PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Map3k1 Birc2 18635759 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G Map3k7 Birc2 19898473 innatedb,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hccs Birc2 16858406 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Tlr4 19898473 innatedb,biogrid exp G G G G G G G G G G G G G G G G G Csf1r Birc2 24656046 innatedb exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf2 Birc2 21765415,15102471 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Cd40 Birc2 20614026,18635759 innatedb,biogrid exp, ortho G G G G G Tnfrsf1a Birc2 18022363 intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Htra2 12815069 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gas1 Birc2 i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Diablo 10929712 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc3 Birc2 15798218 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Tnfsf14 ortho G G Birc2 Smarcc2 ortho Traf6 Birc2 ortho G G G G G G G G G G G G G G G G G G G G Birc2 Hgs ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ccdc101 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Uqcrc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Tubb4a ortho G G G G G G G G G G G G G G G G G G G Rpl23a Birc2 ortho Birc2 Cblc ortho G G G G G G G G G G G G G G Cct2 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Endog Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkg Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k2 Birc2 ortho Birc2 Ilf3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d2 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct3 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Actl6a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Peo1 ortho Ier3 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps16 Birc2 ortho Birc2 Ripk4 ortho G G G G G G G G G G G G G G G G G Birc2 Mocs2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Nfxl1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snrpd2 Birc2 ortho Wdr1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ikbke ortho G G G G G G G G G G G G G Casp3 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pacs2 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Fsd1 ortho Hspa9 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ltbr Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Nubpl ortho Hspa8 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Smarcb1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ampd2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnfaip3 Birc2 ortho G G G G G Birc2 Ube2w ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tradd Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Ubr4 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps28 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Gsk3b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Chmp4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Nod2 ortho Birc2 Taf6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Arhgap26 ortho Prkcsh Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Cnn3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rela Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chek1 Birc2 ortho G G G G G G G G G G G G G G G Fbxo7 Birc2 ortho Birc2 Dctn2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf3 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd27 Birc2 ortho G G Egfr Birc2 ortho G G G G G G G G G G G G G G G G G G Tnf Birc2 ortho Birc2 Ccdc43 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Dzip3 ortho Tnfrsf1b Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G Bmpr1b Birc2 ortho G G G Birc2 Abhd17a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ddx58 ortho Birc2 Ppm1k ortho Ube2n Birc2 ortho Dhx9 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Rer1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Usp15 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Uncharacterized protein KIAA1143 homolog ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Mavs ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ubxn1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ube2l6 ortho G G G G G G G G G Uba1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ubxn7 ortho Xiap Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ripk1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Hsd17b10 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tas2r7 Birc2 ortho Birc2 Ubr5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2l3 Birc2 ortho Birc2 Wdr43 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ripk2 Birc2 ortho G G G G G G G G G G G G G G G G G G G G Birc2 Slc39a13 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tuft1 Birc2 ortho G G G G G G G G G G G G G G G G G G G Casp8 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ik ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctbp2 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps3 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp9x Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Bcl10 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Rpl24 ortho Rpl12 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Wdr82 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Atp2a1 ortho G G G G G G G G G G G G G G G G G G Usp19 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casp2 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Gcc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Exosc5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ilf2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Aimp2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct5 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Jup Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eef2 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fhl2 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Rhoa ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ube2j1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Tollip ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnfsf12 Birc2 ortho Birc2 Pcsk9 ortho Birc2 Nmb ortho G G G G G G G G G G G G G G G Birc2 Bola1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Rnf181 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prdx3 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc7 