PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Tnfrsf1a Rnf31 24461064 biogrid exp Ikbkb Rnf31 19136968 biogrid exp P Chuk Rnf31 19136968 biogrid exp Musk Rnf31 14678832 biogrid exp Cd40 Rnf31 20614026 innatedb exp, ortho Sharpin Rnf31 21455180,24461064,21455181,23942237 biogrid,intact,dip exp, ortho Rnf31 Rbck1 21455180,24461064,19136968,21455181,23942237 biogrid,intact,dip exp, ortho P Ube2d3 Rnf31 19136968 biogrid exp, ortho P Vcp Rnf31 24461064 biogrid exp, ortho P Cyld Rnf31 24461064 biogrid exp, ortho Traf1 Rnf31 15102471 intact exp, ortho Ikbkg Rnf31 19136968,24469399,21811235,21455181,doi:21811235 biogrid,mint,intact exp, ortho P Otulin Rnf31 24461064 biogrid exp, ortho P Tnf Rnf31 24469399 biogrid exp, ortho Socs3 Rnf31 ortho Rnf31 Kifc1 ortho P Smad3 Rnf31 ortho Ccdc14 Rnf31 ortho Atxn1 Rnf31 ortho Traf2 Rnf31 ortho Arhgef10 Rnf31 ortho P Atn1 Rnf31 ortho Rnf31 Tssc4 ortho P Trim25 Rnf31 ortho P Tnfaip3 Rnf31 ortho Atxn7 Rnf31 ortho Pitx1 Rnf31 ortho Wrnip1 Rnf31 ortho P Prkcb Rnf31 ortho P Ddx58 Rnf31 ortho P Aes Rnf31 ortho Ldlrad4 Rnf31 ortho Endov Rnf31 ortho Rnf31 Akap8l ortho Ltbr Rnf31 ortho Rnf31 Lipf ortho Nr0b1 Rnf31 ortho Rnf31 Azi2 ortho Nos3 Rnf31 ortho Nr0b2 Rnf31 ortho Prkca Rnf31 ortho P Ppard Rnf31 ortho Ube2d1 Rnf31 ortho Ripk2 Rnf31 ortho P Nod2 Rnf31 ortho Gfi1b Rnf31 ortho Irak1 Rnf31 ortho Ubc Rnf31 ortho P Rnf31 Rnf31 ortho P Rnf31 Vasn ortho Esr1 Rnf31 ortho Malt1 Rnf31 ortho Birc2 Rnf31 ortho Birc3 Rnf31 ortho Ntrk1 Rnf31 ortho Ube2l3 Rnf31 ortho P Ube2d2 Rnf31 ortho P Rnf31 Ndufa8 ortho P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q924T7 - 14678832 - X 2 Q91WA6 Q924T7 affinity chromatography technology 24461064 physical association X 2 Q91WA6 Q924T7 affinity chromatography technology 21455181 physical association X 2 Q91WA6 Q924T7 affinity chromatography technology 21455181 physical association X 2 P06804 Q924T7 affinity chromatography technology 24469399 physical association X 2 Q924T7 O88522 affinity chromatography technology 24469399 physical association X 2 Q924T7 O88522 enzymatic study 21455181 direct interaction X 2 Q924T7 O88522 affinity chromatography technology 19136968 physical association X 2 Q924T7 O88522 affinity chromatography technology 19136968 physical association X 2 Q924T7 O88522 enzymatic study 19136968 direct interaction X 2 Q924T7 Q3TPN9 affinity chromatography technology 19136968 physical association X 2 Q924T7 affinity chromatography technology 19136968 physical association X 2 Q924T7 O88522 pull down 19136968 direct interaction X 2 Q924T7 O88522 affinity chromatography technology 19136968 physical association X 2 Q924T7 affinity chromatography technology 24461064 physical association X 2 Q924T7 affinity chromatography technology 24461064 physical association X 2 Q924T7 pull down 24461064 direct interaction X 2 Q924T7 enzymatic study 24461064 direct interaction X 2 P0CG50 Q924T7 pull down 24461064 direct interaction X 2 Q3UCV8 Q924T7 affinity chromatography technology 24461064 physical association X 2 Q3UCV8 Q924T7 affinity chromatography technology 24461064 physical association X 2 Q3UCV8 Q924T7 pull down 24461064 direct interaction X 2 Q3UCV8 Q924T7 enzymatic study 24461064 direct interaction X 2 P25118 Q924T7 affinity chromatography technology 24461064 physical association X 2 Q9WUB0 Q924T7 affinity chromatography technology 24461064 physical association X 2 Q9WUB0 Q924T7 affinity chromatography technology 21455181 physical association X 2 Q9WUB0 Q924T7 affinity chromatography technology 21455181 physical association X 2 Q9WUB0 Q924T7 affinity chromatography technology 19136968 physical association X 2 Q9WUB0 Q924T7 affinity chromatography technology 19136968 physical association X 2 Q61006-3 Q924T7 affinity chromatography technology 14678832 physical association X 2 Q01853 Q924T7 affinity chromatography technology 24461064 physical association X 2 Q01853 Q924T7 affinity chromatography technology 24461064 physical association X 2 Q924T7 anti bait coimmunoprecipitation 21455181 - C 3 Q91WA6 Q924T7 molecular sieving 21455180 physical association X 2 Q91WA6 Q924T7 anti bait coimmunoprecipitation 21455181 physical association X 2 Q91WA6 Q924T7 anti bait coimmunoprecipitation 21455180 physical association X 2 Q91WA6 Q924T7 anti bait coimmunoprecipitation 21455181 physical association X 2 Q91WA6 Q924T7 anti bait coimmunoprecipitation 21455181 physical association X 2 Q91WA6 Q924T7 anti bait coimmunoprecipitation 21455180 physical association X 2 Q91WA6 Q924T7 anti bait coimmunoprecipitation 21455180 physical association X 2 Q91WA6 Q924T7 anti bait coimmunoprecipitation 21455180 physical association X 2 Q91WA6 Q924T7 anti bait coimmunoprecipitation 21455181 physical association X 2 Q924T7 anti bait coimmunoprecipitation 21455181 physical