PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus trx Suppressor of fused homolog 15710747 biogrid,i2d,mint,intact exp G G G G G G G G G Sbf trx unassigned4 intact exp nej trx unassigned4 intact exp trx ash1 unassigned4 intact exp G G G trx AT16570p, CG12679 14605208 biogrid,i2d,mint,intact exp trx trx 24235145,11313484,10656681 biogrid,intact exp G G G G G G G G G trx Usp10 25294943 intact exp G G G G G G G G G His3, His3:CG31613, His3:CG33803, His3:CG33806, His3:CG33809, His3:CG33812, His3:CG33815, His3:CG33818, His3:CG33821, His3:CG33824, His3:CG33827, His3:CG33830, His3:CG33833, His3:CG33836, His3:CG33839, His3:CG33842, His3:CG33845, His3:CG33848, His3:CG33851, His3:CG33854, His3:CG33857, His3:CG33860, His3:CG33863, His3:CG33866 trx 12408863,unassigned4 mint,intact exp MutL homolog PMS2 trx 15710747 intact exp trx ft 25215488 intact exp sgg trx 25294943 intact exp G G G trx GH08712p, SNR1, Snf5-related 1 unassigned4 intact exp G G G G G G G G G trx CG5059-PA, isoform A, RE48077p 25294943 intact exp G G G G G G G G G Pms2 trx 15710747 biogrid exp G G G trx Nrx-IV 25294943 intact exp G G G G G G G G G trx cyp33 11976948 intact exp G G G G G G G G G Spinophilin, isoform J trx 25294943 intact exp G G G G G G trx NetB 25294943 intact exp G G G G G ps trx 25294943 intact exp G G G G G G G G Pp1-87B trx 17007873,unassigned4 intact exp G G G G G G G G G trx Pp1-13C 17007873 intact exp trx Pp1alpha-96A 17007873 intact exp G G G G G G G G G trx flw 17007873 intact exp G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P20659 - 15710747 - X 2 Q9VR87 P20659 - 14605208 - X 2 P20659 Q9VG38 - 15710747 - X 2 P20659 P20659 enzymatic study 24235145 direct interaction X 2 P20659 two hybrid 15710747 direct interaction X 2 Q9VR87 P20659 two hybrid 14605208 direct interaction X 2 P20659 Q9VG38 two hybrid 15710747 direct interaction X 2 Q9VR87 P20659 two hybrid 14605208 physical association X 2 P20659 Q9VG38 two hybrid 15710747 physical association X 2 Q05547 P20659 two hybrid 17007873 physical association X 2 P20659 P20659 anti tag coimmunoprecipitation 10656681 direct interaction X 2 P20659 P20659 anti tag coimmunoprecipitation 10656681 physical association X 2 P20659 P20659 two hybrid 10656681 physical association X 2 P20659 P20659 two hybrid 10656681 physical association X 2 P20659 P20659 anti bait coimmunoprecipitation 10656681 physical association X 2 P20659 P20659 pull down 10656681 direct interaction X 2 P20659 P20659 two hybrid 11313484 physical association X 2 P20659 Q9UNP9 pull down 11976948 physical association X 2 P20659 O76417 two hybrid fragment pooling approach 15710747 physical association X 2 P20659 H5V895 two hybrid 17007873 physical association X 2 P20659 P12982 two hybrid 17007873 physical association X 2 P20659 H5V895 two hybrid 17007873 physical association X 2 P20659 P12982 experimental interaction detection - physical association X 2 P02299 P20659 experimental interaction detection 12408863 methylation reaction X 2 P02299 P20659 experimental interaction detection 12408863 methylation reaction X 2 P02299 P20659 experimental interaction detection 12408863 methylation reaction X 2 P02299 P20659 experimental interaction detection 12408863 methylation reaction X 2 P02299 P20659 experimental interaction detection 12408863 methylation reaction X 2 P02299 P20659 experimental interaction detection 12408863 methylation reaction X 2 P02299 P20659 experimental interaction detection 12408863 methylation reaction X 2 P02299 P20659 experimental interaction detection - physical association X 2 P20659 anti tag coimmunoprecipitation 25294943 association C 25 P20659 anti tag coimmunoprecipitation 25294943 association C 16 Q9V3G3 P20659 pull down 11976948 physical association X 2 Q9V3G3 P20659 anti tag coimmunoprecipitation 11976948 physical association X 2 P33450 P20659 two hybrid 25215488 physical association X 2 Q9VR87 P20659 two hybrid 14605208 physical association X 2 Q9VW15 P20659 experimental interaction detection - physical association X 2 P48461 P20659 two hybrid 17007873 physical association X 2 O01368 P20659 experimental interaction detection - physical association X 2 P20659 Q27279 two hybrid fragment pooling approach 15710747 physical association X 2 P20659 O96610 experimental interaction detection - physical association