PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus LD37736p, Zpr1 Roc1a 14605208 biogrid,i2d,mint,intact exp G G G G G G G G G Roc1a Brinker, Brk, Putative transcription factor, RE18244p 14605208 biogrid,i2d,mint,intact exp Cullin 2, isoform A, Cullin 2, isoform B, LD36177p Roc1a 15331761,18698375 biogrid exp, ortho G G G G G G G G G Cullin 4, isoform A, Cullin 4, isoform B, FI05474p, LP02965p Roc1a 18698375 biogrid exp, ortho G G G G G G G G G slmb Roc1a 24068890,unassigned4 intact,dip exp, ortho G G G G G G G G G Cullin 3, isoform F, FI19425p1 Roc1a 18698375 biogrid exp, ortho G G G G G G G G G lin19 Roc1a 15331761,18698375,unassigned4 biogrid,intact exp, ortho G G G G G G G G G E(z) Roc1a ortho G G G G G G G Prosalpha2 Roc1a ortho G G G G G G G G G Cyclin D, isoform D, Cyclin D, isoform E, Cyclin D, isoform F Roc1a ortho G G G G G G Roc1a CSN5 ortho G G G G G G G G G Medea Roc1a ortho G G G G G G G G G Roc1a Roc1a ortho G G G G G G G G G CG7656-RA Roc1a ortho G G G G G G G G G Su(z)12 Roc1a ortho G G G G G G G G G CG11658, isoform A, CG11658, isoform B, CG11658, isoform C, CG11658, isoform D, CG11658, isoform E, LD30288p Roc1a ortho G G G G G G G G CG40045-RA Roc1a ortho G G G G G G G G G Elongin C, isoform A, Elongin C, isoform B, RE05591p, RH71704p Roc1a ortho G G G G G G G G G SkpA Roc1a ortho G G G G G G G G G CycA Roc1a ortho G mahj Roc1a ortho G G G G G G G G G MED8 Roc1a ortho G G G G G G G G G FBXO11 Roc1a ortho G G G G G G G G Hsc70-1 Roc1a ortho G G Cand1 Roc1a ortho G G G G G G G G G Cullin 5, FI20194p1 Roc1a ortho G G G G G G G G G FI11917p, KEAP1, Keap1, isoform B Roc1a ortho G G G G G G G G CG8060 Roc1a ortho G G G G eff Roc1a ortho G G G G G G G G G kel Roc1a ortho G G G Gprk2 Roc1a ortho G G G G G G G G dco Roc1a ortho G G G G G G G G G CG43980, isoform C Roc1a ortho Defective in cullin neddylation protein Roc1a ortho G G G G G G G G G S6k-RA Roc1a ortho G G G G G G G G G SD21818p, Seryl-tRNA synthetase, isoform A, Seryl-tRNA synthetase, isoform B Roc1a ortho G G G G G G G G G Jetlag, isoform A Roc1a ortho G G CSN1b Roc1a ortho G G G G G G G G G Fbw5, GH09073p Roc1a ortho G G G G G G G G G Pgam5 Roc1a ortho G G G G G G G G G Nedd8 Roc1a ortho G G G G G G G G G Ubc7 Roc1a ortho G G G G G G G G G arm Roc1a ortho G G G G G G G G G Atg6 Roc1a ortho G G G G G G G G G Skp2, isoform A, Skp2, isoform E Roc1a ortho G G G G CSN3 Roc1a ortho G G G G G G G G G CG30493 Roc1a ortho G DCN1-like protein Roc1a ortho G G G G G G G G G Roc1a pic ortho G G G G G G G G G CSN4 Roc1a ortho G G G G G G G G G His4, His4r, His4:CG31611, His4:CG33869, His4:CG33871, His4:CG33873, His4:CG33875, His4:CG33877, His4:CG33879, His4:CG33881, His4:CG33883, His4:CG33885, His4:CG33887, His4:CG33889, His4:CG33891, His4:CG33893, His4:CG33895, His4:CG33897, His4:CG33899, His4:CG33901, His4:CG33903, His4:CG33905, His4:CG33907, His4:CG33909 Roc1a ortho Mcm10 Roc1a ortho G Act5C Roc1a ortho G G G G G G G G G Fem-1 Roc1a ortho G G G G G G G G G Ubc12 Roc1a ortho G G G G G G G G G CG2862, isoform C, CG2862-PA, isoform A, RH02823p, RH49748p Roc1a ortho G G G G G G G G G CSN6 Roc1a ortho G G G G G G G G G GH06740p, Leucine-rich repeat 47, isoform A, Leucine-rich repeat 47, isoform B Roc1a ortho G CG11982, LD47007p Roc1a ortho G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9W379 Q9W5E1 - 14605208 - X 2 Q5BI50 Q9W5E1 affinity chromatography technology 18698375 physical association X 2 Q9W5E1 Q24311 affinity chromatography technology 15331761 physical association X 2 Q9W5E1 Q24311 affinity chromatography technology 15331761 physical association X 2 Q9W5E1 Q9V9R2 affinity chromatography technology 15331761 physical association X 2 Q9W5E1 Q24311 affinity chromatography technology 18698375 physical association X 2 Q9W5E1 Q9V9R2 affinity chromatography technology 18698375 physical association X 2 Q9W5E1 Q8IP45 affinity chromatography technology 18698375 physical association X 2 Q9W379 Q9W5E1 two hybrid 14605208 direct interaction