PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Sec61a1 Stub1 24218449 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nanog Stub1 23892456 biogrid,intact exp Hyou1 Stub1 24218449 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa1b Stub1 24251647 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhab Stub1 16635246 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Il4r Stub1 24251647 biogrid exp G G G G G G G G G G G G G G G G G G G Tcf3 Stub1 15456869 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stub1 Stub1 11435423,16307917 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bag5 Stub1 24510904 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tlr9 Stub1 21911421 innatedb exp, ortho G G Mapt Stub1 14962978 biogrid exp, ortho P G G G G G G G G G G G G G G G Src Stub1 21911421 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Dyx1c1 Stub1 19737534,15189447 biogrid exp, ortho G Map3k2 Stub1 20588253 biogrid,mint,intact exp, ortho Ppp2r1a Stub1 19818709 mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G App Stub1 17317785 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf6 Stub1 21911421,24578159 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G Hspa8 Stub1 21911421,23612611 innatedb,biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr3c2 Stub1 20861078 biogrid exp, ortho Prkcz Stub1 21911421 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G Ube2n Stub1 16307917 intact exp, ortho P Akt1 Stub1 18292230 biogrid,dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atxn3 Stub1 15664989 biogrid exp, ortho P Lrrk2 Stub1 19196961 biogrid,dip exp, ortho GP G G G G G G G G G G G G G G G G G G G G Hsp90ab1 Stub1 23612611 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ilk Stub1 23612611 biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxp3 Stub1 23973223 biogrid exp, ortho Tlr4 Stub1 21911421 innatedb exp, ortho G G G G G G G G G G G G G G G G G Pfn1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nqo1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G Peli3 Stub1 ortho Pcsk9 Stub1 ortho Aimp2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k11 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G Ube2v1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dnaja3 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk4 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspb1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Slc12a3 Stub1 ortho G Prpf19 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kiaa1524 Stub1 ortho G G G G G G G G G G G Stub1 Katna1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k3 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epm2a Stub1 ortho G G G Nlrp12 Stub1 ortho Runx1 Stub1 ortho G G G G G G G G G G G G G G G G Stk11 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rela Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dvl3 Stub1 ortho Smarcd2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad4 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfkb1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Klhl29 Stub1 ortho Ywhae Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Epas1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G Dnm3 Stub1 ortho P G G G G G G G G G G G G G G G Ahcyl1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lims1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pten Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Uba1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cyp2e1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Mib1 Stub1 ortho P G G G G G G G G G Stub1 Dyrk1b ortho G G G G G G G G G G G G G G G G G G G G G G G G G Mcm5 Stub1 ortho P G G G G G G G G G G G G G G Hus1b Stub1 ortho Bag2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Josd2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sim2 Stub1 ortho G G Phkg2 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2w Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ahr Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dnajc5 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Maoa Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Stub1 ortho G G G G G G G G G G G G G G G G G G G G Cd4 Stub1 ortho G G Rad23b Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Avpr2 Stub1 ortho G G G Nubp2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Gucy1a2 Stub1 ortho Ube2l3 Stub1 ortho P Txn2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gtf3c5 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Raf1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2q1 