Birc2 ortho Birc2 Ruvbl2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2b Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Rnf2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Dnase2b ortho G G Birc2 Trim32 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ruvbl1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casp7 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ptges2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Xaf1 Birc2 ortho Mxd1 Birc2 ortho G G G G G G G Tank Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Tsga10 ortho Protein Magea4 Birc2 ortho Birc2 Eif2s1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Nfkb2 ortho G G G G G G G G G G G G G Birc2 Eaf2 ortho G G G G G G Cct6a Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Raf1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct7 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctsl Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd40lg Birc2 ortho G Ubc Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ripk3 ortho G G G G G G G G G G G Tsg101 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc5 Birc2 ortho G G G G G G G G G G G G G G Tubb4b Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Pgam5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct8 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Wdyhv1 ortho Fmnl2 Birc2 ortho Clec11a Birc2 ortho G G G G G G G G G G G G G G G Atp5a1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Usp7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ube2q2 ortho Map3k5 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ube2v1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Sh3kbp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prdx2 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cct4 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps4b Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gfap Birc2 ortho G G G G G G Birc2 Tnfrsf12a ortho G G G G G G G G G G G G G G G G G G G G G Birc2 Etfb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Eif2a ortho Smarcd1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G Akr1b8 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G E2f1 Birc2 ortho G G G G G Birc2 Nhp2l1 ortho Map3k3 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Lta Birc2 ortho G G Birc2 Rnf31 ortho Birc2 Adrm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gnb2l1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rps20 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Eef1a2 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Gspt1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cpox Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Pmpcb ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Dnajb2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prdx4 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ube2s ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Ephb1 ortho Traf1 Birc2 ortho G G G Map4k4 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Bub3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpl22 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snap25 Birc2 ortho G G G G G G G G G G G G G G G Hspd1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dcaf7 Birc2 ortho Birc2 Casp9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Rac1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tcp1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Nfkbia ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Smarca1 ortho G G G G G G G G G G G G G G G Igf2bp1 Birc2 ortho G G Birc2 Tln2 ortho Birc2 Map3k14 ortho G G G G G G G G G Stim1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2d3 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsp90b1 Birc2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Birc2 Pdia6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q62210 affinity chromatography technology 18635759 physical association X 2 Q62210 Q9JIY5 enzymatic study 12815069 direct interaction X 2 Q62210 Q9QUK6 affinity chromatography technology 19898473 physical association X 2 Q62210 affinity chromatography technology 19898473 physical association X 2 Q62210 affinity chromatography technology 18635759 physical association X 2 Q62210 anti bait coimmunoprecipitation 18635759 association C 7 Q62210 anti bait coimmunoprecipitation 18635759 association C 9 Q62210 anti bait coimmunoprecipitation 21765415 association C 7 Q62210 anti bait coimmunoprecipitation 18022363 association C 5 P39429 Q62210 two hybrid 15102471 physical association X 2 P53702 Q62210 anti tag coimmunoprecipitation 16858406 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Traf2 Birc2 MI:0018(two hybrid)|MI:0424(protein kinase assay)|MI:0424(protein kinase assay) 15102471,21765415 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact) UniProt_164874|UniProt_113516|UniProt_171878 bait|bait|bait prey|prey|prey Cd40 Birc2 MI:0004(affinity chromatography technology) 18635759 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319902 bait prey Hccs Birc2 MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation) 16858406 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_166924|MINT_82126 prey|prey bait|bait Birc2 Tlr4 MI:0004(affinity chromatography technology) 19898473 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319307 prey bait Birc2 Htra2 MI:0004(affinity chromatography technology) 12815069 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_316240 bait prey Map3k7 Birc2 MI:0004(affinity chromatography technology) 19898473 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319309 bait prey

PPI - HINT Gene A Gene B PMID Method Quality TRAF2 BIRC2 15102471 0018 LC BIRC2 HTRA2 12815069 0415 LC BIRC3 BIRC2 15798218 0096 LC TNFRSF1A BIRC2 18022363 0006 LC CD40 BIRC2 18635759 0004 LC TRAF2 BIRC2 21765415 0006 LC MAP3K1 BIRC2 18635759 0004 LC HCCS BIRC2 16858406 0007 LC MAP3K7 BIRC2 19898473 0004 LC BIRC2 DIABLO 10929712 0007 LC BIRC2 TLR4 19898473 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q62210 P53702 BIRC2 HCCS 0.21 16858406 Q62210 Q62073 BIRC2 MAP3K7 0.21 19898473 Q62210 P25118 BIRC2 TNFRSF1A 0.21 18022363 Q9JIY5 Q62210 HTRA2 BIRC2 0.309 12815069 Q62210 P39429 BIRC2 TRAF2 0.183 15102471 Q62210 P27512 BIRC2 CD40 0.21 18635759 Q9QUK6 Q62210 TLR4 BIRC2 0.21 19898473