PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Hif1a Vhl 19950214 biogrid exp, ortho G G G G G G G G Vhl Epas1 12675925 biogrid exp, ortho Pls3 Vhl ortho G G G G G G G G Prkcz Vhl ortho G G G G PHD finger protein 17 (Predicted), isoform CRA_a, Protein Jade1 Vhl ortho G G G G G G G G Itgal Vhl ortho COP9 (Constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana), COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), Protein Cops5 Vhl ortho G G G G G G G G Lman1 Vhl ortho G G G G G Atp5o Vhl ortho G G G G G G G G Vhl Hnrpu ortho G G G G G G G G Vars Vhl ortho Txn Vhl ortho G G G G G G G G Aarsd1 Vhl ortho G G G G G G G G Rps14 Vhl ortho Rlc-a Vhl ortho G G G G G G G G Tceb3 Vhl ortho G G G G Chaperonin containing Tcp1, subunit 6A (Zeta 1), Chaperonin subunit 6a (Zeta), Protein Cct6a Vhl ortho G G G G G G G LOC100360260 Vhl ortho Kng1 Vhl ortho G Lpp Vhl ortho Rb1cc1_predicted Vhl ortho Influenza virus NS1A binding protein (Predicted), isoform CRA_a, Myocardium ischemic preconditioning associated protein, Protein Ivns1abp Vhl ortho G G G G G G G G Uqcrfs1 Vhl ortho G G G G G G G G Cntf Vhl ortho G G G G G Cul3 Vhl ortho G G G G G G G G Fzr1_predicted Vhl ortho G G G G G G G Protein Rbpms Vhl ortho G G G G G G G G Dctn1 Vhl ortho G G G G G G G G Tuba1a Vhl ortho Histone H2B Vhl ortho Rpl7a Vhl ortho Ccdc59_predicted Vhl ortho Pitpnb Vhl ortho G G G G G G G G RGD1309922 Vhl ortho G G G G G G G G Pgrmc1 Vhl ortho G G G G G G G G Protein Cct7, RCG55994, isoform CRA_c Vhl ortho G G G G G G G G Protein Cer1, RCG55280, RGD1563046 protein Vhl ortho Hspe1 Vhl ortho G G G G G G G G Vhl Slc3a2 ortho G G G G G G G G Tmco1 Vhl ortho G G G G G G G G Vhl Ilf3 ortho G G G G G G G G Lrrc59 Vhl ortho G G G G G G G G Eukaryotic translation elongation factor 1 beta 2, Protein Eef1b2, RCG22471, isoform CRA_b Vhl ortho G G G G G G G G Rit1_predicted Vhl ortho G G G G G Vhl Complement component 2, Protein C2 ortho Pld1 Vhl ortho G G G G G G G Flna_predicted Vhl ortho G G G G G G G Vhl Hnrnph2 ortho Vhl Hnrnpd ortho G G G G G G G G Tkt Vhl ortho G G G G G G G G Vhl Vhl ortho G G G G G G G G Glrx5_predicted Vhl ortho G G G G G G G G Ubc Vhl ortho Egln3 Vhl ortho G G G G G Aurka Vhl ortho G G Lypla1 Vhl ortho G G G G G G G G RGD1309441_predicted Vhl ortho G G G G G G G G Fkbp1a Vhl ortho G G G G G G G G Hif1an_predicted Vhl ortho Pfdn5_predicted Vhl ortho G G G G G G G G Vhl Xrcc5 ortho G G G G G Protein Rbbp4, RCG30896, Rbbp4 protein Vhl ortho Rps2 Vhl ortho Rps11 Vhl ortho G G G G G G G G Hdac2 Vhl ortho G G G G G G G G Nudc Vhl ortho Tpt1 Vhl ortho G G G G G G G G Ssb Vhl ortho G G G G G G G G Kinesin-like protein Vhl ortho G Grpel1 Vhl ortho G G G G G G G G Urkl1_predicted Vhl ortho Protein Fblim1 Vhl ortho G G G G G G G G Rplp0 Vhl ortho G G G G G G G G DNA helicase Vhl ortho G G G G G G G G Prkci Vhl ortho G G G G G G G G