PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Rpgrip1l Cdc16 21565611 intact exp Ppargc1a Cdc16 i2d exp G G G G G G G G G G G G G G G G G G G G G Ywhae Cdc16 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cad Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc16 Anapc7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Taf4a Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad3 Cdc16 ortho G G G G G G G G G G G G G G G Gmppb Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smarcad1 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nsun5 Cdc16 ortho P G Pold1 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G Taf5 Cdc16 ortho Cdc16 Cdc7 ortho G G G G G G G G G G G G G G G G G G G G Hecw2 Cdc16 ortho Cdc16 Ttll1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc16 Bub1b ortho G G G G G G G G G G G G Cdc16 Pycr1 ortho P G G G G G G G G G G G Crebbp Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc27 Cdc16 ortho G G G G G G Mov10 Cdc16 ortho G G G G G G G G G G G G G G G G G G G G Ep300 Cdc16 ortho P Cdc16 Cdc20 ortho G G G G G G G G G G G G G G G G G G G G G G Dnaja1 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc16 Bub3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Phf8 Cdc16 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk2 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Cdc16 Anapc11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc16 Sh3kbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ttk Cdc16 ortho G G G G G G G G Cdc16 Fzr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc16 Pycr2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nap1l4 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc5 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc16 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tubb4b Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G B4galt7 Cdc16 ortho G G G G G G G G G G G G G G G G G G G G G G Nek2 Cdc16 ortho G G G G G G G G Plk1 Cdc16 ortho G G G G G G G G G G G G G G Cdc16 Mad2l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Hint1 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UPF0705 protein C11orf49 homolog Cdc16 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cfap97 Cdc16 ortho G G G Atp6v1b2 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc10 Cdc16 ortho Smad2 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp5j Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc16 Anapc4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc2 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa4 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Magix Cdc16 ortho G G G G Anapc1 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smcr8 Cdc16 ortho P Ppp5c Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fth1 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pkm Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc16 Cdc26 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brca1 Cdc16 ortho G G G G G G G G G G G G G Cdc16 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc5l Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rb1 Cdc16 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53bp1 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc23 Cdc16 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Skil Cdc16 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpl5 Cdc16 ortho P Cdc16 Anapc16 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc16 Snw1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxo5 Cdc16 ortho Taf3 Cdc16 ortho Cdc16 Trim33 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr2 Cdc16 ortho G Dab2 Cdc16 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdc1 Cdc16 ortho P Ywhah Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anapc2 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tuba1c Cdc16 ortho P Anapc13 Cdc16 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Xrcc5 Cdc16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Cdc16 Mus81 ortho G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q13257 Q8R349 affinity chromatography technology 20360068 physical association X 2 Q9UJX5 Q8R349 affinity chromatography technology 20360068 physical association X 2 Q8R349 Q9NYG5 affinity chromatography technology 20360068 physical