PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Bcar1 Crk 9348226,9915838,11146548 biogrid,i2d exp, ortho G G G G G Crk Pxn 9348226,11146548 biogrid exp, ortho G G G G G G G G Protein Cbl Crk 9348226,11146548 biogrid exp, ortho Nans_predicted Crk ortho G G G G G G G G Ap2a1_predicted Crk ortho Protein Sh2d2a, SH2 domain protein 2A, SH2 domain protein 2A, isoform CRA_a Crk ortho Asap1 Crk ortho G G G G G G G Dok1 Crk ortho Nkrf Crk ortho G G G G G G G G Polyhomeotic-like 2 (Drosophila), Protein Phc2 Crk ortho G G G G G G G G Crk Lrwd1 ortho G G G G G G G G Ccdc123 protein, Protein Cep89 Crk ortho Tuba1a Crk ortho Mpdz Crk ortho G G G G G G G Tpx2_predicted Crk ortho Nfasc Crk ortho G G G G Tyr_mapped Crk ortho Rgs20 Crk ortho Crk Krt5 ortho Spr Crk ortho G G G G G G G Crk Abi1 ortho G G G G G G G G Crk Sh3kbp1 ortho G G G G G G G G Psmc4 Crk ortho G G G G G G G G Crk Eef1g ortho G G G G G G G G Eps15 Crk ortho G G G G G G G G Protein Zfp167 Crk ortho Protein LOC688459, RCG43687, isoform CRA_a, Uncharacterized protein Crk ortho G G Crk Set ortho G G G G G G G G Epha3 Crk ortho Cnr1 Crk ortho G G G G G Pdgfrb Crk ortho Ywhae Crk ortho G G G G G G G G Protein Vav2 Crk ortho G G G G Hspb1 Crk ortho G G G G G G G Fer Crk ortho Protein Rag1, Recombination activating gene 1 Crk ortho Pik3cd_predicted Crk ortho G Ywhaz Crk ortho G G G G G G G G Crk Krt12 ortho G Ywhag Crk ortho G G G G G G G G Dok3 Crk ortho Crk Klf15 ortho G G G G G G G G Protein Irs2, RCG43183 Crk ortho G G G G G G G G Protein Sh3bp1 Crk ortho G Protein Shb Crk ortho G G G G G G G G Crk Rtcb ortho G G G G G G G G Tubb4 Crk ortho Crk Syk ortho G G G Mylip Crk ortho G G G G Atic Crk ortho Crk Dab1 ortho Hsp90ab1 Crk ortho G G G G G G G G Igf1r Crk ortho G G G G G G G G DEAD (Asp-Glu-Ala-Asp) box polypeptide 41, Protein Ddx41, RCG24134 Crk ortho Gfpt1 Crk ortho G G Protein Ppfibp2, Protein tyrosine phosphatase, receptor-type, F interacting protein, binding protein 2, isoform CRA_f Crk ortho G G G G Crk Coronin ortho G G G G G G G G Crk Hspbp1 ortho G G G G G G G G Snx3 Crk ortho G G G G G G G G Ptk2 Crk ortho G G G G G G G G Engulfment and cell motility 2, ced-12 homolog (C. elegans), isoform CRA_b, Protein Elmo2 Crk ortho G G G G G G G Crk Mepe ortho G Slc25a5 Crk ortho Crk Cep19 ortho G G G G G G G G Dlgap4 Crk ortho G G G G G G ELK1, Potassium voltage-gated channel subfamily H member 8, RCG42928 Crk ortho G Sp1 Crk ortho G G G G G G G G Crk Kb9 ortho Psmd2 Crk ortho G G G G G G G G Rps24 Crk ortho Nckipsd_predicted Crk ortho Glycoprotein 9, Protein Gp9 Crk ortho Aire_predicted Crk ortho Dhx9_predicted Crk ortho G G G G G G G G Protein Ubash3b Crk ortho Crk Rac1 ortho G G G G G G G G LOC317380 Crk ortho Tubb5 Crk ortho G G G G G G G G RGD1309170_predicted Crk ortho Smad3 Crk ortho G G G LOC100365869 Crk ortho Kat6a Crk ortho Pttg1 Crk ortho G G G Crk Agpat4 ortho G G G G G Lmna Crk ortho G G G G G G G G Protein Sos2 Crk ortho G G G G G G G G RGD1563523_predicted Crk ortho Flna_predicted Crk ortho G G G G G G G Fstl1 Crk ortho G G G G G G G G RGD1566416_predicted Crk ortho G