PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Mer wts 24012335 biogrid,intact exp G G G G G G G G G wts CG14614-RA 23955303 dip exp G G G G G G G G G mats wts 24012335 i2d,intact exp G G G G G G G G G wts jub 20303269 biogrid exp G G G G G G Myosin heavy chain-like, isoform B wts 14605208 biogrid,i2d exp G G G G Cdc37 wts 15575970 biogrid,i2d exp G G G G G G G G G yki wts 19584286,17889654 biogrid,i2d,intact exp G G G G G G G G G mnb wts 23955303 dip exp G G G G G G G G G Zyx102 protein, Zyx102.44 isoform, Zyxin, isoform B, Zyxin, isoform L wts 21666802 dip exp G G G G G G G G G wts GH01133p, RASSF8 14605208 biogrid,i2d,mint,intact exp G G G G G G G hpo wts 24012335,16906135 intact,dip exp G G G G G G G G G wts wts i2d exp G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q24276 Q9VA38 - 15575970 - X 2 Q95RA8 Q9VA38 - 15766530 - X 2 Q8INC1 Q9VA38 - 14605208 - X 2 Q8INC3 Q9VA38 two hybrid 14605208 direct interaction X 2 Q24276 Q9VA38 two hybrid 15575970 direct interaction X 2 Q45VV3-2 Q9VA38 affinity chromatography technology 19584286 physical association X 2 Q45VV3-2 Q9VA38 affinity chromatography technology 19584286 physical association X 2 Q9VBP2 Q9VA38 two hybrid 14605208 direct interaction X 2 Q9VA38 anti tag coimmunoprecipitation 23955303 - C 3 Q9VBP2 Q9VA38 two hybrid 14605208 physical association X 2 Q9VA38 P49657 anti tag coimmunoprecipitation 23955303 physical association X 2 Q9VA38 P49657 anti tag coimmunoprecipitation 23955303 physical association X 2 Q9VA38 P49657 anti tag coimmunoprecipitation 23955303 physical association X 2 Q9N675 Q9VA38 anti tag coimmunoprecipitation 21666802 physical association X 2 Q9N675 Q9VA38 anti tag coimmunoprecipitation 21666802 physical association X 2 Q9N675 Q9VA38 anti tag coimmunoprecipitation 21666802 physical association X 2 Q9N675 Q9VA38 anti tag coimmunoprecipitation 21666802 physical association X 2 Q9VA38 anti tag coimmunoprecipitation 21666802 - C 3 Q9VA38 two hybrid 14605208 physical association X 2 Q9VR53 Q9VA38 anti tag coimmunoprecipitation 23955303 physical association X 2 Q9VR53 Q9VA38 anti bait coimmunoprecipitation 23955303 physical association X 2 Q8T0S6 Q9VA38 anti tag coimmunoprecipitation 16906135 physical association X 2 Q9VA38 anti tag coimmunoprecipitation 21666802 physical association X 2 Q9VA38 anti tag coimmunoprecipitation 21666802 physical association X 2 Q45VV3 Q9VA38 protein kinase assay 17889654 phosphorylation reaction X 2 Q9VBP2 Q9VA38 two hybrid 14605208 physical association X 2 Q95RA8 Q9VA38 anti tag coimmunoprecipitation 24012335 physical association X 2 Q9VA38 anti tag coimmunoprecipitation 24012335 physical association C 3 Q24564 Q9VA38 anti tag coimmunoprecipitation 24012335 physical association X 2 Q24564 Q9VA38 anti tag coimmunoprecipitation 24012335 physical association X 2 Q24564 Q9VA38 fluorescence microscopy 24012335 colocalization X 2 Q24564 Q9VA38 anti tag coimmunoprecipitation 24012335 physical association X 2 Q24564 Q9VA38 fluorescence microscopy 24012335 colocalization X 2 Q24564 Q9VA38 anti bait coimmunoprecipitation 24012335 physical association X 2 Q24564 Q9VA38 anti tag coimmunoprecipitation 24012335 physical association X 2 Q8T0S6 Q9VA38 fluorescence microscopy 24012335 colocalization X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Mhcl wts MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_10587 - - Mhcl wts MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_37436 prey bait Q8INC4 wts MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_64606|MINT_25683 bait|bait prey|prey mats wts MI:0007(anti tag coimmunoprecipitation) 24012335 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_45216 prey bait yki wts MI:0424(protein kinase assay)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17889654,19584286 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0217(phosphorylation reaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_44734|BIOGRID_75354|BIOGRID_75355 neutral component|bait|prey neutral component|prey|bait Cdc37 wts MI:0018(two hybrid) 15575970 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_58852 bait prey wts RASSF8 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint) UniProt_64607|BIOGRID_37437|MINT_25684 prey|bait|prey bait|prey|bait Mer wts MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 24012335 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_45220|UniProt_45218|UniProt_45227|UniProt_45225|UniProt_45217|UniProt_45224|UniProt_45221|UniProt_45222 bait|bait|bait|neutral component|bait|neutral component|prey|bait prey|prey|prey|neutral component|prey|neutral component|bait|prey hpo wts MI:0007(anti tag coimmunoprecipitation) 24012335 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0403(colocalization) (intact) UniProt_45226 neutral component neutral component

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9VA38 Q8T0S6 WTS HPO 0.126 24012335 Q9VBP2 Q9VA38 RASSF8 WTS 0.21 14605208 Q9VA38 Q24564 WTS MER 0.702 24012335 Q9VA38 Q95RA8 WTS MATS 0.21 24012335 Q9VY77 Q9VA38 JUB WTS 0.21 20303269 Q9VA38 Q24276 WTS CDC37 0.183 15575970 Q9VA38 Q45VV3 WTS YKI 0.396 17889654,19584286