PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Vps41 Ywhab 16635246 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ywhae Vps41 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps41 Eed 24457600 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps41 Vps18 14668490 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm5c Vps41 ortho P G G G G G G G G Vps41 Vps41 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps41 Xrcc4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps41 Vipas39 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps41 Mrpl13 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps41 Nabp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G App Vps41 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps41 Utp20 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ap3d1 Vps41 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps41 Znf512b ortho Vps41 Rilp ortho Vps41 Sec61a2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps41 Aktip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps41 Mon1b ortho Hsp90ab1 Vps41 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps33b Vps41 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Tgfbrap1 Vps41 ortho Vps41 Hook2 ortho P G G G G G G G G G G G G G G Rab7a Vps41 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2u Vps41 ortho Vps41 Vps33a ortho P Esr2 Vps41 ortho G Vps41 Vps11 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps41 Vps16 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90aa1 Vps41 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ap2m1 Vps41 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps41 Fzd5 ortho G G Vps41 Hook3 ortho P Vps41 Hook1 ortho P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5KU39 Q8R307 affinity chromatography technology 14668490 physical association X 2 Q5KU39 Q921E6 affinity chromatography technology 24457600 physical association X 2 Q5KU39 cosedimentation through density gradient 16635246 colocalization C 608

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Vps41 Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332636 prey bait Vps41 Vps18 MI:0004(affinity chromatography technology) 14668490 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328017 prey bait

PPI - HINT Gene A Gene B PMID Method Quality YWHAE VPS41 16615898 0027 LC VPS41 YWHAB 16635246 0029 LC VPS41 VPS18 14668490 0004 LC VPS41 EED 24457600 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5KU39 P62259 VPS41 YWHAE 0.081 16615898 Q8R307 Q5KU39 VPS18 VPS41 0.21 14668490 Q9UJV9 Q5KU39 DDX41 VPS41 0.236 26496610 Q9P253 Q5KU39 VPS18 VPS41 0.236 26496610 Q9NWV8 Q5KU39 BABAM1 VPS41 0.236 26496610 Q9H270 Q5KU39 VPS11 VPS41 0.236 26496610 Q6SJ93 Q5KU39 FAM111B VPS41 0.236 26496610 Q9H269 Q5KU39 VPS16 VPS41 0.236 26496610 Q8WUH2 Q5KU39 TGFBRAP1 VPS41 0.236 26496610 Q96AX1 Q5KU39 VPS33A VPS41 0.236 26496610 Q921E6 Q5KU39 EED VPS41 0.126 24457600 Q9CQV8 Q5KU39 YWHAB VPS41 0.081 16635246