PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Foxp3 Cd2ap 22922362 biogrid exp Ywhae Cd2ap 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hmga2 Cd2ap 26045162 intact exp G G G G Hsd3b7 Cd2ap 16615898 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pgls Cd2ap 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Flt1 Cd2ap 15001553 biogrid exp G G G G G G G G G G G G G G G G G G Grb2 Cd2ap 15102471 mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rpgrip1l Cd2ap 21565611 intact exp, ortho Cbl Cd2ap 12559036,15001553 biogrid,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rab4a Cd2ap 12559036 mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pkd2 Cd2ap 10913159 biogrid,i2d exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd2ap Cd2ap 12559036 mint,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Slc25a41 Cd2ap ortho Yes1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G Kiaa0196 Cd2ap ortho P Hck Cd2ap ortho G G G G G G G G G G G G G G G G G G G G Itga4 Cd2ap ortho G G G G Zyx Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Actc1 Cd2ap ortho GP G G G G G G G G G G G G G G G Ppa2 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pstpip1 Cd2ap ortho G G G G G G G G G Khdrbs1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Sec24d, Sec24 related gene family, member D (S. cerevisiae) Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cstf2 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Scpep1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sdcbp Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nrbp1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mvb12a Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cblc Cd2ap ortho G G G G G G G G G G G G G G Huwe1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd2ap Blnk ortho G G G G G G G G G G G G G G G G G G G G G G G Nploc4 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Capza1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sh3gl2 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G Src Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G G G G G Cd2ap Nphs1 ortho G G G G G Lox Cd2ap ortho G G G G G G G G G G G G G G G G G G Tsc22d1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cblb Cd2ap ortho Gale Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bcar1 Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ret Cd2ap ortho G G G G G G G G G G Fyn Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rabep2 Cd2ap ortho P G G G G G G G G G G G Ube2i Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd2ap Pdcd6ip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pfdn2 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ufd1l Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wdhd1 Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G Kif15 Cd2ap ortho P Spag9 Cd2ap ortho P Hoxc11 Cd2ap ortho Nit1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Brcc3 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp34 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Arhgap17 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Frs3 Cd2ap ortho G G G G G G G G G G G G G