Stub1 ortho P Ambra1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nkd1 Stub1 ortho G G G G G G Xiap Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Egfr Stub1 ortho GP G G G G G G G G G G G G G G G G G Adi1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddx11 Stub1 ortho Klhl38 Stub1 ortho Tgfbr1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mlf1 Stub1 ortho G G G G G G G G G G G Atcay Stub1 ortho G G G G G G Sh3bgrl Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fmr1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myc Stub1 ortho G G G G G G G G G G G G G G G G G G G G G Abl1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prdm1 Stub1 ortho G G G G G G G G G G G G G G G G Fbxo2 Stub1 ortho P G G G G G G G G G G Atxn1 Stub1 ortho Shb Stub1 ortho P Nos2 Stub1 ortho G Pot1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gpr37 Stub1 ortho G G G G G G G G G Hsf1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube4b Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc37l1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dnajb1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stam Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2v2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspd1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa1l Stub1 ortho P G G G Smad5 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mlf2 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hif1a Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mapkapk5 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stxbp2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk20 Stub1 ortho G G G G G G G Rad54l2 Stub1 ortho G G G G G G G G G G G G G G Hspa5 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lman1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Asb10 Stub1 ortho G G G G G Tomm40 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Jak3 Stub1 ortho G G G G G G G G G G G G G G G Sirt6 Stub1 ortho Srxn1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Inpp1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Irak1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stub1 Nos1 ortho G G G G G G G G G G G G Yap1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Irf1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bag3 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vhl Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Galnt10 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Nefm Stub1 ortho G G G G G G G Eif5a Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mif Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dvl2 Stub1 ortho G G G G G G G G G G G G Psmd2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nhlrc1 Stub1 ortho Axin2 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G Arrb2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Men1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Llgl1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Araf Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Drd4 Stub1 ortho G G G Terf2 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Evc2 Stub1 ortho Hcfc1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tinf2 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Shfm1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psma3 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cul4b Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pgr Stub1 ortho G Hspa4 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Mcf2 Stub1 ortho G G Rusc1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stub1 Park2 ortho G G G G Bag4 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chuk Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lrrk1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G Chtf18 Stub1 ortho G Ube2d2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smurf1 Stub1 ortho Myocd Stub1 ortho G G G G G G Dnajb6 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stub1 Gsk3b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mapk3 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RME-8 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tead3 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp49 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Snai2 Stub1 ortho G G G G G G G G Dpm1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Crem Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctbp2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr3c1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mkks Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pacrg