X 2 Q9XTN4 Q9W5E1 two hybrid 14605208 direct interaction X 2 Q9W5E1 anti tag coimmunoprecipitation 24068890 - C 4 Q9VDE3 Q9W5E1 anti tag coimmunoprecipitation 24068890 physical association X 2 Q9W379 Q9W5E1 two hybrid 14605208 physical association X 2 Q9XTN4 Q9W5E1 two hybrid 14605208 physical association X 2 Q9W5E1 O44382 experimental interaction detection - physical association X 2 Q9W5E1 Q24311 experimental interaction detection - physical association X 2 Q9W379 Q9W5E1 two hybrid 14605208 physical association X 2 Q9XTN4 Q9W5E1 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B lin19 Roc1a MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0045(experimental interaction detection)|MI:0004(affinity chromatography technology) 15331761,18698375 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(biogrid) BIOGRID_77111|BIOGRID_77113|UniProt_45866|BIOGRID_61812 prey|prey|unspecified role|prey bait|bait|unspecified role|bait AttB Roc1a MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_427191 prey bait CG14621 Roc1a MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_427182 prey bait anon-35F/36A Roc1a MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_427192 prey bait Roc1a eIF5 MI:0004(affinity chromatography technology) 22271760 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_632789 prey bait Pros45 Roc1a MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_427184 prey bait Pig1 Roc1a MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_427200 prey bait Ptp10D Roc1a MI:0004(affinity chromatography technology) 16429126 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_394009 bait prey CG8858 Roc1a MI:0686(unspecified method) 16606443 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_613682 bait prey Cul-2 Roc1a MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15331761,18698375 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_77114|BIOGRID_61813 prey|prey bait|bait ana Roc1a MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_427226 prey bait RpS6 Roc1a MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_427205 prey bait Roc1a brk MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|MI:0471(mint)|(biogrid)|MI:0465(dip) UniProt_61231|MINT_9542|BIOGRID_41762|DIP_17276 bait|bait|bait|- prey|prey|prey|- Gapdh1 Roc1a MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_427213 prey bait CG32699 Roc1a MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16429126,22770215 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_390556|BIOGRID_644778 bait|bait prey|prey TER94 Roc1a MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_427225 prey bait PPP4R2r Roc1a MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_427165 prey bait Ssb-c31a Roc1a MI:0686(unspecified method) 16606443 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0407(direct interaction) (biogrid) BIOGRID_613576 bait prey Zpr1 Roc1a MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0398(two hybrid pooling approach) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint) UniProt_61232|BIOGRID_41761|MINT_9541 bait|prey|bait prey|bait|prey Cul-3 Roc1a MI:0004(affinity chromatography technology) 18698375 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_61814 prey bait cos Roc1a MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_427215 prey bait Syx4 Roc1a MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_427199 prey bait sug Roc1a MI:0004(affinity chromatography technology) 17200106 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_427187 prey bait slmb Roc1a MI:0045(experimental interaction detection) pubmed:unassigned4 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (intact) UniProt_46027 unspecified role unspecified role

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9W5E1 O44382 ROC1A SLMB 0.126 unassigned4 Q9XTN4 Q9W5E1 BRK ROC1A 0.183 14605208 Q9W5E1 Q24311 ROC1A LIN19 0.454 18698375,unassigned4,15331761 Q9W5E1 Q9W379 ROC1A ZPR1 0.183 14605208