PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus neur Drep3 14605208 biogrid,i2d,intact exp G G neur Ocho-RB 16459303 biogrid exp neur La 14605208 biogrid,i2d,mint,intact,dip exp G G G G G G Traffic jam, isoform C neur 14605208 i2d,mint,intact,dip exp koi neur 14605208 biogrid,intact exp G G G G G G neur barbu 16459303,14605208 biogrid,i2d,mint,intact exp Brd-RA neur 16459303 biogrid exp malpha neur 16459303 biogrid exp G Dl neur 16459303,17065551,unassigned4 biogrid,intact exp G G G m6 neur 16459303 biogrid exp Ser neur 17006545 mint,intact exp G neur CG12487-PA, IP06720p 16459303 biogrid exp neur CG34401, isoform A 14605208 biogrid exp G G G G G G m4 neur 16459303 biogrid exp Abl neur ortho G G G G G G Dynamin associated protein 160, isoform D neur ortho G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q0E9B7 P29503 two hybrid 14605208 physical association X 2 P29503 two hybrid 14605208 physical association X 2 P29503 Q9V3S6 two hybrid 14605208 physical association X 2 P29503 M9ZVK8 two hybrid 14605208 physical association X 2 P29503 two hybrid 14605208 physical association X 2 A1Z6Q1 P29503 two hybrid 14605208 physical association X 2 A4V346 P29503 experimental interaction detection - physical association X 2 P18168 P29503 anti bait coimmunoprecipitation 17006545 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B neur Q9V996 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_18170 null prey neur Q9V651 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_18173 null bait neur Tom MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208,16459303 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|MI:0471(mint)|(intact)|(biogrid)|MI:0465(dip) BIOGRID_75410|BIOGRID_75413|MINT_18172|UniProt_64481|BIOGRID_30673|DIP_10466 bait|bait|null|null|bait|- prey|prey|prey|prey|prey|- neur Q9VWN8 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_64480|MINT_18171 null|null bait|bait neur CG34401 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_61542 bait prey neur tj MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(intact) DIP_5550|MINT_17818|UniProt_57618 -|null|null -|bait|bait neur koi MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(intact)|(biogrid) DIP_10464|UniProt_64479|BIOGRID_30672 -|null|bait -|prey|prey neur La MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(biogrid)|(intact) DIP_7780|MINT_17977|BIOGRID_35538|UniProt_53853 -|null|prey|null -|bait|bait|bait neur Drep-3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0465(dip)|(biogrid) UniProt_64482|DIP_10467|BIOGRID_37360 null|-|bait bait|-|prey m6 neur MI:0018(two hybrid) 16459303 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_75408 prey bait neur BobA MI:0018(two hybrid) 16459303 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_75411 bait prey Ser neur MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 17006545 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_44958|MINT_29566 prey|prey bait|bait Dl neur MI:0004(affinity chromatography technology)|MI:0045(experimental interaction detection)|MI:0018(two hybrid) 16459303,17065551 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid) BIOGRID_64152|UniProt_45609|BIOGRID_75414 prey|unspecified role|prey bait|unspecified role|bait m4 neur MI:0018(two hybrid) 16459303 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_75407 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID R9PY27 P29503 R9PY27 NEUR 0.033 14605208 P29503 P10041 NEUR DL 0.454 17065551,unassigned4,16459303 P29503 A1Z6Q1 NEUR KOI 0.21 14605208 P29503 O97178 NEUR MALPHA 0.309 16459303 P29503 O97179 NEUR M6 0.309 16459303 P29503 P13095 NEUR M4 0.309 16459303 P29503 P18168 NEUR SER 0.21 17006545 P40796 P29503 LA NEUR 0.354 14605208 P97677 P29503 DLL1 NEUR 0.21 26355680 Q0E9B7 P29503 DREP-3 NEUR 0.21 14605208 Q96JN8 P29503 NEURL4 NEUR 0.21 26355680 Q9V3S6 P29503 TOM NEUR 0.21 14605208 Q9VIW0 P29503 TJ NEUR 0.21 14605208