PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Mad dor 15575970 biogrid,i2d,mint,intact exp G G G G G G G G dor dap-RA 15575970 biogrid exp G G G G G G G G dor CG18259-RA 14605208 biogrid,i2d,mint,intact exp G G G G G G G G dor CG13993, isoform B, CG13993-PA, RE41391p 14605208 biogrid,i2d,mint,intact exp G G G G G G G G dor CG6961, LD35981p i2d exp G G G G G G G G EG:8D8.5 protein, Pan gu, Protein kinase PAN GU dor 15575970 biogrid,i2d exp G dor CG11286, isoform A 15575970 biogrid,i2d,mint,intact exp dap dor 15575970 i2d,mint,intact exp dor RE09533p 15575970 mint,intact exp dor car 10549280 biogrid exp, ortho G G G G G G G G dor TER94 ortho G G G G G G G G dor cbx ortho G G G G G G G G dor Syx1A ortho G G G G G G dor HL02043p, Syntaxin 6, isoform E ortho G G G G G G G G dor LD33620p, Light, isoform A, Light, isoform E, Light, isoform F ortho G G G G G G G G dor SD10846p, Vacuolar protein sorting 45 ortho G G G G G G G dor CG10144 ortho G G G G G G G TMS1, isoform F dor ortho G G G G G G G G dor Uridine phosphorylase ortho G dor dor ortho G G G G G G G G betaCop dor ortho G G G G G G G G dor CG4554 ortho G dor RE66051p, Vacuolar protein sorting 16A ortho G G G G G G G G dor Syntaxin 8 ortho G G G G G G G G dor CG5001-RA ortho G G G G G G G dor GH10703p, Vacuolar protein sorting 39 ortho G G G G G dor CG5081-PA, isoform A, LD23667p, Syntaxin 7, isoform A ortho G G G G G G G G RpII215 dor ortho G G G G G G G G MTA1-like dor ortho G G G G G G G G dor MED23 ortho Hsp83 dor ortho G G G G G G G G eff dor ortho G G G G G G G G CG10663, isoform B, CG10663, isoform D dor ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q24314 P42003 two hybrid 15575970 physical association X 2 Q24314 P91668 two hybrid 15575970 physical association X 2 Q8SZA4 Q24314 two hybrid 15575970 physical association X 2 Q24314 Q9VMH8 two hybrid 14605208 physical association X 2 Q24314 Q9VWQ6 two hybrid 14605208 physical association X 2 Q24314 Q9VI02 two hybrid 15575970 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B dor CG18259-RA MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(biogrid)|(intact) DIP_18655|MINT_10808|BIOGRID_42690|UniProt_56583 -|prey|prey|prey -|bait|bait|bait dor CG13993 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0465(dip)|(intact) MINT_28822|BIOGRID_31405|DIP_13874|UniProt_47191 prey|prey|-|prey bait|bait|-|bait dap dor MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_20921|UniProt_40993 bait|bait prey|prey dor car MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10549280 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_60915|BIOGRID_60914|BIOGRID_60913 bait|bait|prey prey|prey|bait dor dap MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_59584 prey bait dor png MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_40991|MINT_20919 prey|prey bait|bait dor Or49a MI:0004(affinity chromatography technology) 19061648 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0796(suppressive genetic interaction defined by inequality) (biogrid) BIOGRID_455141 prey bait Mad dor MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact) BIOGRID_58845|MINT_20565|UniProt_40215 bait|bait|bait prey|prey|prey dor CG11286 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|(biogrid) MINT_20920|UniProt_40992|BIOGRID_59583 prey|prey|prey bait|bait|bait png dor MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_59582 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Y1I2 Q24314 CAR DOR 0.454 10549280 Q9VMH8 Q24314 Q9VMH8 DOR 0.183 14605208 Q24314 P42003 DOR MAD 0.332 15575970 Q24314 P91668 DOR DAP 0.183 15575970 Q8SZA4 Q24314 PNG DOR 0.183 15575970 Q9VI02 Q24314 Q9VI02 DOR 0.183 15575970 Q9VWQ6 Q24314 CG18259-RA DOR 0.183 14605208