PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Esr1 Nedd8 21808025 biogrid,dip exp Ubc Nedd8 22871113 biogrid exp, ortho Srsf2 Nedd8 ortho G G G G G G G G Cops3 Nedd8 ortho G G G G G G G G Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14, Protein Psmd14, Psmd14 protein, RCG26455, isoform CRA_b Nedd8 ortho Rpl10a Nedd8 ortho Ywhaq Nedd8 ortho G G G G G G G G Hibch Nedd8 ortho G G G G G G G G Skp1 Nedd8 ortho G G G G G G G G Hip2_predicted Nedd8 ortho G G G G G G G G Rpl14 Nedd8 ortho G G G G G G G G Psma4 Nedd8 ortho G G G G G G G G Dnajc10 Nedd8 ortho G G G G G G G G Cops8 Nedd8 ortho G G G G G G G G Sec23a_predicted Nedd8 ortho Cnbp Nedd8 ortho G G G G G G G G Flna_predicted Nedd8 ortho G G G G G G G Cirbp Nedd8 ortho G G dnmt3b Nedd8 ortho Ncl Nedd8 ortho G G G G G G G G Psma1 Nedd8 ortho G G G G G G G G Nfkbia Nedd8 ortho G G G G G Hmgcs1 Nedd8 ortho G G G G G G G G Hspa8 Nedd8 ortho Nedd8 Prdx5 ortho G G G G G G G G Mpi Nedd8 ortho G G G G G G G G Protein Cul4a, RGD1563853 protein Nedd8 ortho G G G G G G G G Cops7b_predicted Nedd8 ortho Dnajc8 Nedd8 ortho G G G G G G G G Hras Nedd8 ortho G G G G G G G G Ssrp1 Nedd8 ortho G G G G G G G G Pop1_predicted Nedd8 ortho Nedd8 Ddb1 ortho G G G G G G G Rpl27 Nedd8 ortho G G G G G G G G Tars Nedd8 ortho G G G G G G G G Btbd9 Nedd8 ortho Krt24 Nedd8 ortho Protein Klhl15, RCG36356 Nedd8 ortho Ddx1 Nedd8 ortho G G G G G G G G Rpl15 Nedd8 ortho Ybx1 Nedd8 ortho Krt5 Nedd8 ortho Ctrc Nedd8 ortho G G Nedd8 Khsrp ortho G G G G G G G G Nedd8 Ctnnb1 ortho G G G G G G G G Rps16 Nedd8 ortho G G G G G G G G Cul1_predicted Nedd8 ortho G G G G G G G G Atp6v1f Nedd8 ortho G G G G G G G G Nedd8 Maged1 ortho G G G G G G G G Ssb Nedd8 ortho G G G G G G G G Rpl5 Nedd8 ortho Casp7 Nedd8 ortho G G G G G G G G Usp34 Nedd8 ortho G G G G G G G G LOC497867 Nedd8 ortho G G G G G G G G Emg1_predicted Nedd8 ortho Eef2 Nedd8 ortho G G G G G G G G Lgals3bp Nedd8 ortho G G G G G G G G Snrpd1_predicted Nedd8 ortho Myeloma overexpressed 2, Protein Myeov2, RCG55620, isoform CRA_c Nedd8 ortho G G G G G G G G Ywhah Nedd8 ortho G G G G G G G G Matr3 Nedd8 ortho G G G G G G G G Rpl11 Nedd8 ortho G G G G G G G G RGD1562456_predicted Nedd8 ortho Potassium channel tetramerisation domain containing 3, Protein Kctd3 Nedd8 ortho G G G G G Rps2 Nedd8 ortho Rps14 Nedd8 ortho Nedd8 Sdha ortho G G G G G G G G Klhl9_predicted Nedd8 ortho G G G G G G G G Rpl24 Nedd8 ortho G G G G G G G G Nedd8 Nit1 ortho G G G G G G G G Rpl31 Nedd8 ortho Nedd8 Pabpc1 ortho G G G G G G G G Krt14 Nedd8 ortho Cul2_predicted Nedd8 ortho G G G G G Rps11 Nedd8 ortho G G G G G G G G Tubb5 Nedd8 ortho G G G G G G G G Cdk2 Nedd8 ortho Traf6 Nedd8 ortho Klhl22 Nedd8 ortho G G G G G G G G Ufc1 Nedd8 ortho G G G G G G G G Rpl7 Nedd8 ortho G G G G G G G G Psma3 Nedd8 ortho G G G G G G G G Nedd8 Hgs ortho G G G G G G G G Hnrnpa2b1 Nedd8 ortho G G G G G G G G Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2A, isoform CRA_a Nedd8 ortho Nup155 Nedd8 ortho G G G G G G G G Hspa9 Nedd8 ortho Protein Klhl18 