PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Uba1 Sumo3 22082260 biogrid exp G G G G G G G G Uba1 Ubc 22871113 biogrid exp, ortho Cth Uba1 ortho G G Protein Ipo5 Uba1 ortho G G G G G G G G Uba1 Ddb1 ortho G G G G G G G Rnf125 Uba1 ortho Acox1 Uba1 ortho Ap1m1 Uba1 ortho G G G G G G G G Chaperonin containing Tcp1, subunit 6A (Zeta 1), Chaperonin subunit 6a (Zeta), Protein Cct6a Uba1 ortho G G G G G G G Ube2d2b Uba1 ortho Pias3 Uba1 ortho G G G G G G G G Dpp3 Uba1 ortho Bap1 Uba1 ortho G G G G G G G G Ube2t_predicted Uba1 ortho G Hsp90aa1 Uba1 ortho Nmb_predicted Uba1 ortho G G G G G G G G Uba1 Slc4a4 ortho G G G Hspa4 Uba1 ortho G G G G G G G G RGD1564594 Uba1 ortho Taf9 Uba1 ortho G G G G G G G G LOC679140 Uba1 ortho G G G G G G G G Gars Uba1 ortho G G G G G G G G Protein Smurf1, RCG42768 Uba1 ortho G G G G G G G G Uba1 Cblb ortho G G G G G G G Uba1 RelA ortho G G G G G G G G Jun Uba1 ortho G G G G G G G G Protein Cdc34, RCG29282, isoform CRA_b Uba1 ortho G G G G G G G G Uba1 Dnajb6 ortho Srebf2 Uba1 ortho G G G G G G G G PTEN/MMAC1 Uba1 ortho G G G G G Mcts1 Uba1 ortho Psma6 Uba1 ortho G G G G G G G G Leucyl-tRNA synthetase, Protein Lars Uba1 ortho G G G G G G G G Eed_predicted Uba1 ortho G G G G G G G G Protein Rnf20 Uba1 ortho Ctsl Uba1 ortho G G G G G G G G Uba1 Ube2v2 ortho G G G G G G G G Atp13a1_predicted Uba1 ortho G G G G G G G G RGD1565884_predicted Uba1 ortho Uba1 Gripap1 ortho G G G G G G Trim21_predicted Uba1 ortho Nsun2_predicted Uba1 ortho G G G G G G G G Protein Txlng, Similar to CXORF15 Uba1 ortho Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14, Protein Psmd14, Psmd14 protein, RCG26455, isoform CRA_b Uba1 ortho Atp6v1b2 Uba1 ortho G G G G G G G G Gch1 Uba1 ortho G G G G Uba1 Hip1r ortho G G G G G G G G Uba1 Nfkbia ortho G G G G G Ube2e3_predicted Uba1 ortho G G G G G G G G Uba1 Nhlrc1 ortho Csnk1d Uba1 ortho G G G G G G G G Uba1 Ndufv3 ortho G G G G G G G G Faf2 Uba1 ortho Apex2 Uba1 ortho Creld1 Uba1 ortho G G G G G G G Golgi associated, gamma adaptin ear containing, ARF binding protein 2, isoform CRA_a, Protein Gga2 Uba1 ortho G G G G G G G G Ube2b Uba1 ortho G G G G G G G G Ttc19 Uba1 ortho G G G G G G G G Uba1 Protein Ube2a, Ubiquitin-conjugating enzyme E2A, RAD6 homolog (S. cerevisiae) ortho G G G G G G G G Cul1_predicted Uba1 ortho G G G G G G G G Mgmt Uba1 ortho G G G G G RGD1563141_predicted Uba1 ortho G G G G G G G G Ube2g2_predicted Uba1 ortho G G G G G G G G Trim23 Uba1 ortho Gfpt2 Uba1 ortho Protein Sapcd2, RCG45912, isoform CRA_b, Similar to CG3880-PA Uba1 ortho Ube2i Uba1 ortho G G G G G G G G Nkrf Uba1 ortho G G G G G G G G Protein Ddhd2 Uba1 ortho Protein Ints3 Uba1 ortho G G Uba1 Psat1 ortho G G G G G G Gan_predicted Uba1 ortho Atic Uba1 ortho Uba1 Ankyrin repeat domain 13a, Protein Ankrd13a, RCG21176 ortho G G G G G G G G Uba1 Pabpc1 ortho G G G G G G G G Mtpn Uba1 ortho G G G G G G G G G1p2_predicted Uba1 ortho Uba1 Psmc2 ortho G G G G G G G G Uba1 Hbs1l ortho G G G G G G G G Protein