PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Park7 Vcp 16854843 biogrid exp G G G G G G G G B2m Vcp 12847084 biogrid exp G G G G G G G G RGD1565055_predicted Vcp i2d exp G G G G G G G G Slc2a4 Vcp 16396496 intact exp G G G Vcp Smad1 22051847 biogrid exp G G G G G G G G Vcp Cyp3a62 17550236 biogrid exp Usp34 Vcp 19182904 biogrid exp G G G G G G G G Vcp Ufd1l 12847084,10811609 biogrid exp, ortho G G G G G G G G Nsfl1c Vcp 16601695,20691684,12847084,9214505,10811609 biogrid,mint,intact exp, ortho G G G G G G G G Mapk3 Vcp 19935650 mint,intact exp, ortho G G G G G G G Vcp Ube4a 10811609 biogrid exp, ortho G G G G G G G G Vcp Rad23b 19182904 biogrid exp, ortho G G G G G G G G Itpr1 Vcp 16103111 biogrid exp, ortho G G G G G G G G Ubxn2b Vcp 17141156 biogrid exp, ortho Vcp Nf1 22105171 biogrid exp, ortho Vcp Ubc 22871113,17141156,12847084 biogrid exp, ortho Cacna1c Vcp 21186355 biogrid exp, ortho G G G G G G Vcp Nploc4 10811609 biogrid exp, ortho G G G G G G G G Vcp Vcp 12351637 biogrid exp, ortho G G G G G G G G Canx Vcp 12847084 biogrid exp, ortho G G G G G G G G Clta Vcp 8413590 biogrid exp, ortho G G G G G G G G Vcp Cyclin-dependent kinase inhibitor 1A, Cyclin-dependent kinase inhibitor 1A (P21, Cip1), P21, P21 protein, Protein Cdkn1a ortho G G G G G G G Atxn3 Vcp ortho Vcp Lrwd1 ortho G G G G G G G G Vcp Abcc1 ortho G G G G G G G Vcp Jak2 ortho G Sprtn Vcp ortho Vcp Insig1 ortho G G G G G G G G p27Kip1 Vcp ortho G G G G G G G G Vcp Ptpn9 ortho Vcp Pih1d1 ortho G G G G G G G G Vcp Itgb4 ortho G G G G Vcp Rpl18a ortho G G G G G G G G Vcp Tkt ortho G G G G G G G G Cltc Vcp ortho G G G G G G G G Commd1 protein, Protein Commd1, RCG23272, isoform CRA_b Vcp ortho G G G G G G G G Rhbdl4_predicted Vcp ortho Flnb_predicted Vcp ortho Vcp Cdk2 ortho Vcp CCR4-NOT transcription complex, subunit 8, CCR4-NOT transcription complex, subunit 8, isoform CRA_a, Protein Cnot8 ortho G G G G G G G G Vcp Ubxn10 ortho Vcp Taldo1 ortho G G G G G G G G Vcp Ubxn4 ortho G G G G G G G G Vcp Protein Rnf126, Ring finger protein 126 ortho G Vcp Rps11 ortho G G G G G G G G Vcp Hyou1 ortho G G G G G G G G Disks large-associated protein 3, RCG62665 Vcp ortho G G G G G G G G Vcp LOC683746 ortho Nmd3 Vcp ortho Vcp Psmc4 ortho G G G G G G G G Vcp Ptges3 ortho G G G G G G G G Psma1 Vcp ortho G G G G G G G G Vcp Uba52 ortho G G G G G G G G Rnf7_predicted Vcp ortho G G G G G G G G Vcp Cct3 ortho G G G G G G G G Vcp Usp10 ortho G G G G G G G G Vcp Bop1 ortho Protein Shfm1, RCG28037 Vcp ortho G G G G G G G G Vcp Nasp ortho G G G G G G G G Acaca Vcp ortho G G G G G G G G Vcp Protein Tnfrsf14, Tumor necrosis factor receptor superfamily, member 14 (Herpesvirus entry mediator) ortho G G Hspa5 Vcp ortho G G G G G G G G RGD1309519_predicted Vcp ortho Stmn1 Vcp ortho G G G G G G G G Vcp Chek1 ortho G G Vcp Ciao1 ortho G G G G G G G G Vcp Syf2 ortho G G G G G G G G Vcp Gtf3c1 ortho G G G G G G G G LOC312299 Vcp ortho G Vcp Ankle2 ortho Fbp1 Vcp ortho G G Protein Syvn1, Syvn1 protein Vcp ortho Vcp Hdlbp ortho G G G G G G G G Vcp Sumo1 ortho G G G G G G G G Vcp Lyar ortho G G G G G G G G Rpl13 Vcp ortho Vcp Coil ortho G G G G G G G Vcp Skp1 ortho G G G G G G G G Npm1 Vcp ortho Arrb2 Vcp ortho G G G G G RGD1561457_predicted Vcp ortho Protein Msh4 Vcp ortho RGD1559992_predicted Vcp ortho Vcp CHK2 checkpoint homolog (S. pombe), isoform CRA_a, Checkpoint kinase Chk2, Protein Chek2 ortho G Vcp Nub1 ortho G G G G G G G G Anxa5 Vcp ortho G G G G G G G G Tktl2_predicted Vcp ortho Iqgap1_predicted Vcp ortho G G G G G G G G Vcp Btrc ortho G G G G G G G G Vcp Ppp4c ortho G G G G G G Bccip_predicted Vcp ortho G G G G G G G G Ube2s Vcp ortho G G G G G G G G Hsp90ab1 Vcp ortho G G G G G G G G Sptan1 Vcp ortho G G G G G G G G Vcp Rab11a ortho G G G G G G G G Vcp Rps6ka1 ortho G G G G Ntrk1 Vcp ortho Cftr Vcp ortho Prmt3 Vcp ortho Vcam1 Vcp ortho Aup1 Vcp ortho G G G G G G G G Cul1_predicted Vcp ortho G G G G G G G G Vcp Pfn1 ortho G G G G G G G G Vcp Snx3 ortho G G G G G G G G Ube2m_predicted Vcp ortho G G G G G G G G Vcp Nup107 ortho Vcp Atxn10 ortho G G G G G G G G Vcp