Rps27l Vhl ortho G G Jak2 Vhl ortho G Psma2 Vhl ortho G G G G G G G G Vhl Ufc1 ortho G G G G G G G G Limd1 Vhl ortho Protein Rbpms2, Rbpms2 protein Vhl ortho G G G G G G G G Ar Vhl ortho G G G G G G G Vhl Eef1d ortho G G G G G G G G Diacylglycerol kinase, DAG kinase Vhl ortho G G G G G G G G Vhl Cul5 ortho Hnrpll Vhl ortho Transcription factor BTF3 Vhl ortho G G G G G G G G Mybbp1a Vhl ortho G G G G G G G G Stk16 Vhl ortho G G G G G G G G Tmed10 Vhl ortho G G G G G G G G DNA-directed RNA polymerase Vhl ortho G G G G G G G G Rpl22 Vhl ortho G G G G G G G G Eif5a2_predicted Vhl ortho Acly Vhl ortho G G G G G G G G Vhl Plod2 ortho G G G G G G G G Arf6 Vhl ortho G G G G G G G G Prmt3 Vhl ortho Protein LOC100364748 Vhl ortho G G G G G App Vhl ortho G G G G G G G G Rps5 Vhl ortho G G G G G G G G Akr1b1 Vhl ortho G G G G G G G G C1qb Vhl ortho G G G G G G G G Vhl Protein Sar1a, SAR1 gene homolog A (S. cerevisiae), isoform CRA_b, SAR1 homolog A (S. cerevisiae) ortho G G G G G G G G Tceb2 Vhl ortho G G G G G G G G Vhl Hdac3 ortho G G G G G G G G Tuba4a Vhl ortho G G G G G G G G Dnaja2 Vhl ortho G G G G G G G G Myl6 Vhl ortho Vhl Fastkd3 ortho Vhl Cdkn2a ortho Ppm1b Vhl ortho G G G G G G G G Hdac1 Vhl ortho G G Protein Tle1 Vhl ortho G G G G G Rpl14 Vhl ortho G G G G G G G G Parp1 Vhl ortho G G G G G G G G Protein Spry2, Sprouty homolog 2 (Drosophila) Vhl ortho G G G G Protein Son Vhl ortho G G G G G G G G Park7 Vhl ortho G G G G G G G G Rb1 Vhl ortho G G G G G G Cstb Vhl ortho G G G G G G G G Timm17a Vhl ortho G G G G G G G G Cox5a Vhl ortho G G G G G G G G Capzb Vhl ortho G G G G G G G G Nr4a3 Vhl ortho G G LOC100361515 Vhl ortho Hprt1 Vhl ortho G G G G G G G G Ajuba Vhl ortho G G G G Vhl S100a11 ortho G G G G G G G G Vamp3 Vhl ortho G G G G G G G G Srprb Vhl ortho G G G G G G G G Protein Rab5c, RCG32615, isoform CRA_a, Rab5c protein Vhl ortho G G G G G G G G Nr4a1 Vhl ortho G G G G G G G G Protein Rbx1, Ring-box 1 Vhl ortho G G G G G G G G Hyou1 Vhl ortho G G G G G G G G Vhl Card9 ortho Cd44 Vhl ortho G G G G Mtpn Vhl ortho G G G G G G G G Snrnp200 Vhl ortho G G G G G G G G Sf3a1_predicted Vhl ortho G Sod2 Vhl ortho G G G G G G G G Rnf7_predicted Vhl ortho G G G G G G G G Pcgf2 protein, Polycomb group ring finger 2 (Predicted), isoform CRA_a, Protein LOC100911274 Vhl ortho G Gdi2 Vhl ortho G G G G G G G G Sat2_predicted Vhl ortho G G G G G Vhl Cuta ortho G G G G G G G G Hint1 Vhl ortho G G G G G G G G Nr4a2 Vhl ortho G Set Vhl ortho G G G G G G G G Vhl Lepre1 ortho G G Exosc8_predicted Vhl ortho G G G G G G G G Ate1_predicted Vhl ortho G G G G G G G G Rab14 Vhl ortho G G G G G G G G Rab11a Vhl ortho G G G G G G G G Vhl Mycbpap ortho Rpl18a Vhl ortho G G G G G G G G Vhl Cct3 ortho G G G G G G G G Psmc3 Vhl ortho G G G G G G G G Protein Stub1, STIP1 homology and U-Box containing protein 1, isoform CRA_b Vhl ortho G G G G G G G G