Ube2c, RCG32249 Uba1 ortho G G G G G Uba1 Hsph1 ortho G G G G G G G G LOC681996 protein, Protein Ahsa1, RCG20659, isoform CRA_b Uba1 ortho G G G G G G G G Poli_predicted Uba1 ortho Met Uba1 ortho G Ntrk1 Uba1 ortho Uba1 Rbck1 ortho G G G G G G G Rnf135 Uba1 ortho Aurka Uba1 ortho G G Protein Stub1, STIP1 homology and U-Box containing protein 1, isoform CRA_b Uba1 ortho G G G G G G G G Rad23b Uba1 ortho G G G G G G G G Gmppb_predicted Uba1 ortho G G G Dcun1d4_predicted Uba1 ortho G G G G G G G G Ccdc8 Uba1 ortho G G Rnf4 Uba1 ortho G G G G G G G G Mthfd1 Uba1 ortho G G G G G G G G Uba1 Uchl3 ortho G G G G G G G G Uba1 Mapk13 ortho G RGD1304861 Uba1 ortho Cd74 Uba1 ortho G G G G G G G G Uba1 Trim25 ortho Uba1 Protein Rad23a, RAD23 homolog A (S. cerevisiae) ortho G G G G G Uba1 Ric8a ortho G G G G G G G G Xpnpep1 Uba1 ortho G G G G G G G G Ube2g1 Uba1 ortho G G G G G G G G Dlg4 Uba1 ortho G G G G G G Cdk1 Uba1 ortho G G G Cul3 Uba1 ortho G G G G G G G G Melanocyte-stimulating hormone receptor, MSH-R Uba1 ortho Huntingtin interacting protein 1, isoform CRA_a, Protein Hip1 Uba1 ortho G G G G G G G G DEAD (Asp-Glu-Ala-Asp) box polypeptide 41, Protein Ddx41, RCG24134 Uba1 ortho Protein LOC100911132 Uba1 ortho RGD1309605_predicted Uba1 ortho Uba1 Tubb4b ortho G G G G G G G G Ube2m_predicted Uba1 ortho G G G G G G G G Uba1 Psmc3 ortho G G G G G G G G Hip2_predicted Uba1 ortho G G G G G G G G Atxn3 Uba1 ortho Ube2w Uba1 ortho G G G G G G G G Aimp2 Uba1 ortho G G G G G G G G Uba1 Ctnnb1 ortho G G G G G G G G Uba1 Uba1 ortho G G G G G G G G Ube2d3 Uba1 ortho RGD1562317_predicted Uba1 ortho G G G G G G G G Rbp2 Uba1 ortho Acaca Uba1 ortho G G G G G G G G Uba1 Baculoviral IAP repeat-containing 2, Protein Birc2 ortho G G G G G G G G Pgam2 Uba1 ortho Sema3f_predicted Uba1 ortho Protein Tln1, RCG55135, isoform CRA_b Uba1 ortho G G G G G G G G Uba1 Cdk2 ortho Riok3_predicted Uba1 ortho Uba1 Birc3 ortho G G G G G COP9 (Constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana), COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), Protein Cops5 Uba1 ortho G G G G G G G G Protein Alg3 Uba1 ortho Nudt6 Uba1 ortho G G G Chtf8 Uba1 ortho G G G G G G G G Uba1 Alas2 ortho G Uba1 Dusp7 ortho G Ankrd13d_predicted Uba1 ortho Pgls Uba1 ortho G G G G G G G G Ctps Uba1 ortho G G G G G G Hace1 Uba1 ortho Protein Cct7, RCG55994, isoform CRA_c Uba1 ortho G G G G G G G G Ywhaz Uba1 ortho G G G G G G G G Rhbdd1 Uba1 ortho Nvl_predicted Uba1 ortho G G G G G G G G Uba1 Nploc4 ortho G G G G G G G G Ube2s Uba1 ortho G G G G G G G G Mapk3 Uba1 ortho G G G G G G G Uba1 Chek1 ortho G G Rnf182 Uba1 ortho Ywhae Uba1 ortho G G G G G G G G Pkm Uba1 ortho Dnajb2 Uba1 ortho G G G G G G G G Protein Armc6, RCG38798, isoform CRA_b Uba1 ortho G G G G G G G Protein Arhgap1 Uba1 ortho G G G G G G G G Aurkb Uba1 ortho G G G G Uba1 Rnf34 ortho G G G G G G G G Hsd17b10 Uba1 ortho G G G G G G G G Psma4 Uba1 ortho G G G G G G G G Protein Slc9b2, RCG28722, isoform CRA_a, Similar to