PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Hira Gprk2 25294943 intact exp G G G G G G Hira l(1)G0022 19782028 biogrid exp G G G G G G G G Hira RanGAP 19782028 biogrid exp G G G G G G G G Hira Chd1 17717186 biogrid exp G G G G G G G G Hira ab 19782028 biogrid exp G G Hira CG8258, LD24495p 19782028 biogrid exp G G G G G G G G Hira LD47396p, Tcp-1eta 19782028 biogrid exp G G G G G G G G Hira Fas2 21447707,25294943 biogrid,intact exp G G G G G G Hira Trl 19782028,17344416 biogrid exp G G G G G G G Hira hts 19782028 biogrid exp G G G G G G Hira T-complex protein 1 subunit delta 19782028 biogrid exp G G G G G G G G Hira GM12270p, T-complex chaperonin 5, isoform A 19782028 biogrid exp G G G G G G G G Klp54D-RA Hira 19782028 biogrid exp G G G G Hira G protein-coupled receptor kinase interacting ArfGAP, LD30319p 19782028 biogrid exp G G G G G G G G Hira CG7033, SD02216p 19782028 biogrid exp G G G G G G G G Hira T-cp1 19782028 biogrid exp G G G G G G G G Hira Cctgamma 19782028 biogrid exp G G G G G G G G tum-RA Hira 19782028 biogrid exp G G tacc Hira 19782028 biogrid exp G G G G G G G G msps Hira 19782028 biogrid exp G G G G G G G G Hira asf1 19782028 biogrid exp, ortho G G Hira CG3018-PA, isoform A, Dorsal interacting protein 4, GM08377p, Lesswright, isoform A, Lesswright, isoform C, Lesswright, isoform D, RE25737p, Ubiquitin-conjugating enzyme, Ubiquitin-conjugating enzyme 9, Ubiquitin-conjugating enzyme 9 homolog ortho G G G G G G G G Hira Cell division cycle 5 ortholog, isoform A, Cell division cycle 5 ortholog, isoform B, LD21614p ortho G G G G G G Hira His3, His3:CG31613, His3:CG33803, His3:CG33806, His3:CG33809, His3:CG33812, His3:CG33815, His3:CG33818, His3:CG33821, His3:CG33824, His3:CG33827, His3:CG33830, His3:CG33833, His3:CG33836, His3:CG33839, His3:CG33842, His3:CG33845, His3:CG33848, His3:CG33851, His3:CG33854, His3:CG33857, His3:CG33860, His3:CG33863, His3:CG33866 ortho Hira Hira ortho G G G G G G G G Hira Bx42 ortho G G G G G G G G Hira cdc2c ortho G G G Hira Su(z)12 ortho G G G G G G G G Hira sbr ortho G G G G G G G G Hira Cullin 3, isoform F, FI19425p1 ortho G G G G G G G G Hira CycA ortho G G Hira Upf1 ortho G G G G G G G G Hira His4, His4r, His4:CG31611, His4:CG33869, His4:CG33871, His4:CG33873, His4:CG33875, His4:CG33877, His4:CG33879, His4:CG33881, His4:CG33883, His4:CG33885, His4:CG33887, His4:CG33889, His4:CG33891, His4:CG33893, His4:CG33895, His4:CG33897, His4:CG33899, His4:CG33901, His4:CG33903, His4:CG33905, His4:CG33907, His4:CG33909 ortho Hira RpII215 ortho G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9VIW3 O17468 affinity chromatography technology 19782028 physical association X 2 A4V303 O17468 affinity chromatography technology 19782028 physical association X 2 O17468 Q9VZF5 affinity chromatography technology 19782028 physical association X 2 O17468 Q95RG8 affinity chromatography technology 19782028 physical association X 2 O17468 affinity chromatography technology 19782028 physical association X 2 O17468 E1JIM4 affinity chromatography technology 19782028 physical association X 2 O17468 Q86BB5 affinity chromatography technology 19782028 physical association X 2 O17468 Q9W392 affinity chromatography technology 19782028 physical association X 2 O17468 Q7K3J0 affinity chromatography technology 19782028 physical association X 2 O17468 A4V391 affinity chromatography technology 19782028 physical association X 2 O17468 A4V1Y7 affinity chromatography technology 17344416 physical association X 2 O17468 C0MIY4 affinity chromatography technology 19782028 physical association X 2 O17468 C0MIY4 affinity chromatography technology 19782028 physical association X 2 O17468 A4V1Y7 affinity chromatography technology 19782028 physical association X 2 O17468 Q24174-2 affinity chromatography technology 19782028 physical association X 2 O17468 A1Z9I5 affinity chromatography technology 19782028 physical association X 2 O17468 Q9VHL2 affinity chromatography technology 19782028 physical association X 2 O17468 A1Z8U4 affinity chromatography technology 19782028 physical association X 2 O17468 Q9VXQ5 affinity chromatography technology 19782028 physical association X 2 O17468 Q9VK69 affinity chromatography technology 19782028 physical association X 2 O17468 C0MIY4 affinity chromatography technology 19782028 physical association X 2 O17468 Q7KU24 affinity chromatography technology 17717186 physical association X 2 O17468 pull down 25294943 association C 9

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Hira CG5525 MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63765 bait prey Hira tacc-RA MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63757 bait prey Hira RanGap MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63753 bait prey Hira Tcp-1eta MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63760 bait prey Hira msps MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63756 bait prey Hira Git MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63754 bait prey Hira pav MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63751 bait prey Hira Tcp-1zeta MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63763 bait prey Hira CG7033 MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63759 bait prey Hira CG1354 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0401(biochemical) 11805826,16429126,16554755,17200106,21289098 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_381204|BIOGRID_428087|BIOGRID_394318|BIOGRID_341189|BIOGRID_588837 prey|prey|prey|prey|prey bait|bait|bait|bait|bait Hira ab MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63750 bait prey Hira asf1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_63748|BIOGRID_63835|BIOGRID_63733 bait|bait|prey prey|prey|bait Hira Trl MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17344416,19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_77136|BIOGRID_63749 prey|bait bait|prey Hira T-cp1 MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63764 bait prey Hira CG8258 MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63762 bait prey Hira Cctgamma MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63758 bait prey Hira Chd1 MI:0004(affinity chromatography technology) 17717186 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_64181 bait prey Hira hts MI:0004(affinity chromatography technology) 19782028 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_63755 bait prey