PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ngfr Psen1 19549834 biogrid,dip exp Erlin2 Psen1 22771797 biogrid,intact exp, ortho G G G G G G G G Psen1 Psen1 12297508 intact exp, ortho G G G G G G G G Efnb2_predicted Psen1 16511561 biogrid exp, ortho Psen1 Ncstn 12297508 i2d,intact exp, ortho G G G G G G G G Psen1 Anterior pharynx defective 1 homolog A (C. elegans), Anterior pharynx defective 1a homolog (C. elegans), isoform CRA_b, Protein Aph1a 12297508 intact exp, ortho G G G G G G G G Psen1 Arc 22036569 intact exp, ortho G G G G G G G G Psen1 Notch homolog 4, [Drosophila], Notch homolog 4, isoform CRA_b, Protein Notch4 ortho G G Sec61a1 Psen1 ortho G G G G G G G G Casp1 Psen1 ortho G G G G G G G G Bace1 Psen1 ortho G G Prkaca Psen1 ortho G G G G G G G G Psen1 Kcnip3 ortho Psen1 Clstn1 ortho G G G G G G G G Psen1 Tmed10 ortho G G G G G G G G Stx1a Psen1 ortho G G G G Protein Stt3b, RCG25591, isoform CRA_a, RGD1311563 protein Psen1 ortho G G G G G G G G Psen1 Rpl10 ortho Protein Pkp4 Psen1 ortho G G G G G G Psen1 Bard1 ortho Protein Gsap, Similar to RIKEN cDNA A530088I07 Psen1 ortho Psmb1 Psen1 ortho G G G G G G G G Npr1 Psen1 ortho G Psen1 Grin2a ortho Psen1 Pik3r1 ortho G Psen1 Cdh1 ortho G G G G Calr Psen1 ortho G G G G G G G G App Psen1 ortho G G G G G G G G Psen1 Protein Umps, Uridine monophosphate synthetase, Uridine monophosphate synthetase, isoform CRA_a ortho G G G G G G G G Plxdc2_predicted Psen1 ortho G G G St13 Psen1 ortho G G G G G G G G Tp53 Psen1 ortho G G G G G G G G Psen1 Pemt ortho G Psen1 Cdk5 ortho G G G G G G G Psen1 Catenin (Cadherin associated protein), alpha 1, Catenin (Cadherin-associated protein), alpha 1, isoform CRA_b, Protein Ctnna1 ortho G G G G G G G G Casp3 Psen1 ortho G G G G G Bcl2 Psen1 ortho G G Apba1 Psen1 ortho Psen1 Tdp2 ortho G G G G G G G G Protein Dner Psen1 ortho Psen1 Notch1 ortho G G G G G G G Psen1 Jup ortho G G G G G G G G Efnb1 Psen1 ortho Ensa Psen1 ortho G G G G G G G G Ets2_mapped Psen1 ortho G G G G G G G G Casp7 Psen1 ortho G G G G G G G G Etv1 protein, Protein Etv1 Psen1 ortho Protein Dag1 Psen1 ortho G G G G G G G G Rab3a Psen1 ortho G G G G G G Protein Ern1 Psen1 ortho Psen1 Ctnnb1 ortho G G G G G G G G Apoe Psen1 ortho G G G G G G G G Psen1 Kcnip4 ortho G G G G G Psen1 Tcf4 ortho G G G G G G G Prdx2 Psen1 ortho G G G G G G G G Pld1 Psen1 ortho G G G G G G G Gapdh Psen1 ortho G G G G G G G G Hspa5 Psen1 ortho G G G G G G G G Psen1 Ecsit ortho G G G G G G G G Cyp2c7 Psen1 ortho RGD1559565_predicted Psen1 ortho G G G G G Tgfbr1 Psen1 ortho G G G G G G G G Psen2 Psen1 ortho G G Traf6 Psen1 ortho Psen1 Nos3 ortho Map2 Psen1 ortho G G G G G G Dll1 Psen1 ortho ELK1, Potassium voltage-gated channel subfamily H member 8, RCG42928 Psen1 ortho G Protein Vasn, RCG49849 Psen1 ortho G G G G G G G G Protein Icam5, RCG31795 Psen1 ortho Bcl2l1 Psen1 ortho G G G G G G G G Etfa Psen1 ortho G G G G G G G G Psen1 Casp8 ortho G Psen1 Cdc37 ortho G G G G G G G G Ap1m2 Psen1 ortho G G Ctnnd1_predicted Psen1 ortho G G G G G G G G LOC100360914 Psen1 ortho Psen1 Psenen ortho G G G G G G G G Grb2 Psen1 ortho G G G G G G G G Cfl1 Psen1 ortho G G G G G G G G Riok3_predicted Psen1 ortho Psen1 Sh2b2 ortho G Dhx9_predicted Psen1 ortho G G G G G G G G Grin1 Psen1 ortho G G G G Neurogenic locus notch homolog protein 2, Notch