PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CG2540, GH24869p Crk 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G scrib Crk 14605208 biogrid exp G G G G G G G G G G Crk Crk 14605208 intact exp G G G G G G G G G G EG:100G10.6 Crk 14605208 biogrid,i2d,mint,intact exp G G G G G G C3G Crk unassigned4 intact exp G G G G G G G G G Myosin heavy chain-like, isoform B Crk 14605208 biogrid,i2d exp G G G G CG13458, GH20023p Crk 14605208 biogrid,i2d,mint,intact exp G G G CG3091, isoform A, CG3091, isoform C, RH61816p Crk 22036573 biogrid exp G G G G G G G G G CG43691, isoform C, CG43691, isoform D Crk 14605208 biogrid exp G SD06708p Crk unassigned4 intact exp CG42404, isoform D, CG42404, isoform E Crk 14605208 biogrid,i2d,mint,intact,dip exp G G G Blown fuse, isoform A, Blown fuse, isoform D Crk 14605208 biogrid,intact exp G G G G G G mbc Crk 17030600 mint,intact exp, ortho G G G G G G G G G G emb Crk ortho G G G G G G G G G G RpS19b Crk ortho G STAM Crk ortho G G G G G G G G G G Medea Crk ortho G G G G G G G G G mle Crk ortho G G G G G G G Multifunctional protein ADE2 Crk ortho G G G G G G G G G GM12270p, T-complex chaperonin 5, isoform A Crk ortho G G G G G G G G G G Reduced mechanoreceptor potential A, isoform B Crk ortho 26S proteasome regulatory complex subunit p97, Regulatory particle non-ATPase 1 Crk ortho G G G G G G G G G G Chc Crk ortho G G G G G G G G G G Rpt3-RA Crk ortho G G G G G G G G G G Dreadlocks, isoform B, Dreadlocks, isoform C, Dreadlocks, isoform D, LD42588p Crk ortho G G G G G G G G G cher Crk ortho G G G G G G G CG4390, isoform B Crk ortho G G G G G G G G G G RhoGAP92B Crk ortho G G G G G G G G G G LP21163p, Regulator of G-protein signaling 7, isoform A, Regulator of G-protein signaling 7, isoform B Crk ortho G G RpS13 Crk ortho G G G G G G G G G G NMDA receptor 2, isoform C, NMDA receptor subunit 2-2 Crk ortho eIF-2gamma Crk ortho G G G G G G G G G G AGO1-RC Crk ortho G G G G G G G G G CG10619-PA, isoform A, Tailup, isoform C Crk ortho G G G Neu5Ac synthase, Sialic acid phosphate synthase Crk ortho G G CG10077, isoform D, CG10077-PA, isoform A, GH10652p Crk ortho G G G G G G G G G G LD41209p, Prp31 Crk ortho G G G G G G G G G G Kelch-like protein diablo Crk ortho G G G G G G G G G G protein-coupled receptor kinase interacting ArfGAP, LD30319p Crk ortho G G G G G G G G G G CG10973, LD28549p Crk ortho G G G G G G G G G G CG5608-RA Crk ortho G G G G G G G G G RE17737p, RH44960p, Ribosomal protein L35A Crk ortho G G G G G G G G G G e(r) Crk ortho G G G G G G G G G G Vav Crk ortho G G G G G G G G CG5734-PA, LD15323p Crk ortho G G G G G G G G G G dp110 Crk ortho G G G G G G G G G G bsk Crk ortho G G G G G G G G G G Hsc70-1 Crk ortho G G RpS25 Crk ortho tRNA-splicing ligase RtcB homolog Crk ortho G G G G G G G G G G CG12117-PA, GH04031p, Sepiapterin reductase Crk ortho G G G G G G G G G pod1-RC Crk ortho G G G G G G G G G G Sep2 Crk ortho G G G G G G G G G G RpL18A Crk ortho G G G G G G G G G G Paf-AHalpha Crk ortho G G G G G G G G G G Regulatory particle triple-A ATPase 4 Crk ortho G G G G G G G G G G Src64B Crk ortho G G G G G G G Crk Cas ortho G G G G G G G G G G Crk botv ortho G G G G G G G G G Crk CG8184, isoform H ortho G G G G G G G G G G RpL23 Crk ortho G G G G G G G G G G betaTub60D Crk ortho G G G G G G G GH01724p, p47 Crk