PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Gli3 Spop 20463034 biogrid exp Spop H2afy 12183056 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf1 Spop 15102471 intact exp, ortho G G G Gli2 Spop 19955409,20463034 biogrid,dip exp, ortho G G G G G Pdx1 Spop 17126328 i2d,mint,intact exp, ortho G G G Spop Dek ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spop Pip4k2b ortho Daxx Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ube2e3 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pten Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spop Chrd ortho G G G G G G G G Spop Sirt2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc42bpa Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Man2b1 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf6 Spop ortho G G G G G G G G G G G G G G G G G G G G Esr1 Spop ortho G G G G G Esrrg Spop ortho G G Spop Hcst ortho G G G G G G G G Kpna6 Spop ortho G G G G G G G G G G G G G Spop Cul3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tpt1 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spop Dusp7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Rpl22 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spop Polr3f ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ddit3 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atm Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Crnkl1 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gdi1 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spop Aqr ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Galk2 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cand1 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spop Brms1 ortho G G G G G G G G G G G G G G G G G Ppm1b Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rxrb Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spop Elovl4 ortho G G G G G G G MCG3834, Protein Zbtb16, Zinc finger and BTB domain containing 16 Spop ortho G G G G G G G G G G G G G G G G G G Ncoa3 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Spop Dppa2 ortho Dok2 Spop ortho G G G G G G G G G G G G Hif1a Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf5 Spop ortho G G G G G G G G G G G G G G G G G Spop Nup50 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spop Rtn4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spop Git2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Meis1 Spop ortho G G G G G G G G G G G G G G G Rps3 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ar Spop ortho G G G G G G G G G G G G G G G G Myd88 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp7a Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rap2b Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Trio Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bmi1 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf3 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pip5k1b Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G Spop Wdr26 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spop Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spop Rtn3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pias1 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Spop Gcc1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf2 Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G Spop Pak4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fadd Spop ortho G G G G G G G G G G G G G G G G G G G G G G G G G Traf4 Spop ortho G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P52946 Q6ZWS8 - 15121856 - X 2 Q0VGT2 Q6ZWS8 enzymatic study 20463034 direct interaction X 2 Q0VGT2 Q6ZWS8 affinity chromatography technology 20463034 physical association X 2 Q6ZWS8 Q61602 enzymatic study 20463034 direct interaction X 2 Q6ZWS8 Q61602 affinity chromatography technology 20463034 physical association X 2 Q6ZWS8 two hybrid 12183056 direct interaction X 2 Q6ZWS8 pull down 12183056 direct interaction X 2 Q6ZWS8 pull down 12183056 direct interaction X 2 P10071 Q6ZWS8 anti tag coimmunoprecipitation 19955409 physical association X 2 P10071 Q6ZWS8 anti tag coimmunoprecipitation 19955409 physical association X 2 Q0VGT2 Q6ZWS8 anti tag coimmunoprecipitation 19955409 physical association X 2 Q0VGT2 Q6ZWS8 anti tag coimmunoprecipitation 19955409 physical association X 2 P52946 Q6ZWS8 pull down 17126328 physical association X 2 P52946 Q6ZWS8 anti bait coimmunoprecipitation 17126328 physical association X 2 P52946 Q6ZWS8 pull down 17126328 physical association X 2 P52946 Q6ZWS8 pull down 17126328 physical association X 2 P52946 Q6ZWS8 anti bait coimmunoprecipitation 17126328 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Spop H2afy MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 12183056 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_322470|BIOGRID_322471|BIOGRID_322472 prey|bait|prey bait|prey|bait Pdx1 Spop MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 17126328 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint) UniProt_166999|MINT_84788|MINT_84789|MINT_84787|UniProt_88316|UniProt_167000|UniProt_166995|UniProt_166998|UniProt_166997|MINT_84790|MINT_84791 prey|bait|bait|bait|bait|prey|bait|bait|bait|prey|prey bait|prey|prey|prey|prey|bait|prey|prey|prey|bait|bait Gli2 Spop MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20463034 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_321847|BIOGRID_321849 prey|bait bait|prey

PPI - HINT Gene A Gene B PMID Method Quality TRAF1 SPOP 15102471 0018 LC PDX1 SPOP 15121856,15121856,15121856 0018,0019,0004 LC GLI2 SPOP 20463034,20463034 0415,0004 LC GLI3 SPOP 20463034,20463034 0415,0004 LC SPOP H2AFY 12183056,12183056,12183056,12183056 0096,0428,0004,0018 LC IRF8 SPOP 21731497 0007 LC PDX1 SPOP 15121856,15121856,17126328,15121856,17126328 0018,0019,0096,0004,0006 LC GLI2 SPOP 19955409,20463034,20463034 0007,0415,0004 LC GLI3 SPOP 20463034,20463034 0415,0004 LC SPOP H2AFY 12183056,12183056,12183056,12183056 0096,0428,0004,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q6ZWS8 Q61602 SPOP GLI3 0.21 20463034 Q6ZWS8 Q0VGT2 SPOP GLI2 0.21 20463034 Q8NEA6 Q6ZWS8 GLIS3 SPOP 0.309 26147758 Q9QZQ8 Q6ZWS8 H2AFY SPOP 0.671 12183056 Q6ZWS8 P52946 SPOP PDX1 0.61 17126328