Adck3 ortho G G G RGD1311099_predicted Vcp ortho Vcp Insig2 ortho G G G G G G G G Vcp Ywhaq ortho G G G G G G G G Vcp Tubb3 ortho G G G G G Tyrosine-protein phosphatase non-receptor type Vcp ortho G G G G Taf5_predicted Vcp ortho G G G G Protein Tnpo3, Transportin 3 Vcp ortho G G G G G G G G Vcp Zfand2b ortho G G G G G Vcp Idh3a ortho G G G G G G G G Vcp Actn1 ortho G G G G G G G G Protein Son Vcp ortho G G G G G G G G Vcp Bag6 ortho G G G G G G Vcp Vimp ortho G G G G G G G G Fchsd2_predicted Vcp ortho G G G G G G G G Ppt1 Vcp ortho G G G G G G G G Arih2_predicted Vcp ortho G G G G G G G G Psap Vcp ortho G G G G G G G G Cnn3 Vcp ortho G G G G G G G G Vcp St13 ortho G G G G G G G G Hsd3b7 Vcp ortho G G G G G G G G Vcp Wipi2 ortho G G G G G G G G Ncdn Vcp ortho G G G G G Vcp Protein Sh2d2a, SH2 domain protein 2A, SH2 domain protein 2A, isoform CRA_a ortho Il7r_predicted Vcp ortho Foxp3 Vcp ortho Vcp Protein Rara, Retinoic acid receptor, alpha, Retinoic acid receptor, alpha, isoform CRA_b ortho G G LOC619573 Vcp ortho G G G G G G G Mitogen-activated protein kinase 8 interacting protein 2, Protein Mapk8ip2 Vcp ortho Ipo4_predicted Vcp ortho G G G G G G G G Vcp Dnajc10 ortho G G G G G G G G Cd3d Vcp ortho Gtf3c3_predicted Vcp ortho G G G G G G G G Vcp Park2 ortho Vcp Pno1 ortho Vcp Sumo2 ortho G G G G G G G G Vcp Hnrnpk ortho Vcp Csnk1d ortho G G G G G G G G Nup62 Vcp ortho G G G G G G G G Tcp1 Vcp ortho G G G G G G G G Svip Vcp ortho G G G G G G G Vcp Rps3 ortho G G G G G G G G Vcp Sgk1 ortho G G G G G G G G Prkar2a Vcp ortho G G G G G G G G Hspb1 Vcp ortho G G G G G G G Vcp Ywhag ortho G G G G G G G G Vcp Ndrg1 ortho G G G G G G G G Vcp Nup54 ortho G G G G G G G Psma2 Vcp ortho G G G G G G G G Pik3c3 Vcp ortho G G G G G G G G Vcp Tubb4b ortho G G G G G G G G Pkn2 Vcp ortho G G G G G G G G Vcp Ywhah ortho G G G G G G G G Ncoa1_predicted Vcp ortho G G G G G G G G Vcp Bzw2 ortho G G G G G G Vcp DiGeorge syndrome critical region gene 14, DiGeorge syndrome critical region gene 14 homolog (Human), Protein Dgcr14 ortho Msn Vcp ortho G G G G G G G G Vcp Dtnb ortho G G G G G Protein Supt6h Vcp ortho G G G G G G G G Vcp Catenin (Cadherin associated protein), alpha 1, Catenin (Cadherin-associated protein), alpha 1, isoform CRA_b, Protein Ctnna1 ortho G G G G G G G G Vcp Add1 ortho G G G G G G G G Vcp Tubb5 ortho G G G G G G G G Vcp Polymerase (RNA) I polypeptide C, Protein Polr1c, RNA polymerase 1-1, isoform CRA_a ortho G G G G G G G G Pigt_predicted Vcp ortho G G G G G G G G Vcp Psmc1 ortho G G G G G G G G Beta-galactosidase Vcp ortho G G G G G G G G Nme2 Vcp ortho G G G G G G G G Plec Vcp ortho G G G G G G G G Vcp Casp12 ortho G G G G Cul2_predicted Vcp ortho G G G G G Vcp Psma6 ortho G G G G G G G G Rnf31_predicted Vcp ortho Vcp Polr3c ortho Cul3 Vcp ortho G G G G G G G G Brca1 Vcp ortho G Vcp Lmna ortho G G G G G G G G Myl2 Vcp ortho G Protein Ruvbl2, RuvB-like 2 (E. coli) Vcp ortho G G G G G G G G Raf1 Vcp ortho G G G G G G G G Pdcd6_predicted Vcp ortho G G G G G G G G Vcp Plk1 ortho G G Vcp Becn1 ortho G G G G G G G G LOC679127 Vcp ortho Vcp Anxa2 ortho G G G G G G G G Vcp Rpl23a ortho G G G G G G G G Vcp Gzmk ortho G G G G G G G G Ptgs2 Vcp ortho Tmem129 Vcp ortho General transcription factor IIIC, polypeptide 5, Protein Gtf3c5 Vcp ortho LOC363332 Vcp ortho G G G G G G G G Vcp Vcl ortho G G G G G G G G Mdm2_predicted Vcp ortho G G G G G Vcp Protein Ubox5, Similar to Rnf37-pending protein, U-box domain containing 5 ortho G G G G G Vcp Atad3 ortho G G G G G G G G LOC64038 protein, Protein Otulin Vcp ortho Ryr2 Vcp ortho Vcp Tp63 ortho Vcp Ankzf1 ortho Vcp Ctnnbl1 ortho G G G G G G G G Vcp Tada2a ortho G G G G Vcp Tmed10 ortho G G G G G G G G Serpina1 Vcp ortho G G G G G G Adam8_predicted Vcp ortho G G G G G G G G Vcp Uba5 ortho G G G G G G G G Protein Dsp Vcp ortho G G G G G Vcp Sec61a1 ortho G G G G G G G G G1p2_predicted Vcp ortho Bag2 Vcp ortho G G G G G G G Hspa4 Vcp ortho G G G G G G G G Protein Cct7, RCG55994, isoform CRA_c Vcp ortho G G G G G G G G Mtor Vcp ortho G G G G G G G G LOC100363283 Vcp ortho Protein