PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Sh3gl3 Synj2 i2d exp Sh3gl3 Dnm1 9238017 intact exp, ortho G G G G Sh3gl3 Synj1 9238017 intact exp, ortho G G G G LOC100909609 Sh3gl3 ortho Sh3gl3 Met ortho G Sh3gl3 Hspa9 ortho Sh3gl3 Sh3kbp1 ortho G G G G Bin1 Sh3gl3 ortho G G G Sh3gl3 Htt ortho G G G G Sh3gl3 Tnnt1 ortho Sh3gl3 Sh3gl1 ortho G G G G Sh3gl3 Ptprs ortho G G G G Sh3gl3 Park2 ortho Sh3gl3 Snrpn ortho Sh3gl3 Shc3 ortho Sh3gl3 Hdc ortho G G G Sh3gl3 Gabbr2 ortho G G G G Sh3gl3 Faslg ortho G Sh3gl3 Dnm3 ortho G G G G Sh3gl3 Rbm48 ortho Sh3gl3 COP9 (Constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana), COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), Protein Cops5 ortho G G G G Sh3gl3 Dnm2 ortho LOC361120 Sh3gl3 ortho Pias4 protein, Protein Pias4, Protein inhibitor of activated STAT, 4 Sh3gl3 ortho RGD1309170_predicted Sh3gl3 ortho Sh3gl3 Mta1 ortho Sh3gl3 Arhgef6 ortho Sh3gl3 Pdcd6ip ortho G G G G Sh3gl3 Snx24 ortho Sh3gl3 DiGeorge syndrome critical region gene 14, DiGeorge syndrome critical region gene 14 homolog (Human), Protein Dgcr14 ortho Sh3gl3 Crip1 ortho Sh3gl3 Rer1 ortho G G G G Sh3gl3 Protein Terf1, Telomeric repeat binding factor (NIMA-interacting) 1, Telomeric repeat binding factor 1 ortho Sh3gl3 Adrb1 ortho Sh3gl3 Bles03 ortho G G G G Sh3gl2 Sh3gl3 ortho Sh3gl3 Arhgdia ortho G G G G Protein Rasgef1b Sh3gl3 ortho Sh3gl3 Dpysl4 ortho G G G G Protein Lrrk2 Sh3gl3 ortho Sh3gl3 App ortho G G G G Sh3gl3 Syn1 ortho G G G G Sh3gl3 Snrpb ortho G G G G RGD1306126 Sh3gl3 ortho G G G G Sh3gl3 Emd ortho G G G G Toe1_predicted Sh3gl3 ortho Protein Wdr33 Sh3gl3 ortho G G G G Sh3gl3 Abhd14b ortho G G G G Sh3gl3 Vim ortho G G G G Sh3gl3 Aes ortho G G G G Ndufb9_predicted Sh3gl3 ortho G G G G Protein Cd101 Sh3gl3 ortho Sh3gl3 Snurf ortho Sept8 Sh3gl3 ortho G G G G Protein Cbl Sh3gl3 ortho Sh3gl3 Fh ortho G G G G Sh3gl3 Sh3gl3 ortho G G G G Cblc Sh3gl3 ortho Sh3gl3 Qtrt1 ortho G G G G Sh3gl3 Atp5d ortho G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q62910-2 O35180 two hybrid 9238017 physical association X 2 O35180 cosedimentation through density gradient 22036569 physical association C 11 O35180 pull down 9238017 association C 3 Q62910 O35180 far western blotting 9238017 physical association X 2 O35180 P21575 far western blotting 9238017 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Sh3gl3 Synj1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 9238017 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(intact)|(intact) UniProt_186461|UniProt_186456|UniProt_186464 bait|prey|bait prey|null|prey Sh3gl3 Dnm1 MI:0018(two hybrid)|MI:0018(two hybrid) 9238017 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0914(association)|MI:0915(physical association) (intact)|(intact) UniProt_186464|UniProt_186462 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality SH3GL3 DNM1 9238017,9238017 0096,0047 LC SH3GL3 SYNJ1 9238017,9238017,9238017 0096,0047,0018 LC SH3GL3 DNM1 9238017,9238017 0096,0047 LC SH3GL3 SYNJ1 9238017,9238017,9238017 0096,0047,0018 LC