ortho G G G G G G G G G G Ubi-p63E Crk ortho G G G G G G G G G G 14-3-3epsilon Crk ortho G G G G G G G G G G 14-3-3zeta Crk ortho G G G G G G G Hsc70-5 Crk ortho G G G G G G G G G G Ef1gamma Crk ortho G G G G G G G G G G Hsc70-3 Crk ortho G G G G G G G G G G abs Crk ortho G G G G G G G G G Ptpmeg-RC Crk ortho G G G G G G G G G G bel Crk ortho G G G G G G G G G G La Crk ortho G G G G G G G G G G Top3alpha Crk ortho G G G G G scramb1 Crk ortho G G G G G G G G G spg Crk ortho G G G G Ced-12-RA Crk ortho G G G G G G G G G Spermidine synthase, isoform A, Spermidine synthase, isoform C Crk ortho G G G G Sos Crk ortho G G G G G G G G G G betaTub56D Crk ortho G G G G G G G G G G CG7433, isoform A, CG7433, isoform B, CG7433, isoform C, CG7433, isoform D Crk ortho G G Hsp83 Crk ortho G G G G G G G G G G CG41099, isoform C Crk ortho G G G G G G G G G G me31B Crk ortho G G G G G G G G G G lig3-RA Crk ortho G G G G G G G G G Cutlet Crk ortho G G Fak56D Crk ortho G G G G Fps85D Crk ortho G G G G G G G G CG17337, isoform A, RE11562p Crk ortho G G G G G G G G G G RpS5a Crk ortho G G G G G G G G G G wee Crk ortho G G G G G G G G G beta-Tub97EF Crk ortho G G G G G G G G G Adaptor protein complex 2, mu subunit, isoform A, Adaptor protein complex 2, mu subunit, isoform B, Adaptor protein complex 2, mu subunit, isoform C, Clathrin-associated adaptor complex AP-2 medium chain, Clathrin-associated protein, SD05403p Crk ortho G G G G G G G G G G RpS3 Crk ortho ArfGAP with SH3 domain, ankyrin repeat and PH domain, isoform B, RH04774p Crk ortho G G G G G G G G G Set Crk ortho G G G G G G G G G G LD47396p, Tcp-1eta Crk ortho G G G G G G G G G G 40S ribosomal protein S24 Crk ortho BG:DS02740.2 Crk ortho G G G G dnr1 Crk ortho G G G G G G G G G RE70632p, mRNA-capping-enzyme Crk ortho G G G G G G G G G G IP03705p, Metabotropic GABA-B receptor subtype 1, isoform B, Metabotropic GABA-B receptor subtype 1, isoform C Crk ortho G G l(2)tid Crk ortho G G G G G G G G G G drk Crk ortho G G G G G G G G G G Tho2, isoform B Crk ortho G G G G G G G G G G csw Crk ortho G G G G G G G G G CG11089-RA Crk ortho InR Crk ortho G G G G G G G G G Awh Crk ortho G G G Rpt2 Crk ortho G G G G G G G G G G MAP kinase kinase 4, isoform A, MAP kinase kinase 4, isoform B, MAP kinase kinase 4, isoform C, RE70055p, Stress activated MAP kinase kinase 4 Crk ortho G G G G G G G G G Protein UBASH3A homolog Crk ortho G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9XYM0 A1Z714 two hybrid 14605208 physical association X 2 Q9XYM0 A1Z9C2 two hybrid 14605208 physical association X 2 Q9XYM0 Q8IMR7 two hybrid 14605208 physical association X 2 Q9XYM0 two hybrid 14605208 physical association X 2 Q9XYM0 two hybrid 14605208 physical association X 2 Q9XYM0 Q9VUL2 two hybrid 14605208 physical association X 2 Q9XYM0 Q9VYK7 two hybrid 14605208 physical association X 2 Q9XYM0 Q9W4W7 two hybrid 14605208 physical association X 2 Q9XYM0 A1Z714 two hybrid 14605208 physical association X 2 Q9XYM0 A1Z9C2 two hybrid 14605208 physical association X 2 Q9XYM0 Q8IMR7 two hybrid 14605208 physical association X 2 Q9XYM0 Q9VFA8 two hybrid 14605208 physical association X 2 Q9XYM0 O77086 experimental interaction detection - physical association X 2 Q9XYM0 Q9VUL2 two hybrid 14605208 physical association X 2 Q9XYM0 Q9VYK7 two hybrid 14605208 physical