Nedd8 ortho Psma6 Nedd8 ortho G G G G G G G G Hnrnpa1 Nedd8 ortho G G G G G G G Nedd8 Fbxo11 ortho G G G G G G G G Krt13 Nedd8 ortho LOC689226 protein, Protein LOC689226, RCG54962 Nedd8 ortho G G G G G G G G Fbxo30 Nedd8 ortho COP9 (Constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana), COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), Protein Cops5 Nedd8 ortho G G G G G G G G Psmd2 Nedd8 ortho G G G G G G G G Nedd8 Hnrnpd ortho G G G G G G G G Uchl1 Nedd8 ortho G G G G G Nub1 Nedd8 ortho G G G G G G G G Protein Pwp1 Nedd8 ortho Rplp0 Nedd8 ortho G G G G G G G G Protein Fbxl18 Nedd8 ortho Hsp90aa1 Nedd8 ortho Nedd8 Nedd8 ortho G G G G G G G G Prpf3_predicted Nedd8 ortho G G G G G G G G Nedd8 Klhl12 ortho G G G G G G G G Tkt Nedd8 ortho G G G G G G G G Protein RGD1311345, Similar to CG9752-PA Nedd8 ortho Rps20 Nedd8 ortho Nedd8 Dctpp1 ortho G G G G G G G G Ube2d2 Nedd8 ortho G G G G G G G G Krt1 Nedd8 ortho Protein Tbc1d15, TBC1 domain family, member 15 Nedd8 ortho Pias1 Nedd8 ortho Gdi1 Nedd8 ortho G G G G G G G G Msrb2 Nedd8 ortho G G G G G G G G Protein Arih1 Nedd8 ortho G G G G G Tst Nedd8 ortho G G G G G G G G Rpl13 Nedd8 ortho Rps15a Nedd8 ortho G G G G G G G G Hnrnph2 Nedd8 ortho Cul3 Nedd8 ortho G G G G G G G G Hspa5 Nedd8 ortho G G G G G G G G Ahcy Nedd8 ortho G G G G G G G G Psma2 Nedd8 ortho G G G G G G G G Ube2m_predicted Nedd8 ortho G G G G G G G G Cops4 Nedd8 ortho G G G G G G G G Rpl18 Nedd8 ortho G G G G G G G G Nedd8 Strbp ortho G G G G G G G G Shkbp1 Nedd8 ortho G G G G G Nedd8 Igf2bp1 ortho Fbxo3 Nedd8 ortho G G G G G G G G Cltc Nedd8 ortho G G G G G G G G Nedd8 Cul5 ortho Nedd8 Kctd10 ortho G G G G G G G G Uba2 Nedd8 ortho G G G G G G G G Krt75 Nedd8 ortho Klhdc10 Nedd8 ortho Protein Tfe3 Nedd8 ortho G G G G G G G G Tubb4b Nedd8 ortho G G G G G G G G Atxn3 Nedd8 ortho Sumo3 Nedd8 ortho G G G G G G G G Parp1 Nedd8 ortho G G G G G G G G Vhl Nedd8 ortho G G G G G G G G Protein Srsf7, RCG61762, isoform CRA_d Nedd8 ortho Cplx1 Nedd8 ortho G G G G G G Protein Dsp Nedd8 ortho G G G G G Ctps Nedd8 ortho G G G G G G Ptk2 Nedd8 ortho G G G G G G G G Nedd8 Ilf3 ortho G G G G G G G G Clns1a Nedd8 ortho G G G G G G G G Rpl21 Nedd8 ortho Nedd8 Fbxo6 ortho G G G G G G G G Nedd8 Nae1 ortho G G G G G G G G Actb Nedd8 ortho Dnd1 Nedd8 ortho G G G G G G G G DEAD (Asp-Glu-Ala-Asp) box polypeptide 5, Ddx5, Protein Ddx5 Nedd8 ortho G G G G G G G G Slc25a20 Nedd8 ortho G G G G G G G G Bag4 Nedd8 ortho Senp8 Nedd8 ortho Eef1a2 Nedd8 ortho G G G G G G Mcm5_predicted Nedd8 ortho G G G G G Psma5 Nedd8 ortho G G G G G G G G LOC301334 Nedd8 ortho G G G G Kb9 Nedd8 ortho Psmc5 Nedd8 ortho G G G G G G G G PDZ domain-containing protein 2, Peptidylprolyl cis/trans isomerase, NIMA-interacting 1, Protein (Peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (Predicted), isoform CRA_a Nedd8 ortho G G G G G G G G Protein Tnrc6b Nedd8 ortho G G G G G G G G Protein Rangap1, RCG59652, isoform CRA_b Nedd8 ortho G G G G G G G G Hnrpul1_predicted Nedd8 ortho G G G G G G G G Ston2 Nedd8 