PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ref(2)P ref(2)P 14605208 intact exp G G G G G G G G G G ref(2)P anon-84Eb 14605208 biogrid,i2d,mint,intact,dip exp G G ref(2)P CG6543, isoform A, CG6543, isoform B, LD24265p 22036573 biogrid exp G G G G G G G G G G ref(2)P Differentially expressed in FDCP 8 homolog 22036573 biogrid exp G G G G G G G G G Hsp22 ref(2)P 22036573 biogrid exp Hsp26 ref(2)P 22036573 biogrid exp G G G G G G G G ref(2)P Protein yippee-like CG15309 22036573 biogrid exp G G G G G G G G G G ref(2)P CG6166 14605208 biogrid,i2d exp G G G G G G G G ref(2)P Prosbeta3 22036573 biogrid exp G G G G G G G G G G Atg18 ref(2)P 24374083 biogrid,intact exp G G G G G G G G G G Glutathione S transferase E8, isoform A, Glutathione S transferase E8, isoform B ref(2)P 22036573 biogrid exp ref(2)P LD10783p, Sterol carrier protein X-related thiolase 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G Hsp23 ref(2)P 22036573 biogrid exp G G G G G G G Act42A ref(2)P i2d exp G G G G G G G G G G ref(2)P key 23749869 biogrid exp G G G G G G G G G G ref(2)P 26S proteasome regulatory complex subunit p48B, Regulatory particle triple-A ATPase 1, SD07148p 22036573 biogrid exp G G G G G G G G G G ref(2)P Drp1-RA 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G ref(2)P CG32711-PA, CG32711-PA long isoform, CG32711-PA short isoform, Leg arista wing complex, isoform B, Leg arista wing complex, isoform C, Leg arista wing complex, isoform D, RH09582p 22036573 biogrid exp G G G G G G G Act87E ref(2)P 14605208 biogrid,i2d,mint,intact,dip exp G G G G G G G G Hsp27 ref(2)P 22036573 biogrid exp G G G G G G ref(2)P Prosalpha1 22036573 biogrid exp ref(2)P Drp1 i2d exp ref(2)P Prosalpha4 22036573 biogrid exp G G G G G G G G G G ref(2)P Hsp70Aa 22036573 biogrid exp mbl ref(2)P 14605208 biogrid,i2d,mint,intact,dip exp G G G ref(2)P Regulatory particle triple-A ATPase 4 22036573 biogrid exp G G G G G G G G G G ref(2)P ctp 14605208 biogrid,i2d,mint,intact,dip exp G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P14199 Q8T053 - 14605208 - X 2 P14199 Q9VJ43 - 14605208 - X 2 P10981 P14199 - 14605208 - X 2 P14199 - 14605208 - X 2 P14199 Q9VQE0 - 14605208 - X 2 P14199 M9NDP1 - 14605208 - X 2 P14199 Q8T053 two hybrid 14605208 direct interaction X 2 P14199 affinity chromatography technology 23749869 physical association X 2 P14199 Q9VSF0 affinity chromatography technology 24374083 physical association X 2 P14199 Q9VSF0 affinity chromatography technology 24374083 physical association X 2 P14199 Q9VBF7 two hybrid 14605208 direct interaction X 2 P14199 Q9VJ43 two hybrid 14605208 direct interaction X 2 P14199 P02515 affinity chromatography technology 22036573 physical association X 2 P14199 P02517 affinity chromatography technology 22036573 physical association X 2 P14199 A1ZB73 affinity chromatography technology 22036573 physical association X 2 P14199 Q9VTT9 affinity chromatography technology 22036573 physical association X 2 P14199 P22769 affinity chromatography technology 22036573 physical association X 2 P14199 Q7JR58 affinity chromatography technology 22036573 physical association X 2 P14199 E1JGZ9 affinity chromatography technology 22036573 physical association X 2 Q7KMQ0 P14199 affinity chromatography technology 22036573 physical association X 2 P10981 P14199 two hybrid 14605208 direct interaction X 2 P14199 Q9VQE0 two hybrid 14605208 direct interaction X 2 P14199 M9NDP1 two hybrid 14605208 direct interaction X 2 P14199 two hybrid 14605208 direct interaction X 2 P14199 P02516 affinity chromatography technology 22036573 physical association X 2 P14199 P02518 affinity chromatography technology 22036573 physical association X 2 P14199 P02825 affinity chromatography technology 22036573 physical association X 2 P14199 K7X7R3 affinity chromatography technology 22036573 physical association X 2 P14199 Q9W414 affinity chromatography technology 22036573 physical association X 2 P14199 Q9XYN7 affinity chromatography technology 22036573 physical association X 2 P14199 Q8SXG2 affinity chromatography technology 22036573 physical association X 2 P14199 two hybrid 14605208 physical association X 2 P14199 Q9VJ43 two hybrid 14605208 physical association X 2 P14199 Q8T053 two hybrid 14605208 physical association X 2 P10981 P14199 two hybrid 14605208 physical association X 2 P14199 O16011 two hybrid 14605208 physical association X 2 P14199 two hybrid 14605208 physical association X 2 P14199 Q9VQE0 two hybrid 