PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Socs1 Trim28 20622265 biogrid exp Socs1 Nt5c2 20622265 biogrid exp Socs1 Tceb2 9869640,15601820 innatedb,biogrid exp Socs1 Crebbp 16920712 innatedb exp Socs1 Ptk2b 10679268 biogrid exp Socs1 Ubc 19296467 biogrid exp Socs1 Cul5 19385048 biogrid exp Socs1 Psmc6 15456882 biogrid exp Socs1 Pcsk4 20622265 biogrid exp Socs1 Pcnt 20622265 biogrid exp Socs1 Bclaf1 20622265 biogrid exp Socs1 Csf1r 10679268 biogrid,i2d exp Socs1 Pag1 16920712 biogrid exp Socs1 Shc1 20622265 biogrid exp Socs1 Hspa1b 15456882 biogrid exp Socs1 Pim1 11854514,14764533 innatedb,biogrid exp Socs1 Tceb1 9869640,15304214,15601820 innatedb,biogrid,i2d exp, ortho Socs1 Rela 14690596,19270718 innatedb,mint,intact exp, ortho Socs1 Tirap 19296467 innatedb,biogrid exp, ortho Socs1 Ifngr1 19734231,15522878 innatedb,biogrid exp, ortho Socs1 Tubg1 15456882 biogrid exp, ortho Socs1 Socs2 16956890 innatedb exp, ortho Socs1 Pim2 11854514 biogrid,i2d exp, ortho Socs1 Jak1 15456882,23990909 biogrid exp, ortho Socs1 Kit 10022833,14707129,10679268 innatedb,biogrid exp, ortho Socs1 Ifnar1 21757742 innatedb exp, ortho Socs1 Insr 15169905 biogrid exp, ortho Socs1 Cul2 15456882 biogrid exp, ortho Socs1 Trim8 12163497 biogrid,i2d exp, ortho Socs1 Vav1 15456882 biogrid exp, ortho Socs1 Jak2 18508766,15522878,10064597,10679268 innatedb,biogrid,i2d,mint,intact exp, ortho Socs1 Tyk2 21757742 innatedb exp, ortho Socs1 Tp53 ortho Socs1 Socs5 ortho Socs1 Axl ortho Socs1 Itk ortho Socs1 Traf6 ortho Socs1 Dab1 ortho Socs1 Cytip ortho Socs1 Abl1 ortho Socs1 Irak1 ortho Protein Rasa1 Socs1 ortho Cul4b Socs1 ortho Socs1 Egfr ortho Socs1 Tnfrsf1a ortho Socs1 Jak3 ortho Socs1 Clec7a ortho Socs1 Tceb3 ortho Socs1 Alk ortho Socs1 Crkl ortho Socs1 Met ortho Socs1 Erbb2 ortho Socs1 Irs2 ortho Socs1 Commd1 ortho Socs1 Il2rb ortho Socs1 Tek ortho Socs1 Atr ortho Map3k5 Socs1 ortho Socs1 Ccr1 ortho Socs1 Pdcd1 ortho Socs1 Tnfrsf1b ortho Socs1 Lck ortho Socs1 Nck1 ortho Socs1 Ptpn11 ortho Socs1 Igf1r ortho Socs1 Stat3 ortho Ifnar2 Socs1 ortho Socs1 Csf1 ortho Nedd9 Socs1 ortho Socs1 Pdgfrb ortho Socs1 Stat5a ortho Pik3r2 Socs1 ortho Socs1 Cxcr4 ortho Socs1 Stat5b ortho Socs1 Atm ortho Socs1 Ezh2 ortho Socs1 Tyr ortho Socs1 Tec ortho Socs1 Fyn ortho Socs1 Irf3 ortho Socs1 Socs1 ortho Socs1 Vhl ortho Socs1 Stat4 ortho Socs1 Vav2 ortho Socs1 Crk ortho Socs1 Grb2 ortho Socs1 Stat2 ortho Socs1 Irs1 ortho Socs1 Fgfr2 ortho Socs1 Ghr ortho Socs1 Mpl ortho Socs1 Etv6 ortho Socs1 Cebpa ortho Nmi Socs1 ortho Socs1 Pik3r1 ortho Socs1 Flt3 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O35716 - 12163497 - X 2 Q62070 O35716 - 11854514 - X 2 O35716 P09581 - 11297560 - X 2 O35716 P09581 - 11297560 - X 2 O35716 P83940 - 15304214 - X 2 O35716 - 9869640 - X 2 O35716 - 9202126 - X 2 O35716 P09581 - 11297560 - X 2 O35716 P83887 biochemical 15456882 colocalization X 2 O35716 P62334 biochemical 15456882 colocalization X 2 O35716 Q9D4H8 biochemical 15456882 colocalization X 2 O35716 P27870 biochemical 15456882 colocalization X 2 O35716 G5E852 two hybrid 10679268 direct interaction X 2 O35716 Q9UBF6-2 affinity chromatography technology 15601820 physical association X 2 O35716 Q15370-2 affinity chromatography technology 15601820 physical association X 2 O35716 Q15369-2 affinity chromatography technology 15601820 physical association X 2 O35716 Q8K019-3 affinity chromatography technology 20622265 physical association X 2 O35716 A6H659 two hybrid 16920712 direct interaction X 2 O35716 A6H659 affinity chromatography technology 16920712 physical association X 2 O35716 Q99JY1 affinity chromatography technology 19296467 physical association X 2 O35716 P0CG50 affinity chromatography technology 19296467 physical association X 2 O35716 Q15369-2 biochemical 19385048 association X 2 O35716 Q15370-2 biochemical 19385048 association X 2 O35716 Q15370-2 x-ray crystallography 19385048 association X 2 O35716 Q15369-2 x-ray crystallography 19385048 association X 2 O35716 Q15369-2 pull down 19385048 direct interaction X 2 O35716 Q15370-2 pull down 19385048 direct interaction X 2 P29121 O35716 affinity chromatography