X 2 P20659 Q24090 experimental interaction detection - physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B trx Snr1 MI:0045(experimental interaction detection) pubmed:unassigned4 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_46072 unspecified role unspecified role trx ash1 MI:0045(experimental interaction detection) pubmed:unassigned4 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_45387 unspecified role unspecified role Pp1-87B trx MI:0018(two hybrid)|MI:0045(experimental interaction detection) 17007873 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_44051|UniProt_45997 bait|unspecified role prey|unspecified role trx Su MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0471(mint) DIP_26521|MINT_19552|BIOGRID_62410|MINT_19351|MINT_19753 -|prey|prey|prey|prey -|bait|bait|bait|bait trx Pp1-13C MI:0018(two hybrid) 17007873 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_44120 prey bait trx CG12679 MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact) BIOGRID_38084|MINT_26692|UniProt_50987 prey|prey|prey bait|bait|bait trx flw MI:0018(two hybrid)|MI:0018(two hybrid) 17007873 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_44074|UniProt_44143 prey|prey bait|bait trx Pp1alpha-96A MI:0018(two hybrid) 17007873 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_44097 prey bait Sbf trx MI:0045(experimental interaction detection) pubmed:unassigned4 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_46040 unspecified role unspecified role nej trx MI:0045(experimental interaction detection) pubmed:unassigned4 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_45921 unspecified role unspecified role Pms2 trx MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_42622 bait prey trx Su MI:0399(two hybrid fragment pooling approach) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_41503 prey bait trx cyp33 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 11976948 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_38883|UniProt_70462|UniProt_38886 bait|bait|bait prey|prey|prey trx Q9V7B6 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15710747 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0471(mint) MINT_19405|MINT_19606|MINT_19807 prey|prey|prey bait|bait|bait His3; trx MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection)|MI:0045(experimental interaction detection) 12408863 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0213(methylation reaction)|MI:0213(methylation reaction)|MI:0915(physical association)|MI:0213(methylation reaction)|MI:0213(methylation reaction)|MI:0213(methylation reaction)|MI:0213(methylation reaction)|MI:0213(methylation reaction)|MI:0213(methylation reaction)|MI:0213(methylation reaction)|MI:0213(methylation reaction)|MI:0213(methylation reaction)|MI:0213(methylation reaction)|MI:0213(methylation reaction)|MI:0213(methylation reaction) MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact) MINT_19203|MINT_19209|UniProt_45778|MINT_19214|UniProt_39416|MINT_19211|MINT_19210|UniProt_39406|UniProt_39415|UniProt_39414|MINT_19213|UniProt_39413|MINT_19212|UniProt_39417|UniProt_39412 unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role trx Pms2 MI:0018(two hybrid) 15710747 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_63622 prey bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9GQN4 P20659 PS TRX 0.126 25294943 Q8IPU8 P20659 Q8IPU8 TRX 0.126 25294943 P20659 P02299 TRX HIS3:CG33866 0.183 12408863,unassigned4 Q9V3G3 P20659 CYP33 TRX 0.376 11976948 Q9W0L7 P20659 CG13903 TRX 0.236 25294943 Q24568 P20659 NETB TRX 0.236 25294943 P20659 P12982 TRX PP1-87B 0.286 unassigned4,17007873 P20659 P20659 TRX TRX 0.922 11313484,10656681,24235145 Q94887 P20659 NRX-IV TRX 0.126 25294943 P33450 P20659 FT TRX 0.183 25215488 Q9UNP9 P20659 PPIE TRX 0.21 11976948 P48462 P20659 FLW TRX 0.332 17007873 P20659 P18431 TRX SGG 0.126 25294943 P20659 M9NFI9 TRX M9NFI9 0.126 25294943 P20659 O01368 TRX NEJ 0.126 unassigned4 P20659 O76417 TRX PMS2 0.126 15710747 P20659 O96610 TRX SBF 0.126 unassigned4 P48461 P20659 PP1ALPHA-96A TRX 0.183 17007873 Q24090 P20659 SNR1 TRX 0.126 unassigned4 Q27279 P20659 SU(FU) TRX 0.126 15710747 Q9VR87 P20659 Q9VR87 TRX 0.183 14605208 Q9VW15 P20659 ASH1 TRX 0.126 unassigned4 Q05547 P20659 PP1-13C TRX 0.183 17007873