PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus March2 March3 16428329 biogrid exp March2 Ubc 16428329 biogrid exp March2 Stx8 15689499 biogrid exp G G G G G G G G Stx12 March2 15689499 biogrid exp G G G G G G G G Vamp4_predicted March2 15689499 biogrid exp March2 Lin7a 15689499 biogrid exp G March2 Stx6 16428329,15689499 biogrid exp, ortho G G G G G G G March2 Syne4 ortho March2 Dlg1 ortho G G G G G G G G Protein Cdc34, RCG29282, isoform CRA_b March2 ortho G G G G G G G G Adrb2 March2 ortho G Elavl4 March2 ortho G G G G G G G G Ube2d1 March2 ortho G G G G Cftr March2 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q63429 Q5I0I2 enzymatic study 16428329 direct interaction X 2 G3V7P1 Q5I0I2 pull down 15689499 direct interaction X 2 Q5I0I2 Q63635 affinity chromatography technology 15689499 physical association X 2 Q5I0I2 Q63635 affinity chromatography technology 15689499 physical association X 2 Q5I0I2 Q63635 imaging technique 15689499 colocalization X 2 Q5I0I2 pull down 15689499 direct interaction X 2 Q5I0I2 Q63635 affinity chromatography technology 16428329 physical association X 2 Q5I0I2 Q63635 pull down 15689499 direct interaction X 2 Q5XIE5 Q5I0I2 affinity chromatography technology 16428329 physical association X 2 Q5I0I2 Q9Z2Q7 pull down 15689499 direct interaction X 2 Q5I0I2 pull down 15689499 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B March2 Stx12 MI:0004(affinity chromatography technology) 15689499 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_337656 bait prey March2 Stx8 MI:0004(affinity chromatography technology) 15689499 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_337658 bait prey March2 Lin7a MI:0004(affinity chromatography technology) 15689499 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_335203 prey bait March2 Stx6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 15689499,16428329 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_335201|BIOGRID_335200|BIOGRID_337657|BIOGRID_336905|BIOGRID_335202 prey|bait|bait|bait|prey bait|prey|prey|prey|bait March2 Vamp4 MI:0004(affinity chromatography technology) 15689499 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_337659 bait prey March2 Ubc MI:0415(enzymatic study) 16428329 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_336903 bait prey March2 March3 MI:0415(enzymatic study) 16428329 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_336904 bait prey

PPI - HINT Gene A Gene B PMID Method Quality MARCH2 UBC 16428329 0415 LC VAMP4 MARCH2 15689499 0096 LC STX12 MARCH2 15689499 0096 LC MARCH2 MARCH3 16428329 0004 LC MARCH2 STX6 16428329,15689499,15689499,15689499 0004,0096,0428,0004 LC MARCH2 LIN7A 15689499 0096 LC MARCH2 STX8 15689499 0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5I0I2 G3V7P1 MARCH2 STX12 0.309 15689499 Q5XIE5 Q5I0I2 MARCH3 MARCH2 0.21 16428329 Q63429 Q5I0I2 UBC MARCH2 0.309 16428329 Q9Z2Q7 Q5I0I2 STX8 MARCH2 0.309 15689499 Q9Z250 Q5I0I2 LIN7A MARCH2 0.309 15689499 Q63635 Q5I0I2 STX6 MARCH2 0.702 15689499,16428329