psma7 ortho P Ythdc1 Isg15 ortho P Prdx6 Isg15 ortho P Serpinb5 Isg15 ortho Isg15 Dnajb4 ortho P Isg15 Eef1g ortho P Acot8 Isg15 ortho Ptbp1 Isg15 ortho P Gdi2 Isg15 ortho P Ddx17 Isg15 ortho P Isg15 Snrnp200 ortho P Ccnl1 Isg15 ortho Ppm1b Isg15 ortho P Ercc2 Isg15 ortho Cct2 Isg15 ortho P Isg15 Znf281 ortho Isg15 Pls3 ortho P Xrcc6 Isg15 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P10126 Q64339 affinity chromatography technology 16139798 physical association X 2 P10126 Q64339 affinity chromatography technology 16139798 physical association X 2 P07356 Q64339 affinity chromatography technology 16139798 physical association X 2 P07356 Q64339 affinity chromatography technology 16139798 physical association X 2 Q93092 Q64339 affinity chromatography technology 16139798 physical association X 2 Q9DBK7 Q64339 affinity chromatography technology 16139798 physical association X 2 Q9DBK7 Q64339 affinity chromatography technology 16139798 physical association X 2 Q9DBK7 Q64339 affinity chromatography technology 16139798 physical association X 2 P11499 Q64339 affinity chromatography technology 16139798 physical association X 2 P11499 Q64339 affinity chromatography technology 16139798 physical association X 2 Q8BGQ7 Q64339 affinity chromatography technology 16139798 physical association X 2 Q8BGQ7 Q64339 affinity chromatography technology 16139798 physical association X 2 P17751 Q64339 affinity chromatography technology 16139798 physical association X 2 P08249 Q64339 affinity chromatography technology 16139798 physical association X 2 P08249 Q64339 affinity chromatography technology 16139798 physical association X 2 Q64339 affinity chromatography technology 16139798 physical association X 2 Q6GQT9 Q64339 affinity chromatography technology 16139798 physical association X 2 P56399 Q64339 pull down 14673145 direct interaction X 2 P17182 Q64339 affinity chromatography technology 16139798 physical association X 2 P17182 Q64339 affinity chromatography technology 16139798 physical association X 2 P17182 Q64339 affinity chromatography technology 16139798 physical association X 2 P06745 Q64339 affinity chromatography technology 16139798 physical association X 2 P06745 Q64339 affinity chromatography technology 16139798 physical association X 2 P06745 Q64339 affinity chromatography technology 16139798 physical association X 2 Q64339 Q8C3V4 affinity chromatography technology 16139798 physical association X 2 Q64339 P12388 affinity chromatography technology 16139798 physical association X 2 Q9WTV6 Q64339 pull down 24533902 direct interaction X 2 Q01853 Q64339 affinity chromatography technology 16139798 physical association X 2 Q01853 Q64339 affinity chromatography technology 16139798 physical association X 2 Q8VDD5 Q64339 affinity chromatography technology 16139798 physical association X 2 Q8VDD5 Q64339 affinity chromatography technology 16139798 physical association X 2 Q8VDD5 Q64339 affinity chromatography technology 16139798 physical association X 2 Q9Z1Q9 Q64339 affinity chromatography technology 16139798 physical association X 2 Q9Z1Q9 Q64339 affinity chromatography technology 16139798 physical association X 2 Q9Z1Q9 Q64339 affinity chromatography technology 16139798 physical association X 2 Q62077 Q64339 affinity chromatography technology 15485925 physical association X 2 P99024 Q64339 affinity chromatography technology 16139798 physical association X 2 G5E8N5 Q64339 affinity chromatography technology 16139798 physical association X 2 G5E8N5 Q64339 affinity chromatography technology 16139798 physical association X 2 G5E8N5 Q64339 affinity chromatography technology 16139798 physical association X 2 P06801 Q64339 affinity chromatography technology 16139798 physical association X 2 P09411 Q64339 affinity chromatography technology 16139798 physical association X 