PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus sec13 CG13688-PA 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G Sema-2a sec13 25294943 intact exp G G G G G G G G G AT09434p sec13 i2d exp Succinyl-CoA ligase subunit beta sec13 22036573 biogrid exp G G G G G G G G G G Walrus, isoform A, Walrus, isoform B sec13 22036573 biogrid exp G G G G G G G G G G sec13 Tspo 22036573 biogrid exp G G G G G G G G G G sec13 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial, MCAD 22036573 biogrid exp G G G G G G G G G G Fat-spondin, GH05860p sec13 25294943 intact exp G G G G G G ImpL3 sec13 22036573 biogrid exp G G G G G G sec13 CG11327-RA 14605208 biogrid,i2d,mint,intact exp G Ipk2 sec13 i2d exp Sec31 sec13 14605208 biogrid,intact exp, ortho G G G G G G G G G G sec13 CG1416, isoform A, CG1416, isoform B, CG1416, isoform C, LD43819p 22036573 biogrid exp, ortho G G G G G G G G G G Vps32 sec13 ortho G G G G G G G G G G sec13 BcDNA.LD18761, Nucleoporin 107kD ortho G G G G G G G G G G Drab11 sec13 ortho G G G G G G G G G G sec13 GH10703p, Vacuolar protein sorting 39 ortho G G G G G gammaCop sec13 ortho G G G G G G G G G G sec13 vps2 ortho G G G G G G G G G G CkIalpha sec13 ortho G G G G G G G G G G sec13 cher ortho G G G G G G G sec13 tectonic ortho sec13 CSN5 ortho G G G G G G G G G G sec13 CG7609, isoform B ortho G G G G G G G G bai sec13 ortho G G G G G G G G G G Rab1-RA sec13 ortho G G G G G G G G G G sec13 Sce ortho G G G G G G G sec13 Nicotinate phosphoribosyltransferase, NAPRTase ortho G G G G G G G G G RE34924p, Rpb5, isoform A, Rpb5, isoform B sec13 ortho G G G G G G G G G G sec13 Nprl2 ortho G G G G G G G G dco sec13 ortho G G G G G G G G G G sec13 Nup160 ortho eIF6 sec13 ortho G G G G G G G G G G sec13 Protein YIPF ortho G G G G G G G G G G sec13 CG17259, isoform A, CG17259, isoform B, LP20978p ortho G G G G G G G G G G sec13 sec13 ortho G G G G G G G G G G Arf51F sec13 ortho G G G G G G G G G G sec13 CHOp24, isoform A, CHOp24, isoform B, GH04989p ortho G G G G G G G G G G sec13 CG11498-RA ortho Secretory pathway calcium atpase, isoform G sec13 ortho G G G G G G G sec13 lap ortho G G G G sec13 Gos28 ortho G G G G G G G G G G sec13 Probable ATP-dependent RNA helicase DDX55 homolog, DEAD box protein 55 ortho G sec13 LP09464p, Nucleoporin 133kD ortho G G G G G G G sec13 Probable 6-phosphogluconolactonase, 6PGL ortho G G G G G G G G G G sec13 mio ortho G G G G G G G G G G Nup98-RA sec13 ortho G G G G G G G G sec13 WD repeat-containing protein 59 homolog ortho G G G G G G G G G Cullin 3, isoform F, FI19425p1 sec13 ortho G G G G G G G G G G sec13 ATP8B ortho G G G G G G G G G sec13 Nucleoporin 43kD ortho G G G G G G G G TER94 sec13 ortho G G G G G G G G G G Tip60 sec13 ortho G G G G G G G G G sec13 Nucleoporin 37kD, isoform A, Nucleoporin 37kD, isoform B, SD22926p ortho G G G G AP-1sigma-RA sec13 ortho G G G G G G G G G G BcDNA.LD02793, Prp19 sec13 ortho G G G G G G G G G G sec13 Auxillin, isoform A, Auxillin, isoform B, SD05837p ortho G G G G G G G G G G Sec23 sec13 ortho G G G G G G G G G G sec13 Sirt7 ortho G G G G G sec13 l(3)72Ab ortho G G G G G G G G G G Sodium chloride cotransporter 69, isoform E sec13 ortho Chc sec13 ortho G G G G G G G G G G CG13016-RA sec13 ortho G G G G G G G G G Snap sec13 ortho G G G G G G G G sec13 MED4 ortho G G G emb sec13 ortho G G