PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Prkci Mbp 11500922 biogrid exp G G G Prkci Pard6a i2d exp Prkci Gria1 23511975 intact exp G G G Prkci Prkci 11463795 biogrid exp, ortho G G G G G G G G Prkci Sqstm1 11500922,23511975 biogrid,intact exp, ortho G G G G G G G G Protein Adam19, RCG34059 Prkci ortho G G G G G G G G Tjp1_predicted Prkci ortho G G G G G G G G Prkci Ikbkb ortho G G G G G G G G Pard6g Prkci ortho Prkci Xpo1 ortho G G G G G G G G Prkci Map2k5 ortho G G G G G G G G Prkci Hras ortho G G G G G G G G Protein Eif4enif1, RCG35971, isoform CRA_a Prkci ortho Ripk1_predicted Prkci ortho G G G G G Prkci Map1lc3a ortho G G G G G G G G Prkci Centa1 ortho G G G G G Prkci Pawr ortho G G Prkci Pard3 ortho Prkci Ssb ortho G G G G G G G G Prkci Casp8 ortho G Prkci Ywhaz ortho G G G G G G G G Prkci Chuk_predicted ortho G G G G G G G G Prkci Gapdh ortho G G G G G G G G Prkci Ikbkg ortho Prkci Mark2 ortho G G G G G G G Prkci Vhl ortho G G G G G G G G Protein Mark4 Prkci ortho G G G G G G G G Prkci GLI-Kruppel family member GLI1, Protein Gli1 ortho Frs2_predicted Prkci ortho Irak1_predicted Prkci ortho G G G G G G G G Pard6b_predicted Prkci ortho Prkci Ppm1a ortho G G G G G G Prkci Prkcq ortho G G G G G G G G Prkci Sfpq ortho G G G G G G G Prkci Rac1 ortho G G G G G G G G Prkci Mpi ortho G G G G G G G G Prkci Cone-rod homeobox protein, Protein Crx ortho Smarcd1_predicted Prkci ortho G G G Prkci Bad ortho G G G G G G G G Prkci Fabp4 ortho G G Prkci Src ortho G G G G G Prkci Dusp1 ortho G G G G G G G G Prkci Gabarapl1 ortho G G G G G G G G RCG41622, Sulfhydryl oxidase 1 Prkci ortho Protein Cep135 Prkci ortho Prkci Rab2a ortho G G G G G G G G Prkci Ywhae ortho G G G G G G G G Prkci Rhoq ortho Prkci Spata18 ortho Llgl2 protein, Protein Llgl2 Prkci ortho Prkci Hsp90aa1 ortho Prkci Il1rap ortho G Prkci Rab4a ortho G G G G G G G Prkci 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans), isoform CRA_b, Protein Nipsnap1 ortho G G G G G G G Prkci Arhgap17 ortho G G G G G G G G Prkci Frs3 ortho G G G Prkci Pex5 ortho G G G G G G G G LOC315766 Prkci ortho G G G G G G G G Prkci Ywhah ortho G G G G G G G G Prkci Elavl4 ortho G G G G G G G G Prkci Hsp90ab1 ortho G G G G G G G G Prkci Pnma1 ortho G Prkci Map2k1 ortho G G G G G G G G Prkci Anxa1 ortho G G G G G G G G Prkci Apc ortho Prkci Cdc37 ortho G G G G G G G G Prkci App ortho G G G G G G G G Prkci Sell ortho G G Prkci Gabarapl2 ortho Prkci Prkcz ortho G G G G Myo10 Prkci ortho Prkci Map1lc3b ortho Prkci Kpna6 ortho G G G G G G G G Prkci Ppm1b ortho G G G G G G G G Prkci Ttr ortho G G G G G G G G Prkci Pdpk1 ortho G Mtss1_predicted Prkci ortho G G G G G G G G Prkci Hpd ortho G G G Prkci Tsc22d1 ortho G G G G G G G G Prkci LOC498174 ortho Prkci Tmem17 ortho Protein Rassf8 Prkci ortho Prkci Npm1 ortho Prkci Melanoma antigen, family D, 2, Melanoma antigen, family D, 2, isoform CRA_a, Protein Maged2 ortho G G G G G G Prkci Gabarap ortho G G G G G G G G Prkci Protein Rhoj, Ras homolog gene family, member J ortho G Usp21 Prkci ortho G G G G G G G G Prkci Nfkbia ortho G G G G G Prkci Cdc42 ortho G G G G G G G G RGD1560953_predicted Prkci ortho G G G G G G G G Prkci Trappc13 ortho G G G G G G G G Usp34 Prkci ortho G G G G G G G G Rapgef2 Prkci ortho G G G G G G G G Prkci Pak1 ortho G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants F1M7Y5 - 15723051 - C 3 F1M7Y5 - 15723051 - C 6 F1M7Y5 Q6B4M5-2 - 15723051 - X 2 F1M7Y5 - 15723051 - C 5 F1M7Y5 F1M7Y5 enzymatic study 11463795 direct interaction X 2 F1M7Y5 O08623 affinity chromatography technology 11500922 physical association X 2 F1M7Y5 P02688-3 enzymatic study 11500922 direct interaction X 2 F1M7Y5 anti bait coimmunoprecipitation 19885391 - C 3 Q62824 F1M7Y5 anti bait coimmunoprecipitation 19885391 physical association X 2 Q62824 F1M7Y5 anti bait coimmunoprecipitation 19885391 physical association X 2 F1M7Y5 anti bait coimmunoprecipitation 23511975 association C 3 F1M7Y5 anti bait coimmunoprecipitation 23511975 association C 3 F1M7Y5 anti bait coimmunoprecipitation 23511975 association C 3

PPI - HINT Gene A Gene B PMID Method Quality PRKCI PRKCI 11463795 0415 LC PRKCI MBP 11500922 0415 LC PRKCI PARD6A 15723051 0019 LC PRKCI SQSTM1 23511975,11500922 0006,0004 LC PRKCI GRIA1 23511975 0006 LC PRKCI EXOC4 19885391 0006 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID F1M7Y5 F1M7Y5 PRKCI PRKCI 0.332 11463795 O08623 F1M7Y5 SQSTM1 PRKCI 0.507 23511975,11500922 P02688 F1M7Y5 MBP PRKCI 0.309 11500922 P19490 F1M7Y5 GRIA1 PRKCI 0.376 23511975 Q62824 F1M7Y5 EXOC4 PRKCI 0.21 19885391