14605208 physical association X 2 P14199 M9NDP1 two hybrid 14605208 physical association X 2 P14199 Q9VJ43 two hybrid 14605208 physical association X 2 P14199 Q8T053 two hybrid 14605208 physical association X 2 P14199 Q9VSF0 anti tag coimmunoprecipitation 24374083 physical association X 2 P10981 P14199 two hybrid 14605208 physical association X 2 P14199 O16011-3 two hybrid 14605208 physical association X 2 P14199 Q9VQE0 two hybrid 14605208 physical association X 2 P14199 M9NDP1 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ref(2)P GstE8 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_67667 bait prey Act87E ref(2)P MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip)|(intact)|MI:0471(mint) BIOGRID_29882|DIP_6545|UniProt_58618|MINT_21918 prey|-|bait|bait bait|-|prey|prey ref(2)P Src42A MI:0018(two hybrid) 18719252 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_459252 prey bait ref(2)P CG33970 MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_60603 bait prey ref(2)P Q9VBG0 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact) MINT_21916|UniProt_58616 prey|prey bait|bait ref(2)P CG6543 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_72871 bait prey Hsp26 ref(2)P MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_64642 bait prey ref(2)P ScpX MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|MI:0471(mint)|(intact) DIP_6544|BIOGRID_29881|MINT_21917|UniProt_58617 -|bait|prey|prey -|prey|bait|bait ref(2)P Drp1 MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|(biogrid)|(intact) MINT_21920|BIOGRID_34694|UniProt_58620 bait|bait|bait prey|prey|prey ref(2)P CG11534 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68268 bait prey ref(2)P Atg18 MI:0007(anti tag coimmunoprecipitation) 24374083 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_46735 bait prey ref(2)P Rpt4 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_71487 bait prey ref(2)P CG15309 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_70984 bait prey ref(2)P eIF5 MI:0004(affinity chromatography technology) 22271760 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_633119 prey bait ref(2)P key MI:0004(affinity chromatography technology) 23749869 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_75782 prey bait ref(2)P ctp MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(biogrid)|(intact) DIP_6548|MINT_21921|BIOGRID_34695|UniProt_58621 -|prey|bait|prey -|bait|prey|bait ref(2)P Hsp70Aa MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_65342 bait prey ref(2)P Rpt1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66023 bait prey ref(2)P Ogg1 MI:0018(two hybrid) 18719252 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_459061 bait prey ref(2)P CG11981 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_71829 bait prey ref(2)P anon-84Eb MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(intact)|(biogrid)|MI:0471(mint) DIP_6546|UniProt_58619|BIOGRID_34693|MINT_21919 -|bait|bait|bait -|prey|prey|prey Hsp23 ref(2)P MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_64592 bait prey ref(2)P Prosalpha1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_73643 bait prey Hsp27 ref(2)P MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_64666 bait prey mbl ref(2)P MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0465(dip)|(intact) MINT_17937|BIOGRID_47935|DIP_6542|UniProt_58615 null|prey|-|null bait|bait|-|bait ref(2)P Pros28.1 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68631 bait prey ref(2)P lawc MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74252 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P14199 O16011 REF(2)P MBL 0.354 14605208 Q9GYV5 P14199 KEY REF(2)P 0.126 23749869 Q8T053 P14199 ANON-84EB REF(2)P 0.354 14605208 P14199 P10981 REF(2)P ACT87E 0.354 14605208 P14199 P02515 REF(2)P HSP22 0.126 22036573 P14199 P02516 REF(2)P HSP23 0.126 22036573 P14199 P02517 REF(2)P HSP26 0.126 22036573 P14199 P02518 REF(2)P HSP27 0.126 22036573 P14199 P02825 REF(2)P HSP70AB 0.126 22036573 P22769 P14199 PROSALPHA4 REF(2)P 0.126 22036573 P82910 P14199 HSP70AA REF(2)P 0.126 22036573 Q9VTT9 P14199 Q9VTT9 REF(2)P 0.126 22036573 Q9W2X7 P14199 Q9W2X7 REF(2)P 0.126 22036573 Q9XYN7 P14199 PROSBETA3 REF(2)P 0.126 22036573 Q9XZJ4 P14199 PROSALPHA1 REF(2)P 0.126 22036573 Q9VQE0 P14199 DRP1 REF(2)P 0.21 14605208 Q9VJ43 P14199 SCPX REF(2)P 0.21 14605208 Q9VSF0 P14199 ATG18A REF(2)P 0.21 24374083 Q24117 P14199 CTP REF(2)P 0.354 14605208