2 Q5I2A0 Q64339 affinity chromatography technology 16139798 physical association X 2 Q5I2A0 Q64339 affinity chromatography technology 16139798 physical association X 2 Q64339 affinity chromatography technology 16139798 physical association X 2 Q64339 affinity chromatography technology 16139798 physical association X 2 D2KHZ9 Q64339 affinity chromatography technology 16139798 physical association X 2 Q8BMJ2 Q64339 affinity chromatography technology 16139798 physical association X 2 Q8BMJ2 Q64339 affinity chromatography technology 16139798 physical association X 2 Q8BMJ2 Q64339 affinity chromatography technology 16139798 physical association X 2 Q91V92 Q64339 affinity chromatography technology 16139798 physical association X 2 Q91V92 Q64339 affinity chromatography technology 16139798 physical association X 2 Q91V92 Q64339 affinity chromatography technology 16139798 physical association X 2 B2RRX1 Q64339 affinity chromatography technology 16139798 physical association X 2 B2RRX1 Q64339 affinity chromatography technology 16139798 physical association X 2 B2RRX1 Q64339 affinity chromatography technology 16139798 physical association X 2 Q9D0R2 Q64339 affinity chromatography technology 16139798 physical association X 2 Q9D0R2 Q64339 affinity chromatography technology 16139798 physical association X 2 Q64339 P07901 affinity chromatography technology 16139798 physical association X 2 Q64339 P07901 affinity chromatography technology 16139798 physical association X 2 Q64339 Q8BU30 affinity chromatography technology 16139798 physical association X 2 Q64339 F8WJE0 affinity chromatography technology 16139798 physical association X 2 Q64339 F8WIT2 affinity chromatography technology 16139798 physical association X 2 Q64339 Q8BU30 affinity chromatography technology 16139798 physical association X 2 Q64339 F8WJE0 affinity chromatography technology 16139798 physical association X 2 Q64339 F8WIT2 affinity chromatography technology 16139798 physical association X 2 Q64339 Q8BU30 affinity chromatography technology 16139798 physical association X 2 Q64339 F8WJE0 affinity chromatography technology 16139798 physical association X 2 Q64339 F8WIT2 affinity chromatography technology 16139798 physical association X 2 P63017 Q64339 affinity chromatography technology 16139798 physical association X 2 P63017 Q64339 affinity chromatography technology 16139798 physical association X 2 P52480 Q64339 affinity chromatography technology 16139798 physical association X 2 Q64442 Q64339 affinity chromatography technology 16139798 physical association X 2 P58252 Q64339 affinity chromatography technology 16139798 physical association X 2 P58252 Q64339 affinity chromatography technology 16139798 physical association X 2 P05064 Q64339 affinity chromatography technology 16139798 physical association X 2 Q9D0I9 Q64339 affinity chromatography technology 16139798 physical association X 2 Q9D0I9 Q64339 affinity chromatography technology 16139798 physical association X 2 Q91ZJ5 Q64339 affinity chromatography technology 16139798 physical association X 2 Q64339 cosedimentation 16615898 colocalization C 1216 Q9WTV6 Q64339 microscale thermophoresis 24533902 direct interaction X 2 Q9WTV6 Q64339 enzymatic study 24533902 cleavage reaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Usp5 Isg15 MI:0096(pull down)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 14673145,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(intact)|(intact)|(intact) BIOGRID_323115|UniProt_167130|UniProt_167118|UniProt_167134 prey|neutral component|neutral component|neutral component bait|neutral component|neutral component|neutral component Isg15 Usp18 MI:0096(pull down)|-|- 24533902 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0194(cleavage reaction)|MI:0407(direct interaction) (biogrid)|(intact)|(intact) BIOGRID_332931|UniProt_177659|UniProt_177658 prey|neutral component|neutral component bait|neutral component|neutral component Plcg1 Isg15 MI:0004(affinity chromatography technology) 15485925 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322282 prey bait