Supt16h_predicted Vhl ortho G G G G G G G G Atm_mapped Vhl ortho Egln1 Vhl ortho G G G G G G G Protein Msh4 Vhl ortho Rpl10a Vhl ortho Dnaja3 Vhl ortho G G G G G G G G Vhl DEAD (Asp-Glu-Ala-Asp) box polypeptide 5, Ddx5, Protein Ddx5 ortho G G G G G G G G PDZ domain-containing protein 2, Peptidylprolyl cis/trans isomerase, NIMA-interacting 1, Protein (Peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (Predicted), isoform CRA_a Vhl ortho G G G G G G G G Psmb3 Vhl ortho G G G G G G G G Hspb11 protein, Protein Hspb11, RCG50296, isoform CRA_a Vhl ortho G G G G G G G Vhl Lancl1 ortho G G G G G G G G C3 Vhl ortho G G G G G G G G Vhl Hyaluronan synthase 1, Protein Has1 ortho Protein Rnf139, RCG60186 Vhl ortho G G G G G G G G Trip12 Vhl ortho G G G G G G G G Bcl2l11 Vhl ortho Gnb2l1 Vhl ortho G G G G G G G G Mcts1 Vhl ortho Sumo1 Vhl ortho G G G G G G G G Cul2_predicted Vhl ortho G G G G G Stmn1 Vhl ortho G G G G G G G G Vhl Dctpp1 ortho G G G G G G G G Rab2a Vhl ortho G G G G G G G G Cdk2 Vhl ortho Vhl CHK2 checkpoint homolog (S. pombe), isoform CRA_a, Checkpoint kinase Chk2, Protein Chek2 ortho G Ireb2 Vhl ortho Vhl Rasgrp1 ortho Ezr Vhl ortho G G G G G G G G Iars_predicted Vhl ortho G G G G G G G G Elavl4 Vhl ortho G G G G G G G G Dtymk_predicted Vhl ortho Anxa2 Vhl ortho G G G G G G G G Bsg Vhl ortho G G G G G G G G Txnl5_predicted Vhl ortho G G G G G G G G Usp34 Vhl ortho G G G G G G G G Psma6 Vhl ortho G G G G G G G G Fscn1 Vhl ortho Ncl Vhl ortho G G G G G G G G Dnaja1 Vhl ortho G G G G G G G G Pias4 protein, Protein Pias4, Protein inhibitor of activated STAT, 4 Vhl ortho G G G Protein Mrps16, RCG41911 Vhl ortho G G G G G G G G Trim28 Vhl ortho G G G G G G G G Pfdn2 Vhl ortho G G G G G G G G Hnrnpm Vhl ortho G G G G G G G G Vhl Nedd8 ortho G G G G G G G G Protein Malt1 Vhl ortho Protein Prmt8 Vhl ortho Protein Srp14, RCG26543, isoform CRA_b, Signal recognition particle 14 Vhl ortho G G G G G G G G Mif Vhl ortho G G G G G G G G RGD1562456_predicted Vhl ortho Cdo1 Vhl ortho G G G G G G G G Nup155 Vhl ortho G G G G G G G G Cct8_predicted Vhl ortho G G G G G G G G Vhl Hif3a ortho Hist1h4b, Hist1h4m, Hist4h4 Vhl ortho G G G G G Hspa8 Vhl ortho Fkbp8 Vhl ortho G G G G G G G G Tcp1 Vhl ortho G G G G G G G G Psmb5 Vhl ortho G G G G G G G G Vhl Egln2 ortho G G G G G G G G Glycosyltransferase 25 domain containing 1, Glycosyltransferase 25 domain containing 1 (Predicted), Protein Colgalt1 Vhl ortho G G G G G G G G Eif3s12_predicted Vhl ortho G G G G G G G G Vhl Ltv1 ortho G G G G G G G G Vhl Trafd1 ortho G G G G G G G G Tmed2 Vhl ortho G G G G G G G G Vhl Cct5 ortho G G G G G G G G Ppib Vhl ortho G G G G G G G G Protein Cbx1, RCG35120, isoform CRA_a Vhl ortho Vhl Ube2n ortho G G G G G G G G Ube2d1 Vhl ortho G G G G Kif5b Vhl ortho Vhl Mrpl14 ortho G G G G Snx3 Vhl ortho G G G G G G G G Hsp90aa1 Vhl ortho Protein Kirrel2 Vhl