association X 2 Q9XYM0 Q9W4W7 two hybrid 14605208 physical association X 2 Q9XYM0 Q9VCH4 anti tag coimmunoprecipitation 17030600 physical association X 2 Q9XYM0 Q9VCH4 anti tag coimmunoprecipitation 17030600 physical association X 2 Q9XYM0 Q9VCH4 two hybrid 17030600 physical association X 2 Q9XYM0 Q8MQW7 experimental interaction detection - physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B C3G Crk MI:0045(experimental interaction detection) pubmed:unassigned4 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_45451 unspecified role unspecified role mbc Crk MI:0045(experimental interaction detection) pubmed:unassigned4 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_45540 unspecified role unspecified role CG13458 Crk MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|MI:0471(mint)|(intact) DIP_13074|MINT_28053|UniProt_52392 -|prey|prey -|bait|bait rbcS Crk MI:0018(two hybrid) 14605208 taxid:76904() taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_41456 prey bait Crk blow MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_52705 bait prey Mhcl Crk MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0465(dip) DIP_16805 - - Crk CG17050 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0465(dip)|(biogrid)|(intact) DIP_16802|BIOGRID_41454|UniProt_60760 -|bait|bait -|prey|prey Mhcl Crk MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_32039 prey bait Q8INC4 Crk MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint) UniProt_60763|MINT_9093 prey|prey bait|bait mbc Crk MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 10,17030600 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint) UniProt_45159|MINT_19940|UniProt_45158|UniProt_45157|MINT_19938|MINT_19939 prey|prey|bait|bait|bait|bait bait|bait|prey|prey|prey|prey Q9V6P1 Crk MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_9090 prey bait CG42404 Crk MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|(intact)|MI:0471(mint)|(biogrid) DIP_16807|UniProt_60765|MINT_9095|BIOGRID_32040 -|prey|prey|prey -|bait|bait|bait Q9V4N9 Crk MI:0398(two hybrid pooling approach) 14605208 taxid:0() taxid:7227(Drosophila melanogaster) MI:0915(physical association) MI:0471(mint) MINT_28357 prey bait CG2540 Crk MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0465(dip)|MI:0471(mint)|(biogrid) UniProt_60761|DIP_16803|MINT_9091|BIOGRID_41455 bait|-|bait|prey prey|-|prey|bait blow Crk MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_31307|DIP_13386 bait|- prey|- CG3091 Crk MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_71416 prey bait scrib Crk MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0465(dip)|(intact)|MI:0471(mint) DIP_16806|UniProt_60764|MINT_9094 -|prey|prey -|bait|bait EG:100G10.6 Crk MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0465(dip)|MI:0471(mint)|(biogrid) UniProt_60762|DIP_16804|MINT_9092|BIOGRID_32038 prey|-|prey|prey bait|-|bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9XYM0 Q8MQW7 CRK MBC 0.126 unassigned4 Q9XYM0 Q7KRY7 CRK SCRIB 0.183 14605208 Q9XYM0 O77086 CRK C3G 0.126 unassigned4 Q9XYM0 Q9VYK7 CRK Q9VYK7 0.21 14605208 Q9XYM0 Q9VFA8 CRK Q9VFA8 0.21 14605208 Q9XYM0 Q9VUL2 CRK Q9VUL2 0.21 14605208 Q9XYM0 Q9W4W7 CRK EG:100G10.6 0.21 14605208 Q9XYM0 Q9VCH4 CRK MBC 0.569 17030600 Q9XYM0 A1Z714 CRK BLOW 0.21 14605208