ortho Rpl6 Nedd8 ortho G G G G G G G G Cul4b_predicted Nedd8 ortho Nedd8 Xiap ortho Scn1a Nedd8 ortho G G G Nedd8 Dffb ortho Igbp1 Nedd8 ortho G G G G G G G G Tp53 Nedd8 ortho G G G G G G G G C1qbp Nedd8 ortho G G G G G G G G Btrc Nedd8 ortho G G G G G G G G Fem1b Nedd8 ortho Protein Zyx Nedd8 ortho G G G G G G G G Gps1 Nedd8 ortho G G G G G G G G Pcna Nedd8 ortho G G G G G G G G Rps8 Nedd8 ortho G G G G G G G G Ahr Nedd8 ortho G Antisecretory factor, Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 4, isoform CRA_a, Protein Psmd4 Nedd8 ortho G G G G G G G G Dhx9_predicted Nedd8 ortho G G G G G G G G Rpl7a Nedd8 ortho RGD1565411_predicted Nedd8 ortho G G G G G G G G Dcun1d4_predicted Nedd8 ortho G G G G G G G G Wdr21_predicted Nedd8 ortho G G G G G G G G Ywhaz Nedd8 ortho G G G G G G G G Protein RGD1562284, Similar to Glutaminyl-peptide cyclotransferase (QC) (Predicted), isoform CRA_b Nedd8 ortho G G G G Rnf187 Nedd8 ortho G G G G G G G G Asb8_predicted Nedd8 ortho G G G G G G G G Asl Nedd8 ortho G G G Cops6_predicted Nedd8 ortho G G G G G G G G Protein Cdc34, RCG29282, isoform CRA_b Nedd8 ortho G G G G G G G G Arih2_predicted Nedd8 ortho G G G G G G G G Fbxo4_predicted Nedd8 ortho Dcaf11 Nedd8 ortho G G G G G G G G Rpl4 Nedd8 ortho G G G G G G G G Rps3 Nedd8 ortho G G G G G G G G Eef1a1 Nedd8 ortho G G G G G G G G Cav1 Nedd8 ortho G G G G G G Ywhag Nedd8 ortho G G G G G G G G Rplp1 Nedd8 ortho Memo1 Nedd8 ortho G G G G G G G G Nedd8 Uba3 ortho G G G G G G G G Tial1_mapped Nedd8 ortho G G G G G G G G Rpl23 Nedd8 ortho G G G G G G G G Eef1g Nedd8 ortho G G G G G G G G Protein Ddi2 Nedd8 ortho Sptan1 Nedd8 ortho G G G G G G G G Protein Sf3b3 Nedd8 ortho G G G G G G G G Hspa1l Nedd8 ortho Klhdc3 Nedd8 ortho G G G G G G G G Nedd8 Uchl3 ortho G G G G G G G G Hnrpr Nedd8 ortho G G G G G G G G Hnrnpk Nedd8 ortho Ube2d3 Nedd8 ortho Fbxo42_predicted Nedd8 ortho Hnrpu Nedd8 ortho G G G G G G G G Sptbn1 Nedd8 ortho G G G G G G G G Rpl19 Nedd8 ortho G G G G G G G G Tuba4a Nedd8 ortho G G G G G G G G H2afv Nedd8 ortho G G G G G G Lysine--tRNA ligase Nedd8 ortho G G G G G G G G Hspa4 Nedd8 ortho G G G G G G G G Nedd8 Hnrnpf ortho G G G G G G G Ybx3 Nedd8 ortho G G G G G G G G Rps23 Nedd8 ortho G G G G G G G G Pias2 Nedd8 ortho G G G G G G G G Protein Mcm4, RCG36531, isoform CRA_b Nedd8 ortho G G Rpl35 Nedd8 ortho G G G G G G G G Mei1_predicted Nedd8 ortho Rab8b Nedd8 ortho G G G G G G RGD1309504_predicted Nedd8 ortho Protein Shfm1, RCG28037 Nedd8 ortho G G G G G G G G Gapdh Nedd8 ortho G G G G G G G G Protein Cops7a Nedd8 ortho G G G G G G G G Ywhae Nedd8 ortho G G G G G G G G Hspd1 Nedd8 ortho G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q63429 Q71UE8 affinity chromatography technology 22871113 physical association X 2 Q71UE8 P06211 affinity chromatography technology 21808025 physical association X 2 Q71UE8 P06211 anti bait coimmunoprecipitation 21808025 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q71UE8 Q63429 NEDD8 UBC 0.126 22871113 Q71UE8 P06211 NEDD8 ESR1 0.21 21808025