association X 2 Q8R349 Q9UJX4-2 affinity chromatography technology 20360068 physical association X 2 Q8R349 Q9NSC5-4 affinity chromatography technology 20360068 physical association X 2 Q8R349 F6U4U2 affinity chromatography technology 20360068 physical association X 2 C5H3H2 Q8R349 affinity chromatography technology 20360068 physical association X 2 Q9UJX6 Q8R349 affinity chromatography technology 20360068 physical association X 2 A0A024R832 Q8R349 affinity chromatography technology 20360068 physical association X 2 O60566 Q8R349 affinity chromatography technology 20360068 physical association X 2 A8K3Z6 Q8R349 affinity chromatography technology 20360068 physical association X 2 Q8R349 Q9UKT4-2 affinity chromatography technology 20360068 physical association X 2 Q8R349 Q9UJX2 affinity chromatography technology 20360068 physical association X 2 Q8R349 Q13042-2 affinity chromatography technology 20360068 physical association X 2 Q8R349 affinity chromatography technology 20360068 physical association X 2 Q9UM13 Q8R349 affinity chromatography technology 20360068 physical association X 2 Q9H1A4 Q8R349 affinity chromatography technology 20360068 physical association X 2 Q9UM11 Q8R349 affinity chromatography technology 20360068 physical association X 2 Q8R349 affinity chromatography technology 20360068 physical association X 2 Q86YM7 Q8R349 affinity chromatography technology 20360068 physical association X 2 Q12834 Q8R349 affinity chromatography technology 20360068 physical association X 2 Q8R349 coimmunoprecipitation 10318877 association C 9 Q8R349 tandem affinity purification 20360068 physical association C 22

PPI - HINT Gene A Gene B PMID Method Quality YWHAE CDC16 16615898 0027 LC RPGRIP1L CDC16 21565611 0007 HT CDC16 CHAF1A 26365490 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8R349 Q8CG73 CDC16 RPGRIP1L 0.126 21565611 Q8R349 P62259 CDC16 YWHAE 0.081 16615898 Q8R349 F5GXB9 CDC16 ANAPC15 {ECO:0000313|ENSEMBL:ENSP00000440380} 0.126 26496610 Q8R349 F5H6Z0 CDC16 CDK17 {ECO:0000313|ENSEMBL:ENSP00000442926} 0.126 26496610 Q8R349 G5EA36 CDC16 G5EA36 0.126 26496610 Q8R349 I3L3H6 CDC16 CDC27 {ECO:0000313|ENSEMBL:ENSP00000460454} 0.126 26496610 Q8R349 P60006 CDC16 ANAPC15 0.126 26496610 Q8R349 Q00537 CDC16 CDK17 0.126 26496610 Q8R349 Q13042 CDC16 CDC16 0.236 20360068 Q8R349 Q03519 CDC16 TAP2 0.236 26496610 Q8R349 O14828 CDC16 SCAMP3 0.236 26496610 Q8R349 P31350 CDC16 RRM2 0.236 26496610 Q8R349 O95168 CDC16 NDUFB4 0.236 26496610 Q8R349 P38435 CDC16 GGCX 0.236 26496610 Q8R349 P32322 CDC16 PYCR1 0.236 26496610 Q8R349 P35613 CDC16 BSG 0.236 26496610 Q8R349 Q86YM7 CDC16 HOMER1 0.236 20360068 Q8R349 Q13616 CDC16 CUL1 0.236 26496610 Q8R349 Q13509 CDC16 TUBB3 0.236 26496610 Q8R349 Q7Z3U7 CDC16 MON2 0.236 26496610 Q8R349 Q3T906 CDC16 GNPTAB 0.236 26496610 Q8R349 Q5T9L3 CDC16 WLS 0.236 26496610 Q96C36 Q8R349 PYCR2 CDC16 0.236 26496610 Q8R349 Q8IV48 CDC16 ERI1 0.236 26496610 Q8R349 Q8N4S0 CDC16 CCDC82 0.236 26496610 Q969M3 Q8R349 YIPF5 CDC16 0.236 26496610 Q8R349 Q8NI77 CDC16 KIF18A 0.236 26496610 Q92833 Q8R349 JARID2 CDC16 0.236 26496610 Q9P2B7 Q8R349 KIAA1430 CDC16 0.236 26496610 Q9H936 Q8R349 SLC25A22 CDC16 0.236 26496610 Q9NYG5 Q8R349 ANAPC11 CDC16 0.236 20360068 Q9NX61 Q8R349 TMEM161A CDC16 0.236 26496610 Q9UJJ9 Q8R349 GNPTG CDC16 0.236 26496610 Q9Y696 Q8R349 CLIC4 CDC16 0.236 26496610 Q8R349 Q12834 CDC16 CDC20 0.416 26496610,20360068 Q8R349 O60566 CDC16 BUB1B 0.416 26496610,20360068 Q8R349 P51955 CDC16 NEK2 0.416 26496610,20360068 Q8R349 P30260 CDC16 CDC27 0.416 26496610,20360068 Q9UM13 Q8R349 ANAPC10 CDC16 0.416 26496610,20360068 Q8R349 Q13257 CDC16 MAD2L1 0.416 26496610,20360068 Q96DE5 Q8R349 ANAPC16 CDC16 0.416 26496610,20360068 Q8R349 Q8NHZ8 CDC16 CDC26 0.416 26496610,20360068 Q9UM11 Q8R349 FZR1 CDC16 0.416 26496610,20360068 Q9BS18 Q8R349 ANAPC13 CDC16 0.416 26496610,20360068 Q9H1A4 Q8R349 ANAPC1 CDC16 0.416 26496610,20360068 Q9NSC5 Q8R349 HOMER3 CDC16 0.416 26496610,20360068 Q9UKT4 Q8R349 FBXO5 CDC16 0.416 26496610,20360068 Q9UJX3 Q8R349 ANAPC7 CDC16 0.416 26496610,20360068 Q9UJX2 Q8R349 CDC23 CDC16 0.416 26496610,20360068 Q9UJX6 Q8R349 ANAPC2 CDC16 0.416 26496610,20360068 Q9UJX4 Q8R349 ANAPC5 CDC16 0.416 26496610,20360068 Q9UJX5 Q8R349 ANAPC4 CDC16 0.416 26496610,20360068 Q9QWF0 Q8R349 CHAF1A CDC16 0.126 26365490