PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UbcD4 dod 22036573 biogrid exp G G G G UbcD4 Cysteine and histidine-rich protein 1 homolog 14605208,22036573 biogrid,i2d,mint,intact,dip exp G G G G G G G G G G UbcD4 Rpn10 11862484 intact exp G G G G G G G G G G UbcD4 Mst84Da 14605208 biogrid,i2d,mint,intact,dip exp G UbcD4 CSN8 14605208 biogrid exp G G G G G G G G G G UbcD4 LD11581p, Pmp70, isoform A, Pmp70, isoform B, Pmp70, isoform D 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G UbcD4 CG8974, isoform A, CG8974, isoform B, CG8974, isoform C, CG8974, isoform D, CG8974, isoform E, GH14055p 14605208 biogrid exp G G G G G G G G G G UbcD4 CG32581-RA 14605208 biogrid,i2d,mint,intact exp Pp2A-29B UbcD4 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G G UbcD4 CG3356, LP03102p 11862484 intact exp G G G G G G G G G G Mushroom-body expressed, isoform K UbcD4 14605208 biogrid,i2d,mint,intact exp G G G UbcD4 Sce ortho G G G G G G G UbcD4 GH24511p, Ubiquitin activating enzyme 1, isoform A ortho G G G G G G G G G G UbcD4 CG5196-RA ortho G G G G G G G G G UbcD4 CG3000-PA, isoform A, GH07620p, RE20929p, Retina aberrant in pattern, isoform B ortho G G G G G G G G G G UbcD4 CG3018-PA, isoform A, Dorsal interacting protein 4, GM08377p, Lesswright, isoform A, Lesswright, isoform C, Lesswright, isoform D, RE25737p, Ubiquitin-conjugating enzyme, Ubiquitin-conjugating enzyme 9, Ubiquitin-conjugating enzyme 9 homolog ortho G G G G G G G G G G RpL40 UbcD4 ortho G G G G G G G G G G Ts UbcD4 ortho G UbcD4 AT16033p, CG3473, isoform A, CG3473, isoform B ortho G RpS27A UbcD4 ortho G G G G G G G G G G UbcD4 flr ortho G G G G G G G G G UbcD4 CG2218, isoform A, CG2218, isoform B, FI06144p ortho G G G G G G G G G G UbcD4 clot ortho G G G G G G G G G G UbcD4 CG12339 ortho G G G G G G G G G G UbcD4 Prosbeta2R1 ortho G G G G G G G G G G UbcD4 UbcD4 ortho G G G G G G G G G G sina UbcD4 ortho G G G G G G G G G UbcD4 Adenylyltransferase and sulfurtransferase MOCS3 ortho G G G G G G G G G G Rab1-RA UbcD4 ortho G G G G G G G G G G UbcD4 CG3909 ortho G G G G G G G G G G UbcD4 Early girl, isoform A, Early girl, isoform B, LD41235p ortho G G G G G G G G G G UbcD4 Adk2 ortho G G G G G G G G G G UbcD4 14-3-3epsilon ortho G G G G G G G G G G UbcD4 sbr ortho G G G G G G G G G G UbcD4 Nedd8 ortho G G G G G G G G G G CycB UbcD4 ortho G G G UbcD4 AT07979p2, Lemming B, isoform A, Lemming B, isoform B, Lemming B, isoform C, Lemming B, isoform D ortho Ubi-p63E UbcD4 ortho G G G G G G G G G G UbcD4 CG10640-PA, isoform A, LD28904p, Uev1A, isoform C ortho G G G G G G G G G G UbcD4 Trx-2 ortho G G G G G G G G G G eff UbcD4 ortho G G G G G G G G G G UbcD4 LD47396p, Tcp-1eta ortho G G G G G G G G G G UbcD4 Nedd4 ortho G G G G G G G G G Dynamin associated protein 160, isoform D UbcD4 ortho G G G G G G G G G G UbcD4 Cdc6 ortho G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P52486 - 14605208 - X 2 P52486 Q01642 - 14605208 - X 2 M9MQH9 P52486 - 14605208 - X 2 Q9VZV5 P52486 - 14605208 - X 2 P52486 Q8IR26 two hybrid 14605208 direct interaction X 2 Q9VWC8 P52486 two hybrid 14605208 direct interaction X 2 Q7KTH8 P52486 two hybrid 14605208 direct interaction X 2 P52486 Q01642 two hybrid 14605208 direct interaction X 2 P52486 A4IJ59 two hybrid 14605208 direct interaction X 2 P52486 Q9VXP1 two hybrid 14605208 