PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Amph Sh3gl2 9315708 mint,intact exp Sh3gl2 Synj1 14704270,9238017 biogrid,intact exp, ortho Sh3gl2 Dnm1 14704270,17437541,16221862,9238017 biogrid,mint,intact exp, ortho Sh3gl2 Slc17a7 16606361 mint,intact exp, ortho Sh3gl2 Map4k3 i2d exp, ortho Sh3gl2 Ywhae ortho Protein Srgap3 Sh3gl2 ortho Sh3gl2 Protein Zfp219, Zinc finger protein 219, Zinc finger protein 219, isoform CRA_a ortho Sh3gl2 Drd2 ortho Sh3gl2 Pak2 ortho Sh3gl2 Gch1 ortho Sh3gl2 Met ortho Sh3gl2 Tcea2 ortho RGD1307595_predicted Sh3gl2 ortho Sh3gl2 Dyrk1a ortho Protein LOC100912012, RCG25681 Sh3gl2 ortho Protein Synm, RCG24674, isoform CRA_b Sh3gl2 ortho Sh3gl2 SLP76 ortho Sh3gl2 Acta1 ortho Sh3gl2 Tyms ortho Saps1_predicted Sh3gl2 ortho Protein Lrrk2 Sh3gl2 ortho Sh3gl2 Ptprs ortho Sh3gl2 Sh3gl1 ortho Sh3gl2 RT1-Ba ortho Sh3gl2 Emd ortho Sh3gl2 Dnm3 ortho Mast2_predicted Sh3gl2 ortho Cd2ap Sh3gl2 ortho Sh3gl2 Sh3gl3 ortho Sh3gl2 Ubc ortho Sh3gl2 Cabin1 ortho Sh3gl2 Il6 ortho Sh3gl2 Park2 ortho Sh3gl2 Adam9 ortho Sh3gl2 Arnt2 ortho Sh3gl2 Pdcd6ip ortho Protein Adam19, RCG34059 Sh3gl2 ortho RGD1564491_predicted Sh3gl2 ortho Protein Cbl Sh3gl2 ortho Sh3gl2 Protein Terf1, Telomeric repeat binding factor (NIMA-interacting) 1, Telomeric repeat binding factor 1 ortho Sh3gl2 Htt ortho Sh3gl2 Adam15 ortho Sh3gl2 Syn1 ortho Sh3gl2 Sh3kbp1 ortho Sh3gl2 Cblb ortho F13a1 Sh3gl2 ortho Phf2_predicted Sh3gl2 ortho Sh3gl2 Ywhaz ortho LOC100362710 Sh3gl2 ortho Sh3gl2 Rasd1 ortho Sh3gl2 Scyl1 ortho Sh3gl2 Itch ortho Sh3gl2 Dpysl4 ortho Sh3gl2 Adrb1 ortho C8g_predicted Sh3gl2 ortho Sh3gl2 Asap1 ortho Sh3gl2 Dlg4 ortho Sh3gl2 Actg1 ortho LOC687750 Sh3gl2 ortho Sh3gl2 Sh3gl2 ortho Sh3gl2 Dnm2 ortho Sh3gl2 Itsn1 ortho Sh3gl2 Dlgap4 ortho Sh3gl2 App ortho Protein Dennd1a Sh3gl2 ortho Protein Tango2, Similar to Ser/Thr-rich protein T10 in DGCR region (Predicted), isoform CRA_a Sh3gl2 ortho Protein Dact1 Sh3gl2 ortho Protein Tmem8b Sh3gl2 ortho Bin1 Sh3gl2 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O35179 - 11384986 - X 2 O35179 pull down 9694653 association C 11 Q62910-2 O35179 two hybrid 9238017 physical association X 2 Q62910 O35179 far western blotting 9238017 physical association X 2 Q62634 O35179 two hybrid 16606361 physical association X 2 Q62634 O35179 two hybrid 16606361 physical association X 2 O35179 pull down 24687852 association C 66 O35179 pull down 9238017 association C 3 O35179 P21575 pull down 16221862 physical association X 2 O35179 P21575 anti bait coimmunoprecipitation 17437541 physical association X 2 O35179 P21575 anti bait coimmunoprecipitation 17437541 physical association X 2 O35179 P21575 competition binding 17437541 physical association X 2 O35179 P21575 pull down 17437541 physical association X 2 O35179 P21575 far western blotting 9238017 physical