Stub1 ortho G G G G G G G G G G G G Khdrbs1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd14 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct5 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Elavl4 Stub1 ortho G G G G G G G G G Senp3 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mitf Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Snca Stub1 ortho P G G G G G G G G G G G G G G G G Cdc37 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mpp1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kcnq4 Stub1 ortho Smg5 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Arrb1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chic2 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Olfm3 Stub1 ortho G G G G G G G G G Vcp Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp6ap2 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ola1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Utp18 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Esr1 Stub1 ortho G G G G G Bmpr1b Stub1 ortho G G G Cftr Stub1 ortho G G G G G G G G Ralgps1 Stub1 ortho Kiaa0753 Stub1 ortho Ar Stub1 ortho G G G G G G G G G G G G G G G G Stub1 Asb4 ortho G G G G G G G G Tert Stub1 ortho Card11 Stub1 ortho Nadsyn1 Stub1 ortho Llgl2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G Ccl28 Stub1 ortho G G G G G Traf2 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Clcn2 Stub1 ortho P G G G G G G G G G G G G G G Cdk18 Stub1 ortho G G G G G G G G G G G G G G G G Psmd4 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stub1 Skp2 ortho G G G G G G G G G G G G G Smad3 Stub1 ortho G G G G G G G G G G G G G G G Ctcfl Stub1 ortho Mos Stub1 ortho Cct7 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ern1 Stub1 ortho G G G G G Kcnh2 Stub1 ortho G G G G G G G G G G G G G G G Stub1 Rps6kb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Stub1 Mapk11 ortho G G G G G G G G Hsf2 Stub1 ortho Nxf1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pa2g4 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspbp1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcr Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tet3 Stub1 ortho Stub1 Map3k14 ortho G G G G G G G G G Erbb2 Stub1 ortho P G G G G G G G G G G G G Trub2 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ercc3 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Daxx Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Endog Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Stil Stub1 ortho G G G Tal1 Stub1 ortho G G G G G G Nkd2 Stub1 ortho G G Runx2 Stub1 ortho G G G G G G G G G G G G G Bag1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec23a Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxo27 Stub1 ortho Ube2e1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k5 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Terf1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Dvl1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Malt1 Stub1 ortho Stub1 Sgk1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Polb Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ptk2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rec8 Stub1 ortho G G G G G G G G G G G G Txlng Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G S100a6 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa4l Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ago2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Park7 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eif4e Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bdkrb2 Stub1 ortho Ube2q2 Stub1 ortho Mst1r Stub1 ortho G G G G G G G G Stub1 Hdac6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Gucy1a3 Stub1 ortho GP G G G G G G G G G G G G G G G G Dnajc7 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e3 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ago1 Stub1 ortho P Stub1 Nfkbia ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tssc1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Paics Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nudcd2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Axl Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sod1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tln2 Stub1 ortho P Acd Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad2 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sec24a Stub1 ortho P Ghr Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Foxo1 Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk1e Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fbxo24 Stub1 ortho Nup88 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gucy1b3 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Cflar Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Met Stub1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P16382 Q9WUD1 affinity chromatography technology 24251647 physical association X 2 P16382 Q9WUD1 affinity chromatography technology 24251647 physical association X 2 P34932 Q9WUD1 affinity chromatography technology 15189447 physical association X 2 P11499 Q9WUD1 affinity chromatography technology 23612611 physical association X 2 Q9WUD1 Q9CVZ5 two hybrid 19737534 direct interaction X 2 Q9WUD1 P0CG50 enzymatic study 11435423 direct interaction X 2 Q9WUD1 Q53GL0 two hybrid 20368287 direct interaction X 2 Q9WUD1 affinity chromatography technology 20861078 physical association X 2 Q9WUD1 affinity chromatography technology 20861078 physical association X 2 Q9WUD1 A0A087WW00 pull down 23612611 direct interaction X 2 Q9WUD1 A2RS90 affinity chromatography technology 23892456 physical association X 2 Q9WUD1 Q53Z59 affinity chromatography technology 23973223 physical association X 2 Q9WUD1 Q53Z59 affinity chromatography technology 23973223 physical association X 2 Q9WUD1 P70196 affinity chromatography technology 24578159 physical association X 2 Q9WUD1 P70196 affinity chromatography technology 24578159 physical association X 2 Q9WUD1 P02829 pull down 18412542 direct interaction X 2 Q9WUD1 P31750 affinity chromatography technology 18292230 physical association X 2 Q9WUD1 P10637-3 affinity chromatography technology 14962978 physical association X 2 Q9WUD1 Q5M8S1 enzymatic study 21855799 direct interaction X 2 Q9WUD1 affinity chromatography technology 20588253 physical association X 2 Q9WUD1 Q8WXU2-3 two hybrid 15189447 direct interaction X 2 Q9WUD1 Q9CVZ5 affinity chromatography technology 15189447 physical association X 2 Q9WUD1 P36897 affinity chromatography technology 15761153 physical association X 2 Q9WUD1 Q5M8S1 affinity chromatography technology 15664989 physical association X 2 Q9WUD1 A0A090N7U0 affinity chromatography technology 15456869 physical association X 2 Q9WUD1 Q13309-2 affinity chromatography technology 15456869 physical association X 2 Q9JKR6 Q9WUD1 affinity chromatography technology 24218449 physical association X 2 Q9JKR6 Q9WUD1 affinity chromatography technology 24218449 physical association X 2 Q9WUD1 affinity chromatography technology 23612611 physical association X 2 Q9WUD1 affinity chromatography technology 23612611 physical association X 2 Q9WUD1 P63017 affinity chromatography technology 23612611 physical association X 2 Q9WUD1 enzymatic study 23612611 direct interaction X 2 Q9WUD1 P17879 affinity chromatography technology 24251647 physical association X 2 Q9WUD1 Q9WUD1 x-ray crystallography 16307917 association X 2 Q9WUD1 P07900-2 x-ray crystallography 16307917 association X 2 Q9WUD1 Q13404 x-ray crystallography 16307917 association X 2 Q9WUD1 P61088 x-ray crystallography 16307917 association X 2 Q9WUD1 Q5S006 affinity chromatography technology 19196961 physical association X 2 Q9WUD1 affinity chromatography technology 17317785 physical association X 2 Q9WUD1 affinity chromatography technology 17317785 physical association X 2 Q9WUD1 A0A024RAH0 two hybrid 20588253 direct interaction X 2 Q9WUD1 P07900-2 affinity chromatography technology 15189447 physical association X 2 Q9WUD1 affinity chromatography technology 15761153 physical association X 2 Q9WUD1 E9PVV2 affinity chromatography technology 15456869 physical association X 2 Q9WUD1 E9PVV2 affinity chromatography technology 15456869 physical association X 2 Q9WUD1 P00441 affinity chromatography technology 15198682 physical association X 2 O00238 Q9WUD1 affinity chromatography technology 15761153 physical association X 2 P61620 Q9WUD1 affinity chromatography technology 24218449 physical association X 2 Q9WUD1 P31750 anti bait coimmunoprecipitation 18292230 physical association X 2 Q9WUD1 anti tag coimmunoprecipitation 19196961 physical association X 2 Q9WUD1 anti tag coimmunoprecipitation 19196961 physical association X 2 Q9WUD1 Q5S006 anti bait coimmunoprecipitation 19196961 physical association X 2 Q9WUD1 cosedimentation through density gradient 16635246 colocalization C 608 Q9WUD1 x-ray crystallography 16307917 physical association C 3 Q9WUD1 anti tag coimmunoprecipitation 23612611 association C 4 Q9WUD1 anti bait