PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Dhx36_predicted Hdac4 21590736 biogrid exp G Mef2d Hdac4 22357862 biogrid exp, ortho G Hdac4 Runx2 20097749 biogrid exp, ortho Rest Hdac4 17011572 biogrid exp, ortho Csrp3 Hdac4 ortho C2ta Hdac4 ortho G Jdp2 Hdac4 ortho LOC500904 Hdac4 ortho Protein Mef2c Hdac4 ortho Runx3 Hdac4 ortho Krt31 Hdac4 ortho Map1s Hdac4 ortho Mif4gd Hdac4 ortho G Leucine-zipper-like transcription regulator 1, Protein Lztr1, RCG36595 Hdac4 ortho G LOC100910438 Hdac4 ortho Zfp145 Hdac4 ortho Suv39h1 Hdac4 ortho G Golga2 Hdac4 ortho G Hdac4 Ctnnb1 ortho G Nr2c1 Hdac4 ortho Protein Rfxank, Regulatory factor X-associated ankyrin-containing protein Hdac4 ortho Elavl4 Hdac4 ortho G Ppp2r4_predicted Hdac4 ortho G Sin3a_predicted Hdac4 ortho Tnf Hdac4 ortho Tbl1xr1_predicted Hdac4 ortho G Nr2c2 Hdac4 ortho Smad3 Hdac4 ortho G Dnajb5_predicted Hdac4 ortho Acta1 Hdac4 ortho Creb1 Hdac4 ortho GATA binding protein 3, GATA-3, Protein Gata3 Hdac4 ortho Protein Hira Hdac4 ortho Syk Hdac4 ortho Protein Bcor Hdac4 ortho RGD1561981_predicted Hdac4 ortho Myocyte enhancer factor 2B, Protein Mef2b, Similar to Myocyte-specific enhancer factor 2B, isoform CRA_a Hdac4 ortho G Lrwd1 Hdac4 ortho G Mapk3 Hdac4 ortho G Ppp2ca Hdac4 ortho G App Hdac4 ortho G Gli2_predicted Hdac4 ortho Protein Tnfrsf14, Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator) Hdac4 ortho Hif1a Hdac4 ortho G Esr1 Hdac4 ortho Ncor2_predicted Hdac4 ortho G Nr1h2 Hdac4 ortho G Stat3 Hdac4 ortho G Atf2 Hdac4 ortho Protein Sfn, RCG31390 Hdac4 ortho Protein Rbbp4, RCG30896, Rbbp4 protein Hdac4 ortho Hdac1 Hdac4 ortho G Ywhag Hdac4 ortho G Cerebellar degeneration-related 2, Cerebellar degeneration-related 2, isoform CRA_a, Protein Cdr2 Hdac4 ortho Sp1 Hdac4 ortho G Cebpb Hdac4 ortho G Ywhae Hdac4 ortho G Cbx5_predicted Hdac4 ortho G Camk4 Hdac4 ortho Ywhaq Hdac4 ortho G Znf148 Hdac4 ortho G Histone deacetylase Hdac4 ortho Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a, Protein Nfkb2 Hdac4 ortho Ahrr Hdac4 ortho Ywhah Hdac4 ortho G Camk2d Hdac4 ortho G Ar Hdac4 ortho G Hdac4 Gcm1 ortho Foxo1 Hdac4 ortho G Hist1h4b, Hist1h4m, Hist4h4 Hdac4 ortho G Tpd52_predicted Hdac4 ortho Pnma1 Hdac4 ortho Mef2a Hdac4 ortho Cacna1c Hdac4 ortho G Gnb1 Hdac4 ortho G Cyclin-dependent kinase inhibitor 1A, Cyclin-dependent kinase inhibitor 1A (P21, Cip1), P21, P21 protein, Protein Cdkn1a Hdac4 ortho G Ss18l1 Hdac4 ortho Myocd Hdac4 ortho EGF-containing fibulin-like extracellular matrix protein 2, Protein Efemp2 Hdac4 ortho Gja1 Hdac4 ortho G Ube2i Hdac4 ortho G Gsk3b Hdac4 ortho Ywhab Hdac4 ortho G RGD1559787_predicted Hdac4 ortho G Protein Bcorl1 Hdac4 ortho Camk1 Hdac4 ortho G Mapk1 Hdac4 ortho G Ywhaz Hdac4 ortho G Rfx5_predicted Hdac4 ortho G Hdac4 Park2 ortho Krt40 