PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Atxn3 Tuba1a 19666135 biogrid exp, ortho Atxn3 Vcp ortho Atxn3 Crebbp ortho Atxn3 Pja1 ortho Atxn3 Gsk3b ortho Atxn3 Psrc1 ortho Atxn3 Csnk2b ortho UPF0183 protein C16orf70 homolog Atxn3 ortho Psmd7_predicted Atxn3 ortho Atxn3 Slc3a2 ortho Atxn3 Haao ortho Atxn3 Casp3 ortho Atxn3 Psmc5 ortho Atxn3 Nfkbia ortho Bcl7c_predicted Atxn3 ortho Atxn3 Trim54 ortho Sqstm1 Atxn3 ortho Atxn3 Ubc ortho Atxn3 Rffl ortho Protein Dnd1, RCG49342, isoform CRA_a Atxn3 ortho Atxn3 Rps6ka1 ortho Atxn3 Trim63 ortho Traf6 Atxn3 ortho Atxn3 Ube2n ortho Otub2_predicted Atxn3 ortho Atxn3 Ubqln1 ortho Atxn3 Park2 ortho Atxn3 Sdc2 ortho Atxn3 Asic1 ortho Atxn3 Dnm2 ortho Atxn3 Bcl2l1 ortho Atxn3 Bcl2-associated athanogene 3, Protein Bag3, RCG40209, isoform CRA_b ortho Atxn3 Uba1 ortho Atxn3 Atxn3 ortho LOC683667 protein, Protein Sri Atxn3 ortho RGD1561201_predicted Atxn3 ortho Atxn3 Uba52 ortho Usp34 Atxn3 ortho Ube2s Atxn3 ortho Atxn3 Dnaja1 ortho Protein Syvn1, Syvn1 protein Atxn3 ortho Atxn3 Nedd8 ortho Atxn3 Cyclin-dependent kinase inhibitor 1A, Cyclin-dependent kinase inhibitor 1A (P21, Cip1), P21, P21 protein, Protein Cdkn1a ortho Atxn3 Itch ortho Atxn3 Tubb5 ortho Atxn3 Hspa8 ortho Atxn3 App ortho Atxn3 Casp1 ortho Atxn3 Protein Rad23a, RAD23 homolog A (S. cerevisiae) ortho Sprtn Atxn3 ortho Atxn3 Kctd10 ortho Atxn3 Tk1 ortho Atxn3 Mgrn1 ortho Atxn3 Anxa6 ortho Atxn3 Hdac3 ortho Atxn3 Tmco1 ortho Dnajb2 Atxn3 ortho Atxn3 Rad23b ortho Atxn3 Trim55 ortho Atxn3 Polynucleotide kinase 3'-phosphatase, Polynucleotide kinase 3'-phosphatase, isoform CRA_a, Protein Pnkp ortho Atxn3 Hap1 ortho Protein Stub1, STIP1 homology and U-Box containing protein 1, isoform CRA_b Atxn3 ortho Atxn3 Cnot6 ortho Atxn3 Arhgdia ortho Atxn3 Canx ortho Atxn3 LOC683746 ortho Aebp2_predicted Atxn3 ortho Protein Camsap3, RCG58914 Atxn3 ortho Atxn3 Pick1 ortho Usp21 Atxn3 ortho Atxn3 Creb1 ortho Atxn3 Mknk1 ortho Atxn3 Sumo1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O35815 P68370 affinity chromatography technology 19666135 physical association X 2 O35815 P68370 affinity chromatography technology 19666135 physical association X 2 O35815 O60260-5 pull down 20940148 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Atxn3 Tuba1a MI:0096(pull down)|MI:0096(pull down) 19666135 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_335128|BIOGRID_335127 prey|bait bait|prey

PPI - HINT Gene A Gene B PMID Method Quality ATXN3 TUBA1A 19666135 0004 LC