coimmunoprecipitation 24510904 association C 4 Q9WUD1 anti tag coimmunoprecipitation 23892456 association C 143 Q61083 Q9WUD1 anti bait coimmunoprecipitation 20588253 physical association X 2 Q9WUD1 Q53GL0 two hybrid 20368287 physical association X 2 O55222 Q9WUD1 anti tag coimmunoprecipitation 23612611 physical association X 2 O55222 Q9WUD1 anti tag coimmunoprecipitation 23612611 physical association X 2 O55222 Q9WUD1 anti bait coimmunoprecipitation 23612611 physical association X 2 O55222 Q9WUD1 fluorescence technology 23612611 colocalization X 2 Q76MZ3 Q9WUD1 anti bait coimmunoprecipitation 19818709 physical association X 2 Q9WUD1 pull down 23612611 physical association C 3 Q9WUD1 anti tag coimmunoprecipitation 23612611 association C 41 Q9WUD1 K9JA46 x-ray crystallography 16307917 direct interaction X 2 Q9WUD1 P61088 isothermal titration calorimetry 16307917 direct interaction X 2 Q9WUD1 P61088 isothermal titration calorimetry 16307917 direct interaction X 2 Q9WUD1 A0A024RAH0 two hybrid 20588253 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality ILK STUB1 23612611,23612611,23612611,23612611,23612611,23612611 0415,0004,0096,0007,0006,0051 LC CDK5 STUB1 26206088,26206088,26206088 0415,0004,0096 LC UBE2N STUB1 16307917 0114 LC DYX1C1 STUB1 19737534 0018 LC UBXN2A STUB1 26265139,26265139 0004,0018 LC YWHAB STUB1 16635246 0029 LC ATXN3 STUB1 21855799 0415 LC STUB1 STUB1 16307917,26206088,11435423 0114,0415,0415 LC NR3C2 STUB1 20861078 0004 LC ILK STUB1 23612611,23612611,23612611,23612611,23612611,23612611 0415,0004,0096,0007,0006,0051 LC MAPT STUB1 14962978 0004 LC HSP90AB1 STUB1 23612611 0004 LC APP STUB1 17317785 0004 LC TCF3 STUB1 15456869 0004 LC IL4R STUB1 24251647 0004 LC HSPA1B STUB1 24251647 0004 LC AKT1 STUB1 18292230,18292230 0006,0004 LC CDK5 STUB1 26206088,26206088,26206088 0415,0004,0096 LC SEC61A1 STUB1 24218449 0004 LC HSPA8 STUB1 21911421,23612611,21911421 0096,0004,0007 LC TRAF6 STUB1 24578159,21911421 0004,0007 LC PRKCZ STUB1 21911421,21911421 0096,0007 LC DYX1C1 STUB1 15189447 0004 LC LRRK2 STUB1 19196961,19196961 0006,0004 LC TRAF3 STUB1 25792747 0004 LC MAP3K2 STUB1 20588253,20588253 0004,0006 LC TAU STUB1 14962978 0004 LC PPP2R1A STUB1 19818709 0006 LC NANOG STUB1 23892456,23892456 0007,0004 LC BAG5 STUB1 24510904 0006 LC CHRNA3 STUB1 26265139 0004 LC SP7 STUB1 25818514 0004 LC FOXP3 STUB1 23973223 0004 LC UBXN2A STUB1 26265139,26265139 0004,0018 LC ATXN3 STUB1 15664989 0004 LC HYOU1 STUB1 24218449 0004 LC CHAF1A STUB1 26365490 0004 LC STUB1 MAP3K14 25792747 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9WUD1 P15806 STUB1 TCF3 0.376 15456869 Q9WUD1 P61620 STUB1 SEC61A1 0.21 24218449 Q9WUD1 Q8CI32 STUB1 BAG5 0.126 24510904 Q9WUD1 Q9HCE7 STUB1 SMURF1 0.126 15761153 Q9WUD1 Q9JKR6 STUB1 HYOU1 0.376 24218449 Q9WUD1 P16382 STUB1 IL4R 0.376 24251647 Q9WUD1 P12023 STUB1 APP 0.376 17317785 Q9WUD1 P11499 STUB1 HSP90AB1 0.126 23612611 Q9WUD1 P10637 STUB1 MAPT 0.21 14962978 Q9WUD1 P02829 STUB1 HSP82 0.309 18412542 Q9WUD1 Q60803 STUB1 TRAF3 0.21 25792747 Q9WUD1 P61088 STUB1 UBE2N 0.309 16307917 Q9WUD1 P19120 STUB1 HSPA8 0.126 23612611 Q9WUD1 P17879 STUB1 HSPA1B 0.21 24251647 Q9WUD1 P61077 STUB1 UBE2D3 0.309 11435423 Q9WUD1 P34932 STUB1 HSPA4 0.21 15189447 Q9WUD1 P51668 STUB1 UBE2D1 0.183 23612611 Q9WUD1 Q5S006 STUB1 LRRK2 0.21 19196961 Q9WUD1 Q13309 STUB1 SKP2 0.21 15456869 Q9WUD1 P63017 STUB1 HSPA8 0.126 23612611 Q9WUD1 Q53GL0 STUB1 PLEKHO1 0.454 20368287 Q9WUD1 Q13404 STUB1 UBE2V1 0.309 16307917 Q9WUD1 Q13616 STUB1 CUL1 0.21 15456869 Q9WUD1 Q76MZ3 STUB1 PPP2R1A 0.21 19818709 Q9WUD1 Q61083 STUB1 MAP3K2 0.21 20588253 Q9WUD1 Q8WXU2 STUB1 DYX1C1 0.309 15189447 Q9WUD1 Q8R4G9 STUB1 CHRNA3 0.21 26265139 Q9WUD1 Q9JM53 STUB1 AIFM1 0.21 26206088 Q9Y2U5 Q9WUD1 MAP3K2 STUB1 0.523 20588253 Q9WUL6 Q9WUD1 MAP3K14 STUB1 0.376 25792747 Q9WUD1 P00441 STUB1 SOD1 0.21 15198682 Q9WUD1 P07900 STUB1 HSP90AA1 0.454 15189447,16307917 Q9WUD1 P31750 STUB1 AKT1 0.376 18292230 Q9WUD1 P49615 STUB1 CDK5 0.702 26206088 Q9WUD1 Q8R368 STUB1 DYX1C1 0.454 15189447,19737534 Q9WUD1 Q80Z64 STUB1 NANOG 0.236 23892456 Q9WUD1 Q9WUD1 STUB1 STUB1 0.702 26206088,16307917,11435423 Q9WUD1 O55222 STUB1 ILK 0.665 23612611 Q9WUD1 Q8VI67 STUB1 SP7 0.376 25818514 Q9WUD1 P36897 STUB1 TGFBR1 0.126 15761153 Q9WUD1 Q99JB6 STUB1 FOXP3 0.376 23973223 Q9WUD1 Q99KJ0 STUB1 UBXN2A 0.454 26265139 Q9WUD1 Q9CQV8 STUB1 YWHAB 0.081 16635246 Q9WUD1 Q9CVD2 STUB1 ATXN3 0.21 15664989 Q9WUD1 Q9QWF0 STUB1 CHAF1A 0.126 26365490 Q9WUD1 P70196 STUB1 TRAF6 0.376 24578159 Q9WUD1 O00238 STUB1 BMPR1B 0.126 15761153