ortho Hnrnpa1 Vhl ortho G G G G G G G Protein Col4a1 Vhl ortho G G G G G G G G Rap1a Vhl ortho G G G G G G G G Hnrpr Vhl ortho G G G G G G G G Rpsa Vhl ortho Vhl Sept2 ortho G G G G G G G G Sec22b Vhl ortho G G G G G G G G Vhl Nob1 ortho G G G G G G G G Tars Vhl ortho G G G G G G G G Protein Trmt112, Similar to RIKEN cDNA 0610038D11 (Predicted), isoform CRA_b, Uncharacterized protein Vhl ortho G G G G G G G G Protein Rhoc, Ras homolog gene family, member C Vhl ortho G G G G G G G G Tagln2 Vhl ortho G G G G G G G G Ankrd40 protein, Protein Ankrd40, RCG34017, isoform CRA_a Vhl ortho G G G G G G G G Vhl Cct4 ortho G G G G G G G G Ube2d3 Vhl ortho Vhl Mob4 ortho G G G G G G G G Uxt Vhl ortho G G G G G G G G Cbx5_predicted Vhl ortho G G G G G Alas1 Vhl ortho G G G G G G G G Hspa4 Vhl ortho G G G G G G G G Ddt Vhl ortho G G G G G G G G Sp1 Vhl ortho G G G G G G G G Vhl Tgm2 ortho G G G G G G G G Mknk2 Vhl ortho G G G G G Grn Vhl ortho G G G G G G G G Vhl Kat5 ortho G G G G G G G G Vhl Tubb4b ortho G G G G G G G G Uqcc2 Vhl ortho G G G G G G G G Ppp2r2b Vhl ortho G G G G Vhl Ccna1 ortho Rwdd3 Vhl ortho Met Vhl ortho G Ptges3 Vhl ortho G G G G G G G G Pebp1 Vhl ortho G G G G G G G G Rpl21 Vhl ortho Vhl Gut-enriched kruppel-like factor, Kruppel-like factor 4 (Gut), Kruppel-like factor 4 (Gut), isoform CRA_a, Protein Klf4 ortho G G G G G G G Lyz2 Vhl ortho G G G G G G G G Vhl Ssr1 ortho G G G G G G G G Myc Vhl ortho G Vhl Tbca ortho G G G G G G G G Protein Ict1 Vhl ortho G G G G G G G G Vhl Prkch ortho G G G G G Sarnp Vhl ortho G G G G G G G G Vhl Socs1 ortho Dgkz Vhl ortho G G G G G Csnk2a1 Vhl ortho Vhl Vapb ortho G G G G G G G G Rpl11 Vhl ortho G G G G G G G G Smarcc1_predicted Vhl ortho G G G G G G G G Cotl1 Vhl ortho G G G G G G G G Polr2g Vhl ortho G G G G G G G G Uchl1 Vhl ortho G G G G G Protein RGD1565297, RCG36598 Vhl ortho G Rpl35 Vhl ortho G G G G G G G G Grwd1 Vhl ortho G G G G G G G G Eif5a Vhl ortho G G G G G G G G Cct2 Vhl ortho G G G G G G G G Rps16 Vhl ortho G G G G G G G G Plod3 Vhl ortho G G G G G G G G Ube2m_predicted Vhl ortho G G G G G G G G Hnrnpk Vhl ortho Nudt21 Vhl ortho G G G G G G G G Gcn5l2_predicted Vhl ortho Impdh2 Vhl ortho G G G G G G G G Clu Vhl ortho G G G G G G G G Rps15a Vhl ortho G G G G G G G G Rps3 Vhl ortho G G G G G G G G Vhl Rps27 ortho Protein Zyx Vhl ortho G G G G G G G G Ube2d2 Vhl ortho G G G G G G G G Cyba Vhl ortho G G G G G G G G GLI-Kruppel family member GLI1, Protein Gli1 Vhl ortho Vhl Bcl2l14 ortho E2f1 Vhl ortho Vhl Plp2 ortho G G G G G G G G Papss2 protein, Protein Papss2 Vhl ortho G G G G G G G Vhl Pard3 ortho Protein Mycbp, RCG31143 Vhl ortho Protein Cdc34, RCG29282, isoform CRA_b Vhl ortho G G G G G G G G Tp53 Vhl ortho G G G G G G G G Socs3 Vhl ortho G G Rab35 Vhl ortho G G G G G G Protein C1qtnf2 Vhl ortho Vhl Eif1a ortho LOC100363376 Vhl ortho G G G G G G G G Protein