gene homolog 2 (Drosophila), isoform CRA_a Psen1 ortho Ndufs8_predicted Psen1 ortho G G G G G G G G Atp6v0a1 Psen1 ortho G G G G G G G G Psen1 Rheb ortho G G G G G G G G Psen1 Erythrocyte protein band 4.1-like 3, isoform CRA_d, Protein Epb41l3, Type II brain 4.1 ortho G G G G G G G Gfap Psen1 ortho G G G G G G Psen1 Ncln ortho G G G G G G G G Gdi1 Psen1 ortho G G G G G G G G Scn1a Psen1 ortho G G G Psen1 Fgf13 ortho G G G G G G Protein Unk Psen1 ortho G Psen1 Ndufa9 ortho G G G G G G G G Psma5 Psen1 ortho G G G G G G G G Psen1 F-box and leucine-rich repeat protein 12, F-box and leucine-rich repeat protein 12, isoform CRA_b, Protein Fbxl12 ortho Cxcr1 Psen1 ortho G Oxct1 Psen1 ortho G G G G G G G Psen1 Pdcd4 ortho G G G G G G G Prkcz Psen1 ortho G G G G Psen1 Stx5 ortho G G G G G G G G Psen1 Rmdn3 ortho Cd44 Psen1 ortho G G G G Protein Dsp Psen1 ortho G G G G G Psen1 Actn1 ortho G G G G G G G G Psen1 Cib1 ortho G G G G G G G G Gsk3b Psen1 ortho G G Psen1 Cadherin 15, M-cadherin, Protein Cdh15 ortho Flnb_predicted Psen1 ortho Psen1 Srpk1 ortho G G G G G G Psen1 SUP ortho G G G G G G G G HtrA serine peptidase 2, Protein Htra2, RCG56292, isoform CRA_d Psen1 ortho G G G G G G G G Mtch1 protein, Protein Mtch1 Psen1 ortho G G G G G G G G Psen1 Ubqln1 ortho G G G G G G G G Flna_predicted Psen1 ortho G G G G G G G Rab11a Psen1 ortho G G G G G G G G Gcdh_predicted Psen1 ortho G G G G G G G G Casp6 Psen1 ortho G G G Psen1 Protein Rad23a, RAD23 homolog A (S. cerevisiae) ortho G G G G G LOC687696 protein, Protein Stambpl1, RCG48274 Psen1 ortho Psen1 B-cell receptor-associated protein 31, B-cell receptor-associated protein 31, isoform CRA_a, Protein Bcap31 ortho G G G G G G G G Psen1 RNCASP9 ortho G G G G G G G Psen1 Irak2 ortho Psen1 Ubc ortho Psen1 Notch3 ortho G G G G G G G G Psen1 Tp63 ortho

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ngfr Psen1 MI:0006(anti bait coimmunoprecipitation) 19549834 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) MI:0465(dip) DIP_5314 - - Psen1 Ncstn MI:0006(anti bait coimmunoprecipitation) 12297508 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (intact) UniProt_181321 null prey Psen1 Arc MI:0071(molecular sieving) 22036569 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0403(colocalization) (intact) UniProt_184534 neutral component neutral component

PPI - HINT Gene A Gene B PMID Method Quality APP PSEN1 27036734 0055 LC PSEN1 ARC 22036569 0040 LC PSEN1 NCSTN 12297508,12297508 0019,0006 LC APH1A PSEN1 27036734,12297508 0006,0006 LC EFNB2 PSEN1 16511561 0004 LC ERLIN2 PSEN1 22771797,22771797 0004,0006 LC NGFR PSEN1 19549834,19549834 0004,0006 LC SYT1 PSEN1 27036734 0006 LC PSEN1 PSEN1 12297508 0006 LC PSEN1 PSENEN 27036734 0006 LC PSEN1 NCSTN 12297508,12297508 0019,0006 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q63053 P97887 ARC PSEN1 0.126 22036569 P97887 P08592 PSEN1 APP 0.126 27036734 P97887 P07174 PSEN1 NGFR 0.376 19549834 P97887 A0A0G2K6H8 PSEN1 A0A0G2K6H8 0.126 27036734 P97887 B5DEH2 PSEN1 ERLIN2 0.507 22771797 P97887 P21707 PSEN1 SYT1 0.126 27036734 P97887 P97887 PSEN1 PSEN1 0.236 12297508 Q02410 P97887 APBA1 PSEN1 0.21 11083918 Q5PQQ3 P97887 APH1A PSEN1 0.21 12297508 Q6QI68 P97887 PSENEN PSEN1 0.126 27036734 Q8CGU6 P97887 NCSTN PSEN1 0.21 12297508 P97887 P21579 PSEN1 SYT1 0.126 27036734