technology 20622265 physical association X 2 Q62070 O35716 affinity chromatography technology 11854514 physical association X 2 Q62070 O35716 affinity chromatography technology 11854514 physical association X 2 Q62070 O35716 enzymatic study 11854514 direct interaction X 2 P62869 O35716 affinity chromatography technology 9869640 physical association X 2 P62869 O35716 pull down 9869640 direct interaction X 2 O35716 biochemical 15456882 colocalization X 2 O35716 P05532 two hybrid 10679268 direct interaction X 2 O35716 P09581 two hybrid 10679268 direct interaction X 2 O35716 K7QD41 two hybrid 10679268 direct interaction X 2 O35716 Q93034 affinity chromatography technology 15601820 physical association X 2 O35716 pull down 23990909 direct interaction X 2 O35716 P83940 affinity chromatography technology 15304214 physical association X 2 O35716 Q99PJ2 two hybrid 12163497 direct interaction X 2 O35716 Q99PJ2 affinity chromatography technology 12163497 physical association X 2 O35716 Q99PJ2 affinity chromatography technology 12163497 physical association X 2 O35716 Q93034 pull down 11384984 direct interaction X 2 O35716 Q13617 pull down 11384984 direct interaction X 2 O35716 P83940 affinity chromatography technology 9869640 physical association X 2 O35716 P83940 pull down 9869640 direct interaction X 2 O35716 affinity chromatography technology 20622265 physical association X 2 O35716 affinity chromatography technology 20622265 physical association X 2 O35716 Q3V1L4 affinity chromatography technology 20622265 physical association X 2 O35716 Q9D5V5 pull down 19385048 direct interaction X 2 P15208 O35716 affinity chromatography technology 15169905 physical association X 2 P15261 O35716 affinity chromatography technology 19734231 physical association X 2 P17879 O35716 biochemical 15456882 colocalization X 2 O35716 affinity chromatography technology 11854514 physical association X 2 Q62318 O35716 affinity chromatography technology 20622265 physical association X 2 O35716 Q62120 two hybrid 10064597 physical association X 2 O35716 Q62120 coimmunoprecipitation 10064597 association X 2 O35716 anti tag coimmunoprecipitation 15601820 association C 5 O35716 anti tag coimmunoprecipitation 15601820 association C 5 O35716 Q04207 anti tag coimmunoprecipitation 19270718 physical association X 2 O35716 P09581 two hybrid 11297560 - X 2 O35716 P09581 copurification 11297560 - X 2 O35716 P09581 coimmunoprecipitation 11297560 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Socs1 Tirap MI:0004(affinity chromatography technology) 19296467 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319335 bait prey Socs1 Shc1 MI:0004(affinity chromatography technology) 20622265 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315430 bait prey Socs1 Psmc6 MI:0401(biochemical) 15456882 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (biogrid) BIOGRID_321746 bait prey Socs1 Pim1 MI:0004(affinity chromatography technology) 11854514 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328160 bait prey Socs1 Pag1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16920712 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_316027|BIOGRID_316026 bait|prey prey|bait Socs1 Kit MI:0018(two hybrid) 10679268 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_324990 bait prey Socs1 Cul5 MI:0401(biochemical) 19385048 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_319468 prey bait Socs1 Hspa1b MI:0401(biochemical) 15456882 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (biogrid) BIOGRID_321747 bait prey Socs1 Tceb2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 9869640 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_315425|BIOGRID_315417 bait|bait prey|prey Socs1 Cul2 MI:0401(biochemical) 15456882 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (biogrid) BIOGRID_321748 bait prey Socs1 Pcsk4 MI:0004(affinity chromatography technology) 20622265 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315434 bait prey Socs1 Csf1r MI:0018(two hybrid) 10679268 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_324991 bait prey Socs1 Insr MI:0004(affinity chromatography