Lmna Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cttn Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sh3kbp1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Dph5 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vcam1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Elp2 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tas2r7 Cd2ap ortho Cd2ap Stap1 ortho G G G G G G G Capzb Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sos1 Cd2ap ortho P G G G G G G G G G Arhgef10 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G Msn Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Wtip Cd2ap ortho Vps28 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tsg101 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kiaa1033 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Med4 Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sh3bp1 Cd2ap ortho G G G G G G G G G G G G Pik3cg Cd2ap ortho G G G G G G G G G G G G Abl1 Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr2c2 Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Capza2 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd2ap Racgap1 ortho G G G G G G G G G G G G G G G G G G G G Dnm2 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd2 Cd2ap ortho G G G G G G Hbp1 Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Iqgap1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd2ap Mta2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Heterogeneous nuclear ribonucleoprotein R, Protein Hnrnpr Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkap Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prdx6 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr4a1 Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nr3c1 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Larp7 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Egfr Cd2ap ortho GP G G G G G G G G G G G G G G G G G Nphs2 Cd2ap ortho G Inpp5d Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G G Protein Sec24c, SEC24 related gene family, member C (S. cerevisiae), isoform CRA_a Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vps37b Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Kif23 Cd2ap ortho G G G G G G G G G G G G G G Nras Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ttc27 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Asns Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccdc6 Cd2ap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sos2 Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp6ap2 Cd2ap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96P48-1 Q9JLQ0 affinity chromatography technology 20360068 physical association X 2 Q9JLQ0 affinity chromatography technology 20360068 physical association X 2 Q9JLQ0 affinity chromatography technology 20360068 physical association X 2 Q53Z59 Q9JLQ0 affinity chromatography technology 22922362 physical association X 2 Q8NEM2 Q9JLQ0 affinity chromatography technology 20360068 physical association X 2 P22682 Q9JLQ0 affinity chromatography technology 15001553 physical association X 2 A0A024R136 Q9JLQ0 affinity chromatography technology 20360068 physical association X 2 O35245 Q9JLQ0 affinity chromatography technology 10913159 physical association X 2 O35245 Q9JLQ0 affinity