PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus beta'Cop 4E-binding protein THOR, CG8846-PA, HL08053p, Thor, isoform B 25294943 intact exp G G G G G G G G G G beta'Cop CG15482-RA 14605208 biogrid,i2d,mint,intact exp G beta'Cop fz2 25294943 intact exp G G G G G G G G G beta'Cop CG7878, LD33749p 22036573 biogrid exp G G G G G G G G G G beta'Cop PAPLA1 25294943 intact exp G G G G G G G G G G beta'Cop Coatomer subunit alpha 22036573 biogrid exp, ortho G G G G G G G G G G beta'Cop Clc ortho G G G G G G G G G G beta'Cop CG16908 ortho G G beta'Cop Chc ortho G G G G G G G G G G beta'Cop Prosalpha7 ortho G G G G G G G G G G beta'Cop Prosalpha3 ortho G G G G G G G G G G beta'Cop CG16928-PA, Endo/exonuclease Mre11 ortho G G G G G G G G G beta'Cop EF2 ortho G G G G G G G G G G beta'Cop betaCop ortho G G G G G G G G G G beta'Cop gammaCop ortho G G G G G G G G G G Hsp60 beta'Cop ortho G G G G G G G G G G beta'Cop Rpt3-RA ortho G G G G G G G G G G beta'Cop Dbi ortho G G G G G G G G G beta'Cop LD47396p, Tcp-1eta ortho G G G G G G G G G G beta'Cop bai ortho G G G G G G G G G G beta'Cop Nedd4 ortho G G G G G G G G G beta'Cop Vha36-1 ortho G G G G G G G G G G beta'Cop CG7033, SD02216p ortho G G G G G G G G G G beta'Cop Pkc98E ortho G G G G G G G G G beta'Cop nup44A ortho G G G G G G G G G G beta'Cop blw ortho G G G G G G G G G G beta'Cop Act5C ortho G G G G G G G G G G beta'Cop Tip60 ortho G G G G G G G G G beta'Cop emb ortho G G G G G G G G G G Rpt6 beta'Cop ortho G G G G G G G G G G alc-RA beta'Cop ortho beta'Cop Hsc70-5 ortho G G G G G G G G G G beta'Cop Cullin 3, isoform F, FI19425p1 ortho G G G G G G G G G G beta'Cop Arpc3A-RC ortho G G G beta'Cop Ubiquitin-like modifier-activating enzyme 5, Ubiquitin-activating enzyme 5 ortho G G G G G G G G G G beta'Cop Sac1 ortho G G G G G G G G G G beta'Cop Galt ortho G G G G G G G G beta'Cop Ubi-p63E ortho G G G G G G G G G G CG17493, isoform B, CG17493, isoform C, CG17493, isoform D beta'Cop ortho G G G G G G G G G G beta'Cop Updo ortho G G G G G G G G G G beta'Cop Ciao1 ortho G G G G G G G G G G Hsc70Cb, isoform G, Hsc70Cb, isoform H beta'Cop ortho G G G G G G G G G G beta'Cop ILK ortho G G G G G G G G G G beta'Cop Probable 6-phosphogluconolactonase, 6PGL ortho G G G G G G G G G G beta'Cop nero ortho G G G G G G G G G G Trip1 beta'Cop ortho G G G G G G G G G G beta'Cop Pgk ortho G G G G G G G G G G beta'Cop Taf5 ortho G G G G G G G G beta'Cop RpII140 ortho G G G G G G G G G G beta'Cop Mannose-1-phosphate guanyltransferase beta ortho G G G G G G G G G G beta'Cop RuvB-like helicase 2 ortho G G G G G G G G G G beta'Cop CG3948-PA, isoform A, Nonclathrin coat protein zeta-COP ortho G G G beta'Cop Bx42 ortho G G G G G G G G G G beta'Cop CG8184, isoform H ortho G G G G G G G G G G beta'Cop CG2720-PA, LD03220p ortho G G G G G G G G G G beta'Cop beta'Cop ortho G G G G G G G G G G beta'Cop E(z) ortho G G G G G G G beta'Cop not ortho G G G G G G G G G G Sec22 ortholog, isoform B beta'Cop ortho G G G G G G G G G G beta'Cop EG:65F1.1 ortho G G G G G G G G G beta'Cop betaTub56D ortho G G G G G G G G G G Acetyl-CoA carboxylase, isoform A beta'Cop ortho G G G G G G G G G G beta'Cop Upf1 ortho G G G G G G G G G G beta'Cop epsilonCOP ortho G G G G G G G G G G beta'Cop T-complex protein 1 subunit delta ortho G G G G G G G G G G beta'Cop r ortho G G beta'Cop l(1)G0022 ortho G G G G G G G G G G beta'Cop RnrS ortho G G G G G G G