technology) 15169905 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324059 bait prey Socs1 Ifngr1 MI:0004(affinity chromatography technology) 19734231 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324493 bait prey Socs1 Jak1 MI:0401(biochemical) 15456882 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (biogrid) BIOGRID_321749 bait prey Socs1 Pcnt MI:0004(affinity chromatography technology) 20622265 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315429 bait prey Socs1 Rela MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 10,19270718 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_169359|MINT_74115 prey|prey bait|bait Socs1 Jak2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10064597,10679268 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint) BIOGRID_324993|UniProt_161301|UniProt_161302|MINT_79938|MINT_79937 bait|unspecified role|unspecified role|unspecified role|unspecified role prey|unspecified role|unspecified role|unspecified role|unspecified role Socs1 Pim2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11854514 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_328158|BIOGRID_328159|BIOGRID_328161 bait|prey|prey prey|bait|bait Socs1 Bclaf1 MI:0004(affinity chromatography technology) 20622265 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315433 bait prey Socs1 Ubc MI:0004(affinity chromatography technology) 19296467 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319336 prey bait Socs1 Nt5c2 MI:0004(affinity chromatography technology) 20622265 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315432 bait prey Socs1 Tceb1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15304214,9869640 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_310914|BIOGRID_315426|BIOGRID_315418 prey|bait|bait bait|prey|prey Socs1 Tubg1 MI:0401(biochemical) 15456882 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (biogrid) BIOGRID_321745 bait prey Socs1 Trim28 MI:0004(affinity chromatography technology) 20622265 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315431 bait prey Socs1 Ptk2b MI:0018(two hybrid) 10679268 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_324992 bait prey Socs1 Trim8 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12163497 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_311809|BIOGRID_311811|BIOGRID_311810 bait|prey|bait prey|bait|prey

PPI - HINT Gene A Gene B PMID Method Quality SOCS1 KIT 10679268,14707129,10022833 0018,0018,0018 LC SOCS1 CSF1R 10679268,11297560,11297560,11297560 0018,0018,0025,0019 LC SOCS1 HSPA1B 15456882 0401 LC SOCS1 VAV1 15456882 0401 LC SOCS1 JAK1 15456882 0401 LC SOCS1 PSMC6 15456882 0401 LC SOCS1 TUBG1 15456882 0401 LC SOCS1 PAG1 16920712,16920712 0004,0018 LC SOCS1 JAK2 10064597,10064597,10679268,9869640 0019,0018,0018,0019 LC SOCS1 PIM2 11854514,11854514 0004,0415 LC SOCS1 TRIM8 12163497,12163497,12163497 0004,0018,0019 LC SOCS1 CUL2 15456882 0401 LC SOCS1 PTK2B 10679268 0018 LC SOCS1 SOCS2 16956890 0007 LC SOCS1 PIM1 14764533,11854514 0007,0004 LC SOCS1 CSF1R 11297560,11297560,11297560 0018,0025,0019 LC SOCS1 UBC 19296467 0004 LC SOCS1 INSR 15169905 0004 LC SOCS1 IFNGR1 19734231,19734231,15522878 0007,0004,0007 LC SOCS1 HSPA1B 15456882 0401 LC SOCS1 IRF8 21731497 0007 LC SOCS1 VAV1 15456882 0401 LC SOCS1 PCSK4 20622265 0004 LC SOCS1 IFNAR1 21757742 0007 LC SOCS1 CREBBP 16920712 0007 LC SOCS1 PCNT 20622265 0004 LC SOCS1 JAK1 23990909,15456882 0096,0401 LC SOCS1 PSMC6 15456882 0401 LC SOCS1 TCEB2 9869640,15601820,9869640,9869640 0096,0007,0004,0007 LC SOCS1 TUBG1 15456882 0401 LC SOCS1 TCEB1 15304214,9869640,15601820,9869640,9869640 0004,0096,0007,0004,0007 LC SOCS1 SHC1 20622265 0004 LC SOCS1 RELA 14690596,19270718 0007,0007 LC SOCS1 PAG1 16920712,16920712 0004,0018 LC SOCS1 NT5C2 20622265 0004 LC SOCS1 JAK2 15522878,18508766 0007,0007 LC SOCS1 TRIM28 20622265 0004 LC SOCS1 BCLAF1 20622265 0004 LC SOCS1 PIM2 11854514,11854514 0004,0415 LC SOCS1 TIRAP 19296467,19296467 0004,0007 LC SOCS1 TRIM8 12163497,12163497,12163497 0004,0018,0019 LC SOCS1 CUL2 15456882 0401 LC SOCS1 CUL5 19385048 0096 LC SOCS1 TYK2 21757742 0007 LC