G G G G G G G G EG:65F1.1 sec13 ortho G G G G G G G G G sec13 CG5196-RA ortho G G G G G G G G G nup44A sec13 ortho G G G G G G G G G G Ak6 sec13 ortho G G G G G G G G G G Sec22 ortholog, isoform B sec13 ortho G G G G G G G G G G sec13 CG3500-RA ortho G G G G G G G G G G CG5081-PA, isoform A, LD23667p, Syntaxin 7, isoform A sec13 ortho G G G G G G G G G G Rpn11 sec13 ortho G G G G G G G G G G rab8 sec13 ortho G G G G G G G G G G Nucleoporin 75kD, Nup75 sec13 ortho G G G G G G G G G sec13 Cystathionine beta-synthase ortho G G G G G G G G G sec13 Lst8 ortho G G G G G G G G G SelD sec13 ortho G G G G G G G G G G sec13 STAM ortho G G G G G G G G G G Prosbeta6 sec13 ortho G G G G G G G G G G 14-3-3epsilon sec13 ortho G G G G G G G G G G Charged multivesicular body protein 1, isoform A, Charged multivesicular body protein 1, isoform B, GH26351p sec13 ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A1Z7J6 Q9V3J4 - 14605208 - X 2 Q9V3J4 Q9VM98 - 14605208 - X 2 Q9V3J4 Q9VPR6 - 14605208 - X 2 Q9VSA3 Q9V3J4 affinity chromatography technology 22036573 physical association X 2 Q9V3J4 Q9VM98 two hybrid 14605208 direct interaction X 2 Q9V3J4 Q9V470 affinity chromatography technology 22036573 physical association X 2 Q9V3J4 Q7KN94 affinity chromatography technology 22036573 physical association X 2 Q9V3J4 Q9V9Q4 affinity chromatography technology 22036573 physical association X 2 Q95028 Q9V3J4 affinity chromatography technology 22036573 physical association X 2 Q9V3J4 Q9VPR6 two hybrid 14605208 direct interaction X 2 Q9V3J4 Q9VPR1 affinity chromatography technology 22036573 physical association X 2 Q9V3J4 A1Z7J7 two hybrid 14605208 direct interaction X 2 A1Z7J6 Q9V3J4 two hybrid 14605208 physical association X 2 Q9V3J4 Q9VM98 two hybrid 14605208 physical association X 2 Q9V3J4 Q9VPR6 two hybrid 14605208 physical association X 2 Q9V3J4 Q9VM98 two hybrid 14605208 physical association X 2 Q9V3J4 Q9VPR6 two hybrid 14605208 physical association X 2 Q9V3J4 A1Z7J7 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B sec13 Q9V4Z0 MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:0() MI:0915(physical association) MI:0471(mint) MINT_16830 prey bait sec13 CG1416 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74041 bait prey sec13 Sucb MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_68005 bait prey sec13 sec31 MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_63077|BIOGRID_33695 prey|bait bait|prey sec13 Ipk2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0471(mint) BIOGRID_39298|UniProt_52775|MINT_28426 prey|prey|prey bait|bait|bait sec13 CG2789 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_70595 bait prey sec13 CG11327-RA MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(intact) BIOGRID_36521|MINT_24323|UniProt_55171 prey|prey|prey bait|bait|bait sec13 CG12262 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_71242 bait prey wal sec13 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_70160 bait prey ImpL3 sec13 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_71378 bait prey

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9V3J4 Q7KN04 SEC13 FAT-SPONDIN 0.126 25294943 Q9V3J4 A1Z7J7 SEC13 SEC31 0.183 14605208 Q9VM98 Q9V3J4 CG11327-RA SEC13 0.183 14605208 Q9VPR6 Q9V3J4 IPK2 SEC13 0.183 14605208 Q9V3J4 Q24323 SEC13 SEMA-2A 0.126 25294943