PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ppara Ubc 19103650 biogrid exp Mdm2_predicted Ppara 19103650 biogrid exp Ppara Calm1, Calm2, Calm3 18073110 dip exp Ppara Dut 8910358 biogrid exp, ortho Ppara Gata4 ortho Pcmt1 Ppara ortho Ppara Hdac3 ortho Ncor2_predicted Ppara ortho Ppara Mecr ortho Foxa3 Ppara ortho Ppara Gata6 ortho Rb1 Ppara ortho Ppara Rxrg ortho Fasn Ppara ortho Disks large-associated protein 3, RCG62665 Ppara ortho Ppara Ncoa2 ortho Ppara Ppara ortho Ppara Hmga1 ortho Ppara Prmt1 ortho Ppara Nr1h3 ortho A kinase (PRKA) anchor protein 13, isoform CRA_b, Protein Akap13 Ppara ortho Ppara GATA binding protein 3, GATA-3, Protein Gata3 ortho RGD1563102_predicted Ppara ortho Ppara Mapk1 ortho Ppara Men1 ortho Ppara Gadd45a ortho Ppara Med24 ortho RGD1559552_predicted Ppara ortho Creb1 Ppara ortho Ppara Ppargc1b ortho Ppara Aip ortho Ppara Stat5b ortho Ppara Gadd45g ortho Nr3c1 Ppara ortho Ppara Lpl ortho Brd1_predicted Ppara ortho Hbxip_predicted Ppara ortho Protein E2f4, RCG51568 Ppara ortho Ppara Lrwd1 ortho Ppara HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae), isoform CRA_c, Protein Prmt2, Protein arginine methyltransferase 2 ortho Ncoa1_predicted Ppara ortho Ppara Growth arrest and DNA-damage-inducible 45 beta, Growth arrest and DNA-damage-inducible, beta, Protein Gadd45b ortho Ppara Grb2 ortho Ppara Ppargc1a ortho Ppara Pik3r3 ortho Ppara RelA ortho Pou1f1 Ppara ortho E2f1 Ppara ortho Ppara Rxra ortho Protein Prmt8 Ppara ortho Prkcd Ppara ortho Mapk3 Ppara ortho Fabp1 Ppara ortho Ppara Ube2i ortho Ppara Hsp90aa1 ortho Ppara PPARb ortho Stac3_predicted Ppara ortho Ppara Lipin 1, Protein Lpin1, RCG61514, isoform CRA_a ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9JL19 P37230 - 10681503 - X 2 Q9JL19 P37230 - 10681503 - X 2 P37230 P07900-2 affinity chromatography technology 12962497 physical association X 2 P37230 P70583 two hybrid 8910358 direct interaction X 2 P37230 P70583 pull down 8910358 direct interaction X 2 Q63429 P37230 affinity chromatography technology 19103650 physical association X 2 P37230 P48552 two hybrid 9626662 direct interaction X 2 P37230 affinity chromatography technology 19103650 physical association X 2 P37230 pull down 19103650 direct interaction X 2 P37230 two hybrid 19103650 direct interaction X 2 P37230 pull down 19103650 direct interaction X 2 P37230 affinity chromatography technology 19103650 physical association X 2 Q8BYH8 P37230 coimmunoprecipitation 16554032 association X 2 P37230 P62161 classical fluorescence spectroscopy 18073110 direct interaction X 2 P37230 P62161 x-ray crystallography 18073110 direct interaction X 2 Q9JL19 P37230 two hybrid 10681503 - X 2 Q9JL19 P37230 copurification 10681503 - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Ppara Dut MI:0096(pull down)|MI:0096(pull down) 8910358 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_333246|BIOGRID_333242 prey|bait bait|prey Ppara Calm1 MI:0017(classical fluorescence spectroscopy) 18073110 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction) MI:0465(dip) DIP_5171 - - Ppara Mdm2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19103650 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_334536|BIOGRID_334535|BIOGRID_334538|BIOGRID_334537|BIOGRID_334539 prey|prey|bait|prey|bait bait|bait|prey|bait|prey Ppara Ubc MI:0004(affinity chromatography technology) 19103650 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334534 prey bait

PPI - HINT Gene A Gene B PMID Method Quality MDM2 PPARA 19103650,19103650,19103650 0018,0096,0004 LC PPARA CALM1|CALM2|CALM3 18073110,18073110 0114,0017 LC PPARA DUT 8910358,8910358 0018,0096 LC MDM2 PPARA 19103650,19103650,19103650 0018,0096,0004 LC PPARA DUT 8910358,8910358 0018,0096 LC PPARA UBC 19103650 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q63429 P37230 UBC PPARA 0.21 19103650 P37230 P07900 PPARA HSP90AA1 0.21 12962497 P62161 P37230 CALM3 PPARA 0.523 18073110 P48552 P37230 NRIP1 PPARA 0.309 9626662 P70583 P37230 DUT PPARA 0.523 8910358