Sesn2, RCG31441, Similar to Sestrin 2 (Hi95) Vcp ortho Vcp Actb ortho Vcp Scfd1 ortho G G G G G G G G Protein Ddias, RGD1559690 protein Vcp ortho Vcp Prkaa2 ortho G Piwil2_predicted Vcp ortho Rplp0 Vcp ortho G G G G G G G G Vcp Abcg2 ortho Vcp Prpf19 ortho Cyclin-dependent kinase 2-associated protein Vcp ortho G G G G G G G G Vcp Fermitin family homolog 2 (Drosophila), Protein Fermt2, RCG61183, isoform CRA_b ortho G G G G G G G G Casp7 Vcp ortho G G G G G G G G Bcar3_predicted Vcp ortho G G Vcp Hsp90b1 ortho G G G G G G G G Vcp Atp6v1b2 ortho G G G G G G G G Ikbke_predicted Vcp ortho Vcp Protein Tom1, Target of myb1 homolog (Chicken) ortho G G G G G G G G Protein Ppp1r18, RGD1309543 protein Vcp ortho G G Wac Vcp ortho Comt Vcp ortho G G G G G G G G Smarca5_predicted Vcp ortho Ulk3 Vcp ortho Hspe1 Vcp ortho G G G G G G G G Vcp Eif4a2 ortho G G G G G G G G Vcp Prkaa1 ortho G G G G G G G G Vcp Dusp7 ortho G Vcp Pik3r2 ortho G G G G G G G G Methylosome subunit pICln, RNA terminal phosphate cyclase-like 1 Vcp ortho G G G G G G G G Vcp Tubb2b ortho G G G G G G G Golgi associated, gamma adaptin ear containing, ARF binding protein 2, isoform CRA_a, Protein Gga2 Vcp ortho G G G G G G G G Vcp Dgat2 ortho G G G G G G G G Protein Cops7a Vcp ortho G G G G G G G G Protein Ccdc132 Vcp ortho Vcp Arhgef2 ortho Vcp Ppgb ortho G G G G G G G G Protein Cul4a, RGD1563853 protein Vcp ortho G G G G G G G G Vcp Cebpd ortho G G G Vcp Fa2h ortho Vcp Ppp6c ortho G G G G G G G Vcp Stx5 ortho G G G G G G G G Vcp Csnk2b ortho G G G G G G G G Ptcra Vcp ortho Als2 Vcp ortho Prkcd Vcp ortho G G G G G G G G Vcp Kbp ortho G G G G G G G G Cdk4 Vcp ortho G G G G G G G G Protein Tnks1bp1 Vcp ortho Vcp Txn2 ortho G G G G G G G G Vcp Kpnb1 ortho G G G G G G G G Vcp Hnrnph2 ortho Vcp Wrnip1 ortho G G G G G G G G Ttk_predicted Vcp ortho Vcp Sec22b ortho G G G G G G G G Ribosomal protein S6 kinase Vcp ortho G G G G G G G G Vcp Cul5 ortho Ap2a2 Vcp ortho G G G G G G G G Protein Atl2 Vcp ortho G G G G G G G G Vcp Taf9 ortho G G G G G G G G Vcp Pgls ortho G G G G G G G G Vcp Grb2 ortho G G G G G G G G Lsm1_predicted Vcp ortho Vcp Ptprs ortho G G G G G G G G Vcp Mapk13 ortho G Vcp Pik3r3 ortho G Protein Cln6 Vcp ortho G G G G G G G Vcp Fbxo32 ortho Protein Espl1 Vcp ortho G Protein Gbf1 Vcp ortho G G G G G G G Protein Telo2 Vcp ortho G G G G G G Vcp Napa ortho G G G G G G G G Vcp Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, isoform CRA_a, Protein Nfkb2 ortho G Vcp Pdcd10 ortho G G G G G G G G Vcp Actn4 ortho G G G G G G G G Vcp CCR4-NOT transcription complex, subunit 2, Protein Cnot2 ortho G G G G G G G G Psma3 Vcp ortho G G G G G G G G Vcp Rnf8 ortho G G G G G G G G Bad Vcp ortho G G G G G G G G Psmb2 Vcp ortho G G G G G G G G Supt16h_predicted Vcp ortho G G G G G G G G Cog4_predicted Vcp ortho G G G G G G G G RGD1310147_predicted Vcp ortho G G G G G G G G Vcp Cndp2 ortho G G G G G G G G Esr1 Vcp ortho Vcp Fructose-bisphosphate aldolase ortho G G Calr Vcp ortho G G G G G G G G Pik3r4 Vcp ortho G G G G G G G G LOC360830 Vcp ortho G G G G G G G G Vcp Wdyhv1 ortho Vcp Crmp1 ortho G G G G G Ar Vcp ortho G G G G G G G Vcp Trim13 ortho Vcp Bax ortho G G G G G G G Iqcb1_predicted Vcp ortho G G G G G Vcp Rqcd1 ortho G G G G G G G G Vcp MGC124653 ortho G G G G G G G G Vcp Hspd1 ortho G G G G G G G G Vcp Cops3 ortho G G G G G G G G Vcp Dxo ortho P4hb Vcp ortho G G G G G G G G Vcp Protein Ppp2r1a, Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform, isoform CRA_a, Protein phosphatase 2 (Formerly 2A), regulatory subunit A, alpha isoform ortho G G G G G G G G Vcp Rpl23 ortho G G G G G G G G RGD1311660_predicted Vcp ortho G G G G G G G G Vcp Hsph1 ortho G G G G G G G G Vcp Drg1 ortho Vcp Hsbp1 ortho G G G G G G G G Vcp Ccdc134 ortho G G G G G G G Vcp Nsf ortho G G G G G G G G Vcp Nupl1 ortho G G G G G G G G Abcc3 Vcp ortho Vcp Fbxo2 ortho G G G Stip1 Vcp ortho G G G G G G G G Vcp Bid ortho G G G G G G G G Vcp Optn ortho G G G G G G G G Vcp Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, Protein Nfkbie, Solute carrier family 35, member B2, isoform CRA_b