PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Pias3 Gria1 17486098 dip exp G G G Pias3 Grik2 17486098 dip exp G G G Pias3 Grm8 18555800 biogrid,mint,intact exp G G G G G G G Pias3 Gria2 17486098 dip exp G G G G G Pias3 Siah1 ortho G G G Pias3 Uba1 ortho G G G G G G G G Protein Smap2, Smap2 protein Pias3 ortho G G G G G G G G Pias3 Rac1 ortho G G G G G G G G Pias3 Lrwd1 ortho G G G G G G G G Pias3 Ar ortho G G G G G G G Pias3 Smad2 ortho G G G G G G G G Pias3 Gfi1 ortho G Pias3 Hnrnpk ortho Pias3 Smad3 ortho G G G Rai17_predicted Pias3 ortho G G G G G G G G Pias3 Sumo3 ortho G G G G G G G G Pias3 Stat5a ortho G G G G G G G G Pias3 Hdac1 ortho G G Nkrf Pias3 ortho G G G G G G G G Pias3 Protein Trim32, Tripartite motif protein 32 ortho G G G G G G G G Pias3 Siah2 ortho Pias3 Sumo2 ortho G G G G G G G G Pias3 Pgr ortho Pias3 Sept3 ortho Pias3 Nr3c2 ortho G G G G G G G Protein Skil Pias3 ortho Pias3 Esr1 ortho Pias3 RelA ortho G G G G G G G G Pias3 Irf1 ortho G G G G G G G G Prpf40a_predicted Pias3 ortho Pias3 Carhsp1 ortho G G G G G G G G Protein Trim8 Pias3 ortho G G G G G G G G Protein Bcl11a Pias3 ortho Pias3 Srebf2 ortho G G G G G G G G Pias3 Erbb4 ortho Pias3 Smad4 ortho G G G G G G G G Pias3 Creb1 ortho Pias3 Trim55 ortho Pias3 Mitf ortho G G G G G G Trim27 Pias3 ortho G G G G G G G G Pias3 Methyl-CpG binding domain protein 1, Protein Mbd1 ortho Pias3 DNA-binding protein SATB ortho Pias3 Tab2 ortho G G G G G G G G RGD1566239_predicted Pias3 ortho G G G G G G G G Pias3 Stat3 ortho G G G G G G G G RGD1563715_predicted Pias3 ortho G G G G G G Sept8 Pias3 ortho G G G G G G G Protein Zmiz2, Similar to D11Bwg0280e protein, isoform CRA_c Pias3 ortho G G G G G G G G Pias3 Protein Tbp, TATA box binding protein, TATA box binding protein, isoform CRA_a ortho G G G G G G G Pias3 Grb2 ortho G G G G G G G G Pias3 Glul ortho G G G G G G G G Pias3 Psmc1 ortho G G G G G G G G Pias3 Esr2 ortho Pias3 Stat5b ortho G Pias3 Ube2i ortho G G G G G G G G Habp4_predicted Pias3 ortho G G G G G G G G Pias3 Crebbp ortho G G G G G G G Pias3 Crem ortho G G G G G G G Pias3 Sumo1 ortho G G G G G G G G Pias3 Ncoa2 ortho Pias1 Pias3 ortho Pias3 Trim63 ortho Elavl4 Pias3 ortho G G G G G G G G Pias3 Ppp1ca ortho G G G G G G G G Klf1_predicted Pias3 ortho Pias3 Wnk1 ortho G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O70260 P70579 two hybrid 18555800 direct interaction X 2 P19490 O70260 two hybrid 17486098 physical association X 2 O70260 P19491 two hybrid 17486098 physical association X 2 O70260 anti bait coimmunoprecipitation 17486098 physical association X 2 O70260 two hybrid 17486098 physical association X 2 O70260 two hybrid 17486098 physical association X 2 O70260 P97555 two hybrid 18555800 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Pias3 Grm8 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 18555800 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|(intact) UniProt_183496|MINT_65662|UniProt_95717 prey|prey|prey bait|bait|bait Pias3 Grm8 MI:0096(pull down) 18555800 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) (biogrid) BIOGRID_334145 prey bait

PPI - HINT Gene A Gene B PMID Method Quality PIAS3 GRIA1 17486098 0018 LC PIAS3 GRIA2 17486098 0018 LC PIAS3 GRIK2 17486098,17486098 0006,0018 LC PIAS3 GRM8 18555800 0018 LC PIAS3 MGLUR8B 18555800 0018 LC PIAS3 GRIK2 17486098,17486098 0006,0018 LC