Snrnp70, Snrp70 protein, U1 small nuclear ribonucleoprotein polypeptide A (Predicted), isoform CRA_c Vhl ortho G G G G G G G G LOC102555086 Vhl ortho G G G G G G Atic Vhl ortho Vhl Ccdc82 ortho Prmt1 Vhl ortho Rhpn2_predicted Vhl ortho Mrps23_predicted Vhl ortho G G G G G G G G Fabp5 Vhl ortho G G G G G G G G Hip2_predicted Vhl ortho G G G G G G G G Rpl5 Vhl ortho Vps35_mapped Vhl ortho G G G G G G G G RGD1306781_predicted Vhl ortho G G G G G G G G Osr1 Vhl ortho P4hb Vhl ortho G G G G G G G G Aprt Vhl ortho G G G G G G G G Hspa5 Vhl ortho G G G G G G G G Vhl Rbbp7 ortho G G G G G G G G Kntc1_predicted Vhl ortho LOC100911572 Vhl ortho Protein Mdfi, RGD1560271 protein, Similar to inhibitor of MyoD family-a (Predicted), isoform CRA_c Vhl ortho Psmd13 Vhl ortho G G G G G G G G Rpl37a Vhl ortho Rps9 Vhl ortho Actb Vhl ortho Capn7 Vhl ortho G G G G G G G G Hnrnpa2b1 Vhl ortho G G G G G G G G Slc2a1 Vhl ortho G G G G G G G G Adrb2 Vhl ortho G Vhl Rab6a ortho G G G G G G G G Top2a Vhl ortho G Rab7a Vhl ortho G G G G G G G G Psmb1 Vhl ortho G G G G G G G G Prkcd Vhl ortho G G G G G G G G Cstf3 Vhl ortho Vhl Tgfb1i1 ortho G G G G G G G G Atp5j2 Vhl ortho G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9JHS1 Q64259 affinity chromatography technology 12675925 physical association X 2 Q64259 Q15369-2 affinity chromatography technology 9122164 physical association X 2 Q64259 Q15369-2 affinity chromatography technology 7660122 physical association X 2 Q64259 affinity chromatography technology 19950214 physical association X 2 Q64259 Q15370-2 affinity chromatography technology 9122164 physical association X 2 Q64259 Q8N726 biochemical 7604013 colocalization X 2 Q64259 Q96B26 biochemical 7604013 colocalization X 2 Q64259 Q15370-2 affinity chromatography technology 7660122 physical association X 2 Q64259 Q16665-3 pull down 17942596 direct interaction X 2 Q64259 molecular sieving 10213691 association C 5 Q64259 chromatography technology 10213691 association C 5 Q64259 coimmunoprecipitation 11384984 association C 5 Q64259 coimmunoprecipitation 11384984 association C 5

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Vhl Epas1 MI:0004(affinity chromatography technology) 12675925 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334691 bait prey Hif1a Vhl MI:0004(affinity chromatography technology) 19950214 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334068 bait prey

PPI - HINT Gene A Gene B PMID Method Quality HIF1A VHL 19950214 0004 LC VHL EPAS1 12675925 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q64259 Q15369 VHL TCEB1 0.21 7660122 Q64259 P42771 VHL CDKN2A 0.126 7604013 Q9JHS1 Q64259 EPAS1 VHL 0.21 12675925 Q8N726 Q64259 CDKN2A VHL 0.126 7604013 Q96B26 Q64259 EXOSC8 VHL 0.126 7604013 Q64259 O35800 VHL HIF1A 0.21 19950214 Q64259 Q15370 VHL TCEB2 0.376 7660122,9122164 Q64259 Q16665 VHL HIF1A 0.309 17942596