PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Cbx4 Foxp3 22922362 biogrid exp Cbx4 H3f3a, H3f3b 16537902 biogrid exp Cbx4 Rnf2 17296600 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Pcgf2 22325148 intact exp, ortho G G G G G Cbx4 Lnx2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Wiz ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Smc3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Cbx4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Mrpl55 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Ss18l2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Dnmt3a ortho G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Fer ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Ywhah ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Asap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 ortho G G G G Cbx4 Hnrnpk ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Mbd1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Med9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Ube2i ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Eed ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Hist1h2ab, Hist1h2ac, Hist1h2ad, Hist1h2ae, Hist1h2ag, Hist1h2ai, Hist1h2an, Hist1h2ao ortho Cbx4 Ywhag ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Ercc6 Cbx4 ortho Cbx4 Kdm4c ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Cdc25a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Tma16 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Hif1a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Slc25a5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Mapkapk3 ortho Cbx4 Kdm2a ortho Chd7 Cbx4 ortho G G G G G G G G G G G G G G G G G Cbx4 Cbx2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Hecw2 ortho Cbx4 PcgF3 ortho Cbx4 Wdhd1 ortho G G G G G G G G G G G G G G G G G G G G G Cbx4 Pola1 ortho G G G G G G G G G G G G G G Cbx4 Dcaf6 ortho Cbx4 Ctbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Hoxa2 ortho Cbx4 Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 ortho G G G G G G G G G G G G G G Cbx4 Kdm3a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk2a2 Cbx4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Npm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Cbx8 ortho G G G G G G G G G G G Cbx4 Rad51 ortho G G G G G G G G G G G G G Cbx4 Msh2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Csnk2b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Impact Cbx4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Mki67 Cbx4 ortho G G G G G G G G G G G G G G G G G G G G G Cbx4 Rbl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Sox2 ortho G G G G G G G G G G G Cbx4 Pcna ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zfp167 Cbx4 ortho Cbx4 Kmt2a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Zeb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Myl6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ring1 Cbx4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Suv39h1 Cbx4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Phc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Orc1 ortho G G G G Cbx4 Ywhab ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Cenpe ortho G G G G G Cbx4 Mycbp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Kdm5b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Hist1h2bc, Hist1h2be, Hist1h2bg ortho Cbx4 Ap4m1 ortho G G G G G G G Cbx4 Dhfr ortho G G G G G G G G G G G G G G G G G Cbx4 Ccdc158 ortho Cbx4 Khdrbs2 ortho G G G G G Cbx4 Cbx6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Stambpl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Phc3 ortho Cbx4 Ruvbl2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Scmh1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Ccne1 ortho G G G G G G G G G Cbx4 Bmi1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Csnk2a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Ttc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mga Cbx4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Usp11 ortho G G G G G G G G G G G G G G G G G G G G G G Cbx4 Sumo1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Ywhaz ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Lama1 ortho G G G G G G Cbx4 Dis3l2 ortho Protein Cenpf Cbx4 ortho G G G G G G G G G G G G G G G G Cbx4 Isg15 ortho Cbx4 Ankrd26 ortho Cbx4 Sdc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Mcm3 ortho G G G G G G G G G G G G G G G G G G G Cbx4 Pcgf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Kctd17 Cbx4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Mdm1 ortho G G G G G G Cbx4 Phc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Cdc6 ortho G G G G G G G G Cbx4 Parp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Parp12 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Psme3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Hist1h2bb ortho Cbx4 Trank1 ortho Cbx4 Rnf17 ortho G Cbx4 Mov10 ortho G G G G G G G G G G G G G G G G G G G G Cbx4 Sfn ortho G G G G G G G G Cbx4 Zfp11 ortho Cbx4 Rb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Vegfa ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Skil ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Usp7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Usmg5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Ctbp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Hells ortho G G G G G G G G G G G G G G Cbx4 Ywhae ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Smg1 ortho Cbx4 Satb1 ortho G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Hipk2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cbx4 Fhl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG11933, Protein Fam46a Cbx4 ortho Cbx4 Gtf2i ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snca Cbx4 ortho G G G G G G G G G G G G G G G G Cbx4 Znf131 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Cbx4 Rnf2 MI:0096(pull down)|MI:0004(affinity chromatography technology) 17296600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_166511|BIOGRID_315725 prey|prey prey|bait Cbx4 Foxp3 MI:0004(affinity chromatography technology) 22922362 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_324634 prey bait Cbx4 H3f3a MI:0004(affinity chromatography technology) 16537902 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_314639 prey bait

PPI - HINT Gene A Gene B PMID Method Quality CBX4 PCGF2 22325148 0007 LC CBX4 FOXP3 22922362 0004 LC CBX4 RNF2 17296600,17296600 0096,0004 LC