ortho Vcp Slc3a2 ortho G G G G G G G G Protein Ddx54 Vcp ortho G G G G Vps18_predicted Vcp ortho Pdk3_mapped Vcp ortho G G G G G G G G Vim Vcp ortho G G G G G G G G Ubl4a Vcp ortho G G G G G G G G Vcp Akt1 ortho G G G G G G G G Vcp Anxa6 ortho G G G G G G G G Vcp Dio2 ortho Ubxd6_predicted Vcp ortho Vcp Avpr2 ortho G G G G Csk Vcp ortho G G G G G G G G Vcp Rnf103 ortho G G G G G G G G Vcp SUP ortho G G G G G G G G Vcp Cct4 ortho G G G G G G G G Vcp Rps8 ortho G G G G G G G G Hnrnpa1 Vcp ortho G G G G G G G Timm44 Vcp ortho Prmt5_predicted Vcp ortho G G G G G G G G Kinesin-like protein Vcp ortho G Map2 Vcp ortho G G G G G G Protein Tfcp2, Tcfcp2 protein Vcp ortho RGD1307235_predicted Vcp ortho G G G G G G G G Vcp Yod1 ortho Vcp Ppp3ca ortho G G G G G G G G Rcn1_predicted Vcp ortho G G G G G G G G Rab11b Vcp ortho G G G G G G G Vcp Top2b ortho G G G G G G G G Cav1 Vcp ortho G G G G G G Vcp Lman1 ortho G G G G G Vcp Eef1a2 ortho G G G G G G PDZ domain-containing protein 2, Peptidylprolyl cis/trans isomerase, NIMA-interacting 1, Protein (Peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (Predicted), isoform CRA_a Vcp ortho G G G G G G G G Vcp Dusp1 ortho G G G G G G G G Vil1_predicted Vcp ortho Vcp Cdkn2aip ortho Protein Tmprss13, Tmprss13 protein Vcp ortho Vps53_predicted Vcp ortho G G G G G G G G Hook1_predicted Vcp ortho G G G G G G Protein Stub1, STIP1 homology and U-Box containing protein 1, isoform CRA_b Vcp ortho G G G G G G G G Vcp Cdc27 ortho Pik3c2a_predicted Vcp ortho Elavl4 Vcp ortho G G G G G G G G Vcp RNCASP9 ortho G G G G G G G Vcp Sf3a2 ortho Tusc4 Vcp ortho G G G G G G G G Riok3_predicted Vcp ortho Protein Chmp4b, RCG63680 Vcp ortho Terf2_predicted Vcp ortho G G Cdk1 Vcp ortho G G G Map3k3_predicted Vcp ortho G G G G G G G Vcp Rnf2 ortho Protein Hs1bp3 Vcp ortho G G G G G G G Mitochondrial ribosomal protein S18B, isoform CRA_a, Protein Mrps18b Vcp ortho G G G G G G G G Protein Pdxdc1, Similar to expressed sequence AA415817 (Predicted) Vcp ortho Sec24b_predicted Vcp ortho G G G G G G Dkc1 Vcp ortho G G G G G G G G Anpep Vcp ortho G G G G G Vcp Isyna1 ortho G G G G G G Ccnb1 Vcp ortho G G G G G Cdc42ep4_predicted Vcp ortho G G G G G G G G Vcp Casr ortho G Rpn1 Vcp ortho G G G G G G G G Vcp Vcpip1 ortho Vcp Cidec ortho Rnf19_predicted Vcp ortho G G G G G G G G Vcp Faf2 ortho Obsl1 Vcp ortho Vcp Pdia6 ortho G G G G G G G G Vcp Rfc2 ortho G G G G G G G G Prpf31_predicted Vcp ortho Vcp Faf1 ortho G G G G G G G G Vcp Arfgef2 ortho G G G G Vcp Ppp2cb ortho G G G G G G G G Vcp Golph3l ortho Vcp Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 14, Protein Psmd14, Psmd14 protein, RCG26455, isoform CRA_b ortho Vcp Hspa9 ortho Vcp Ppp1ca ortho G G G G G G G G Pkm Vcp ortho Anapc7_predicted Vcp ortho G G G G G G G Vcp Ccdc8 ortho G G Vcp COP9 (Constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana), COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis), Protein Cops5 ortho G G G G G G G G Vcp Dnajb9 ortho G G G G G G G G Vcp Atxn1 ortho G G Protein RGD1310335 Vcp ortho Protein Stag2 Vcp ortho G G G G G G G G Vcp Actr2 ortho G G G G G G G G Vcp Wrap73 ortho G G G G G G Vcp Top1 ortho G G G G G G G G Vcp Epor ortho G G G G G G G Vcp Ngly1 ortho Protein Sympk Vcp ortho G G G Vcp Golgi associated, gamma adaptin ear containing, ARF binding protein 1, Protein Gga1 ortho G G G G G G G G Rab10 Vcp ortho G G G G G G G G Taf6l Vcp ortho G G G Ppfibp1_predicted Vcp ortho G G G G G G G G H2afv Vcp ortho G G G G G G Adrb2 Vcp ortho G Scd1 Vcp ortho G G G G G G Trip12 Vcp ortho G G G G G G G G Copb2 Vcp ortho G G G G G G G G Polr1a Vcp ortho G G G G G G G G Vcp Tmem33 ortho G G G G G G G G Cxcr2 Vcp ortho G Vcp Chaperonin containing Tcp1, subunit 6A (Zeta 1), Chaperonin subunit 6a (Zeta), Protein Cct6a ortho G G G G G G G Vcp Sec13 ortho G G G G G G G G Vcp Kcnma1 ortho G G G G G Vcp Rps25 ortho Apoa1 Vcp ortho G PRP4 pre-mRNA processing factor 4 homolog (Yeast), Protein Prpf4 Vcp ortho Sirt7 Vcp ortho G G G G G G G G Vcp Cep19 ortho G G G G G G G G Vcp Tdp1 ortho G G G G G G G G Tp53 Vcp ortho G G G G G G