association C 3 Q924T7 anti bait coimmunoprecipitation 21455180 physical association C 3 Q924T7 molecular sieving 21455180 physical association C 3 Q924T7 anti bait coimmunoprecipitation 21455180 physical association C 3 Q924T7 anti bait coimmunoprecipitation 21455180 physical association C 3 Q924T7 molecular sieving 21455180 physical association C 3 Q9WUB0 Q924T7 anti bait coimmunoprecipitation 21455181 physical association X 2 Q9WUB0 Q924T7 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9WUB0 Q924T7 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9WUB0 Q924T7 anti bait coimmunoprecipitation 21455181 physical association X 2 Q9WUB0 Q924T7 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9WUB0 Q924T7 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9WUB0 Q924T7 molecular sieving 21455180 physical association X 2 Q924T7 anti bait coimmunoprecipitation 23942237 association C 4 Q924T7 anti bait coimmunoprecipitation 23942237 association C 4 Q924T7 anti bait coimmunoprecipitation 21811235 association C 3 P39428 Q924T7 two hybrid 15102471 physical association X 2 Q924T7 O88522 anti bait coimmunoprecipitation 21811235 physical association X 2 Q924T7 molecular sieving 23942237 association C 3

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Rnf31 Rbck1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19136968,21455181,24461064 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_316537|BIOGRID_316539|BIOGRID_332972|BIOGRID_316225|BIOGRID_316227 prey|bait|bait|bait|prey bait|prey|prey|prey|bait Vcp Rnf31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24461064 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_332963|BIOGRID_332961 prey|prey bait|bait Tnfrsf1a Rnf31 MI:0004(affinity chromatography technology) 24461064 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332975 bait prey Cyld Rnf31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24461064 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_332965|BIOGRID_332971|BIOGRID_332968|BIOGRID_332967 prey|bait|prey|prey bait|prey|bait|bait Fam105b Rnf31 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24461064 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_332964|BIOGRID_332970|BIOGRID_332969|BIOGRID_332966 prey|bait|prey|prey bait|prey|bait|bait Musk Rnf31 MI:0004(affinity chromatography technology) 14678832 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320060 prey bait Tnf Rnf31 MI:0004(affinity chromatography technology) 24469399 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_333084 bait prey Traf1 Rnf31 MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_163018 bait prey Ikbkb Rnf31 MI:0004(affinity chromatography technology) 19136968 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_316552 prey bait Ikbkg Rnf31 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 19136968,21455181,21811235,24469399 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact) UniProt_173331|BIOGRID_316232|BIOGRID_333083|BIOGRID_316540|BIOGRID_316556|BIOGRID_316542|BIOGRID_316545|BIOGRID_316554|UniProt_173332 bait|prey|bait|prey|bait|bait|prey|bait|bait prey|bait|prey|bait|prey|prey|bait|prey|prey Rnf31 Sharpin MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21455181,24461064 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_332973|BIOGRID_316230|BIOGRID_316226 bait|prey|bait prey|bait|prey

PPI - HINT Gene A Gene B PMID Method Quality IKBKG RNF31 19136968,19136968,21455181,19136968 0415,0004,0415,0096 LC TRAF1 RNF31 15102471 0018 LC SHARPIN RNF31 21455180,21455180 0071,0006 LC RNF31 RBCK1 21455180,23942237,21455180 0071,0071,0006 LC IKBKB RNF31 19136968 0004 LC IKBKG RNF31 24469399,19136968,19136968,19136968,24469399,21811235 0007,0415,0004,0096,0004,0006 LC TNF RNF31 24469399 0004 LC TNFRSF1A RNF31 24461064 0004 LC UBE2D3 RNF31 19136968 0096 LC VCP RNF31 24461064 0004 LC OTULIN RNF31 24461064,24461064 0096,0004 LC CHUK RNF31 19136968 0004 LC MUSK RNF31 14678832 0004 LC CYLD RNF31 24461064,24461064 0096,0004 LC SHARPIN RNF31 21455180,24461064,23942237,21455181,21455180,21455181 0071,0004,0006,0004,0006,0006 LC RNF31 RBCK1 19136968,21455180,24461064,21455181,21455180,21455181 0004,0071,0004,0004,0006,0006 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q924T7 P25118 RNF31 TNFRSF1A 0.21 24461064 Q924T7 P06804 RNF31 TNF 0.21 24469399 Q924T7 Q91WA6 RNF31 SHARPIN 0.61 21455181,24461064,23942237 Q924T7 Q3UCV8 RNF31 OTULIN 0.454 24461064 Q924T7 Q80TQ2 RNF31 CYLD 0.454 24461064 Q9WUB0 Q924T7 RBCK1 RNF31 0.757 21455181,19136968,24461064,23942237 Q924T7 O88522 RNF31 IKBKG 0.92 21455181,19136968,21811235,24469399 Q924T7 P61079 RNF31 UBE2D3 0.309 19136968 Q924T7 O88351 RNF31 IKBKB 0.21 19136968 Q924T7 P39428 RNF31 TRAF1 0.183 15102471 Q924T7 Q61006 RNF31 MUSK 0.21 14678832 Q924T7 Q01853 RNF31 VCP 0.21 24461064