PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Socs1 Tceb2 9869640,15601820 innatedb,biogrid exp Vhl Tceb2 15601820 innatedb,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G Tceb2 Neurl2 i2d exp Hoxa10 Tceb2 20211142 biogrid exp G G G G G G G G G Tceb2 Nrbp1 22510880 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Socs3 Tceb2 18590740,9869640,15601820 innatedb,biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G Wsb1 Tceb2 9869640 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rara Tceb2 9869640 biogrid exp G G Ywhae Tceb2 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Socs2 Tceb2 16684815 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tceb2 Ywhah 21311561 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tceb2 Asb2 9869640 biogrid exp Tceb2 Tceb1 23897481,16498413 biogrid,mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr3c1 Tceb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tceb2 Homer2 ortho P G G G G G G G G G G G G G G G G G G G G G Tceb2 Mapk3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tceb2 Tceb3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Slc2a4 Tceb2 ortho G G G G G G G G G G G G G G G G G G G G Tceb2 Lrrc41 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adam19 Tceb2 ortho G G G G G G G G G G G G G G G G G G G G G G G Tceb2 Klhdc3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tceb2 Prmt6 ortho G G G G G G G G G Tceb2 Ppp5c ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P62869 Q99J45 affinity chromatography technology 22510880 physical association X 2 P62869 O35717 affinity chromatography technology 16684815 physical association X 2 P62869 O35718 pull down 18590740 direct interaction X 2 P62869 P83940 x-ray crystallography 23897481 association X 2 P62869 O35718 affinity chromatography technology 9869640 physical association X 2 P62869 O54927 pull down 9869640 direct interaction X 2 P62869 Q3U5E7 pull down 9869640 direct interaction X 2 P62869 O35718 pull down 9869640 direct interaction X 2 Q8K0L0 P62869 pull down 9869640 direct interaction X 2 P62869 P40337-3 affinity chromatography technology 15601820 physical association X 2 P62869 O14543 affinity chromatography technology 15601820 physical association X 2 P62869 A1Z6E0-2 x-ray crystallography 16498413 association X 2 P62869 P31310-2 two hybrid 20211142 direct interaction X 2 P62869 O35716 affinity chromatography technology 9869640 physical association X 2 P62869 O35716 pull down 9869640 direct interaction X 2 P62869 coimmunoprecipitation 14960280 association C 5 P62869 tandem affinity purification 22510880 association C 7 P62869 P83940 x-ray crystallography 16498413 direct interaction X 2 P62869 anti bait coimmunoprecipitation 15601820 association C 5 P62869 anti bait coimmunoprecipitation 15601820 association C 5

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Tceb2 Asb2 MI:0004(affinity chromatography technology) 9869640 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_315419 prey bait Socs3 Tceb2 MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15601820,18590740,9869640 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid) UniProt_164465|BIOGRID_325572|BIOGRID_315427|BIOGRID_315415 bait|bait|bait|bait prey|prey|prey|prey Tceb2 Tceb1 MI:0027(cosedimentation)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography)|MI:0416(fluorescence microscopy) 16498413,16615898,21311561,23897481 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact)|MI:0471(mint)|(biogrid)|(intact) UniProt_167137|UniProt_43192|UniProt_167635|MINT_81696|BIOGRID_331195|UniProt_173252 neutral component|neutral component|neutral component|neutral component|prey|unspecified role neutral component|neutral component|neutral component|neutral component|bait|unspecified role Rara Tceb2 MI:0004(affinity chromatography technology) 9869640 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_315423 bait prey Socs1 Tceb2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 9869640 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_315425|BIOGRID_315417 bait|bait prey|prey Hoxa10 Tceb2 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313156 bait prey Wsb1 Tceb2 MI:0004(affinity chromatography technology) 9869640 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_315421 bait prey Socs2 Tceb2 MI:0004(affinity chromatography technology) 16684815 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_325480 bait prey Tceb2 Nrbp1 MI:0004(affinity chromatography technology)|MI:0027(cosedimentation) 16615898,22510880 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(intact) BIOGRID_325318|UniProt_167134 prey|neutral component bait|neutral component

PPI - HINT Gene A Gene B PMID Method Quality HOXA10 TCEB2 20211142 0018 HT YWHAE TCEB2 16615898 0027 LC TCEB2 YWHAH 21311561 0030 LC TCEB2 TCEB1 16498413,23897481 0114,0114 LC SOCS1 TCEB2 9869640,15601820,9869640,9869640 0096,0007,0004,0007 LC SOCS2 TCEB2 16684815 0004 LC SOCS3 TCEB2 15601820,9869640,15601820,18590740,9869640,9869640 0006,0096,0007,0096,0004,0007 LC WSB1 TCEB2 9869640 0096 LC RARA TCEB2 9869640 0096 LC VHL TCEB2 15601820,15601820 0006,0007 LC TCEB2 ASB2 9869640 0096 LC TCEB2 RAB40B 26885862 0676 LC TCEB2 RAB40C 26885862 0676 LC TCEB2 NRBP1 22510880 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62869 P62259 TCEB2 YWHAE 0.081 16615898 Q8K0L0 P62869 ASB2 TCEB2 0.309 9869640 P62869 O54927 TCEB2 WSB1 0.309 9869640 P62869 O35717 TCEB2 SOCS2 0.21 16684815 P62869 P11416 TCEB2 RARA 0.309 9869640 P62869 O35716 TCEB2 SOCS1 0.454 9869640 P62869 O35718 TCEB2 SOCS3 0.671 15601820,18590740,9869640 Q8VHP8 P62869 RAB40B TCEB2 0.126 26885862 Q8VHQ4 P62869 RAB40C TCEB2 0.126 26885862 P62869 P31310 TCEB2 HOXA10 0.183 20211142 Q99J45 P62869 NRBP1 TCEB2 0.21 22510880 Q9UHY1 P62869 NRBP1 TCEB2 0.21 22510880 P62869 P40337 TCEB2 VHL 0.126 15601820 P62869 P40338 TCEB2 VHL 0.126 15601820 P68510 P62869 YWHAH TCEB2 0.126 21311561 P83940 P62869 TCEB1 TCEB2 0.523 16498413,23897481 P62869 A1Z6E0 TCEB2 GUS 0.309 16498413 P62869 O14543 TCEB2 SOCS3 0.126 15601820