G G Vcp Mapk1 ortho G G G G G G G G Vcp Itgb1 ortho G G G G G G G G Protein Smarca1 Vcp ortho Vcp Ubqln1 ortho G G G G G G G G Vcp Htt ortho G G G G G G G Vcp Dnajb11 ortho G G G G G G G G Protein Rbbp4, RCG30896, Rbbp4 protein Vcp ortho DNA-directed RNA polymerase Vcp ortho G G G G G G G G Nup205_predicted Vcp ortho G G G G G G G G Vcp Rab3gap2 ortho G G G G G G G G Vcp Hsp90aa1 ortho Vcp Lymphocyte cytosolic protein 1, Protein Lcp1 ortho G G G G G G G G Vcp Lysine--tRNA ligase ortho G G G G G G G G Vcp Ppp2ca ortho G G G G G G G G Tom1l1 Vcp ortho Mark2 Vcp ortho G G G G G G G Ncam1 Vcp ortho G G G G Protein Txndc5, RCG43947 Vcp ortho G G G G G G G G Vcp Ubxn11 ortho Vcp Trim25 ortho Ywhab Vcp ortho G G G G G G G G Jun Vcp ortho G G G G G G G G Ppm1b Vcp ortho G G G G G G G G Vcp Rdx ortho G G G G G G G G Vcp Protein Rfc3, Replication factor C (Activator 1) 3 ortho G G G G G G Vcp Aars ortho G G G G G G G G Vcp Arf6 ortho G G G G G G G G Vcp Map1lc3a ortho G G G G G G G G Vcp Eif2b2 ortho G G G G G G G Mrps23_predicted Vcp ortho G G G G G G G G Trim21_predicted Vcp ortho Rbfox2 Vcp ortho G G G G G G Vcp Cct2 ortho G G G G G G G G Dnaja2 Vcp ortho G G G G G G G G Protein Clgn, RCG51682 Vcp ortho Ddx49 Vcp ortho G G G G Pycs_predicted Vcp ortho G G G G G G Smarcc1_predicted Vcp ortho G G G G G G G G Vcp Eef1d ortho G G G G G G G G Traf6 Vcp ortho Vcp Grin2d ortho G Protein Smurf1, RCG42768 Vcp ortho G G G G G G G G Vcp Nfkbia ortho G G G G G Vcp Vapb ortho G G G G G G G G Protein Caap1, Uncharacterized protein Vcp ortho Spast Vcp ortho G G G G G Vcp Cdk5 ortho G G G G G G G Vcp Derl1 ortho G G G G G G G G Cct8_predicted Vcp ortho G G G G G G G G Vcp Hspa8 ortho Vcp Pdcd4 ortho G G G G G G G Vcp Os9 ortho G G G G G G G G Protein LOC100363321 Vcp ortho Vcp F7 ortho Vcp Protein Rad23a, RAD23 homolog A (S. cerevisiae) ortho G G G G G Eed_predicted Vcp ortho G G G G G G G G Vcp Vapa ortho G G G G G G G G Sftpc Vcp ortho G G Vcp Hip1r ortho G G G G G G G G Vcp Cnot10 ortho G G G G G G G G Protein Wapal Vcp ortho G G G G Vcp Ywhaz ortho G G G G G G G G Sec23a_predicted Vcp ortho Hif1a Vcp ortho G G G G G G G G Vcp Ap1b1 ortho G G G G G G G G Vcp Tsg101 ortho G G G G G G G G Vcp Cct5 ortho G G G G G G G G Vcp Wnk1 ortho G G G G G G G G Vcp Psmc3 ortho G G G G G G G G Vcp Rpl24 ortho G G G G G G G G Gpr21_predicted Vcp ortho G G G G G G G G Pik3c2b_predicted Vcp ortho Vcp Protein O-mannosyltransferase 2, Protein Pomt2, RCG20643 ortho Protein Slirp, RCG20695, isoform CRA_b Vcp ortho G G G G G G G G Vcp Psmc2 ortho G G G G G G G G Cd4 Vcp ortho G G G G G G G Vcp Protein Srsf11, Similar to splicing factor p54, isoform CRA_b, Splicing factor, arginine/serine-rich 11 ortho Vcp Prkag1 ortho G G G G G G G G Vcp Ywhae ortho G G G G G G G G Vcp Ubr4 ortho G G G G G G G G Vcp Plaa ortho G G G G G G G G Mdh2 Vcp ortho G G G G G G G G Vcp Arhgap17 ortho G G G G G G G G Il2rb Vcp ortho G G G G Tbc1d10b_predicted Vcp ortho G G G G G G G G Vcp Sars ortho G G G G G G G G Vcp Hmgcr ortho G G G G G G G G Potassium channel tetramerisation domain containing 3, Protein Kctd3 Vcp ortho G G G G G Bsg Vcp ortho G G G G G G G G Vcp Gabarapl1 ortho G G G G G G G G Vcp Cnbp ortho G G G G G G G G Vcp Cdc37 ortho G G G G G G G G Fvt1_predicted Vcp ortho Vcp Dnm3 ortho G G G G G G G G Vcp Tax1bp1 ortho G G G G G G G G Vcp Dync1li1 ortho G G G G G G G G Pdia3 Vcp ortho G G G G G G G G Vcp Rpl22 ortho G G G G G G G G Vcp Nfkbib ortho G G G G G G G G Vcp Cep55 ortho Rpl6 Vcp ortho G G G G G G G G Vcp Protein Srsf3, RCG61099, isoform CRA_c ortho Vcp Tomm34 ortho G G G G G G G G Vcp LOC498174 ortho Antisecretory factor, Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 4, isoform CRA_a, Protein Psmd4 Vcp ortho G G G G G G G G Protein Arih1 Vcp ortho G G G G G Kcmf1 Vcp ortho G G G G G G G G Vcp Phb ortho Vcp Arfgap2 ortho G G G G G G G G Vcp Tpd52l2 ortho G G G G G G Rab7a Vcp ortho G G G G G G G G Psma4 Vcp ortho G G G G G G G G Pgk1 Vcp ortho G G G G G G G G Protein Dcaf7, WD repeat domain 68, WD repeat domain 68 (Predicted) Vcp ortho G G G G G G G