PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus sgg hyd 25294943 intact exp G G G hyd Usp10 25294943 intact exp G G G G G G G G G G hyd Thrombospondin, isoform A, Thrombospondin, isoform F 25294943 intact exp G Hsp22 hyd 22036573 biogrid exp hyd CG5059-PA, isoform A, RE48077p 25294943 intact exp G G G G G G G G G G hyd Hsp70Aa 22036573 biogrid exp hyd CG5281-RA 25294943 intact exp G G hyd Sema-1a 21447707,25294943 biogrid,intact exp G G hyd 26S proteasome regulatory complex subunit p48B, Regulatory particle triple-A ATPase 1, SD07148p 22036573 biogrid exp, ortho G G G G G G G G G G hyd Ef1alpha-like factor, isoform A, Ef1alpha-like factor, isoform B, Ef1alpha-like factor, isoform D, RE07731p ortho G G G G G G G G G G hyd l(1)dd4 ortho G G G G G G hyd LD07294p, Two A-associated protein of 42kDa ortho G G G G G G G G G G arm hyd ortho G G G G G G G G G G Arp1 hyd ortho G G G G G G G G G G FI03211p, Spindle B hyd ortho G lok hyd ortho G G G G G Trip1 hyd ortho G G G G G G G G G G hyd Sirt6 ortho G hyd CG8993-PA, RE49388p ortho G G G G G G G G G G Fs(2)Ket hyd ortho G G G G G G G G G G Bx42 hyd ortho G G G G G G G G G G hyd pic ortho G G G G G G G G G G hyd hyd ortho G G G G G G G G G G hyd Hr96 ortho G G G G G G G G G G TfIIFbeta hyd ortho G G G G G G G G G G hyd Pih1D1, isoform D ortho G G G G G G G G G G hyd Iap2 ortho G G G G G G G G G G hyd Dyrk3 ortho G G G G G G G G G TfIIE-beta hyd ortho G G G G G G G G G G hyd Sirt7 ortho G G G G G hyd fzy-RA ortho G G hyd WD repeat-containing protein 48 homolog ortho G G G G G G G r hyd ortho G G hyd mahj ortho G G G G G G G G G hyd Set ortho G G G G G G G G G G hyd TER94 ortho G G G G G G G G G G hyd Pen ortho G G hyd CG6459 protein, CG6459-PA, LD29590p, P32 ortho G G G G G G G G G G CG30349-RA hyd ortho G G G G G G G G G G hyd EG:25E8.3 ortho G G G G G G G G G hyd UbcD2 ortho G G G G G G G G G G gammaTub37C hyd ortho G hyd Cullin 3, isoform F, FI19425p1 ortho G G G G G G G G G G hyd CG9581, GH19483p ortho G G G G G G G G G G hyd Klp10A ortho G G G G G G G G hyd p28/SF2 ortho G G G G G G G G G G hyd Fas-associated factor, isoform A, Fas-associated factor, isoform B, GH16914p ortho G G G G G G G G G G hyd Bub3-RA ortho G G G G G G G G G G hyd emb ortho G G G G G G G G G G hyd CG10924, isoform A, RE12569p ortho G G G hyd UQCR-C2 ortho G G G G G G G G G G rl hyd ortho G G G G G G G G G G Cyclin-dependent kinase 9, GH21935p, Positive transcription elongation factor b small subunit hyd ortho G G G G G G G G G G hyd CG8209, GM09977p ortho G G G G G G G G G G hyd HdacX-RA ortho G G G G G hyd Rcd5 ortho G G G G G G G G G G hyd CG8963, isoform A, CG8963, isoform B, CG8963, isoform C, SD01637p ortho G G G G G G G G G G eff hyd ortho G G G G G G G G G G Ubi-p63E hyd ortho G G G G G G G G G G hyd Vha14-1 ortho G G G G G G G G G G hyd LD33485p, Mitochondrial ribosomal protein L4 ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q7KMQ0 P51592 affinity chromatography technology 22036573 physical association X 2 P02515 P51592 affinity chromatography technology 22036573 physical association X 2 P51592 P02825 affinity chromatography technology 22036573 physical association X 2 P51592 anti tag coimmunoprecipitation 25294943 association C 14

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B hyd CELE_T07H6.4 MI:0018(two hybrid) 14704431 taxid:7227(Drosophila melanogaster) taxid:6239(Caenorhabditis elegans) MI:0407(direct interaction) (biogrid) BIOGRID_23999 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8IPU8 P51592 Q8IPU8 HYD 0.126 25294943 P51592 P02515 HYD HSP22 0.126 22036573 Q24322 P51592 SEMA-1A HYD 0.236 21447707 Q0E8S4 P51592 SEMA1A {ECO:0000313|FLYBASE:FBGN0011259} HYD 0.236 25294943 Q9VGN4 P51592 SALS HYD 0.126 25294943 Q9VM97 P51592 TSP HYD 0.126 25294943 Q9W0L7 P51592 CG13903 HYD 0.126 25294943 P51592 P18431 HYD SGG 0.126 25294943 P51592 P02825 HYD HSP70AB 0.126 22036573 P82910 P51592 HSP70AA HYD 0.126 22036573