G G G G G G G Crk Hexa ortho G G G G G G G G RGD1563421_predicted Crk ortho Edc4 Crk ortho G G G G G G G G Grin2d Crk ortho G Gga3_predicted Crk ortho G G G G G G G Crk PDIP1, Protein Kctd13, RCG40132, isoform CRA_c ortho G G G G G G Dnaja3 Crk ortho G G G G G G G G Rgs7 Crk ortho G G G G Crk Snx17 ortho G G G G G G G G Wdr83 Crk ortho Crk Pik3cb ortho Frs2_predicted Crk ortho Crk Pik3r2 ortho G G G G G G G G Rpl18a Crk ortho G G G G G G G G Protein Rpp38, RCG55882, Ribonuclease P/MRP 38 subunit (Human) Crk ortho Plec Crk ortho G G G G G G G G Protein Pdia2 Crk ortho Protein Hsh2d, RCG38847 Crk ortho Crk Krt17 ortho Protein Dock5 Crk ortho Dspg3_predicted Crk ortho Rngtt_predicted Crk ortho G G G G G G G G Crk Gab2 ortho Cse1l_predicted Crk ortho G G G G G G G G Crk Khdrbs1 ortho G G G G G G G G Protein Tm4sf19, RCG52991, isoform CRA_f Crk ortho Crk Wee1 ortho G G G G G Fgfr1 Crk ortho G G G G G G G G Crk Inppl1 ortho G G G G G G G G Rras Crk ortho G G G G G G G G Ubc Crk ortho Abl2_mapped Crk ortho G G G G G G G Flnc Crk ortho G G G G Ap2m1 Crk ortho G G G G G G G G Crk Krt1 ortho Protein Sos1, Son of sevenless homolog 1 (Drosophila) Crk ortho G G G G G G G G Dnaja1 Crk ortho G G G G G G G G Dlx4_predicted Crk ortho Crk Krt77 ortho Terf2ip Crk ortho G G G G G G G G Nsfl1c Crk ortho G G G G G G G G Crk Pik3r3 ortho G Cfl1 Crk ortho G G G G G G G G LOC683720 Crk ortho G Crk Chac2 ortho G G Wasf1 Crk ortho Protein Cct7, RCG55994, isoform CRA_c Crk ortho G G G G G G G G Protein Rab2b, RAB2B, member RAS oncogene family, RCG61209, isoform CRA_a Crk ortho G G G G G G G G Protein Peak1, Similar to RIKEN cDNA C230081A13 (Predicted) Crk ortho Was_predicted Crk ortho Nck1 Crk ortho G G G G G G G G LOC100361515 Crk ortho Pomgnt2 Crk ortho G G G G G G G G RGD1307595_predicted Crk ortho G G G G G G G G Kif22 Crk ortho G G G Histone H2A type 3 Crk ortho G G G G G G Arpc1b Crk ortho G G G G G G G G Protein argonaute Crk ortho G G G G G G G G Stat5a Crk ortho G G G G G G G G Crk Shank3 ortho G G G G G G Crk Id4 ortho G G G G Lyz2 Crk ortho G G G G G G G G Ywhaq Crk ortho G G G G G G G G Map4k1_predicted Crk ortho G Kdr Crk ortho G G G G G G G G Protein Cdh11 Crk ortho G G G G G G G Abat Crk ortho G G G G G Vav1 Crk ortho G Twist2 Crk ortho Hspa5 Crk ortho G G G G G G G G Crk Gabbr1 ortho G G G G G G G G Crk Spdya ortho Stam2 Crk ortho Fyn Crk ortho G G G G G Pik3c2b_predicted Crk ortho Stat5b Crk ortho G Crk Socs1 ortho Mybbp1a Crk ortho G G G G G G G G Tubb3 Crk ortho G G G G G Crk Trim39 ortho Cast Crk ortho G G G G G G G G Ghr Crk ortho G G G Mrpl48_predicted Crk ortho G G G G G G G G Protein Arhgap32 Crk ortho G G G G G G Crk F2rl2 ortho G Ptpn11 Crk ortho G G G G G G G G Prkaca Crk ortho G G G G G G G G LIM homeobox 8, Protein Lhx8 Crk ortho Irs1 Crk ortho LOC100909609 Crk ortho Atf3 Crk ortho Eef1a1 Crk ortho G G G G G G G G Crk Pag1 ortho Crk Lasp1 ortho G G G G G G G G Protein Sfn, RCG31390 Crk ortho Crk Cd93 ortho G G Crk Ino80e ortho RGD1311793_predicted Crk ortho Ttbk1_predicted Crk ortho Neural cell expressed, developmentally down-regulated 