G Vcp Proteasome (Prosome, macropain) 26S subunit, non-ATPase, 12, Protein Psmd12 ortho Vcp Cd3z ortho G G Lnx1_predicted Vcp ortho G Vcp Ube2b ortho G G G G G G G G Rps9 Vcp ortho Vcp Grwd1 ortho G G G G G G G G Cope Vcp ortho G G G G G G G G Vcp Protein RGD1311458, Putative uncharacterized protein RGD1311458, Uncharacterized protein ortho Vcp Rab14 ortho G G G G G G G G Vcp Map2k1 ortho G G G G G G G G 4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans), isoform CRA_b, Protein Nipsnap1 Vcp ortho G G G G G G G Protein Tfe3 Vcp ortho G G G G G G G G Vcp Stam2 ortho Vcp Eif5a ortho G G G G G G G G Ctnnd1_predicted Vcp ortho G G G G G G G G Vcp Baiap2l1 ortho G G Rfc5_predicted Vcp ortho Hnf1a Vcp ortho G G Vcp Ncstn ortho G G G G G G G G Vcp Cdc25a ortho G G G G Vcp Dcaf11 ortho G G G G G G G G Protein Wdr43, RCG61879 Vcp ortho G G G G G G G G Rpn2 Vcp ortho G G G G G G G G Vcp Ick ortho G G G G G G G G Slc25a3 Vcp ortho G G G G G G G G Coatomer subunit alpha Vcp ortho G G G G G G G G Bclaf1 Vcp ortho G G Vcp Apob ortho G G G G Calu Vcp ortho G G G G G G G G Vcp Fbxo6 ortho G G G G G G G G Cdc42ep1 Vcp ortho G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P46462 - 10811609,9214505 - C 9 P46462 - 10811609,9214505 - C 9 P46462 - 10811609,9214505 - C 9 P46462 - 10811609,9214505 - C 9 P46462 - 10811609,9214505 - C 9 P46462 - 10811609,9214505 - C 9 P46462 - 10811609,9214505 - C 6 P46462 - 10811609,9214505 - C 6 P46462 - 10811609,9214505 - C 6 P46462 - 10811609,9214505 - C 6 P46462 - 10811609,9214505 - C 6 P46462 - 10811609,9214505 - C 6 P46462 biochemical 19182904 colocalization X 2 Q63429 P46462 affinity chromatography technology 12847084 physical association X 2 Q63429 P46462 affinity chromatography technology 22871113 physical association X 2 Q63429 P46462 pull down 17141156 direct interaction X 2 Q9ES53 P46462 affinity chromatography technology 12847084 physical association X 2 Q9ES53 P46462 affinity chromatography technology 10811609 physical association X 2 Q9ES53 P46462 affinity chromatography technology 10811609 physical association X 2 Q9ES53 P46462 affinity chromatography technology 10811609 physical association X 2 Q9ES53 P46462 biochemical 10811609 colocalization X 2 P46462 Q4KMA2 affinity chromatography technology 19182904 physical association X 2 P46462 Q5M8S1 affinity chromatography technology 19666135 physical association X 2 P46462 O35987 affinity chromatography technology 12847084 physical association X 2 P46462 P08081 affinity chromatography technology 8413590 physical association X 2 P46462 affinity chromatography technology 17550236 physical association X 2 P46462 O35987 affinity chromatography technology 10811609 physical association X 2 P46462 Q6P7A2 affinity chromatography technology 10811609 physical association X 2 P46462 Q9ES54 affinity chromatography technology 10811609 physical association X 2 P46462 Q9ES54 affinity chromatography technology 10811609 physical association X 2 P46462 Q9ES54 affinity chromatography technology 10811609 physical association X 2 P46462 Q9ES54 biochemical 10811609 colocalization X 2 P46462 O35987 biochemical 10811609 colocalization X 2 P46462 O35987 affinity chromatography technology 10811609 physical association X 2 P0C627 P46462 affinity chromatography technology 17141156 physical association X 2 P0C627 P46462 pull down 17141156 direct interaction X 2 P35565 P46462 biochemical 12847084 colocalization X 2 P97526 P46462 affinity chromatography technology 22105171 physical association X 2 P97526 P46462 affinity chromatography technology 22105171 physical association X 2 Q9Y2K9 P46462 affinity chromatography technology 25002582 physical association X 2 P07151 P46462 biochemical 12847084 colocalization X 2 O88767 P46462 affinity chromatography technology 16854843 physical association X 2 P46462 P46462 biochemical 12351637 colocalization X 2 P46462 P46462 affinity chromatography technology 12351637 physical association X 2 P46462 P46462 pull down 12351637 direct interaction X 2 P46462 P22002 affinity chromatography technology 21186355 physical association