beta'Cop BcDNA.GH02220 ortho G G G G G G G G G G beta'Cop CG3756, LP03982p ortho G G G G G G G G G G beta'Cop CG5790-RA ortho G beta'Cop hay ortho G G G G G G G G G beta'Cop me31B ortho G G G G G G G G G G beta'Cop CG6439, isoform A, CG6439, isoform B, GH26270p ortho G G G G G G G G G G beta'Cop 26S proteasome regulatory complex subunit p50, GH12068p, Regulatory particle triple-A ATPase 5 ortho G G G G G G G G G G beta'Cop Ergic53, isoform A, Ergic53, isoform B, LD43551p, Rhea ortho G G G G G G G G G G beta'Cop l(1)G0156 ortho G G G G G G G G G G beta'Cop Sirt7 ortho G G G G G beta'Cop Drp1-RA ortho G G G G G G G G G G beta'Cop 14-3-3epsilon ortho G G G G G G G G G G beta'Cop Adenylyl cyclase-associated protein ortho G G G G G G G G G G beta'Cop Slh ortho G G G G G G G G G G beta'Cop RINT1-like protein, DmRINT-1 ortho G G G G G G G G G G beta'Cop Ef1beta ortho G G G G G G G G G G beta'Cop CG8336, isoform A, CG8336, isoform B, CG8336, isoform C, CG8336, isoform D, GH06403p ortho G G G G G G G G G G beta'Cop Rpn10 ortho G G G G G G G G G G beta'Cop PICK1 ortholog, isoform E ortho G G G G beta'Cop CG11089-RA ortho beta'Cop CG9510, isoform C, CG9510, isoform D, CG9510-PB, isoform B ortho beta'Cop CG4849, LD28793p ortho G G G G G G G G G G beta'Cop Inos ortho G G G G G G G G G G beta'Cop HERC2 ortho G G G G G G G G G G beta'Cop Vha55 ortho G G G G G G G G G G beta'Cop Pglym87 ortho G beta'Cop Serine/threonine-protein kinase RIO1 ortho G beta'Cop TER94 ortho G G G G G G G G G G Sec23 beta'Cop ortho G G G G G G G G G G beta'Cop RNA 3'-terminal phosphate cyclase, RNA cyclase, RNA-3'-phosphate cyclase ortho G G G G l(2)03709 beta'Cop ortho G G G G G G G G G G beta'Cop TH1 ortho G G G G G G G G G G beta'Cop Snap ortho G G G G G G G G beta'Cop CG10347, isoform A, CG10347, isoform B, LD06533p ortho G G G G G G G G G G beta'Cop CG8258, LD24495p ortho G G G G G G G G G G beta'Cop CG4196-RB ortho G G G G G G G G G G beta'Cop Sce ortho G G G G G G G beta'Cop l(2)tid ortho G G G G G G G G G G beta'Cop Cell division cycle 5 ortholog, isoform A, Cell division cycle 5 ortholog, isoform B, LD21614p ortho G G G G G G G beta'Cop 26S proteasome regulatory complex subunit p97, Regulatory particle non-ATPase 1 ortho G G G G G G G G G G beta'Cop Rpn11 ortho G G G G G G G G G G beta'Cop delta-COP ortho G G G G G G G G G G beta'Cop T-cp1 ortho G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O62621 Q9VK23 - 14605208 - X 2 O62621 Q9VK23 two hybrid 14605208 direct interaction X 2 Q9W0B8 O62621 affinity chromatography technology 22036573 physical association X 2 O62621 Q7K4L8 affinity chromatography technology 22036573 physical association X 2 O62621 Q9VK23 two hybrid 14605208 physical association X 2 O62621 Q9VK23 two hybrid 14605208 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B beta'Cop alphaCop MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_66741 bait prey beta'Cop CG15482-RA MI:0018(two hybrid)|MI:0398(two hybrid pooling approach)|MI:0018(two hybrid)|MI:0018(two hybrid) 14605208 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0465(dip)|MI:0471(mint)|(intact)|(biogrid) DIP_16263|MINT_8566|UniProt_60216|BIOGRID_41085 -|prey|prey|prey -|bait|bait|bait beta'Cop CG7878 MI:0004(affinity chromatography technology) 22036573 taxid:7227(Drosophila melanogaster) taxid:7227(Drosophila melanogaster) MI:0915(physical association) (biogrid) BIOGRID_74401 bait prey