9, Protein Nedd9, RCG44232, isoform CRA_b Crk ortho G G G G G G G G Rps25 Crk ortho Protein Optc Crk ortho Crk Protein Serpinb6, Serine (Or cysteine) peptidase inhibitor, clade B, member 6a, Serine (Or cysteine) peptidase inhibitor, clade B, member 6a, isoform CRA_a ortho G G G G G G G Crk Krt4 ortho G Ywhab Crk ortho G G G G G G G G Mpg Crk ortho G G G G Hspa9 Crk ortho Ap2b1 Crk ortho G G G G G G G G Rps3 Crk ortho G G G G G G G G Prrg2_predicted Crk ortho Psmc1 Crk ortho G G G G G G G G DNA ligase Crk ortho G G Erbb3 Crk ortho G Crk Tubb4b ortho G G G G G G G G Crk Krt14 ortho Mapk8 Crk ortho G G G G G G G G Crk Pcdha4 ortho G G Crk Coro6 ortho G G G Crk Arhgef11 ortho Protein Thoc2 Crk ortho Crk Celsr2 ortho G G G G Protein Strn4 Crk ortho G G G G G G G G Bub1_predicted Crk ortho Syn1 Crk ortho G G G G G G G G Ntrk1 Crk ortho Rps5 Crk ortho G G G G G G G G Crk Eya2 ortho Nkx2-1 Crk ortho G G G G Mapk9 Crk ortho G G Hspa1l Crk ortho Elmo1_predicted Crk ortho Crk Avil ortho Map2k4 Crk ortho Actb Crk ortho Protein Pot1, Similar to POT1-like telomere end-binding protein Crk ortho G G G G G G G G Dok2_predicted Crk ortho Crk Erythrocyte protein band 4.1-like 3, isoform CRA_d, Protein Epb41l3, Type II brain 4.1 ortho G G G G G G G Flnb_predicted Crk ortho Crk Src ortho G G G G G Crk Grip2 ortho Rest Crk ortho Pafah1b2 Crk ortho G G G G G G G Ssb Crk ortho G G G G G G G G Ppp1ca Crk ortho G G G G G G G G Esd Crk ortho G G G G G G G G Chtf18_predicted Crk ortho Protein Asb9 Crk ortho G Protein Cass4 Crk ortho Shc1 Crk ortho Crk Krt15 ortho G G RGD1311154_predicted Crk ortho G G G G G G G Batf3 Crk ortho G G G G Protein Ift140 Crk ortho Crk Shank2 ortho G G G G G G G Dusp15_predicted Crk ortho Krt8 Crk ortho G G G G G G Akap2 Crk ortho Protein Clnk Crk ortho E2f7 Crk ortho Crk Crk ortho G G G G G G G G Crk DEAD (Asp-Glu-Ala-Asp) box polypeptide 5, Ddx5, Protein Ddx5 ortho G G G G G G G G Crk Protein Snx7, RCG28719, Sorting nexin 7 ortho Cntnap1 Crk ortho Bcl2-associated athanogene 3, Protein Bag3, RCG40209, isoform CRA_b Crk ortho G G G G G G G G Hspa8 Crk ortho LOC687424 Crk ortho G G G G G G G G Crk Pik3r1 ortho G Cblc Crk ortho Crk Nxph3 ortho G Mical1 Crk ortho Klhl20 Crk ortho Protein Nufip2 Crk ortho Protein Gabpb2 Crk ortho Dnm2 Crk ortho G G Dlgap1 Crk ortho G G G G G G Crk Srcin1 ortho Protein Gltscr1 Crk ortho Met Crk ortho G Ash1l_predicted Crk ortho G G G G G G G G Serpinh1 Crk ortho G G G G G G G Crk Xpo1 ortho G G G G G G G G Tp53 Crk ortho G G G G G G G G Crk RegR ortho Efs_predicted Crk ortho G G G G Erbb4 Crk ortho Tyrosine-protein kinase Crk ortho G G G G Tubb2a Crk ortho G G G G G G G G Faslg Crk ortho G G G G Eif2s3 Crk ortho G G G G G G G G Crk Ago2 ortho G G G G G G G Fcgr2 Crk ortho G G G G G Dok4_predicted Crk ortho Habp4_predicted Crk ortho G G G G G G G G Grb2 Crk ortho G G G G G G G G Ywhah Crk ortho G G G G G G G G Dlgap2 Crk ortho Atxn1 Crk ortho G G Rpl23 Crk ortho G G G G G G G G Protein Pax7 Crk ortho Rin3_predicted Crk ortho G G G G Nr5a1 Crk ortho Ephb6 Crk ortho Protein Pnma2, RCG52129 Crk ortho Crk Cct5 ortho G