X 2 P46462 affinity chromatography technology 16103111 physical association X 2 P46462 affinity chromatography technology 22051847 physical association X 2 P46462 pull down 11740563 association C 3 P46462 affinity chromatography technology 10811609 association C 3 P46462 electron microscopy 10930451 association C 3 P46462 O35987 coimmunoprecipitation 11740563 association X 2 P46462 O35987 coimmunoprecipitation 10811609 association X 2 P46462 O35987 molecular sieving 9214505 association X 2 P46462 anti bait coimmunoprecipitation 16103111 association C 4 P46462 O35987 isothermal titration calorimetry 16601695 direct interaction X 2 P46462 O35987 isothermal titration calorimetry 16601695 direct interaction X 2 P46462 O35987 electron microscopy 16601695 direct interaction X 2 P46462 O35987 molecular sieving 16601695 colocalization X 2 P46462 O35987 competition binding 20691684 direct interaction X 2 P46462 O35987 pull down 20691684 direct interaction X 2 P46462 Q0KL01 pull down 20691684 direct interaction X 2 P46462 O35987 molecular sieving 9214505 physical association X 2 P46462 O35987 anti tag coimmunoprecipitation 9214505 physical association X 2 P46462 O35987 anti bait coimmunoprecipitation 9214505 physical association X 2 P46462 O35987 molecular sieving 9214505 physical association X 2 P46462 pull down 15215856 association C 3 P21708 P46462 anti bait coimmunoprecipitation 19935650 association X 2 P70362 P46462 pull down 20691684 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Cacna1c Vcp MI:0004(affinity chromatography technology) 21186355 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334037 bait prey Mapk3 Vcp MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 19935650 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0914(association)|MI:0914(association) MI:0471(mint)|(intact) MINT_71480|UniProt_185636 bait|bait prey|prey Vcp Rad23b MI:0004(affinity chromatography technology) 19182904 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334886 prey bait Vcp Cyp3a62 MI:0004(affinity chromatography technology) 17550236 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_335771 prey bait Vcp Usp5 MI:0004(affinity chromatography technology) 19182904 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0403(colocalization) (biogrid) BIOGRID_334891 bait prey Ubxn2b Vcp MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17141156 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_333911|BIOGRID_333910 prey|bait bait|prey Clta Vcp MI:0004(affinity chromatography technology) 8413590 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_335437 bait prey Canx Vcp MI:0415(enzymatic study) 12847084 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0403(colocalization) (biogrid) BIOGRID_335267 prey bait Vcp Nf1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22105171 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_335438|BIOGRID_335439 prey|bait bait|prey Vcp Smad1 MI:0004(affinity chromatography technology) 22051847 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_335502 bait prey Vcp Ubc MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 12847084,17141156,22871113 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_336870|BIOGRID_335269|BIOGRID_333912 prey|bait|prey bait|prey|bait Vcp Nploc4 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10811609 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_336144|BIOGRID_336145|BIOGRID_336142|BIOGRID_336150 bait|prey|bait|bait prey|bait|prey|prey Vcp Ufd1l MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10811609,12847084 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_336147|BIOGRID_335265|BIOGRID_336143|BIOGRID_336140|BIOGRID_336149 prey|bait|bait|bait|bait bait|prey|prey|prey|prey Nsfl1c Vcp MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0096(pull down)|MI:0071(molecular sieving)|MI:0401(biochemical)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0071(molecular sieving)|MI:0096(pull down)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0096(pull