association X 2 O35179 O08838 pull down 9315708 direct interaction X 2 Q96J02 O35179 pull down 14684745 physical association X 2 P0CG48 O35179 pull down 19343052 association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Sh3gl2 Synj1 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid) 14704270,9238017 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(biogrid)|(intact)|(intact) UniProt_186457|BIOGRID_335698|UniProt_186454|UniProt_186463 bait|bait|prey|bait prey|prey|null|prey Sh3gl2 Slc17a7 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10,16606361 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint) UniProt_84682|UniProt_84683|UniProt_183532|UniProt_183533|MINT_71180|MINT_71181 bait|prey|bait|prey|bait|prey prey|bait|prey|bait|prey|bait Sh3gl2 Dnm1 MI:0028(cosedimentation in solution)|MI:0405(competition binding)|MI:0405(competition binding)|MI:0405(competition binding)|MI:0416(fluorescence microscopy)|MI:0096(pull down)|MI:0405(competition binding)|MI:0096(pull down)|MI:0096(pull down)|MI:0416(fluorescence microscopy)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid) 10,14704270,16221862,17437541,19562802,9238017 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|(intact)|(biogrid)|(intact)|(intact) UniProt_183106|MINT_71868|MINT_71859|MINT_71858|UniProt_184414|UniProt_183609|MINT_71869|UniProt_183611|MINT_69806|UniProt_165839|UniProt_183613|UniProt_183600|BIOGRID_335699|UniProt_186458|UniProt_186463 neutral component|bait|prey|prey|bait|prey|prey|prey|bait|bait|bait|prey|bait|bait|bait neutral component|prey|bait|bait|prey|bait|bait|bait|prey|prey|prey|bait|prey|prey|prey Amph Sh3gl2 MI:0096(pull down)|MI:0096(pull down) 9315708 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|(intact) MINT_85519|UniProt_186983 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality SH3GL2 SH3GL2 20064468 0114 LC SH3GL2 DNM1 9238017,17437541,9238017,17437541,17437541 0047,0405,0096,0096,0006 LC SH3GL2 SLC17A7 16606361 0018 LC SH3GL2 SYNJ1 9238017,9238017,9238017 0096,0047,0018 LC SH3GL2 PARK2 20064468 0114 LC AMPH SH3GL2 9315708 0096 LC SH3GL2 DNM1 9238017,17437541,9238017,17437541,14704270,16221862,17437541 0047,0405,0096,0096,0004,0096,0006 LC SH3GL2 SYNJ1 9238017,9238017,14704270,9238017 0096,0047,0004,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5S007 O35179 LRRK2 SH3GL2 0.126 24687852 O43295 O35179 SRGAP3 SH3GL2 0.454 25819436 O35179 O08838 SH3GL2 AMPH 0.309 9315708 Q62634 O35179 SLC17A7 SH3GL2 0.309 16606361 P0CG48 O35179 UBC SH3GL2 0.21 19343052 P50570 O35179 DNM2 SH3GL2 0.21 25471590 P39053 O35179 DNM1 SH3GL2 0.21 25471590 Q96J02 O35179 ITCH SH3GL2 0.21 14684745 Q62910 O35179 SYNJ1 SH3GL2 0.21 14704270 Q9WVS6 O35179 PARK2 SH3GL2 0.21 25471590 O60260 O35179 PARK2 SH3GL2 0.376 25471590 P21575 O35179 DNM1 SH3GL2 0.692 17437541,14704270,16221862