chromatography technology 10913159 physical association X 2 Q8IZC4 Q9JLQ0 affinity chromatography technology 20360068 physical association X 2 Q14677-3 Q9JLQ0 affinity chromatography technology 20360068 physical association X 2 Q9JLQ0 affinity chromatography technology 20360068 physical association X 2 Q9JLQ0 Q02241-3 affinity chromatography technology 20360068 physical association X 2 Q00610 Q9JLQ0 affinity chromatography technology 20360068 physical association X 2 Q62915 Q9JLQ0 affinity chromatography technology 15331416 physical association X 2 Q9JLQ0 pull down 15331416 direct interaction X 2 Q9Y5K6 Q9JLQ0 affinity chromatography technology 20360068 physical association X 2 A0A024RBJ2 Q9JLQ0 affinity chromatography technology 20360068 physical association X 2 Q9JLQ0 affinity chromatography technology 15001553 physical association X 2 P10144 Q9JLQ0 enzymatic study 17283187 direct interaction X 2 Q9JLQ0 pull down 15331416 association C 4 Q9JLQ0 coimmunoprecipitation 15331416 association C 4 Q9JLQ0 anti bait coimmunoprecipitation 15001553 association C 3 Q8CC35 Q9JLQ0 anti bait coimmunoprecipitation 16628251 association X 2 P22682 Q9JLQ0 anti bait coimmunoprecipitation 15001553 association X 2 P39688 Q9JLQ0 coimmunoprecipitation 16628251 association X 2 Q9JLQ0 cosedimentation 16615898 colocalization C 1216 P22682 Q9JLQ0 two hybrid 12559036 physical association X 2 P56371 Q9JLQ0 two hybrid 12559036 physical association X 2 P56371 Q9JLQ0 pull down 12559036 physical association X 2 P56371 Q9JLQ0 pull down 12559036 direct interaction X 2 Q60631 Q9JLQ0 two hybrid 15102471 physical association X 2 Q9JLQ0 tandem affinity purification 20360068 physical association C 14 Q9JLQ0 Q9JLQ0 two hybrid 12559036 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality CBL CD2AP 12559036 0018 LC FYN CD2AP 16628251 0019 LC RAB4A CD2AP 12559036,12559036 0096,0018 LC YWHAE CD2AP 16615898 0027 LC GRB2 CD2AP 15102471 0018 LC PGLS CD2AP 16615898 0027 LC HSD3B7 CD2AP 16615898 0027 LC CD2AP CD2AP 12559036 0018 LC PKD2 CD2AP 10913159 0004 LC CBL CD2AP 15001553,15001553 0006,0004 LC FLT1 CD2AP 15001553 0004 LC HMGA2 CD2AP 26045162 0096 LC RAB4A CD2AP 12559036,12559036 0096,0018 LC SYNPO CD2AP 16628251 0006 LC RPGRIP1L CD2AP 21565611 0007 HT FOXP3 CD2AP 22922362 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9JLQ0 P22682 CD2AP CBL 0.523 12559036,27474268,15001553 Q9JLQ0 Q8CG73 CD2AP RPGRIP1L 0.126 21565611 Q9JLQ0 P62259 CD2AP YWHAE 0.081 16615898 Q9JLQ0 A5D8V6 CD2AP VPS37C 0.126 26496610 Q9JLQ0 B4DG94 CD2AP B4DG94 0.126 20360068 Q9JLQ0 B4E2V5 CD2AP B4E2V5 0.126 26496610 Q9JLQ0 B7ZMI2 CD2AP ARAP1 0.126 20360068 Q9JLQ0 D6RA89 CD2AP PEX10 {ECO:0000313|ENSEMBL:ENSP00000423051} 0.126 26496610 Q9JLQ0 E9PSI1 CD2AP E9PSI1 0.126 26496610 Q9JLQ0 F5H4Q5 CD2AP VPS37C {ECO:0000313|ENSEMBL:ENSP00000446013} 0.126 26496610 Q9JLQ0 O15056 CD2AP SYNJ2 0.126 20360068 Q9JLQ0 O15321 CD2AP TM9SF1 0.126 26496610 Q9JLQ0 O35245 CD2AP PKD2 0.376 10913159 Q9JLQ0 O60683 CD2AP PEX10 0.126 26496610 Q9JLQ0 P27105 CD2AP STOM 0.126 26496610 Q9JLQ0 P35969 CD2AP FLT1 0.21 15001553 Q9JLQ0 P55327 CD2AP TPD52 0.126 26496610 Q9JLQ0 Q60631 CD2AP GRB2 0.183 15102471 Q9JLQ0 Q62915 CD2AP CASK 0.21 15331416 Q9JLQ0 Q9JLQ0 