direct interaction X 2 P52486 P54353 affinity chromatography technology 22036573 physical association X 2 M9MQH9 P52486 two hybrid 14605208 direct interaction X 2 Q9VZV5 P52486 two hybrid 14605208 direct interaction X 2 Q9VZV5 P52486 affinity chromatography technology 22036573 physical association X 2 P52486 Q8IR26 two hybrid 14605208 physical association X 2 P91632 P52486 two hybrid 14605208 physical association X 2 Q9VWC8 P52486 two hybrid 14605208 physical association X 2 Q7KTH8 P52486 two hybrid 14605208 physical association X 2 P52486 Q01642 two hybrid 14605208 physical association X 2 P52486 Q9VXP1 two hybrid 14605208 physical association X 2 Q9VZV5 P52486 two hybrid 14605208 physical association X 2 P52486 Q9W196 two hybrid 11862484 physical association X 2 P52486 Q8IR26 two hybrid 14605208 physical association X 2 P91632 P52486 two hybrid 14605208 physical association X 2 Q9VWC8 P52486 two hybrid 14605208 physical association X 2 P55035 P52486 two hybrid 11862484 physical association X 2 P55035 P52486 coimmunoprecipitation 11862484 physical association X 2 P52486 Q01642 two hybrid 14605208 physical association X 2 M9MQH9 P52486 two hybrid 14605208 physical association X 2 Q9VZV5 P52486 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UbcD4 mub MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|MI:0465(dip) UniProt_63452|MINT_17193|DIP_25538 bait|bait|- prey|prey|- UbcD4 CG3356 MI:0018(two hybrid) 11862484 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_38985 bait prey UbcD4 Mst84Da MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|MI:0471(mint)|(intact) DIP_18468|BIOGRID_42580|MINT_10630|UniProt_56399 -|prey|bait|bait -|bait|prey|prey UbcD4 mub MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_47416 prey bait UbcD4 CG32486 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208,22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(biogrid)|MI:0471(mint)|(intact) DIP_21684|BIOGRID_65231|BIOGRID_44696|MINT_13557|UniProt_48886 -|bait|prey|bait|bait -|prey|bait|prey|prey UbcD4 Pmp70 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint) UniProt_51011|BIOGRID_38104|MINT_26715 bait|prey|bait prey|bait|prey UbcD4 CSN8 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_60668|DIP_12929 prey|- bait|- Pp2A-29B UbcD4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint) BIOGRID_60448|UniProt_52255|MINT_27916 bait|prey|prey prey|bait|bait UbcD4 dod MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74650 bait prey UbcD4 CG32581-RA MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint)|MI:0465(dip) BIOGRID_48476|UniProt_48958|MINT_13628|DIP_21765 prey|bait|bait|- bait|prey|prey|- UbcD4 Pros54 MI:0018(two hybrid)|MI:0018(two hybrid) 11862484 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_38986|UniProt_38987 bait|prey prey|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q7KTH8 P52486 CSN8 UBCD4 0.183 14605208 Q9VZV5 P52486 Q9VZV5 UBCD4 0.436 22036573,14605208 P91632 P52486 MUB UBCD4 0.21 14605208 P52486 P36179 UBCD4 PP2A-29B 0.332 14605208 Q8IR26 P52486 CG32581-RA UBCD4 0.21 14605208 Q9VWC8 P52486 PMP70 UBCD4 0.21 14605208 P54353 P52486 DOD UBCD4 0.126 22036573 P55035 P52486 RPN10 UBCD4 0.454 11862484 Q01642 P52486 MST84DA UBCD4 0.354 14605208 Q9VXP1 P52486 Q9VXP1 UBCD4 0.033 14605208 Q9W196 P52486 Q9W196 UBCD4 0.309 11862484