PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Tom1 Ywhae 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Eed 24457600 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Tollip 14563850 i2d,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Wdr12 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Yap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Park2 ortho G G G G Tom1 Hgs ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Xpo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Ntrk1 ortho Tom1 Vcp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Tbcd ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Ube2d1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Rps27a ortho P Tom1 Cltc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Myo19 ortho G G G G G G G G G G G G G G G Tom1 Gars ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Rac1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Il1r1 ortho G G G G G G G G G G G G G G G G G G G Tom1 Ptbp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Tom1l1 ortho P G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Exosc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Dohh ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Me1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Map3k1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 App ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Znf512b ortho Tom1 Ssbp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Eea1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Tsg101 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Zfyve16 ortho GP G G G G G G G G G G G G G G G G G Tom1 Ubc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tom1 Ilvbl ortho P Ddi2 Tom1 ortho P Tom1 Myo6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O88746 Q9QZ06 - 14563850 - X 2 O88746 enzymatic study 25260751 direct interaction X 2 O88746 Q921E6 affinity chromatography technology 24457600 physical association X 2 P51693 O88746 anti tag coimmunoprecipitation 14563850 physical association X 2 O88746 P0CG47 two hybrid 14563850 physical association X 2 O88746 Q9QZ06 two hybrid 14563850 physical association X 2 O88746 Q9QZ06 coimmunoprecipitation 14563850 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Tom1 Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332741 prey bait Tom1 Tollip MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14563850 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_72238|UniProt_162273|UniProt_162275 bait|bait|bait prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality TOM1 YWHAE 16615898 0027 LC TOM1 TOLLIP 14563850,14563850,14563850 0018,0004,0019 LC TOM1 EED 24457600 0004 LC TOM1 TOLLIP 14563850,14563850,14563850 0018,0004,0019 LC