G G G G G G G Dlgap3 Crk ortho Protein Ascl4 Crk ortho Ret Crk ortho G G G Egf Crk ortho Cltc Crk ortho G G G G G G G G Protein Ddx6, RCG58047 Crk ortho G G G G G G G Crk Krt73 ortho Crk Akap6 ortho Mapk4 Crk ortho G G G G G Prpf31_predicted Crk ortho Crk Cndp2 ortho G G G G G G G G Crk Arhgap17 ortho G G G G G G G G Isl1 Crk ortho G G G G G Crk Vac14 ortho G G G G G G G G Tyrosine-protein phosphatase non-receptor type Crk ortho G G G G Crk Krt24 ortho Ar Crk ortho G G G G G G G Prx Crk ortho G Fubp1 Crk ortho Cntfr Crk ortho G G G G G G G Phactr2 Crk ortho Crk G protein-coupled receptor kinase interacting ArfGAP 2, Protein Git2 ortho G G G G G G G Ptk2b Crk ortho G G Plscr1 Crk ortho G G Insr Crk ortho G G G G G G G G Krt19 Crk ortho G RGD1304792_predicted Crk ortho Crk Cblb ortho G G G G G G G Crk Tdg ortho G G G G Tnk2 Crk ortho G G G G G G Crk Ankzf1 ortho Hnrpr Crk ortho G G G G G G G G Paics Crk ortho Pdgfra Crk ortho G G G G G G G Ptpn1 Crk ortho G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q63768 Q63767 - 8631760 - X 2 Q63768 affinity chromatography technology 11146548 physical association X 2 Q63768 Q63767 affinity chromatography technology 9915838 physical association X 2 Q63768 Q63767 affinity chromatography technology 11146548 physical association X 2 Q63768 Q66H76 affinity chromatography technology 11146548 physical association X 2 Q63768 Q66H76 affinity chromatography technology 9348226 physical association X 2 Q63768 Q63767 affinity chromatography technology 9348226 physical association X 2 Q63768 affinity chromatography technology 11146548 physical association X 2 Q63768 affinity chromatography technology 9348226 physical association X 2 Q63768 Q61140 anti bait coimmunoprecipitation 12023880 physical association X 2 Q63768 A8K3M3 pull down 12023880 physical association X 2 Q63768 A8K3M3 pull down 8940134 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Bcar1 Crk MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11146548,9348226,9915838 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_335264|BIOGRID_337652|BIOGRID_335464 prey|prey|prey bait|bait|bait Crk Cbl MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11146548,9348226 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_335466|BIOGRID_337653 bait|bait prey|prey Crk Gab1 MI:0004(affinity chromatography technology) 11146548 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_335467 bait prey Crk Pxn MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11146548,9348226 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_337651|BIOGRID_335465 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality BCAR1 CRK 8631760,8631760,8631760 0004,0405,0019 LC CBL CRK 11146548,9348226 0004,0004 LC BCAR1 CRK 8631760,9915838,9348226,8631760,11146548,8631760 0004,0004,0004,0405,0004,0019 LC CRK PXN 11146548,9348226 0004,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q63768 Q61140 CRK BCAR1 0.21 12023880 Q63768 P18031 CRK PTPN1 0.376 12023880,8940134 Q66H76 Q63768 PXN CRK 0.376 11146548,9348226 Q63768 Q63767 CRK BCAR1 0.507 11146548,9348226,9915838