PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Nbr1 Trim55 15802564 biogrid exp Nbr1 Trim63 15802564 biogrid exp Nbr1 Ubc 22871113 biogrid exp, ortho Sqstm1 Nbr1 15802564 biogrid exp, ortho Map3k3_predicted Nbr1 ortho Nbr1 Nbr1 ortho Gabarapl1 Nbr1 ortho Tollip Nbr1 ortho Uba52 Nbr1 ortho RGD1305031 Nbr1 ortho Spred2 Nbr1 ortho Map1b Nbr1 ortho Usp34 Nbr1 ortho Sod1 Nbr1 ortho Cep55 Nbr1 ortho Protein Atxn1l Nbr1 ortho Nbr1 Cib1 ortho RGD1563164_predicted Nbr1 ortho Fez1 Nbr1 ortho Gabarapl2 Nbr1 ortho Gabarap Nbr1 ortho Jun Nbr1 ortho Nbr1 Vapb ortho Map2k4 Nbr1 ortho Gsk3b Nbr1 ortho Protein Lamtor2, RCG62440, isoform CRA_b Nbr1 ortho Syt4 Nbr1 ortho Nbr1 Map1lc3a ortho Nbr1 Lymphotoxin B receptor, Lymphotoxin beta receptor (TNFR superfamily, member 3), Protein Ltbr ortho Gsk3a Nbr1 ortho Htt Nbr1 ortho Protein Cep135 Nbr1 ortho Plcg2 Nbr1 ortho Nbr1 Tnk2 ortho Mapk7 Nbr1 ortho Nbr1 Scgn ortho Nbr1 Map1lc3b ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q501R9 Q5PQN5 affinity chromatography technology 15802564 physical association X 2 Q501R9 Q63429 affinity chromatography technology 22871113 physical association X 2 Q501R9 imaging technique 15802564 colocalization X 2 Q501R9 O08623 affinity chromatography technology 15802564 physical association X 2 Q91Z63 Q501R9 affinity chromatography technology 15802564 physical association X 2 Q501R9 pull down 15802564 association C 3

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Sqstm1 Nbr1 MI:0018(two hybrid) 15802564 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_335113 prey bait Nbr1 Ttn MI:0018(two hybrid) 15802564 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0403(colocalization) (biogrid) BIOGRID_335110 bait prey Nbr1 Trim63 MI:0018(two hybrid) 15802564 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_335111 bait prey Nbr1 Trim55 MI:0018(two hybrid) 15802564 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_335112 bait prey Nbr1 Ubc MI:0004(affinity chromatography technology) 22871113 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_336545 prey bait

PPI - HINT Gene A Gene B PMID Method Quality SQSTM1 NBR1 15802564 0004 LC NBR1 TRIM55 15802564 0004 LC NBR1 TTN 15802564 0428 LC NBR1 TRIM63 15802564 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q63429 Q501R9 UBC NBR1 0.126 22871113 Q501R9 O08623 NBR1 SQSTM1 0.21 15802564 Q5PQN5 Q501R9 TRIM55 NBR1 0.21 15802564 Q91Z63 Q501R9 TRIM63 NBR1 0.21 15802564