PPI - HINT Gene A Gene B PMID Method Quality YWHAE ISG15 16615898 0027 LC YWHAZ ISG15 16615898 0027 LC HSD3B4 ISG15 16615898 0027 LC ISG15 ISG15 PDB_5CHF 0114 LC ISG15 PGLS 16615898 0027 LC ISG15 HSD3B7 16615898 0027 LC ISG15 USP18 24533902,PDB_5CHV,24533902,24533902 0415,0114,1247,0096 LC ALDOA ISG15 16139798 0004 LC LDHA ISG15 16139798 0004 LC GPI ISG15 16139798 0004 LC ME1 ISG15 16139798 0004 LC ANXA2 ISG15 16139798 0004 LC HSP90AA1 ISG15 16139798 0004 LC MDH2 ISG15 16139798 0004 LC PGK1 ISG15 16139798 0004 LC EEF1A1 ISG15 16139798 0004 LC HSP90AB1 ISG15 16139798 0004 LC ANXA6 ISG15 16139798 0004 LC GAPDH ISG15 16139798 0004 LC ENO1 ISG15 16139798 0004 LC TPI1 ISG15 16139798 0004 LC STAT1 ISG15 18287094,15644321,16139798 0007,0007,0004 LC PKM ISG15 16139798 0004 LC USP5 ISG15 14673145 0096 LC EEF2 ISG15 16139798 0004 LC ACTB ISG15 16139798 0004 LC HSPA8 ISG15 16139798 0004 LC TUBB5 ISG15 16139798 0004 LC VCP ISG15 16139798 0004 LC UBA1 ISG15 16139798 0004 LC SERPINB2 ISG15 16139798 0004 LC SERPINA3G ISG15 16139798,15485925 0004,0004 LC SAMHD1 ISG15 16139798 0004 LC PLCG1 ISG15 15485925 0004 LC MAPK3 ISG15 15485925 0004 LC ISG15 ISG15 18606809 0096 LC ISG15 SORD 16139798 0004 LC ISG15 NOMO1 16139798 0004 LC ISG15 AARS 16139798 0004 LC ISG15 LARS 16139798 0004 LC ISG15 IARS 16139798 0004 LC ISG15 MYH9 16139798 0004 LC ISG15 ACLY 16139798 0004 LC ISG15 UGP2 16139798 0004 LC ISG15 TALDO1 16139798 0004 LC ISG15 RARS 16139798 0004 LC ISG15 TARS 16139798 0004 LC ISG15 UBA7 16139798 0004 LC ISG15 USP18 24533902,24533902,24533902 0415,1247,0096 LC ISG15 ALDH18A1 16139798 0004 LC ISG15 VARS 16139798 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q64339 P58252 ISG15 EEF2 0.236 16139798 Q64339 P60710 ISG15 ACTB 0.236 16139798 Q64339 P17182 ISG15 ENO1 0.236 16139798 Q64339 Q60710 ISG15 SAMHD1 0.236 16139798 Q64339 Q61767 ISG15 HSD3B4 0.081 16615898 Q64339 Q62077 ISG15 PLCG1 0.376 15485925 Q64339 P62259 ISG15 YWHAE 0.081 16615898 Q8VDD5 Q64339 MYH9 ISG15 0.236 16139798 Q9WTV6 Q64339 USP18 ISG15 0.539 24533902 Q64339 P07901 ISG15 HSP90AA1 0.236 16139798 Q9Z1Q9 Q64339 VARS ISG15 0.236 16139798 Q64339 P08249 ISG15 MDH2 0.236 16139798 Q91ZJ5 Q64339 UGP2 ISG15 0.126 16139798 Q64339 Q63844 ISG15 MAPK3 0.376 15485925 Q8BU30 Q64339 IARS ISG15 0.236 16139798 Q8BMJ2 Q64339 LARS ISG15 0.236 16139798 Q8BGQ7 Q64339 AARS ISG15 0.236 16139798 Q64339 P06151 ISG15 LDHA 0.236 16139798 Q64339 P05064 ISG15 ALDOA 0.126 16139798 Q64339 P07356 ISG15 ANXA2 0.236 16139798 Q64339 P06745 ISG15 GPI 0.236 16139798 Q64339 P06801 ISG15 ME1 0.126 16139798 Q64339 P16858 ISG15 GAPDH 0.126 16139798 Q64339 P10126 ISG15 EEF1A1 0.236 16139798 Q64339 P09411 ISG15 PGK1 0.126 16139798 Q64339 P11499 ISG15 HSP90AB1 0.236 16139798 Q64339 P12388 ISG15 SERPINB2 0.126 16139798 Q6GQT9 Q64339 NOMO1 ISG15 0.126 16139798 Q64339 P52480 ISG15 PKM 0.126 16139798 Q64339 P17751 ISG15 TPI1 0.126 16139798 Q64339 P56399 ISG15 USP5 0.309 14673145 Q64442 Q64339 SORD ISG15 0.126 16139798 Q64339 P99024 ISG15 TUBB5 0.126 16139798 Q9Z110 Q64339 ALDH18A1 ISG15 0.126 16139798 Q93092 Q64339 TALDO1 ISG15 0.126 16139798 Q64339 Q5I2A0 ISG15 SERPINA3G 0.523 15485925,16139798 Q91V92 Q64339 ACLY ISG15 0.236 16139798 Q9CQ60 Q64339 PGLS ISG15 0.081 16615898 Q9D0I9 Q64339 RARS ISG15 0.236 16139798 Q9D0R2 Q64339 TARS ISG15 0.236 16139798 Q9EQC1 Q64339 HSD3B7 ISG15 0.081 16615898 Q64339 P63017 ISG15 HSPA8 0.236 16139798 Q64339 P14824 ISG15 ANXA6 0.236 16139798 Q64339 P63101 ISG15 YWHAZ 0.081 16615898 Q64339 Q01853 ISG15 VCP 0.236 16139798 Q64339 Q02053 ISG15 UBA1 0.236 16139798