CG10806-PB, isoform B Uba1 ortho Protein Unk Uba1 ortho G Coiled-coil domain containing 21, Protein Cep85 Uba1 ortho G G G G G G G G Uba1 Lysine--tRNA ligase ortho G G G G G G G G Toll-like receptor Uba1 ortho Fh Uba1 ortho G G G G G G G G Ube2d1 Uba1 ortho G G G G Uba1 Smad5 ortho G G G G G Uba1 Pdcd6ip ortho G G G G G G G G Uba1 Gda ortho G G G G G G G G Aars Uba1 ortho G G G G G G G G Uba1 Ubd ortho G G G G G Uba1 Trip13 ortho G G Grb2 Uba1 ortho G G G G G G G G Impact Uba1 ortho G G G G G G G G Uba1 Tssc4 ortho G G G G G G G G Nmd3 Uba1 ortho Ezr Uba1 ortho G G G G G G G G Rnf111_predicted Uba1 ortho G G G G G G G G Ube2d2 Uba1 ortho G G G G G G G G Uba1 Chac2 ortho G G Epn1 Uba1 ortho G G Eukaryotic translation elongation factor 1 epsilon 1, Protein Eef1e1, RCG43901 Uba1 ortho G G G G G G G G Uba1 Protein Ube2j2, Similar to Ubc6p homolog, isoform CRA_b, Ubiquitin-conjugating enzyme E2, J2 ortho G G G G G G G G p27Kip1 Uba1 ortho G G G G G G G G Cct8_predicted Uba1 ortho G G G G G G G G Iars_predicted Uba1 ortho G G G G G G G G Psmd2 Uba1 ortho G G G G G G G G High mobility group AT-hook 2, Non-histone chromosomal architectural protein HMGI-C, Protein Hmga2 Uba1 ortho LOC689226 protein, Protein LOC689226, RCG54962 Uba1 ortho G G G G G G G G Uba1 Epm2a ortho Tbl3 Uba1 ortho G G G G G G G G Ube2l6 Uba1 ortho G G G G G G G G Gfpt1 Uba1 ortho G G Protein Rad21, RAD21 homolog (S. pombe), Similar to HR21spA Uba1 ortho G G G G G G G G Tspan17 Uba1 ortho G G G G G G G Bub3 Uba1 ortho G G G G G G G G Ap1b1 Uba1 ortho G G G G G G G G Dnph1 Uba1 ortho G Thra Uba1 ortho G G G G G G G Hsp90ab1 Uba1 ortho G G G G G G G G Asns Uba1 ortho G G G G G G G Uba1 Nup93 ortho G G G G G G G G Interferon regulatory factor Uba1 ortho Uba1 Ube2n ortho G G G G G G G G Uba1 Protein Krt36, Type I hair keratin KA31 ortho Uba1 Ciapin1 ortho G G G G G G G G Bcl2-associated athanogene 3, Protein Bag3, RCG40209, isoform CRA_b Uba1 ortho G G G G G G G G Uba1 Mdm4 ortho Hspd1 Uba1 ortho G G G G G G G G Stip1 Uba1 ortho G G G G G G G G Antisecretory factor, Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 4, isoform CRA_a, Protein Psmd4 Uba1 ortho G G G G G G G G Uba1 Lcmt2 ortho Obsl1 Uba1 ortho Uba1 Hemgn ortho G Vars Uba1 ortho Uba1 LRRGT00050, Protein Eprs ortho G G G G G G G G Uba1 Hgs ortho G G G G G G G G RGD1308012_predicted Uba1 ortho Fkbp6 Uba1 ortho Myc Uba1 ortho G Ap1g1 Uba1 ortho G G G G G G G Usp34 Uba1 ortho G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ubc Uba1 MI:0004(affinity chromatography technology) 22871113 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_336850 bait prey Uba1 Sumo3 MI:0004(affinity chromatography technology) 22082260 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334319 prey bait

PPI - HINT Gene A Gene B PMID Method Quality UBA1 SUMO3 22082260 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5XIF4 Q5U300 SUMO3 UBA1 0.126 22082260 Q63429 Q5U300 UBC UBA1 0.126 22871113 Q5U300 Q3UQN2 UBA1 FCHO2 0.21 20448150