Hdac4 ortho Zcwcc1_predicted Hdac4 ortho Atxn1 Hdac4 ortho Hdac4 Ctbp1 ortho G Protein Esco2, RCG52137, isoform CRA_a Hdac4 ortho Protein Myef2 Hdac4 ortho Htt Hdac4 ortho G Zbtb7b_predicted Hdac4 ortho yy1 Hdac4 ortho Protein Rara, Retinoic acid receptor, alpha, Retinoic acid receptor, alpha, isoform CRA_b Hdac4 ortho G Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, Protein Nfkbie, Solute carrier family 35, member B2, isoform CRA_b Hdac4 ortho PPARb Hdac4 ortho G Zfpn1a3_predicted Hdac4 ortho Nacc1 Hdac4 ortho Sumo2 Hdac4 ortho G Protein Ppp2r1a, Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform, isoform CRA_a, Protein phosphatase 2 (Formerly 2A), regulatory subunit A, alpha isoform Hdac4 ortho G Hdac3 Hdac4 ortho G Ifrd1 Hdac4 ortho G Klf6 Hdac4 ortho Rxra Hdac4 ortho Znf354a Hdac4 ortho Sumo1 Hdac4 ortho G LOC103694876 Hdac4 ortho G Mark3 Hdac4 ortho G Zfpn1a2_predicted Hdac4 ortho DNA polymerase Hdac4 ortho G Protein Ruvbl2, RuvB-like 2 (E. coli) Hdac4 ortho G Prg2 Hdac4 ortho Dnajb6 Hdac4 ortho Foxp3 Hdac4 ortho Nup155 Hdac4 ortho G Atf3 Hdac4 ortho Protein Megf10 Hdac4 ortho Protein Nars, RCG46601, isoform CRA_b Hdac4 ortho G Nfkbia Hdac4 ortho G Protein Rfxap, Regulatory factor X-associated protein Hdac4 ortho Bcl6_predicted Hdac4 ortho Hnf4a Hdac4 ortho Pparg Hdac4 ortho Hdac4 Hdac4 ortho G Zeb2 Hdac4 ortho Nfkb1 Hdac4 ortho G Cdk5 Hdac4 ortho G Cebpd Hdac4 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q99P99 O89038 affinity chromatography technology 22357862 physical association X 2 O54963 Q99P99 affinity chromatography technology 17011572 physical association X 2 Q99P99 affinity chromatography technology 20097749 physical association X 2 Q99P99 affinity chromatography technology 21590736 physical association X 2 Q99P99 anti tag coimmunoprecipitation 15990875 association C 4

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Mef2d Hdac4 MI:0428(imaging technique) 22357862 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334786 bait prey Hdac4 Dhx36 MI:0004(affinity chromatography technology) 21590736 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_335024 prey bait Rest Hdac4 MI:0004(affinity chromatography technology) 17011572 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_333769 bait prey Hdac4 Runx2 MI:0004(affinity chromatography technology) 20097749 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_333737 prey bait

PPI - HINT Gene A Gene B PMID Method Quality SMAD3 HDAC4 15990875,15990875 0019,0004 LC DHX36 HDAC4 21590736 0004 LC REST HDAC4 17011572 0004 LC MEF2D HDAC4 22357862 0004 LC SMAD3 HDAC4 15990875,15990875 0019,0004 LC HDAC4 RUNX2 20097749 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q99P99 O54963 HDAC4 REST 0.21 17011572 Q99P99 O89038 HDAC4 MEF2D 0.21 22357862