PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Kras Cdc27 22045811 biogrid exp Cyclin A2, isoform CRA_b, Protein Ccna2 Cdc27 20466002 mint,intact exp, ortho Cdc27 Cdh1 11340163 biogrid exp, ortho Cdc27 Cdc20 22045811 biogrid exp, ortho Rpl5 Cdc27 ortho Epn3 Cdc27 ortho Ccnb1 Cdc27 ortho Nrcam Cdc27 ortho Comt Cdc27 ortho Cdc27 Crebbp ortho Cdc27 Cyclin-dependent kinase inhibitor 1A, Cyclin-dependent kinase inhibitor 1A (P21, Cip1), P21, P21 protein, Protein Cdkn1a ortho Grap2 Cdc27 ortho Cdc5l Cdc27 ortho Anapc1_predicted Cdc27 ortho LOC316395 Cdc27 ortho Ntrk1 Cdc27 ortho PDZ domain-containing protein 2, Peptidylprolyl cis/trans isomerase, NIMA-interacting 1, Protein (Peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (Predicted), isoform CRA_a Cdc27 ortho Foxo3a_predicted Cdc27 ortho Cdc27 Ctnnb1 ortho Protein Ddhd2 Cdc27 ortho Cdc27 Dclre1c ortho Emilin1_predicted Cdc27 ortho Fbxo5_predicted Cdc27 ortho Ncl Cdc27 ortho ttf-2 Cdc27 ortho Cdc27 Adnp ortho Ttk_predicted Cdc27 ortho Anapc7_predicted Cdc27 ortho Cdc27 Xpo1 ortho Grb2 Cdc27 ortho Protein Anapc13, RCG26082, isoform CRA_a Cdc27 ortho Cdc27 hsf2 ortho Anapc2 protein, Anaphase promoting complex subunit 2, Protein Anapc2 Cdc27 ortho Taf5_predicted Cdc27 ortho Smad3 Cdc27 ortho Anaphase promoting complex subunit 4, isoform CRA_a, Protein Anapc4 Cdc27 ortho Cdc27 Magix ortho Cdc27 Sirt2 ortho Cdc27 Dcps ortho Cuedc2 Cdc27 ortho Cdc27 Cfap97 ortho RGD1561926_predicted Cdc27 ortho Cdc27 Chd8 ortho Cdc27 Pik3r1 ortho Foxp3 Cdc27 ortho Cdc27 Cdc27 ortho Protein Anapc16, RCG22080, isoform CRA_b Cdc27 ortho Protein Cdc23 Cdc27 ortho Cdc27 Fov ortho Cdc27 Fyn ortho Protein Phf8, RCG38940 Cdc27 ortho Ccnd1 Cdc27 ortho Ube2s Cdc27 ortho LOC100362620 Cdc27 ortho Bub3 Cdc27 ortho Cdc27 Ttll1 ortho Usp34 Cdc27 ortho Tead2_mapped Cdc27 ortho Pttg1 Cdc27 ortho Cdc27 MAD2L1 binding protein, Protein Mad2l1bp ortho Anapc5 Cdc27 ortho Ppp5c Cdc27 ortho Notch1 Cdc27 ortho Protein Skil Cdc27 ortho Vcp Cdc27 ortho Protein Smpd5, Similar to sphingomyelin phosphodiesterase 3, neutral membrane (Predicted) Cdc27 ortho Aurkb Cdc27 ortho Smarcad1 Cdc27 ortho LOC687127 Cdc27 ortho Fzr1_predicted Cdc27 ortho Tfdp1 Cdc27 ortho PTEN/MMAC1 Cdc27 ortho Mad2l1_predicted Cdc27 ortho Anapc10_predicted Cdc27 ortho Ssb Cdc27 ortho Cdc27 Nf2 ortho Protein Mad1l1, RCG42782, isoform CRA_a Cdc27 ortho Pcna Cdc27 ortho CDC16 cell division cycle 16 homolog (S. cerevisiae), Protein Cdc16 Cdc27 ortho Smad2 Cdc27 ortho Casp3 Cdc27 ortho Cdc27 Sh3kbp1 ortho Rev1l_predicted Cdc27 ortho Cdc27 Fmr1 ortho E2f1 Cdc27 ortho Homeo box C10, isoform CRA_b, Protein Hoxc10 Cdc27 ortho Cdc27 Fbxo43 ortho Protein Sirt6, Sirtuin 6 (Silent mating type information regulation 2, homolog) 6 (S. cerevisiae), Sirtuin 6 (Silent mating type information regulation 2, homolog) 6 (S. cerevisiae), isoform CRA_a Cdc27 ortho Cdc27 Mdc1 ortho Cdc27 Cdc26 ortho RGD1561880_predicted Cdc27 ortho Penk Cdc27 ortho Nck1 Cdc27 ortho Foxm1 Cdc27 ortho Rb1 Cdc27 ortho NEWGENE_1304700 Cdc27 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q62623 Q4V8A2 affinity chromatography technology 22045811 physical association X 2 Q9R0T4 Q4V8A2 affinity chromatography technology 11340163 physical association X 2 Q4V8A2 affinity chromatography technology 22045811 physical association X 2 Q4V8A2 affinity chromatography technology 22045811 physical association X 2 Q4V8A2 Q9R1K5 affinity chromatography technology 22949615 physical association X 2 Q6GX89 Q4V8A2 anti bait coimmunoprecipitation 20466002 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Kras Cdc27 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22045811 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_334050|BIOGRID_334054 bait|prey prey|bait Cdc27 Ccna2 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 20466002 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_76472|UniProt_185183 bait|bait prey|prey Cdc27 Cdh1 MI:0004(affinity chromatography technology) 11340163 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334710 bait prey Cdc27 Cdc20 MI:0004(affinity chromatography technology) 22045811 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334055 bait prey

PPI - HINT Gene A Gene B PMID Method Quality KRAS CDC27 22045811 0004 LC CDC27 CDC20 22045811 0004 LC CDC27 Q6GX89 20466002 0006 LC CDC27 CDH1 11340163 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9R1K5 Q4V8A2 FZR1 CDC27 0.21 22949615 Q4V8A2 P08644 CDC27 KRAS 0.376 22045811 Q62623 Q4V8A2 CDC20 CDC27 0.21 22045811 Q6GX89 Q4V8A2 Q6GX89 CDC27 0.21 20466002 Q9R0T4 Q4V8A2 CDH1 CDC27 0.21 11340163