CD2AP CD2AP 0.332 12559036 Q9R044 Q9JLQ0 NPHS1 CD2AP 0.309 15331416 Q9JLQ0 P10144 CD2AP GZMB 0.309 17283187 Q9JLQ0 Q8IUH3 CD2AP RBM45 0.236 26496610 Q9JLQ0 Q8IUD2 CD2AP ERC1 0.236 26496610 Q9JLQ0 O00159 CD2AP MYO1C 0.236 26496610 Q9JLQ0 P21281 CD2AP ATP6V1B2 0.236 26496610 Q9JLQ0 O75955 CD2AP FLOT1 0.236 26496610 Q9JLQ0 O43293 CD2AP DAPK3 0.236 26496610 Q9JLQ0 O15083 CD2AP ERC2 0.236 26496610 Q9JLQ0 O75477 CD2AP ERLIN1 0.236 26496610 Q9JLQ0 O43633 CD2AP CHMP2A 0.236 26496610 Q9JLQ0 O43920 CD2AP NDUFS5 0.236 26496610 Q9JLQ0 P14373 CD2AP TRIM27 0.236 26496610 Q9JLQ0 P06396 CD2AP GSN 0.236 26496610 Q9JLQ0 O95782 CD2AP AP2A1 0.236 26496610 Q9JLQ0 O95985 CD2AP TOP3B 0.236 26496610 Q9JLQ0 P09497 CD2AP CLTB 0.236 26496610 Q9JLQ0 P09496 CD2AP CLTA 0.236 26496610 Q9JLQ0 Q86UU1 CD2AP PHLDB1 0.236 26496610 Q9JLQ0 P47756 CD2AP CAPZB 0.236 26496610 Q9JLQ0 P40818 CD2AP USP8 0.236 26496610 Q9JLQ0 P30048 CD2AP PRDX3 0.236 26496610 Q9JLQ0 P38606 CD2AP ATP6V1A 0.236 26496610 Q9JLQ0 P61421 CD2AP ATP6V0D1 0.236 26496610 Q9JLQ0 P51798 CD2AP CLCN7 0.236 26496610 Q9JLQ0 P53990 CD2AP IST1 0.236 26496610 Q9JLQ0 P52907 CD2AP CAPZA1 0.236 26496610 Q9JLQ0 Q86SQ0 CD2AP PHLDB2 0.236 26496610 Q9JLQ0 Q14145 CD2AP KEAP1 0.236 26496610 Q9JLQ0 Q02878 CD2AP RPL6 0.236 26496610 Q9JLQ0 Q01082 CD2AP SPTBN1 0.236 26496610 Q9JLQ0 Q13829 CD2AP TNFAIP1 0.236 26496610 Q9JLQ0 Q03135 CD2AP CAV1 0.236 26496610 Q9JLQ0 Q12894 CD2AP IFRD2 0.236 26496610 Q9JLQ0 Q7RTP6 CD2AP MICAL3 0.236 26496610 Q9JLQ0 Q14677 CD2AP CLINT1 0.236 20360068 Q9JLQ0 Q14254 CD2AP FLOT2 0.236 26496610 Q9JLQ0 Q14573 CD2AP ITPR3 0.236 26496610 Q9JLQ0 Q6XZF7 CD2AP DNMBP 0.236 26496610 Q9JLQ0 Q16540 CD2AP MRPL23 0.236 26496610 Q9UM54 Q9JLQ0 MYO6 CD2AP 0.236 26496610 Q9JLQ0 Q96AG4 CD2AP LRRC59 0.236 26496610 Q9JLQ0 Q8N5U6 CD2AP RNF10 0.236 26496610 Q9JLQ0 Q8IZC4 CD2AP RTKN2 0.236 20360068 Q9JLQ0 Q8IZ21 CD2AP PHACTR4 0.236 26496610 Q9JLQ0 Q93050 CD2AP ATP6V0A1 0.236 26496610 Q9JLQ0 Q8WUH6 CD2AP TMEM263 0.236 26496610 Q9JLQ0 Q93009 CD2AP USP7 0.236 26496610 Q9JLQ0 Q8WUM4 CD2AP PDCD6IP 0.236 26496610 Q9JLQ0 Q8WV92 CD2AP MITD1 0.236 26496610 Q9P2N7 Q9JLQ0 KLHL13 CD2AP 0.236 26496610 Q9JLQ0 Q99816 CD2AP TSG101 0.236 26496610 Q9JLQ0 Q96EY5 CD2AP MVB12A 0.236 26496610 Q9JLQ0 Q96HS1 CD2AP PGAM5 0.236 26496610 Q9NZZ3 Q9JLQ0 CHMP5 CD2AP 0.236 26496610 Q9JLQ0 Q9H0X9 CD2AP OSBPL5 0.236 26496610 Q9NZM1 Q9JLQ0 MYOF CD2AP 0.236 26496610 Q9JLQ0 Q9H444 CD2AP CHMP4B 0.236 26496610 Q9JLQ0 Q9HD42 CD2AP CHMP1A 0.236 26496610 Q9Y5K6 Q9JLQ0 CD2AP CD2AP 0.236 20360068 Q9UQN3 Q9JLQ0 CHMP2B CD2AP 0.236 26496610 Q9JLQ0 P56371 CD2AP RAB4A 0.623 12559036 Q9JLQ0 P47755 CD2AP CAPZA2 0.332 26496610,20360068 Q9JLQ0 Q96P48 CD2AP ARAP1 0.332 26496610,20360068 Q9JLQ0 Q00610 CD2AP CLTC 0.416 26496610,20360068 Q9JLQ0 Q02241 CD2AP KIF23 0.416 26496610,20360068 Q9JLQ0 Q5HYK7 CD2AP SH3D19 0.416 26496610,20360068 Q9JLQ0 Q8NEM2 CD2AP SHCBP1 0.416 26496610,20360068 Q9JLQ0 Q96B97 CD2AP SH3KBP1 0.416 26496610,20360068 Q9JLQ0 Q9H0H5 CD2AP RACGAP1 0.416 26496610,20360068 Q9JLQ0 Q9H3F6 CD2AP KCTD10 0.416 26496610,20360068 Q9JLQ0 Q99JB6 CD2AP FOXP3 0.126 22922362 Q9JLQ0 Q9CQ60 CD2AP PGLS 0.081 16615898 Q9JLQ0 Q9EQC1 CD2AP HSD3B7 0.081 16615898 Q9JLQ0 P52927 CD2AP HMGA2 0.126 26045162