down)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0401(biochemical)|MI:0401(biochemical) 10811609,12847084,16601695,20691684,9214505 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0407(direct interaction) MI:0471(mint)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint) MINT_78644|UniProt_173356|BIOGRID_336151|BIOGRID_336139|BIOGRID_336153|BIOGRID_335266|UniProt_185733|UniProt_186450|MINT_80888|UniProt_186451|UniProt_186452|UniProt_186453|UniProt_185737|UniProt_183335|UniProt_183334|MINT_78643|UniProt_183336|MINT_80890|UniProt_183333|MINT_80894|MINT_80892 neutral component|prey|prey|prey|bait|prey|prey|neutral component|neutral component|bait|bait|neutral component|prey|neutral component|neutral component|prey|neutral component|neutral component|neutral component|neutral component|neutral component bait|bait|bait|bait|prey|bait|bait|neutral component|neutral component|prey|prey|neutral component|bait|neutral component|neutral component|bait|neutral component|neutral component|neutral component|neutral component|neutral component Park7 Vcp MI:0004(affinity chromatography technology) 16854843 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_335692 bait prey Itpr1 Vcp MI:0004(affinity chromatography technology) 16103111 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_334637 bait prey Vcp Ube4a MI:0004(affinity chromatography technology) 10811609 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0915(physical association) (biogrid) BIOGRID_336141 bait prey B2m Vcp MI:0415(enzymatic study) 12847084 taxid:10116(Rattus norvegicus) taxid:10116(Rattus norvegicus) MI:0403(colocalization) (biogrid) BIOGRID_335268 prey bait

PPI - HINT Gene A Gene B PMID Method Quality USP5 VCP 19182904 0401 LC NSFL1C VCP 10811609,9214505,10811609,10811609,9214505,10811609,16601695,9214505,10811609,16601695,20691684,20691684,11740563,16601695 0006,0006,0004,0401,0071,0071,0071,0007,0019,0065,0096,0405,0019,0040 LC B2M VCP 12847084 0401 LC CANX VCP 12847084 0401 LC VCP VCP 12351637,12351637,12351637 0096,0004,0401 LC VCP UFD1L 10811609,10811609,10811609 0006,0004,0401 LC VCP NPLOC4 10811609,10811609,10811609,10811609,10811609 0071,0096,0006,0004,0401 LC UBXN2A VCP 26265139 0004 LC USP5 VCP 19182904 0401 LC STUB1 VCP 26265139 0004 LC NSFL1C VCP 10811609,9214505,10811609,10811609,9214505,10811609,9214505,10811609,12847084,20691684,20691684 0006,0006,0004,0401,0071,0071,0007,0019,0004,0096,0405 LC PARK7 VCP 16854843 0004 LC CHRNA3 VCP 26265139 0004 LC B2M VCP 12847084 0401 LC CLTA VCP 8413590 0004 LC UBXN2B VCP 17141156,17141156 0004,0096 LC SLC2A4 VCP 16396496 0007 LC MAPK3 VCP 19935650 0006 LC CACNA1C VCP 21186355 0004 LC ITPR1 VCP 16103111 0004 LC CANX VCP 12847084 0401 LC VCP VCP 12351637,12351637,12351637 0096,0004,0401 LC VCP NF1 22105171 0004 LC VCP RAD23B 19182904 0004 LC VCP UBC 12847084,17141156 0004,0096 LC VCP UBE4A 10811609 0004 LC VCP SMAD1 22051847 0004 LC VCP CYP3A62 17550236 0004 LC VCP UFD1L 10811609,10811609,10811609,12847084 0006,0004,0401,0004 LC VCP NPLOC4 10811609,10811609,10811609,10811609,10811609 0071,0096,0006,0004,0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q0KL01 P46462 UBXN2B VCP 0.309 20691684 Q9Y2K9 P46462 STXBP5L VCP 0.126 25002582 P46462 P08081 VCP CLTA 0.21 8413590 P46462 O88767 VCP PARK7 0.126 16854843 P46462 O35987 VCP NSFL1C 0.914 10811609,20691684,12847084,16601695 P46462 P46462 VCP VCP 0.569 12351637 P46462 P29994 VCP ITPR1 0.21 16103111 Q99KJ0 P46462 UBXN2A VCP 0.21 26265139 Q9BQB4 P46462 SOST VCP 0.126 22206666 Q9BQE4 P46462 VIMP VCP 0.21 15215856 Q9CVD2 P46462 ATXN3 VCP 0.21 19666135 Q9ES53 P46462 UFD1L VCP 0.569 10811609,12847084 Q9ES54 P46462 NPLOC4 VCP 0.454 10811609 P46462 P07151 VCP B2M 0.126 12847084 P46462 P0C627 VCP UBXN2B 0.454 17141156 P46462 P21708 VCP MAPK3 0.236 19935650 P46462 P35565 VCP CANX 0.126 12847084 P97526 P46462 NF1 VCP 0.376 22105171 Q63429 P46462 UBC VCP 0.523 22871113,17141156,12847084 Q6P7A2 P46462 UBE4A VCP 0.21 10811609 P70362 P46462 UFD1L VCP 0.21 20691684 P46462 P19357 VCP SLC2A4 0.126 16396496 P46462 P22002 VCP CACNA1C 0.21 21186355 Q4KMA2 P46462 RAD23B VCP 0.21 19182904